NAT14 (N-acetyltransferase 14 (putative))

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Gene: NAT14 (N-acetyltransferase 14 (putative)) Homo sapiens

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Symbol:

NAT14

Name:

N-acetyltransferase 14 (putative)

RGD ID:

1601749

HGNC Page

HGNC:28918

Description:

Predicted to enable N-acetyltransferase activity. Predicted to be located in membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

K562 cell-derived leucine-zipper-like protein 1; K562 cells-derived leucine zipper-like protein 1; K562 cells-derived leucine-zipper-like protein 1; KLP1; N-acetyltransferase 14; N-acetyltransferase 14 (GCN5-related, putative); probable N-acetyltransferase 14

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Nat14 (N-acetyltransferase 14)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Nat14 (N-acetyltransferase 14)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Nat14 (N-acetyltransferase 14 (putative))	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	NAT14 (N-acetyltransferase 14 (putative))	NCBI	Ortholog
Canis lupus familiaris (dog):	NAT14 (N-acetyltransferase 14 (putative))	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nat14 (N-acetyltransferase 14 (putative))	NCBI	Ortholog
Sus scrofa (pig):	NAT14 (N-acetyltransferase 14 (putative))	HGNC	Ensembl, NCBI
Chlorocebus sabaeus (green monkey):	NAT14 (N-acetyltransferase 14 (putative))	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Nat14 (N-acetyltransferase 14 (putative))	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Zfp628 (zinc finger protein 628)	HGNC	EggNOG, Treefam
Rattus norvegicus (Norway rat):	Kif9 (kinesin family member 9)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Nat14 (N-acetyltransferase 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nat14 (N-acetyltransferase 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nat14 (N-acetyltransferase 14 (GCN5-related, putative))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Xenopus tropicalis (tropical clawed frog):	nat14	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	nat14.S	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	nat14.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	55,485,188 - 55,487,566 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	55,485,188 - 55,487,568 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	55,996,555 - 55,998,933 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	60,688,406 - 60,690,747 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	53,036,524 - 53,038,865 (+)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	52,309,740 - 52,312,118 (+)	NCBI		HuRef
CHM1_1	19	55,990,597 - 55,992,975 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	58,581,461 - 58,583,839 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (EXP)

amitrole (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

cisplatin (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (EXP)

disulfiram (EXP)

diuron (EXP)

furan (ISO)

methylmercury chloride (EXP)

N-Nitrosopyrrolidine (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

quercetin (EXP)

rotenone (EXP)

sodium arsenite (EXP)

sulforaphane (EXP)

sunitinib (EXP)

thioacetamide (ISO)

thiram (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription initiation (NAS)

positive regulation of DNA-templated transcription (NAS)

Cellular Component

membrane (IEA)

nucleus (NAS)

Molecular Function

acyltransferase activity (IEA)

DNA binding (IEA)

N-acetyltransferase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10873651	PMID:11779635	PMID:12477932	PMID:16341674	PMID:17207965	PMID:19807691	PMID:21873635	PMID:21900206	PMID:21988832	PMID:22810586	PMID:26186194
PMID:26972000	PMID:27173435	PMID:28298427	PMID:28514442	PMID:29656893	PMID:31073040	PMID:31091453	PMID:32353859	PMID:33060197	PMID:33961781	PMID:35271311	PMID:35337019
PMID:35439318	PMID:35696571	PMID:35906200	PMID:35944360	PMID:36215168	PMID:37827155

Genomics

Comparative Map Data

NAT14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	55,485,188 - 55,487,566 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	55,485,188 - 55,487,568 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	55,996,555 - 55,998,933 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	60,688,406 - 60,690,747 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	53,036,524 - 53,038,865 (+)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	52,309,740 - 52,312,118 (+)	NCBI		HuRef
CHM1_1	19	55,990,597 - 55,992,975 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	58,581,461 - 58,583,839 (+)	NCBI		T2T-CHM13v2.0

Nat14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	4,925,250 - 4,928,005 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	4,925,027 - 4,928,005 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	4,918,877 - 4,925,006 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	4,922,028 - 4,925,006 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	4,873,853 - 4,876,608 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	4,525,702 - 4,528,089 (+)	NCBI		MGSCv36	mm8
Celera	7	4,663,815 - 4,666,570 (+)	NCBI		Celera
Cytogenetic Map	7	A1	NCBI
cM Map	7	2.85	NCBI

Nat14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	77,939,430 - 77,941,950 (-)	NCBI		GRCr8
mRatBN7.2	1	68,910,599 - 68,913,452 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	68,910,601 - 68,912,733 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	74,255,664 - 74,257,751 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	82,819,970 - 82,822,057 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	75,968,774 - 75,970,851 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	72,462,403 - 72,465,299 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	72,462,405 - 72,464,492 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	76,071,151 - 76,073,674 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	67,649,231 - 67,651,318 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	68,206,527 - 68,208,614 (+)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

Nat14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955567	809,832 - 812,313 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955567	809,832 - 812,313 (-)	NCBI	ChiLan1.0	ChiLan1.0

