Zfp72 (zinc finger protein 72) - Rat Genome Database

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Gene: Zfp72 (zinc finger protein 72) Mus musculus
Analyze
Symbol: Zfp72
Name: zinc finger protein 72
RGD ID: 1617337
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Zfp7; Zfp74; zinc finger protein 74
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,517,443 - 74,538,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,517,445 - 74,538,955 (-)EnsemblGRCm39 Ensembl
GRCm381374,369,321 - 74,390,861 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,369,326 - 74,390,836 (-)EnsemblGRCm38mm10GRCm38
MGSCv371374,508,874 - 74,514,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,837,129 - 74,842,589 (-)NCBIMGSCv36mm8
Celera1376,701,634 - 76,706,773 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp72Mousepleomorphic xanthoastrocytoma  ISORGD:16262578554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp72Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ZFP72 mRNACTDPMID:36331819
Zfp72Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of ZFP72 mRNACTDPMID:22206623
Zfp72Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ZFP72 mRNACTDPMID:21570461
Zfp72Mousebenzo[a]pyrene decreases methylationISORGD:16262576480464Benzo(a)pyrene results in decreased methylation of ZNF735 exonCTDPMID:27901495
Zfp72Mouseepoxiconazole increases expressionEXP 6480464epoxiconazole results in increased expression of ZFP72 mRNACTDPMID:35436446
Zfp72Mouseperfluorooctane-1-sulfonic acid multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ZFP72 mRNACTDPMID:36331819
Zfp72Mousepotassium dichromate decreases expressionEXP 6480464Potassium Dichromate results in decreased expression of ZFP72 mRNACTDPMID:23608068
Zfp72Mousesodium arsenite decreases expressionISORGD:16262576480464sodium arsenite results in decreased expression of ZNF735 mRNACTDPMID:25879800


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp72Mouseregulation of transcription by RNA polymerase II involved_inIBAPANTHER:PTN002354498|FB:FBgn0004618|UniProtKB:O95201|UniProtKB:P17028|MGI:2442943|FB:FBgn0020309|UniProtKB:O95125|MGI:99159|FB:FBgn0267337|UniProtKB:Q16600|UniProtKB:Q15697|FB:FBgn0004880|UniProtKB:Q9BRR0|UniProtKB:Q9Y5A6|MGI:1338823|MGI:2685243|UniProtKB:O149782290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp72Mousenucleus located_inISOUniProtKB:Q8TBZ52290270 GO_CentralGO_REF:0000119

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp72MouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN002354498|MGI:1338823|FB:FBgn0267337|UniProtKB:Q16600|UniProtKB:O14978|UniProtKB:Q9BRR0|FB:FBgn0004618|UniProtKB:P17028|MGI:2442943|UniProtKB:O95125|MGI:99159|UniProtKB:Q9Y5A62290270 GO_CentralGO_REF:0000033
Zfp72MouseRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAPANTHER:PTN002354498|MGI:1338823|UniProtKB:Q16600|MGI:2442943|UniProtKB:Q9BRR0|UniProtKB:O95125|UniProtKB:Q9Y5A62290270 GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:2542606   PMID:7479878   PMID:8662221   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15329828   PMID:16141072   PMID:16141073  
PMID:21267068   PMID:21873635  



Zfp72
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,517,443 - 74,538,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,517,445 - 74,538,955 (-)EnsemblGRCm39 Ensembl
GRCm381374,369,321 - 74,390,861 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,369,326 - 74,390,836 (-)EnsemblGRCm38mm10GRCm38
MGSCv371374,508,874 - 74,514,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,837,129 - 74,842,589 (-)NCBIMGSCv36mm8
Celera1376,701,634 - 76,706,773 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.23NCBI
ZNF735
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38764,207,203 - 64,220,290 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl764,207,203 - 64,220,290 (+)EnsemblGRCh38hg38GRCh38
GRCh37763,667,581 - 63,680,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36763,305,016 - 63,318,103 (+)NCBINCBI36Build 36hg18NCBI36
Celera757,386,676 - 57,400,338 (+)NCBICelera
Cytogenetic Map7q11.21NCBI
HuRef760,048,400 - 60,061,454 (+)NCBIHuRef
CHM1_1763,762,589 - 63,775,655 (+)NCBICHM1_1
T2T-CHM13v2.0765,415,091 - 65,428,182 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2763,005,175 - 63,018,262 (+)NCBI
LOC100979926
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2680,087,970 - 80,129,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17128,415,119 - 128,458,927 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0761,249,071 - 61,290,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1764,567,357 - 64,577,104 (-)NCBIpanpan1.1PanPan1.1panPan2

