ARHGEF37 (Rho guanine nucleotide exchange factor 37) - Rat Genome Database

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Gene: ARHGEF37 (Rho guanine nucleotide exchange factor 37) Homo sapiens
Analyze
Symbol: ARHGEF37
Name: Rho guanine nucleotide exchange factor 37
RGD ID: 1602402
HGNC Page HGNC:34430
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ41603; Rho guanine nucleotide exchange factor (GEF) 37
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,551,625 - 149,634,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,551,947 - 149,634,968 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,961,061 - 149,014,531 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,941,328 - 148,994,720 (+)NCBINCBI36Build 36hg18NCBI36
Celera5145,043,054 - 145,096,412 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,107,762 - 144,161,236 (+)NCBIHuRef
CHM1_15148,393,556 - 148,446,911 (+)NCBICHM1_1
T2T-CHM13v2.05150,086,803 - 150,169,655 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:21873635   PMID:23377640   PMID:23858473   PMID:26186194   PMID:28611215   PMID:30926623   PMID:32393512   PMID:33961781   PMID:35256949  


Genomics

Comparative Map Data
ARHGEF37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,551,625 - 149,634,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,551,947 - 149,634,968 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,961,061 - 149,014,531 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,941,328 - 148,994,720 (+)NCBINCBI36Build 36hg18NCBI36
Celera5145,043,054 - 145,096,412 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,107,762 - 144,161,236 (+)NCBIHuRef
CHM1_15148,393,556 - 148,446,911 (+)NCBICHM1_1
T2T-CHM13v2.05150,086,803 - 150,169,655 (+)NCBIT2T-CHM13v2.0
Arhgef37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,624,728 - 61,669,994 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,624,728 - 61,669,665 (-)EnsemblGRCm39 Ensembl
GRCm381861,491,657 - 61,536,928 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,491,657 - 61,536,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,653,448 - 61,696,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,619,163 - 61,634,648 (-)NCBIMGSCv36mm8
Celera1862,776,175 - 62,819,028 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.62NCBI
Arhgef37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,205,621 - 57,271,284 (-)NCBIGRCr8
mRatBN7.21854,935,256 - 55,001,017 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,949,110 - 55,000,669 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,051,280 - 57,094,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,765,896 - 57,808,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,581,554 - 55,624,552 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,817,986 - 56,871,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,817,988 - 56,870,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,048,373 - 56,099,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,473,010 - 57,524,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1853,099,857 - 53,151,266 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Arhgef37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,858,355 - 4,900,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,850,120 - 4,900,483 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,780,601 - 144,864,721 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,920,150 - 143,004,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,006,880 - 145,060,447 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,031,688 - 151,068,837 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,986,462 - 151,068,837 (+)Ensemblpanpan1.1panPan2
ARHGEF37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,357,834 - 59,413,012 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,357,822 - 59,412,752 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,123,557 - 59,178,961 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,840,209 - 59,895,600 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,840,209 - 59,895,581 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,627,247 - 59,665,508 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,741,493 - 59,797,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,272,603 - 60,327,820 (-)NCBIUU_Cfam_GSD_1.0
Arhgef37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,703,422 - 143,753,915 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,275,862 - 5,327,928 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,277,448 - 5,328,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,660,685 - 150,747,220 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,662,470 - 150,751,648 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,427,173 - 157,504,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,198,122 - 52,252,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,198,075 - 52,252,273 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603425,468,693 - 25,523,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,911,821 - 8,945,016 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247748,894,678 - 8,944,316 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGEF37
