MIR589 (microRNA 589) - Rat Genome Database

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Gene: MIR589 (microRNA 589) Homo sapiens
Analyze
Symbol: MIR589
Name: microRNA 589
RGD ID: 1603086
HGNC Page HGNC:32845
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-589; mir-589; MIRN589
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3875,495,819 - 5,495,917 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl75,495,819 - 5,495,917 (-)EnsemblGRCh38hg38GRCh38
GRCh3775,535,450 - 5,535,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,501,975 - 5,502,073 (-)NCBINCBI36Build 36hg18NCBI36
Celera75,495,738 - 5,495,836 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,448,245 - 5,448,343 (-)NCBIHuRef
CHM1_175,535,011 - 5,535,109 (-)NCBICHM1_1
T2T-CHM13v2.075,613,363 - 5,613,461 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v275,581,804 - 5,581,902 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:17604727   PMID:21037258   PMID:23118514   PMID:24068947   PMID:26134418   PMID:26646931   PMID:27835990   PMID:27867039   PMID:28440397   PMID:29117863  
PMID:29196128   PMID:29267965   PMID:30249105   PMID:31053300   PMID:31173214   PMID:31424277   PMID:31957821   PMID:32705168   PMID:33541391   PMID:34226983   PMID:34608841   PMID:35320976  
PMID:35840467   PMID:36643863  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.1(chr7:5448387-6276950)x1 copy number loss See cases [RCV000135830] Chr7:5448387..6276950 [GRCh38]
Chr7:5488018..6316581 [GRCh37]
Chr7:5454544..6283106 [NCBI36]
Chr7:7p22.1		 likely pathogenic|benign
GRCh38/hg38 7p22.3-15.2(chr7:54185-26827634)x3 copy number gain See cases [RCV000136557] Chr7:54185..26827634 [GRCh38]
Chr7:54185..26867253 [GRCh37]
Chr7:149268..26833778 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh38/hg38 7p22.3-22.1(chr7:54185-6638027)x3 copy number gain See cases [RCV000136731] Chr7:54185..6638027 [GRCh38]
Chr7:54185..6677658 [GRCh37]
Chr7:149268..6644183 [NCBI36]
Chr7:7p22.3-22.1		 pathogenic
GRCh38/hg38 7p22.3-21.3(chr7:45130-7252065)x3 copy number gain See cases [RCV000137524] Chr7:45130..7252065 [GRCh38]
Chr7:45130..7291696 [GRCh37]
Chr7:140213..7258221 [NCBI36]
Chr7:7p22.3-21.3		 pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:45130-25221165)x3 copy number gain See cases [RCV000137824] Chr7:45130..25221165 [GRCh38]
Chr7:45130..25260784 [GRCh37]
Chr7:140213..25227309 [NCBI36]
Chr7:7p22.3-15.3		 pathogenic
GRCh38/hg38 7p22.1(chr7:4849987-5760088)x3 copy number gain See cases [RCV000137977] Chr7:4849987..5760088 [GRCh38]
Chr7:4889618..5799719 [GRCh37]
Chr7:4856144..5766245 [NCBI36]
Chr7:7p22.1		 likely pathogenic
GRCh38/hg38 7p22.1(chr7:5331115-6340621)x3 copy number gain See cases [RCV000138729] Chr7:5331115..6340621 [GRCh38]
Chr7:5370746..6380252 [GRCh37]
Chr7:5337272..6346777 [NCBI36]
Chr7:7p22.1		 uncertain significance
GRCh38/hg38 7p22.1(chr7:5331115-6751518)x3 copy number gain See cases [RCV000139037] Chr7:5331115..6751518 [GRCh38]
Chr7:5370746..6791149 [GRCh37]
Chr7:5337272..6757674 [NCBI36]
Chr7:7p22.1		 likely pathogenic
GRCh38/hg38 7p22.1(chr7:5378314-5849934)x4 copy number gain See cases [RCV000139038] Chr7:5378314..5849934 [GRCh38]
Chr7:5417945..5889565 [GRCh37]
Chr7:5384471..5856091 [NCBI36]
Chr7:7p22.1		 likely pathogenic
GRCh38/hg38 7p22.1(chr7:5171797-5635439)x3 copy number gain See cases [RCV000140259] Chr7:5171797..5635439 [GRCh38]
Chr7:5211428..5675070 [GRCh37]
Chr7:5177954..5641596 [NCBI36]
Chr7:7p22.1		 uncertain significance
GRCh38/hg38 7p22.3-15.2(chr7:1698124-27207295)x3 copy number gain See cases [RCV000143060] Chr7:1698124..27207295 [GRCh38]
Chr7:1737760..27246914 [GRCh37]
Chr7:1704286..27213439 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh38/hg38 7p22.1(chr7:5331115-5508766)x1 copy number loss See cases [RCV000142674] Chr7:5331115..5508766 [GRCh38]
Chr7:5370746..5548397 [GRCh37]
Chr7:5337272..5514923 [NCBI36]
Chr7:7p22.1		 uncertain significance
GRCh38/hg38 7p22.3-15.2(chr7:43360-27196404)x3 copy number gain See cases [RCV000143586] Chr7:43360..27196404 [GRCh38]
Chr7:43360..27236023 [GRCh37]
Chr7:138443..27202548 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1		 pathogenic
GRCh38/hg38 7p22.3-22.1(chr7:45130-5880375)x1 copy number loss See cases [RCV000052249] Chr7:45130..5880375 [GRCh38]
Chr7:45130..5920006 [GRCh37]
Chr7:140213..5886532 [NCBI36]
Chr7:7p22.3-22.1		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.1(chr7:5062000-6692258)x1 copy number loss See cases [RCV000052256] Chr7:5062000..6692258 [GRCh38]
Chr7:5101631..6731889 [GRCh37]
Chr7:5068157..6698414 [NCBI36]
Chr7:7p22.1		 pathogenic
GRCh38/hg38 7p22.1(chr7:5062000-5825183)x1 copy number loss See cases [RCV000052263] Chr7:5062000..5825183 [GRCh38]
Chr7:5101631..5864814 [GRCh37]
Chr7:5068157..5831340 [NCBI36]
Chr7:7p22.1		 pathogenic
GRCh38/hg38 7p22.1(chr7:5117519-5880375)x1 copy number loss See cases [RCV000052266] Chr7:5117519..5880375 [GRCh38]
Chr7:5157150..5920006 [GRCh37]
Chr7:5123676..5886532 [NCBI36]
Chr7:7p22.1		 pathogenic
GRCh38/hg38 7p22.1(chr7:5331115-6031221)x1 copy number loss See cases [RCV000052268] Chr7:5331115..6031221 [GRCh38]
Chr7:5370746..6070852 [GRCh37]
Chr7:5337272..6037378 [NCBI36]
Chr7:7p22.1		 pathogenic
GRCh38/hg38 7p22.1(chr7:4876621-6492003)x3 copy number gain See cases [RCV000053408] Chr7:4876621..6492003 [GRCh38]
Chr7:4916252..6531634 [GRCh37]
Chr7:4882778..6498159 [NCBI36]
Chr7:7p22.1		 uncertain significance
GRCh38/hg38 7p22.3-22.1(chr7:45130-6270185)x3 copy number gain See cases [RCV000053527] Chr7:45130..6270185 [GRCh38]
Chr7:45130..6309816 [GRCh37]
Chr7:140213..6276341 [NCBI36]
Chr7:7p22.3-22.1		 pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:53985-24361531)x3 copy number gain See cases [RCV000053528] Chr7:53985..24361531 [GRCh38]
Chr7:53985..24401150 [GRCh37]
Chr7:149068..24367675 [NCBI36]
Chr7:7p22.3-15.3		 pathogenic
GRCh38/hg38 7p22.3-21.3(chr7:54185-8274834)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053529]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053529]|See cases [RCV000053529] Chr7:54185..8274834 [GRCh38]
Chr7:54185..8314464 [GRCh37]
Chr7:149268..8280989 [NCBI36]
Chr7:7p22.3-21.3		 pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
GNB1hsa-miR-589-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
FXNhsa-miR-589-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23382970

