Btn2a2 (butyrophilin, subfamily 2, member A2) - Rat Genome Database

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Gene: Btn2a2 (butyrophilin, subfamily 2, member A2) Mus musculus
Analyze
Symbol: Btn2a2
Name: butyrophilin, subfamily 2, member A2
RGD ID: 1618951
MGI Page MGI
Description: Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; and positive regulation of regulatory T cell differentiation. Located in cell surface. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Btn2; butyrophilin 2; butyrophilin subfamily 2 member A2; D030063K05
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,661,219 - 23,673,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)EnsemblGRCm39 Ensembl
GRCm381323,477,049 - 23,488,858 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,568,932 - 23,580,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,485,141 - 23,496,305 (-)NCBIMGSCv36mm8
Celera1323,709,187 - 23,720,981 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20208008  
PMID:21267068   PMID:21873635   PMID:23589618   PMID:26809444   PMID:34421818   PMID:35145516   PMID:37196079   PMID:37356345   PMID:38355793  


Genomics

Comparative Map Data
Btn2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,661,219 - 23,673,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)EnsemblGRCm39 Ensembl
GRCm381323,477,049 - 23,488,858 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,568,932 - 23,580,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,485,141 - 23,496,305 (-)NCBIMGSCv36mm8
Celera1323,709,187 - 23,720,981 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.74NCBI
BTN2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,383,108 - 26,394,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,383,096 - 26,394,874 (+)EnsemblGRCh38hg38GRCh38
GRCh37626,383,336 - 26,395,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,491,333 - 26,503,081 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,491,332 - 26,503,077NCBI
Celera627,612,635 - 27,624,383 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,326,135 - 26,337,913 (+)NCBIHuRef
CHM1_1626,385,400 - 26,397,172 (+)NCBICHM1_1
T2T-CHM13v2.0626,250,301 - 26,263,238 (+)NCBIT2T-CHM13v2.0
Btn2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81742,048,842 - 42,060,650 (+)NCBIGRCr8
mRatBN7.21741,620,807 - 41,632,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,620,839 - 41,632,618 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01743,867,243 - 43,878,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,868,191 - 43,879,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,723,229 - 45,734,752 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,823,679 - 48,834,495 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11748,826,519 - 48,836,663 (+)NCBI
Celera1741,251,502 - 41,263,101 (+)NCBICelera
Cytogenetic Map17p11NCBI
LOC100975566
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2541,026,183 - 41,038,883 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1637,027,645 - 37,041,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0626,215,215 - 26,227,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,873,828 - 26,893,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,873,828 - 26,885,592 (+)Ensemblpanpan1.1panPan2
LOC100855640
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,251,221 - 24,265,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3524,251,799 - 24,262,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3524,108,311 - 24,120,397 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,434,951 - 24,447,038 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,435,256 - 24,446,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13524,216,064 - 24,228,151 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03524,267,686 - 24,279,773 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,732,493 - 25,744,588 (+)NCBIUU_Cfam_GSD_1.0
BTN2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,954,173 - 20,967,794 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1720,954,229 - 20,968,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2722,275,471 - 22,290,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTN2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11745,857,898 - 45,869,901 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1745,744,451 - 45,868,941 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604426,323,318 - 26,335,197 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Btn2a2
431 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1043
Count of miRNA genes:372
Interacting mature miRNAs:412
Transcripts:ENSMUST00000041541, ENSMUST00000110432, ENSMUST00000110433
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000041541   ⟹   ENSMUSP00000048251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,661,846 - 23,673,010 (-)Ensembl
GRCm38.p6 Ensembl1323,477,676 - 23,488,840 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110432   ⟹   ENSMUSP00000106062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,662,058 - 23,673,017 (-)Ensembl
GRCm38.p6 Ensembl1323,477,888 - 23,488,847 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110433   ⟹   ENSMUSP00000106063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,661,846 - 23,673,027 (-)Ensembl
GRCm38.p6 Ensembl1323,477,676 - 23,488,857 (-)Ensembl
Ensembl Acc Id: ENSMUST00000223877   ⟹   ENSMUSP00000153680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,662,053 - 23,673,000 (-)Ensembl
GRCm38.p6 Ensembl1323,477,883 - 23,488,830 (-)Ensembl
RefSeq Acc Id: NM_001289614   ⟹   NP_001276543
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
Celera1323,709,187 - 23,720,981 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289615   ⟹   NP_001276544
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
Celera1323,709,187 - 23,720,981 (-)NCBI
Sequence:
RefSeq Acc Id: NM_175938   ⟹   NP_787952
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,233 - 23,673,027 (-)NCBI
GRCm381323,477,063 - 23,488,857 (-)NCBI
MGSCv371323,568,932 - 23,580,726 (-)RGD
Celera1323,709,187 - 23,720,981 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516664   ⟹   XP_006516727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,673,028 (-)NCBI
GRCm381323,477,049 - 23,488,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315508   ⟹   XP_017170997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,666,203 - 23,673,027 (-)NCBI
GRCm381323,482,033 - 23,488,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158037   ⟹   XP_036013930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,670,388 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001780781
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,661,219 - 23,673,027 (-)NCBI
GRCm381323,477,049 - 23,488,857 (-)NCBI
Sequence:
RefSeq Acc Id: NP_787952   ⟸   NM_175938
- Peptide Label: isoform 1 precursor
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516727   ⟸   XM_006516664
- Peptide Label: isoform X1
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276544   ⟸   NM_001289615
- Peptide Label: isoform 1 precursor
- UniProtKB: Q811T8 (UniProtKB/Swiss-Prot),   A4QPC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276543   ⟸   NM_001289614
- Peptide Label: isoform 2 precursor
- UniProtKB: B9EJ60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017170997   ⟸   XM_017315508
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000153680   ⟸   ENSMUST00000223877
Ensembl Acc Id: ENSMUSP00000106062   ⟸   ENSMUST00000110432
Ensembl Acc Id: ENSMUSP00000106063   ⟸   ENSMUST00000110433
Ensembl Acc Id: ENSMUSP00000048251   ⟸   ENSMUST00000041541
RefSeq Acc Id: XP_036013930   ⟸   XM_036158037
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4QPC6-F1-model_v2 AlphaFold A4QPC6 1-514 view protein structure

Promoters
RGD ID:8679784
Promoter ID:EPDNEW_M17923
Type:single initiation site
Name:Btn2a2_1
Description:Mus musculus butyrophilin, subfamily 2, member A2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381323,488,829 - 23,488,889EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3606486 AgrOrtholog
Ensembl Genes ENSMUSG00000053216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041541.11 UniProtKB/TrEMBL
  ENSMUST00000110432 ENTREZGENE
  ENSMUST00000110432.2 UniProtKB/Swiss-Prot
  ENSMUST00000110433 ENTREZGENE
  ENSMUST00000110433.10 UniProtKB/Swiss-Prot
  ENSMUST00000223877 ENTREZGENE
  ENSMUST00000223877.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTN3A2-like_Ig-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgSF_BTN/MOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY/PRY_BTN1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:238555 UniProtKB/Swiss-Prot
MGD MGI:3606486 ENTREZGENE
NCBI Gene 238555 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BUTYROPHILIN SUBFAMILY 2 MEMBER A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C2-set_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Btn2a2 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4QPC6 ENTREZGENE
  B9EJ60 ENTREZGENE, UniProtKB/TrEMBL
  BT2A2_MOUSE UniProtKB/Swiss-Prot
  I7HIQ7_MOUSE UniProtKB/TrEMBL
  Q811T8 ENTREZGENE
UniProt Secondary Q811T8 UniProtKB/Swiss-Prot