Morc2b (microrchidia 2B) - Rat Genome Database

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Gene: Morc2b (microrchidia 2B) Mus musculus
Analyze
No known orthologs.
Symbol: Morc2b
Name: microrchidia 2B
RGD ID: 1617325
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Located in nucleus. Is expressed in germ cell of testis; ovary; spermatid; spermatocyte; and testis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4932411A10Rik; ATPase MORC2B; MORC family CW-type zinc finger protein 2B; Morc-like protein; Tce6
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,354,562 - 33,369,473 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,332,325 - 33,358,657 (-)EnsemblGRCm39 Ensembl
GRCm381733,135,588 - 33,150,499 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,113,351 - 33,139,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,272,535 - 33,276,628 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361732,872,400 - 32,876,675 (-)NCBIMGSCv36mm8
Celera1734,041,539 - 34,045,632 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
heterochromatin  (ISO)
nuclear matrix  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IMP,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15112104   PMID:16141072   PMID:16141073   PMID:16292313   PMID:21267068   PMID:21873635  
PMID:29329290   PMID:37196079  


Genomics

Variants

.
Variants in Morc2b
286 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:160
Interacting mature miRNAs:170
Transcripts:ENSMUST00000053896, ENSMUST00000131954
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
11038694Pas19_mpulmonary adenoma susceptibility 19 (mouse)172971116434754437Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173266042635520036Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000053896   ⟹   ENSMUSP00000056879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1733,354,562 - 33,358,657 (-)Ensembl
GRCm38.p6 Ensembl1733,135,588 - 33,139,683 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131954   ⟹   ENSMUSP00000123354
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1733,354,617 - 33,358,473 (-)Ensembl
GRCm38.p6 Ensembl1733,135,643 - 33,139,499 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1733,332,325 - 33,358,606 (-)Ensembl
GRCm38.p6 Ensembl1733,113,351 - 33,139,632 (-)Ensembl
RefSeq Acc Id: NM_001360203   ⟹   NP_001347132
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,564 - 33,367,723 (-)NCBI
GRCm381733,135,590 - 33,148,749 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177719   ⟹   NP_808387
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,564 - 33,358,657 (-)NCBI
GRCm381733,135,590 - 33,139,683 (-)NCBI
MGSCv371733,272,535 - 33,276,628 (-)RGD
Celera1734,041,539 - 34,045,632 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524257   ⟹   XP_006524320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,359,025 (-)NCBI
GRCm381733,135,588 - 33,140,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006524258   ⟹   XP_006524321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,359,025 (-)NCBI
GRCm381733,135,588 - 33,140,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246444   ⟹   XP_011244746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,369,473 (-)NCBI
GRCm381733,135,588 - 33,150,499 (-)NCBI
Sequence:
RefSeq Acc Id: NP_808387   ⟸   NM_177719
- UniProtKB: B8JK02 (UniProtKB/Swiss-Prot),   Q8CG24 (UniProtKB/Swiss-Prot),   Q8C5W4 (UniProtKB/Swiss-Prot),   Q0VAW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524321   ⟸   XM_006524258
- Peptide Label: isoform X1
- UniProtKB: B8JK02 (UniProtKB/Swiss-Prot),   Q8CG24 (UniProtKB/Swiss-Prot),   Q8C5W4 (UniProtKB/Swiss-Prot),   Q0VAW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524320   ⟸   XM_006524257
- Peptide Label: isoform X1
- UniProtKB: B8JK02 (UniProtKB/Swiss-Prot),   Q8CG24 (UniProtKB/Swiss-Prot),   Q8C5W4 (UniProtKB/Swiss-Prot),   Q0VAW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244746   ⟸   XM_011246444
- Peptide Label: isoform X1
- UniProtKB: B8JK02 (UniProtKB/Swiss-Prot),   Q8CG24 (UniProtKB/Swiss-Prot),   Q8C5W4 (UniProtKB/Swiss-Prot),   Q0VAW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347132   ⟸   NM_001360203
- UniProtKB: Q8C5W4 (UniProtKB/Swiss-Prot),   B8JK02 (UniProtKB/Swiss-Prot),   Q8CG24 (UniProtKB/Swiss-Prot),   Q0VAW0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000056879   ⟸   ENSMUST00000053896
Ensembl Acc Id: ENSMUSP00000123354   ⟸   ENSMUST00000131954
Protein Domains
CW-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C5W4-F1-model_v2 AlphaFold Q8C5W4 1-1022 view protein structure

Promoters
RGD ID:13675558
Promoter ID:EPDNEW_M21928
Type:initiation region
Name:Morc2b_1
Description:Mus musculus microrchidia 2B , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381733,139,632 - 33,139,692EPDNEW
RGD ID:6828369
Promoter ID:MM_KWN:23087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000087649,   OTTMUST00000082308,   OTTMUST00000082309
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361733,276,446 - 33,276,946 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045293 AgrOrtholog
Ensembl Genes ENSMUSG00000048602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053896 ENTREZGENE
  ENSMUST00000053896.8 UniProtKB/Swiss-Prot
  ENSMUST00000131954.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Morc_S5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:240069 UniProtKB/Swiss-Prot
MGD MGI:3045293 ENTREZGENE
NCBI Gene 240069 ENTREZGENE
PANTHER ATPASE MORC2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Morc6_S5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Morc2b PhenoGen
PROSITE ZF_CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B8JK02 ENTREZGENE
  MOR2B_MOUSE UniProtKB/Swiss-Prot
  Q0VAW0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C5W4 ENTREZGENE
  Q8CG24 ENTREZGENE
UniProt Secondary B8JK02 UniProtKB/Swiss-Prot
  Q8CG24 UniProtKB/Swiss-Prot