47 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
NM_001001669.2(ARHGEF37):c.1423C>T (p.Gln475Ter) single nucleotide variant Malignant melanoma [RCV000066774] Chr5:149624099 [GRCh38]
Chr5:149003662 [GRCh37]
Chr5:148983855 [NCBI36]
Chr5:5q32		 not provided
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q31.3-32(chr5:141113273-149154835)x1 copy number loss See cases [RCV000510497] Chr5:141113273..149154835 [GRCh37]
Chr5:5q31.3-32		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_001001669.3(ARHGEF37):c.779T>G (p.Leu260Arg) single nucleotide variant not specified [RCV004286403] Chr5:149618296 [GRCh38]
Chr5:148997859 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1091G>A (p.Arg364His) single nucleotide variant not specified [RCV004333723] Chr5:149621818 [GRCh38]
Chr5:149001381 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3		 pathogenic
GRCh37/hg19 5q31.3-32(chr5:140424333-148985999)x3 copy number gain not provided [RCV000848228] Chr5:140424333..148985999 [GRCh37]
Chr5:5q31.3-32		 uncertain significance
NM_001001669.3(ARHGEF37):c.191C>T (p.Pro64Leu) single nucleotide variant not specified [RCV004284151] Chr5:149601112 [GRCh38]
Chr5:148980675 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q32(chr5:148953230-149414017)x3 copy number gain not provided [RCV001005741] Chr5:148953230..149414017 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NC_000005.9:g.(?_147774340)_(149681936_?)del deletion not provided [RCV003116332] Chr5:147774340..149681936 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1486C>T (p.Arg496Cys) single nucleotide variant not specified [RCV004330424] Chr5:149627097 [GRCh38]
Chr5:149006660 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q32(chr5:147164969-149315489)x1 copy number loss not provided [RCV002473891] Chr5:147164969..149315489 [GRCh37]
Chr5:5q32		 pathogenic
NM_001001669.3(ARHGEF37):c.196G>A (p.Gly66Arg) single nucleotide variant not specified [RCV004179173] Chr5:149601117 [GRCh38]
Chr5:148980680 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1189G>C (p.Ala397Pro) single nucleotide variant not specified [RCV004158866] Chr5:149621916 [GRCh38]
Chr5:149001479 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1712C>G (p.Pro571Arg) single nucleotide variant not specified [RCV004236634] Chr5:149628860 [GRCh38]
Chr5:149008423 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.283A>C (p.Lys95Gln) single nucleotide variant not specified [RCV004205750] Chr5:149601204 [GRCh38]
Chr5:148980767 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1841T>C (p.Val614Ala) single nucleotide variant not specified [RCV004093221] Chr5:149632004 [GRCh38]
Chr5:149011567 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1601C>G (p.Ala534Gly) single nucleotide variant not specified [RCV004163163] Chr5:149627212 [GRCh38]
Chr5:149006775 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1829C>T (p.Ala610Val) single nucleotide variant not specified [RCV004234093] Chr5:149631992 [GRCh38]
Chr5:149011555 [GRCh37]
Chr5:5q32		 likely benign
NM_001001669.3(ARHGEF37):c.80C>T (p.Ser27Leu) single nucleotide variant not specified [RCV004179192] Chr5:149597849 [GRCh38]
Chr5:148977412 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.647G>A (p.Arg216His) single nucleotide variant not specified [RCV004070929] Chr5:149616755 [GRCh38]
Chr5:148996318 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.421C>G (p.Leu141Val) single nucleotide variant not specified [RCV004208747] Chr5:149609658 [GRCh38]
Chr5:148989221 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.922T>C (p.Tyr308His) single nucleotide variant not specified [RCV004143347] Chr5:149620381 [GRCh38]
Chr5:148999944 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1400C>T (p.Thr467Met) single nucleotide variant not specified [RCV004205543] Chr5:149624076 [GRCh38]
Chr5:149003639 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1665T>A (p.His555Gln) single nucleotide variant not specified [RCV004081874] Chr5:149628813 [GRCh38]
Chr5:149008376 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.101C>G (p.Ala34Gly) single nucleotide variant not specified [RCV004074487] Chr5:149597870 [GRCh38]
Chr5:148977433 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.418G>A (p.Glu140Lys) single nucleotide variant not specified [RCV004297210] Chr5:149609655 [GRCh38]
Chr5:148989218 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1655C>G (p.Thr552Ser) single nucleotide variant not specified [RCV004278576] Chr5:149627266 [GRCh38]
Chr5:149006829 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.799A>G (p.Lys267Glu) single nucleotide variant not specified [RCV004280263] Chr5:149618947 [GRCh38]
Chr5:148998510 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1460C>T (p.Thr487Ile) single nucleotide variant not specified [RCV004279743] Chr5:149624136 [GRCh38]
