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Gene: MORC2 (MORC family CW-type zinc finger 2) Homo sapiens
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Symbol: MORC2
Name: MORC family CW-type zinc finger 2
Description: Exhibits several functions, including ATP binding activity; metal ion binding activity; and protein homodimerization activity. Involved in several processes, including chromatin remodeling; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of gene expression. Localizes to cytosol; heterochromatin; and nuclear lumen. Implicated in Charcot-Marie-Tooth disease axonal type 2Z.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATPase MORC2; CMT2Z; MORC family CW-type zinc finger protein 2; ZCW3; ZCWCC1; zinc finger CW-type coiled-coil domain protein 1; zinc finger, CW type with coiled-coil domain 1; zinc finger, CW-type with coiled-coil domain 1
Orthologs:
Mus musculus (house mouse) : Morc2a (microrchidia 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Morc2 (MORC family CW-type zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Morc2 (MORC family CW-type zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MORC2 (MORC family CW-type zinc finger 2)
Canis lupus familiaris (dog) : MORC2 (MORC family CW-type zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Morc2 (MORC family CW-type zinc finger 2)
Sus scrofa (pig) : MORC2 (MORC family CW-type zinc finger 2)
Chlorocebus sabaeus (African green monkey) : MORC2 (MORC family CW-type zinc finger 2)
Heterocephalus glaber (naked mole-rat) : Morc2 (MORC family CW-type zinc finger 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,925,130 - 30,968,774 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,925,130 - 30,968,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,322,598 - 31,364,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,652,600 - 29,694,187 (-)NCBINCBI36hg18NCBI36
Build 342229,647,153 - 29,688,741NCBI
Celera2215,122,742 - 15,164,330 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,285,133 - 14,326,407 (-)NCBIHuRef
CHM1_12231,280,989 - 31,324,097 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MORC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321976
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.