MIR518E (microRNA 518e) - Rat Genome Database

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Gene: MIR518E (microRNA 518e) Homo sapiens
Analyze
Symbol: MIR518E
Name: microRNA 518e
RGD ID: 1603736
HGNC Page HGNC:32119
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-518e; MIRN518E
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,729,838 - 53,729,925 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,729,838 - 53,729,925 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,233,092 - 54,233,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,924,903 - 58,924,990 (+)NCBINCBI36Build 36hg18NCBI36
Celera1951,274,189 - 51,274,276 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,552,641 - 50,552,728 (+)NCBIHuRef
CHM1_11954,234,891 - 54,234,978 (+)NCBICHM1_1
T2T-CHM13v2.01956,809,332 - 56,809,419 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:17604727   PMID:21037258   PMID:27052995  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.42(chr19:53692245-53808292)x3 copy number gain See cases [RCV000141357] Chr19:53692245..53808292 [GRCh38]
Chr19:54195499..54311546 [GRCh37]
Chr19:58887311..59003358 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.42(chr19:53553042-53899466)x3 copy number gain See cases [RCV000052593] Chr19:53553042..53899466 [GRCh38]
Chr19:54056296..54402720 [GRCh37]
Chr19:58748108..59094532 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.42(chr19:53601298-53773028)x3 copy number gain See cases [RCV000052594] Chr19:53601298..53773028 [GRCh38]
Chr19:54104552..54276282 [GRCh37]
Chr19:58796364..58968094 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NC_000019.10:g.53536530_53981185dup duplication Silver Russell Syndrome-related disorder [RCV000785667] Chr19:53536530..53981185 [GRCh38]
Chr19:54039784..54484439 [GRCh37]
Chr19:19q13.42		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:18092
Count of gene targets:8119
Count of transcripts:14850
Interacting mature miRNAs:hsa-miR-518e-3p, hsa-miR-518e-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 2 4 3 2 28 2 12 1 4 4 21 9 2 6 3
Below cutoff 4 2 2 1 2 1 6 1 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,729,838 - 53,729,925 (+)Ensembl
RefSeq Acc Id: NR_030209
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,729,838 - 53,729,925 (+)NCBI
GRCh371954,233,092 - 54,233,179 (+)RGD
Celera1951,274,189 - 51,274,276 (+)RGD
HuRef1950,552,641 - 50,552,728 (+)ENTREZGENE
CHM1_11954,234,891 - 54,234,978 (+)NCBI
T2T-CHM13v2.01956,809,332 - 56,809,419 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR518E COSMIC
Ensembl Genes ENSG00000207987 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385252 ENTREZGENE
GTEx ENSG00000207987 GTEx
HGNC ID HGNC:32119 ENTREZGENE
Human Proteome Map MIR518E Human Proteome Map
miRBase MI0003169 ENTREZGENE
NCBI Gene 574487 ENTREZGENE
OMIM 620616 OMIM
PharmGKB PA164722784 PharmGKB
RNAcentral URS00005ECFE5 RNACentral
  URS0000651BF7 RNACentral
  URS000075E57D RNACentral