Chr5:149003699 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1018G>A (p.Glu340Lys) single nucleotide variant not specified [RCV004266775] Chr5:149621745 [GRCh38]
Chr5:149001308 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.316A>G (p.Ile106Val) single nucleotide variant not specified [RCV004264421] Chr5:149609553 [GRCh38]
Chr5:148989116 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1814A>T (p.Asn605Ile) single nucleotide variant not specified [RCV004344732] Chr5:149628962 [GRCh38]
Chr5:149008525 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.676G>A (p.Val226Ile) single nucleotide variant not specified [RCV004349351] Chr5:149618193 [GRCh38]
Chr5:148997756 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1277C>T (p.Thr426Ile) single nucleotide variant not specified [RCV004358641] Chr5:149622004 [GRCh38]
Chr5:149001567 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.918C>T (p.His306=) single nucleotide variant not provided [RCV003429880] Chr5:149620377 [GRCh38]
Chr5:148999940 [GRCh37]
Chr5:5q32		 likely benign
NM_001001669.3(ARHGEF37):c.1830G>A (p.Ala610=) single nucleotide variant not provided [RCV003428665] Chr5:149631993 [GRCh38]
Chr5:149011556 [GRCh37]
Chr5:5q32		 likely benign
NM_001001669.3(ARHGEF37):c.1272C>G (p.Phe424Leu) single nucleotide variant not specified [RCV004425160] Chr5:149621999 [GRCh38]
Chr5:149001562 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1302A>C (p.Gln434His) single nucleotide variant not specified [RCV004425161] Chr5:149622029 [GRCh38]
Chr5:149001592 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1537G>A (p.Val513Met) single nucleotide variant not specified [RCV004425162] Chr5:149627148 [GRCh38]
Chr5:149006711 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1622C>G (p.Thr541Ser) single nucleotide variant not specified [RCV004425163] Chr5:149627233 [GRCh38]
Chr5:149006796 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1760G>A (p.Arg587Gln) single nucleotide variant not specified [RCV004425165] Chr5:149628908 [GRCh38]
Chr5:149008471 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.646C>T (p.Arg216Cys) single nucleotide variant not specified [RCV004425166] Chr5:149616754 [GRCh38]
Chr5:148996317 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.669C>T (p.Tyr223=) single nucleotide variant not specified [RCV004425167] Chr5:149618186 [GRCh38]
Chr5:148997749 [GRCh37]
Chr5:5q32		 likely benign
NM_001001669.3(ARHGEF37):c.803A>G (p.Glu268Gly) single nucleotide variant not specified [RCV004425170] Chr5:149618951 [GRCh38]
Chr5:148998514 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.983A>C (p.His328Pro) single nucleotide variant not specified [RCV004425172] Chr5:149620442 [GRCh38]
Chr5:149000005 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.112C>T (p.Leu38Phe) single nucleotide variant not specified [RCV004425158] Chr5:149597881 [GRCh38]
Chr5:148977444 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1061T>C (p.Leu354Pro) single nucleotide variant not specified [RCV004425157] Chr5:149621788 [GRCh38]
Chr5:149001351 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1130A>G (p.Lys377Arg) single nucleotide variant not specified [RCV004425159] Chr5:149621857 [GRCh38]
Chr5:149001420 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.77G>A (p.Arg26Lys) single nucleotide variant not specified [RCV004425169] Chr5:149597846 [GRCh38]
Chr5:148977409 [GRCh37]
Chr5:5q32		 likely benign
NM_001001669.3(ARHGEF37):c.175C>T (p.Arg59Cys) single nucleotide variant not specified [RCV004425164] Chr5:149597944 [GRCh38]
Chr5:148977507 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.745C>T (p.Arg249Trp) single nucleotide variant not specified [RCV004425168] Chr5:149618262 [GRCh38]
Chr5:148997825 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.88C>T (p.His30Tyr) single nucleotide variant not specified [RCV004425171] Chr5:149597857 [GRCh38]
Chr5:148977420 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.1957G>C (p.Gly653Arg) single nucleotide variant not specified [RCV004658258] Chr5:149632120 [GRCh38]
Chr5:149011683 [GRCh37]
Chr5:5q32		 uncertain significance
NM_001001669.3(ARHGEF37):c.722A>G (p.His241Arg) single nucleotide variant not specified [RCV004671864] Chr5:149618239 [GRCh38]
Chr5:148997802 [GRCh37]
Chr5:5q32		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1606
Count of miRNA genes:901
Interacting mature miRNAs:1089
Transcripts:ENST00000333677, ENST00000505810, ENST00000509831
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357314AASTH54_HAllergic/atopic asthma related QTL 54 (human)3.560.0003Reversible airflow obstructiontotal serum IgE5135892246150155845Human
407231218GWAS880194_Hbone density QTL GWAS880194 (human)4e-10bone mineral mass (VT:0005007)bone mineral density (CMO:0001226)5149553388149553389Human
407230200GWAS879176_Hbone density QTL GWAS879176 (human)1e-09bone mineral mass (VT:0005007)bone mineral density (CMO:0001226)5149562008149562009Human

Markers in Region
D5S812  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375149,008,723 - 149,008,884UniSTSGRCh37