Predicted Targets
Summary Value
Count of predictions:28165
Count of gene targets:9964
Count of transcripts:20342
Interacting mature miRNAs:hsa-miR-589-3p, hsa-miR-589-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1643402BMD2_HBone mineral density QTL 2 (human)2.690.0002Bone mineral density7122435431Human
1643247BW130_HBody Weight QTL 130 (human)1.280.008Body weightbody mass index7117453493Human
1643391BW322_HBody weight QTL 322 (human)2.690.0002Body fat amount7122435431Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
490 1073 863 621 1724 656 1166 3 240 1148 195 1185 3070 2652 52 865 390 696 873 57

Sequence


Ensembl Acc Id: ENST00000385238
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl75,495,819 - 5,495,917 (-)Ensembl
RefSeq Acc Id: NR_030318
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3875,495,819 - 5,495,917 (-)NCBI
GRCh3775,535,450 - 5,535,548 (-)RGD
Celera75,495,738 - 5,495,836 (-)RGD
HuRef75,448,245 - 5,448,343 (-)RGD
CHM1_175,535,011 - 5,535,109 (-)NCBI
T2T-CHM13v2.075,613,363 - 5,613,461 (-)NCBI
CRA_TCAGchr7v275,581,804 - 5,581,902 (-)ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR589 COSMIC
Ensembl Genes ENSG00000207973 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385238 ENTREZGENE
GTEx ENSG00000207973 GTEx
HGNC ID HGNC:32845 ENTREZGENE
Human Proteome Map MIR589 Human Proteome Map
miRBase MI0003599 ENTREZGENE
NCBI Gene 693174 ENTREZGENE
PharmGKB PA164722886 PharmGKB
RNAcentral URS00004214BB RNACentral
  URS00005F9DAE RNACentral
  URS000064C5B0 RNACentral