C2cd4c (C2 calcium-dependent domain containing 4C) - Rat Genome Database

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Gene: C2cd4c (C2 calcium-dependent domain containing 4C) Mus musculus
Analyze
Symbol: C2cd4c
Name: C2 calcium-dependent domain containing 4C
RGD ID: 1618134
MGI Page MGI
Description: Is active in cytosol. Is expressed in several structures, including pancreas. Orthologous to human C2CD4C (C2 calcium dependent domain containing 4C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4932409I22Rik; C2 calcium-dependent domain-containing protein 4C; C2cd4cC2CD4 family; Fam148; Fam148c; family with sequence similarity 148, member C; Gm238; MGC86088; nuclear-localized factor 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,442,688 - 79,449,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,442,688 - 79,449,859 (-)EnsemblGRCm39 Ensembl
GRCm381079,606,854 - 79,614,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,606,854 - 79,614,025 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,069,599 - 79,076,770 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,009,983 - 79,017,129 (-)NCBIMGSCv36mm8
Celera1080,620,220 - 80,627,391 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:27349930   PMID:38187761  


Genomics

Comparative Map Data
C2cd4c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,442,688 - 79,449,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,442,688 - 79,449,859 (-)EnsemblGRCm39 Ensembl
GRCm381079,606,854 - 79,614,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,606,854 - 79,614,025 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,069,599 - 79,076,770 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,009,983 - 79,017,129 (-)NCBIMGSCv36mm8
Celera1080,620,220 - 80,627,391 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
C2CD4C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819405,445 - 409,147 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19405,445 - 409,147 (-)EnsemblGRCh38hg38GRCh38
GRCh3719405,445 - 409,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619356,443 - 364,234 (-)NCBINCBI36Build 36hg18NCBI36
Celera19405,821 - 409,548 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19174,453 - 177,414 (-)NCBIHuRef
CHM1_119403,286 - 407,013 (-)NCBICHM1_1
T2T-CHM13v2.019353,898 - 357,600 (-)NCBIT2T-CHM13v2.0
C2cd4c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,742,534 - 10,746,033 (+)NCBIGRCr8
mRatBN7.2710,090,651 - 10,095,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,092,138 - 10,095,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,973,299 - 12,975,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,851,385 - 14,853,543 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,711,194 - 12,713,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,973,338 - 12,978,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,974,169 - 12,976,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,142,884 - 13,146,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,608,670 - 11,610,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera78,264,486 - 8,266,647 (+)NCBICelera
Cytogenetic Map7q11NCBI
C2cd4c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,236,627 - 7,243,099 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,236,627 - 7,243,099 (+)NCBIChiLan1.0ChiLan1.0
C2CD4C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,712,133 - 4,716,777 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,956,193 - 3,960,811 (-)NCBINHGRI_mPanPan1
PanPan1.119356,073 - 359,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19357,716 - 358,981 (-)Ensemblpanpan1.1panPan2
C2CD4C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12058,027,422 - 58,029,144 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2058,027,399 - 58,029,105 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,830,231 - 57,831,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,770,492 - 58,772,163 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12057,824,381 - 57,826,052 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,304,278 - 58,305,949 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,507,742 - 58,509,413 (+)NCBIUU_Cfam_GSD_1.0
C2cd4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,749,706 - 217,752,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493658883,703 - 84,971 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493658882,455 - 85,000 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C2CD4C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,849,526 - 77,850,788 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,847,876 - 77,852,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C2CD4C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16141,694 - 149,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6143,327 - 144,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,977,667 - 8,981,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C2cd4c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,999,273 - 8,002,683 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,999,179 - 8,002,462 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4198
Count of miRNA genes:804
Interacting mature miRNAs:1052
Transcripts:ENSMUST00000059699, ENSMUST00000178228
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000059699   ⟹   ENSMUSP00000059433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,442,688 - 79,449,834 (-)Ensembl
GRCm38.p6 Ensembl1079,606,854 - 79,614,000 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178228   ⟹   ENSMUSP00000136013
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,446,548 - 79,449,859 (-)Ensembl
GRCm38.p6 Ensembl1079,610,714 - 79,614,025 (-)Ensembl
RefSeq Acc Id: NM_001168624   ⟹   NP_001162095
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,442,688 - 79,449,859 (-)NCBI
GRCm381079,606,854 - 79,614,025 (-)ENTREZGENE
MGSCv371079,069,599 - 79,076,770 (-)RGD
Celera1080,620,220 - 80,627,391 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_198614   ⟹   NP_941016
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,442,688 - 79,449,852 (-)NCBI
GRCm381079,606,854 - 79,614,018 (-)NCBI
MGSCv371079,069,599 - 79,076,770 (-)RGD
Celera1080,620,220 - 80,627,391 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001162095 (Get FASTA)   NCBI Sequence Viewer  
  NP_941016 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89008 (Get FASTA)   NCBI Sequence Viewer  
  BAC26694 (Get FASTA)   NCBI Sequence Viewer  
  EDL31686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000059433
  ENSMUSP00000059433.8
  ENSMUSP00000136013
  ENSMUSP00000136013.2
GenBank Protein Q5HZI2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_941016   ⟸   NM_198614
- UniProtKB: Q8CDK0 (UniProtKB/Swiss-Prot),   Q5HZI2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001162095   ⟸   NM_001168624
- UniProtKB: Q8CDK0 (UniProtKB/Swiss-Prot),   Q5HZI2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136013   ⟸   ENSMUST00000178228
RefSeq Acc Id: ENSMUSP00000059433   ⟸   ENSMUST00000059699
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5HZI2-F1-model_v2 AlphaFold Q5HZI2 1-419 view protein structure

Promoters
RGD ID:6819068
Promoter ID:MM_KWN:4767
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001168624,   NM_198614
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,076,586 - 79,077,086 (-)MPROMDB
RGD ID:8672518
Promoter ID:EPDNEW_M14290
Type:initiation region
Name:C2cd4c_1
Description:Mus musculus C2 calcium-dependent domain containing 4C , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,613,970 - 79,614,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685084 AgrOrtholog
Ensembl Genes ENSMUSG00000045912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059699 ENTREZGENE
  ENSMUST00000059699.9 UniProtKB/Swiss-Prot
  ENSMUST00000178228 ENTREZGENE
  ENSMUST00000178228.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  C2C4C/C2C4D UniProtKB/Swiss-Prot
KEGG Report mmu:237397 UniProtKB/Swiss-Prot
MGD MGI:2685084 ENTREZGENE
NCBI Gene 237397 ENTREZGENE
PANTHER PTHR46291 UniProtKB/Swiss-Prot
  PTHR46291:SF5 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
PhenoGen C2cd4c PhenoGen
PROSITE PS50004 UniProtKB/Swiss-Prot
SMART SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
UniProt C2C4C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CDK0 ENTREZGENE
UniProt Secondary Q8CDK0 UniProtKB/Swiss-Prot