Btn2a2 (butyrophilin, subfamily 2, member A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Btn2a2 (butyrophilin, subfamily 2, member A2) Mus musculus
Analyze
Symbol: Btn2a2
Name: butyrophilin, subfamily 2, member A2
RGD ID: 1618951
MGI Page MGI
Description: Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; and positive regulation of regulatory T cell differentiation. Located in cell surface. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Btn2; butyrophilin 2; butyrophilin subfamily 2 member A2; D030063K05
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,661,219 - 23,673,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)EnsemblGRCm39 Ensembl
GRCm381323,477,049 - 23,488,858 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,568,932 - 23,580,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,485,141 - 23,496,305 (-)NCBIMGSCv36mm8
Celera1323,709,187 - 23,720,981 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20208008  
PMID:21267068   PMID:21873635   PMID:23589618   PMID:26809444   PMID:34421818   PMID:35145516   PMID:37356345  


Genomics

Comparative Map Data
Btn2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,661,219 - 23,673,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)EnsemblGRCm39 Ensembl
GRCm381323,477,049 - 23,488,858 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,568,932 - 23,580,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,485,141 - 23,496,305 (-)NCBIMGSCv36mm8
Celera1323,709,187 - 23,720,981 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.74NCBI
BTN2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,383,108 - 26,394,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,383,096 - 26,394,874 (+)EnsemblGRCh38hg38GRCh38
GRCh37626,383,336 - 26,395,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,491,333 - 26,503,081 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,491,332 - 26,503,077NCBI
Celera627,612,635 - 27,624,383 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,326,135 - 26,337,913 (+)NCBIHuRef
CHM1_1626,385,400 - 26,397,172 (+)NCBICHM1_1
T2T-CHM13v2.0626,250,301 - 26,263,238 (+)NCBIT2T-CHM13v2.0
Btn2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81742,048,842 - 42,060,650 (+)NCBIGRCr8
mRatBN7.21741,620,807 - 41,632,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,620,839 - 41,632,618 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01743,867,243 - 43,878,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,868,191 - 43,879,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,723,229 - 45,734,752 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,823,679 - 48,834,495 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11748,826,519 - 48,836,663 (+)NCBI
Celera1741,251,502 - 41,263,101 (+)NCBICelera
Cytogenetic Map17p11NCBI
LOC100975566
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2541,026,183 - 41,038,883 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1637,027,645 - 37,041,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0626,215,215 - 26,227,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,873,828 - 26,893,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,873,828 - 26,885,592 (+)Ensemblpanpan1.1panPan2
LOC100855640
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,251,221 - 24,265,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3524,251,799 - 24,262,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3524,108,311 - 24,120,397 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,434,951 - 24,447,038 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,435,256 - 24,446,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13524,216,064 - 24,228,151 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03524,267,686 - 24,279,773 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,732,493 - 25,744,588 (+)NCBIUU_Cfam_GSD_1.0
BTN2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,954,173 - 20,967,794 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1720,954,229 - 20,968,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2722,275,471 - 22,290,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTN2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11745,857,898 - 45,869,901 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1745,744,451 - 45,868,941 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604426,323,318 - 26,335,197 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Btn2a2
431 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1043
Count of miRNA genes:372
Interacting mature miRNAs:412
Transcripts:ENSMUST00000041541, ENSMUST00000110432, ENSMUST00000110433
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041541   ⟹   ENSMUSP00000048251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,661,846 - 23,673,010 (-)Ensembl
GRCm38.p6 Ensembl1323,477,676 - 23,488,840 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110432   ⟹   ENSMUSP00000106062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,662,058 - 23,673,017 (-)Ensembl
GRCm38.p6 Ensembl1323,477,888 - 23,488,847 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110433   ⟹   ENSMUSP00000106063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)Ensembl
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223877   ⟹   ENSMUSP00000153680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,662,053 - 23,673,000 (-)Ensembl
GRCm38.p6 Ensembl1323,477,883 - 23,488,830 (-)Ensembl
RefSeq Acc Id: NM_001289614   ⟹   NP_001276543
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
Celera1323,709,187 - 23,720,981 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289615   ⟹   NP_001276544
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
Celera1323,709,187 - 23,720,981 (-)NCBI
Sequence:
RefSeq Acc Id: NM_175938   ⟹   NP_787952
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
MGSCv371323,568,932 - 23,580,726 (-)RGD
Celera1323,709,187 - 23,720,981 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516664   ⟹   XP_006516727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,673,028 (-)NCBI
GRCm381323,477,049 - 23,488,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315508   ⟹   XP_017170997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,666,203 - 23,673,027 (-)NCBI
GRCm381323,482,033 - 23,488,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158037   ⟹   XP_036013930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,670,388 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001780781
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,673,027 (-)NCBI
GRCm381323,477,049 - 23,488,857 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_787952   ⟸   NM_175938
- Peptide Label: isoform 1 precursor
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516727   ⟸   XM_006516664
- Peptide Label: isoform X1
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276544   ⟸   NM_001289615
- Peptide Label: isoform 1 precursor
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276543   ⟸   NM_001289614
- Peptide Label: isoform 2 precursor
- UniProtKB: B9EJ60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017170997   ⟸   XM_017315508
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000153680   ⟸   ENSMUST00000223877
RefSeq Acc Id: ENSMUSP00000106062   ⟸   ENSMUST00000110432
RefSeq Acc Id: ENSMUSP00000106063   ⟸   ENSMUST00000110433
RefSeq Acc Id: ENSMUSP00000048251   ⟸   ENSMUST00000041541
RefSeq Acc Id: XP_036013930   ⟸   XM_036158037
- Peptide Label: isoform X2
Protein Domains
B30.2/SPRY   Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4QPC6-F1-model_v2 AlphaFold A4QPC6 1-514 view protein structure

Promoters
RGD ID:8679784
Promoter ID:EPDNEW_M17923
Type:single initiation site
Name:Btn2a2_1
Description:Mus musculus butyrophilin, subfamily 2, member A2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381323,488,829 - 23,488,889EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3606486 AgrOrtholog
Ensembl Genes ENSMUSG00000053216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041541.11 UniProtKB/TrEMBL
  ENSMUST00000110432 ENTREZGENE
  ENSMUST00000110432.2 UniProtKB/Swiss-Prot
  ENSMUST00000110433 ENTREZGENE
  ENSMUST00000110433.10 UniProtKB/Swiss-Prot
  ENSMUST00000223877 ENTREZGENE
  ENSMUST00000223877.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY/PRY_BTN1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:238555 UniProtKB/Swiss-Prot
MGD MGI:3606486 ENTREZGENE
NCBI Gene 238555 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BUTYROPHILIN SUBFAMILY 2 MEMBER A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Btn2a2 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4QPC6 ENTREZGENE
  B9EJ60 ENTREZGENE, UniProtKB/TrEMBL
  BT2A2_MOUSE UniProtKB/Swiss-Prot
  I7HIQ7_MOUSE UniProtKB/TrEMBL
  Q811T8 ENTREZGENE
UniProt Secondary Q811T8 UniProtKB/Swiss-Prot