NAT14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	61,625,102 - 61,627,716 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	63,353,758 - 63,356,221 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	52,529,201 - 52,531,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	61,218,209 - 61,221,375 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NAT14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	102,222,483 - 102,225,299 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	102,223,027 - 102,225,653 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	102,279,186 - 102,282,104 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	102,875,657 - 102,878,575 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	102,875,659 - 102,878,827 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	102,512,870 - 102,515,783 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	102,224,931 - 102,227,845 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	102,988,203 - 102,991,121 (-)	NCBI		UU_Cfam_GSD_1.0

Nat14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	1,845,682 - 1,848,573 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936886	711,427 - 713,538 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936886	711,402 - 713,557 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NAT14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	59,638,605 - 59,641,466 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	59,638,174 - 59,641,072 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NAT14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	48,079,596 - 48,082,546 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	48,080,607 - 48,082,861 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	728,296 - 730,981 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nat14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	1,868,391 - 1,870,258 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	1,868,391 - 1,870,262 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NAT14
16 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3	copy number gain	See cases [RCV000050883]	Chr19:50191219..58535818 [GRCh38] Chr19:50694476..59047185 [GRCh37] Chr19:55386288..63738997 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3	copy number gain	See cases [RCV000052925]	Chr19:49907832..58557889 [GRCh38] Chr19:50411089..59069256 [GRCh37] Chr19:55102901..63761068 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3	copy number gain	See cases [RCV000052926]	Chr19:51141518..58539965 [GRCh38] Chr19:51644775..59051332 [GRCh37] Chr19:56336587..63743144 [NCBI36] Chr19:19q13.41-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3	copy number gain	See cases [RCV000052914]	Chr19:47908540..58539965 [GRCh38] Chr19:48411797..59051332 [GRCh37] Chr19:53103609..63743144 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3	copy number gain	See cases [RCV000052915]	Chr19:47929575..58572206 [GRCh38] Chr19:48432832..59083573 [GRCh37] Chr19:53124644..63775385 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3	copy number gain	See cases [RCV000134174]	Chr19:52612432..58581203 [GRCh38] Chr19:53115685..59092570 [GRCh37] Chr19:57807497..63784382 [NCBI36] Chr19:19q13.41-13.43	pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3	copy number gain	See cases [RCV000134139]	Chr19:52955056..58581203 [GRCh38] Chr19:53458309..59092570 [GRCh37] Chr19:58150121..63784382 [NCBI36] Chr19:19q13.41-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3	copy number gain	See cases [RCV000135843]	Chr19:50152520..58581203 [GRCh38] Chr19:50655777..59092570 [GRCh37] Chr19:55347589..63784382 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.42-13.43(chr19:55048514-56972458)x3	copy number gain	See cases [RCV000138139]	Chr19:55048514..56972458 [GRCh38] Chr19:55595687..57483826 [GRCh37] Chr19:60251694..62175638 [NCBI36] Chr19:19q13.42-13.43	likely pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3	copy number gain	See cases [RCV000142008]	Chr19:52143873..58445521 [GRCh38] Chr19:52647126..58956888 [GRCh37] Chr19:57338938..63648700 [NCBI36] Chr19:19q13.41-13.43	pathogenic
GRCh38/hg38 19q13.42-13.43(chr19:55037146-56982033)x3	copy number gain	See cases [RCV000142245]	Chr19:55037146..56982033 [GRCh38] Chr19:55548514..57493401 [GRCh37] Chr19:60240326..62185213 [NCBI36] Chr19:19q13.42-13.43	uncertain significance
GRCh38/hg38 19q13.42(chr19:55066790-55789870)x3	copy number gain	See cases [RCV000142067]	Chr19:55066790..55789870 [GRCh38] Chr19:55578158..56301236 [GRCh37] Chr19:60269970..60993048 [NCBI36] Chr19:19q13.42	uncertain significance
GRCh37/hg19 19q13.42-13.43(chr19:55549385-57489784)x3	copy number gain	See cases [RCV000510290]	Chr19:55549385..57489784 [GRCh37] Chr19:19q13.42-13.43	uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3	copy number gain	See cases [RCV000445925]	Chr19:50489390..59095359 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.42-13.43(chr19:54344821-58956888)x3	copy number gain	See cases [RCV000448186]	Chr19:54344821..58956888 [GRCh37] Chr19:19q13.42-13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)	copy number gain	See cases [RCV000512296]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19q13.42-13.43(chr19:55844155-57408007)x3	copy number gain	See cases [RCV000511123]	Chr19:55844155..57408007 [GRCh37] Chr19:19q13.42-13.43	uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3	copy number gain	See cases [RCV000511289]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic\|uncertain significance