Build 365148,988,916 - 148,989,077RGDNCBI36
Celera5145,090,610 - 145,090,771RGD
Cytogenetic Map5q32UniSTS
HuRef5144,155,432 - 144,155,593UniSTS
Marshfield Genetic Map5150.34RGD
Marshfield Genetic Map5150.34UniSTS
RH69939  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,978,115 - 148,978,240UniSTSGRCh37
GRCh37247,302,528 - 47,302,653UniSTSGRCh37
Build 36247,156,032 - 47,156,157RGDNCBI36
Celera5145,060,032 - 145,060,157UniSTS
Celera247,141,382 - 47,141,507RGD
Cytogenetic Map5q32UniSTS
Cytogenetic Map2p21UniSTS
HuRef5144,124,751 - 144,124,876UniSTS
HuRef247,039,604 - 47,039,729UniSTS
RH103834  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,982,235 - 148,982,409UniSTSGRCh37
Build 365148,962,428 - 148,962,602RGDNCBI36
Celera5145,064,149 - 145,064,323RGD
Cytogenetic Map5q32UniSTS
HuRef5144,128,857 - 144,129,031UniSTS
GeneMap99-GB4 RH Map5571.66UniSTS
SHGC-144191  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,981,321 - 148,981,592UniSTSGRCh37
Build 365148,961,514 - 148,961,785RGDNCBI36
Celera5145,063,235 - 145,063,506RGD
Cytogenetic Map5q32UniSTS
HuRef5144,127,943 - 144,128,214UniSTS
TNG Radiation Hybrid Map569186.0UniSTS
D10S16   No map positions available.
D10S16  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map2q11.2-q12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map3p22UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map5q21-q22UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map18q12UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map7q21.13UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map22q13.31-q13.33UniSTS
Cytogenetic Map1q24.1UniSTS
Cytogenetic Map7q32.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map11q24UniSTS
Cytogenetic Map2q11.2-q12.1UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map11q14.2UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map2p22-p21UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map1p36.23UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map11p15.3-p15.1UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map3q26UniSTS
Cytogenetic Map12p12.1-p11.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic MapXq23UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map5p15.1UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map17qterUniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map20q12-q13.12UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5q31.2-q34UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map1pter-q31.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map3p23-p21UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map8p11.2UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1p36.1-p34UniSTS
Cytogenetic Map4p13UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.1-q21.2UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map13q12UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map15q24.2UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map3p23UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map4p15.3UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3p25.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map2q37UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map10q22.1UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map18q21.1UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map9p22.3UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map19qterUniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map17pUniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map2p13.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map3q26.2UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2251 4973 1725 2350 5 624 1920 465 2269 7276 6442 52 3733 1 852 1744 1616 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB199796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF508325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF510234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000333677   ⟹   ENSP00000328083
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5149,581,498 - 149,634,968 (+)Ensembl
Ensembl Acc Id: ENST00000505810   ⟹   ENSP00000425621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5149,551,947 - 149,601,231 (+)Ensembl
Ensembl Acc Id: ENST00000509831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5149,626,897 - 149,632,036 (+)Ensembl
RefSeq Acc Id: NM_001001669   ⟹   NP_001001669
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,581,498 - 149,634,968 (+)NCBI
GRCh375148,961,064 - 149,014,531 (+)NCBI
Build 365148,941,328 - 148,994,720 (+)NCBI Archive
Celera5145,043,054 - 145,096,412 (+)RGD
HuRef5144,107,762 - 144,161,236 (+)ENTREZGENE
CHM1_15148,393,556 - 148,446,911 (+)NCBI
T2T-CHM13v2.05150,116,234 - 150,169,655 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005268447   ⟹   XP_005268504
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,596,424 - 149,634,968 (+)NCBI
GRCh375148,961,064 - 149,014,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005268448   ⟹   XP_005268505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,581,498 - 149,634,968 (+)NCBI