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Variants in Zfp72
809 total Variants

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSMUST00000091481
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse

1 to 10 of 27 rows
RH136109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381374,440,576 - 74,440,775UniSTSGRCm38
GRCm386124,935,729 - 124,935,928UniSTSGRCm38
MGSCv371374,578,024 - 74,578,223UniSTSGRCm37
MGSCv376124,885,747 - 124,885,946UniSTSGRCm37
Celera1376,770,879 - 76,771,078UniSTS
Celera6126,612,073 - 126,612,272UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map6F2UniSTS
RH136519  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381374,440,643 - 74,440,847UniSTSGRCm38
GRCm386124,935,796 - 124,936,000UniSTSGRCm38
MGSCv371374,578,091 - 74,578,295UniSTSGRCm37
MGSCv376124,885,814 - 124,886,018UniSTSGRCm37
Celera1376,770,946 - 76,771,150UniSTS
Celera6126,612,140 - 126,612,344UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map6F2UniSTS
RH126138  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381374,440,750 - 74,440,974UniSTSGRCm38
GRCm386124,935,903 - 124,936,127UniSTSGRCm38
MGSCv371374,578,198 - 74,578,422UniSTSGRCm37
MGSCv376124,885,921 - 124,886,145UniSTSGRCm37
Celera1376,771,053 - 76,771,277UniSTS
Celera6126,612,247 - 126,612,471UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map6F2UniSTS







Ensembl Acc Id: ENSMUST00000091481   ⟹   ENSMUSP00000089063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1374,519,545 - 74,524,685 (-)Ensembl
GRCm38.p6 Ensembl1374,371,426 - 74,376,566 (-)Ensembl
Ensembl Acc Id: ENSMUST00000223163   ⟹   ENSMUSP00000152502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1374,517,445 - 74,538,955 (-)Ensembl
GRCm38.p6 Ensembl1374,369,326 - 74,390,836 (-)Ensembl
RefSeq Acc Id: NM_001374038   ⟹   NP_001360967
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391374,517,443 - 74,538,948 (-)NCBI
GRCm381374,369,324 - 74,390,829 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001426443   ⟹   NP_001413372
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391374,517,443 - 74,538,948 (-)NCBI
RefSeq Acc Id: NM_001426445   ⟹   NP_001413374
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391374,517,443 - 74,538,948 (-)NCBI
RefSeq Acc Id: NM_001426446   ⟹   NP_001413375
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391374,517,443 - 74,538,948 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001360967 (Get FASTA)   NCBI Sequence Viewer  
  NP_001413372 (Get FASTA)   NCBI Sequence Viewer  
  NP_001413374 (Get FASTA)   NCBI Sequence Viewer  
  NP_001413375 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52303 (Get FASTA)   NCBI Sequence Viewer  
  AAI18037 (Get FASTA)   NCBI Sequence Viewer  
  AAI18047 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000089063.3
  ENSMUSP00000152502
  ENSMUSP00000152502.3
1 to 10 of 10 rows
RefSeq Acc Id: NP_001360967   ⟸   NM_001374038
- Peptide Label: isoform 1
Ensembl Acc Id: ENSMUSP00000089063   ⟸   ENSMUST00000091481
Ensembl Acc Id: ENSMUSP00000152502   ⟸   ENSMUST00000223163
RefSeq Acc Id: NP_001413372   ⟸   NM_001426443
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001413375   ⟸   NM_001426446
- Peptide Label: isoform 4
- UniProtKB: A0A1Y7VM41 (UniProtKB/TrEMBL),   Q0VFY0 (UniProtKB/TrEMBL)
C2H2-type   KRAB

Name Modeler Protein Id AA Range Protein Structure
AF-Q0VFY0-F1-model_v2 AlphaFold Q0VFY0 1-435 view protein structure



1 to 31 of 31 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000069184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091481.3 UniProtKB/TrEMBL
  ENSMUST00000223163 ENTREZGENE
  ENSMUST00000223163.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Zinc_finger UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
MGD MGI:3033356 ENTREZGENE
NCBI Gene 238722 ENTREZGENE
PANTHER C2H2-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 143 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp72 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A1Y7VM41 ENTREZGENE
  Q0VFY0 ENTREZGENE, UniProtKB/TrEMBL
  Q60916_MOUSE UniProtKB/TrEMBL
UniProt Secondary A0A1Y7VM41 UniProtKB/TrEMBL
1 to 31 of 31 rows