MIR585 (microRNA 585) - Rat Genome Database

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Gene: MIR585 (microRNA 585) Homo sapiens
Analyze
Symbol: MIR585
Name: microRNA 585
RGD ID: 1603090
HGNC Page HGNC:32841
Description: Biomarker of oral squamous cell carcinoma.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-585; mir-585; MIRN585
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385169,263,601 - 169,263,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5169,263,601 - 169,263,694 (-)EnsemblGRCh38hg38GRCh38
GRCh375168,690,605 - 168,690,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,623,182 - 168,623,275 (-)NCBINCBI36Build 36hg18NCBI36
Celera5164,726,768 - 164,726,862 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5163,788,344 - 163,788,437 (-)NCBIHuRef
CHM1_15168,123,012 - 168,123,105 (-)NCBICHM1_1
T2T-CHM13v2.05169,799,175 - 169,799,268 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR585Humanoral squamous cell carcinoma  IEP 152995504mRNA:altered expression:oral mucosa (human)RGD 


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR585Humanarsenite(3-) decreases expressionEXP 6480464arsenite results in decreased expression of MIR585 mRNACTDPMID:22728250
MIR585Humanbenzo[a]pyrene increases methylationEXP 6480464Benzo(a)pyrene results in increased methylation of MIR585 promoterCTDPMID:27901495


#
Reference Title
Reference Citation
1. The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Uesugi A, etal., Cancer Res. 2011 Sep 1;71(17):5765-78. doi: 10.1158/0008-5472.CAN-11-0368. Epub 2011 Jul 27.
PMID:16381832   PMID:16505370   PMID:21037258   PMID:23034410   PMID:27743168   PMID:29550487   PMID:32820394   PMID:33335254   PMID:33826023   PMID:34238324   PMID:35602576   PMID:36268034  



.

1 to 7 of 7 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:164386701-181269805)x3 copy number gain See cases [RCV000135546] Chr5:164386701..181269805 [GRCh38]
Chr5:163813707..180696806 [GRCh37]
Chr5:163746285..180629412 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q34-35.1(chr5:168433412-171417179)x1 copy number loss See cases [RCV000140907] Chr5:168433412..171417179 [GRCh38]
Chr5:167860417..170844183 [GRCh37]
Chr5:167792995..170776788 [NCBI36]
Chr5:5q34-35.1		 uncertain significance
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:168689326-181269946)x3 copy number gain See cases [RCV000051866] Chr5:168689326..181269946 [GRCh38]
Chr5:168116331..180696947 [GRCh37]
Chr5:168048909..180629553 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q34-35.1(chr5:166371405-171390034)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052148]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052148]|See cases [RCV000052148] Chr5:166371405..171390034 [GRCh38]
Chr5:165798410..170817038 [GRCh37]
Chr5:165730988..170749643 [NCBI36]
Chr5:5q34-35.1		 pathogenic
1 to 7 of 7 rows

Predicted Targets
Summary Value
Count of predictions:20205
Count of gene targets:10041
Count of transcripts:17897
Interacting mature miRNAs:hsa-miR-585-3p, hsa-miR-585-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2289409BW320_HBody weight QTL 320 (human)3.50.0002Body weightlean mass5160925164181538259Human

bac51858T  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375168,684,883 - 168,685,013UniSTSGRCh37
Build 365168,617,461 - 168,617,591RGDNCBI36
Celera5164,728,270 - 164,728,400RGD
Cytogenetic Map5q35UniSTS
Cytogenetic Map5q35.1UniSTS
HuRef5163,782,623 - 163,782,753UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
12 12 14 9 38 9 15 5 8 2 22 38 34 3 36 11 16 13 4



Ensembl Acc Id: ENST00000384887
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5169,263,601 - 169,263,694 (-)Ensembl
RefSeq Acc Id: NR_030311
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385169,263,601 - 169,263,694 (-)NCBI
GRCh375168,690,605 - 168,690,698 (-)RGD
Celera5164,726,768 - 164,726,862 (-)RGD
HuRef5163,788,344 - 163,788,437 (-)ENTREZGENE
CHM1_15168,123,012 - 168,123,105 (-)NCBI
T2T-CHM13v2.05169,799,175 - 169,799,268 (-)NCBI
Sequence:


1 to 12 of 12 rows
Database
Acc Id
Source(s)
COSMIC MIR585 COSMIC
Ensembl Genes ENSG00000207619 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384887 ENTREZGENE
GTEx ENSG00000207619 GTEx
HGNC ID HGNC:32841 ENTREZGENE
Human Proteome Map MIR585 Human Proteome Map
miRBase MI0003592 ENTREZGENE
NCBI Gene 693170 ENTREZGENE
PharmGKB PA164722882 PharmGKB
RNAcentral URS000054D341 RNACentral
  URS000075EBA2 RNACentral
  URS000077ACC0 RNACentral
1 to 12 of 12 rows