GRCh375148,961,064 - 149,014,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006714784   ⟹   XP_006714847
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,581,498 - 149,634,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011537642   ⟹   XP_011535944
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,551,625 - 149,634,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017009460   ⟹   XP_016864949
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,581,498 - 149,634,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047417170   ⟹   XP_047273126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,551,625 - 149,634,968 (+)NCBI
RefSeq Acc Id: XM_054352569   ⟹   XP_054208544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,116,234 - 150,169,655 (+)NCBI
RefSeq Acc Id: XM_054352570   ⟹   XP_054208545
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,116,234 - 150,169,655 (+)NCBI
RefSeq Acc Id: XM_054352571   ⟹   XP_054208546
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,086,803 - 150,169,655 (+)NCBI
RefSeq Acc Id: XM_054352572   ⟹   XP_054208547
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,131,166 - 150,169,655 (+)NCBI
RefSeq Acc Id: XM_054352573   ⟹   XP_054208548
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,086,803 - 150,169,655 (+)NCBI
RefSeq Acc Id: XM_054352574   ⟹   XP_054208549
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05150,116,234 - 150,169,655 (+)NCBI
RefSeq Acc Id: NP_001001669   ⟸   NM_001001669
- UniProtKB: Q6ZW51 (UniProtKB/Swiss-Prot),   A1IGU5 (UniProtKB/Swiss-Prot),   B4DUA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005268505   ⟸   XM_005268448
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005268504   ⟸   XM_005268447
- Peptide Label: isoform X1
- UniProtKB: Q6ZW51 (UniProtKB/Swiss-Prot),   A1IGU5 (UniProtKB/Swiss-Prot),   B4DUA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006714847   ⟸   XM_006714784
- Peptide Label: isoform X1
- UniProtKB: Q6ZW51 (UniProtKB/Swiss-Prot),   A1IGU5 (UniProtKB/Swiss-Prot),   B4DUA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011535944   ⟸   XM_011537642
- Peptide Label: isoform X3
- UniProtKB: B4DUA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016864949   ⟸   XM_017009460
- Peptide Label: isoform X2
- UniProtKB: B4DUA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000328083   ⟸   ENST00000333677
Ensembl Acc Id: ENSP00000425621   ⟸   ENST00000505810
RefSeq Acc Id: XP_047273126   ⟸   XM_047417170
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054208546   ⟸   XM_054352571
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054208548   ⟸   XM_054352573
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054208544   ⟸   XM_054352569
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054208545   ⟸   XM_054352570
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054208549   ⟸   XM_054352574
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054208547   ⟸   XM_054352572
- Peptide Label: isoform X1
Protein Domains
BAR   DH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1IGU5-F1-model_v2 AlphaFold A1IGU5 1-675 view protein structure

Promoters
RGD ID:6802869
Promoter ID:HG_KWN:51493
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid
Transcripts:NM_001001669
Position:
Human AssemblyChrPosition (strand)Source
Build 365148,940,906 - 148,941,406 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:34430 AgrOrtholog
COSMIC ARHGEF37 COSMIC
Ensembl Genes ENSG00000183111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000333677 ENTREZGENE
  ENST00000333677.7 UniProtKB/Swiss-Prot
  ENST00000505810.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arfaptin homology (AH) domain/BAR domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000183111 GTEx
HGNC ID HGNC:34430 ENTREZGENE
Human Proteome Map ARHGEF37 Human Proteome Map
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARHGEF37_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARHGEF37_SH3_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin-Rho_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:389337 UniProtKB/Swiss-Prot
NCBI Gene 389337 ENTREZGENE
OMIM 620664 OMIM
PANTHER NUCLEAR FUSION PROTEIN FUS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165660135 PharmGKB
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP BAR/IMD domain-like UniProtKB/TrEMBL
  SH3-domain UniProtKB/TrEMBL
  SSF103657 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot
UniProt A1IGU5 ENTREZGENE, UniProtKB/Swiss-Prot
  B4DUA3 ENTREZGENE, UniProtKB/TrEMBL
  D6RJH4_HUMAN UniProtKB/TrEMBL
  Q6ZW51 ENTREZGENE
UniProt Secondary Q6ZW51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 ARHGEF37  Rho guanine nucleotide exchange factor 37    Rho guanine nucleotide exchange factor (GEF) 37  Symbol and/or name change 5135510 APPROVED
2011-07-27 ARHGEF37  Rho guanine nucleotide exchange factor (GEF) 37  FLJ41603  FLJ41603 protein  Symbol and/or name change 5135510 APPROVED