GRCh37/hg19 19q13.42-13.43(chr19:55779884-56896574)x1	copy number loss	not provided [RCV000684089]	Chr19:55779884..56896574 [GRCh37] Chr19:19q13.42-13.43	uncertain significance
GRCh37/hg19 19q13.42-13.43(chr19:54196216-58759679)x3	copy number gain	not provided [RCV000684095]	Chr19:54196216..58759679 [GRCh37] Chr19:19q13.42-13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3	copy number gain	not provided [RCV000752444]	Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3	copy number gain	not provided [RCV000752439]	Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19q13.42(chr19:55993436-56001665)x3	copy number gain	not provided [RCV000740262]	Chr19:55993436..56001665 [GRCh37] Chr19:19q13.42	benign
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3	copy number gain	not provided [RCV000740208]	Chr19:50740074..59097160 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.42-13.43(chr19:54334195-56434037)x3	copy number gain	not provided [RCV001259948]	Chr19:54334195..56434037 [GRCh37] Chr19:19q13.42-13.43	uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3	copy number gain	not provided [RCV001259944]	Chr19:48463931..57095254 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.42-13.43(chr19:55247893-56503347)x1	copy number loss	not provided [RCV001834407]	Chr19:55247893..56503347 [GRCh37] Chr19:19q13.42-13.43	likely pathogenic
GRCh37/hg19 19q13.42-13.43(chr19:55434660-56463734)x1	copy number loss	not provided [RCV002279751]	Chr19:55434660..56463734 [GRCh37] Chr19:19q13.42-13.43	uncertain significance
NM_020378.4(NAT14):c.415G>A (p.Val139Met)	single nucleotide variant	not specified [RCV004191604]	Chr19:55486750 [GRCh38] Chr19:55998117 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.517G>A (p.Ala173Thr)	single nucleotide variant	not specified [RCV004170056]	Chr19:55486852 [GRCh38] Chr19:55998219 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.433G>T (p.Ala145Ser)	single nucleotide variant	not specified [RCV004186588]	Chr19:55486768 [GRCh38] Chr19:55998135 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.407G>A (p.Arg136His)	single nucleotide variant	not specified [RCV004238055]	Chr19:55486742 [GRCh38] Chr19:55998109 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.379C>T (p.Arg127Cys)	single nucleotide variant	not specified [RCV004205949]	Chr19:55486714 [GRCh38] Chr19:55998081 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.40G>A (p.Asp14Asn)	single nucleotide variant	not specified [RCV004128859]	Chr19:55485748 [GRCh38] Chr19:55997115 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.523G>C (p.Gly175Arg)	single nucleotide variant	not specified [RCV004175407]	Chr19:55486858 [GRCh38] Chr19:55998225 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.490C>T (p.Arg164Trp)	single nucleotide variant	not specified [RCV004263780]	Chr19:55486825 [GRCh38] Chr19:55998192 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.545G>A (p.Gly182Asp)	single nucleotide variant	not specified [RCV004319435]	Chr19:55486880 [GRCh38] Chr19:55998247 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.557A>G (p.Gln186Arg)	single nucleotide variant	not specified [RCV004354888]	Chr19:55486892 [GRCh38] Chr19:55998259 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.371G>A (p.Arg124Gln)	single nucleotide variant	not specified [RCV004357179]	Chr19:55486706 [GRCh38] Chr19:55998073 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.160G>A (p.Gly54Ser)	single nucleotide variant	not specified [RCV004340677]	Chr19:55486495 [GRCh38] Chr19:55997862 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.172G>T (p.Val58Phe)	single nucleotide variant	not specified [RCV004358215]	Chr19:55486507 [GRCh38] Chr19:55997874 [GRCh37] Chr19:19q13.42	uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3	copy number gain	not provided [RCV003485200]	Chr19:49625130..57647352 [GRCh37] Chr19:19q13.33-13.43	likely pathogenic
NM_020378.4(NAT14):c.8C>T (p.Pro3Leu)	single nucleotide variant	not specified [RCV004472128]	Chr19:55485716 [GRCh38] Chr19:55997083 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.485G>A (p.Arg162Gln)	single nucleotide variant	not specified [RCV004472113]	Chr19:55486820 [GRCh38] Chr19:55998187 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.11G>A (p.Ser4Asn)	single nucleotide variant	not specified [RCV004472085]	Chr19:55485719 [GRCh38] Chr19:55997086 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.455G>C (p.Arg152Pro)	single nucleotide variant	not specified [RCV004641196]	Chr19:55486790 [GRCh38] Chr19:55998157 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.113C>A (p.Ala38Asp)	single nucleotide variant	not specified [RCV004652308]	Chr19:55486448 [GRCh38] Chr19:55997815 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.569G>C (p.Gly190Ala)	single nucleotide variant	not specified [RCV004652309]	Chr19:55486904 [GRCh38] Chr19:55998271 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.523G>A (p.Gly175Arg)	single nucleotide variant	not specified [RCV004641197]	Chr19:55486858 [GRCh38] Chr19:55998225 [GRCh37] Chr19:19q13.42	uncertain significance
NM_020378.4(NAT14):c.482C>A (p.Pro161His)	single nucleotide variant	not specified [RCV004641195]	Chr19:55486817 [GRCh38] Chr19:55998184 [GRCh37] Chr19:19q13.42	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2375
Count of miRNA genes:	745
Interacting mature miRNAs:	862
Transcripts:	ENST00000205194, ENST00000587400, ENST00000588985, ENST00000591590, ENST00000592719
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559110	SCL22_H	Serum cholesterol level QTL 22 (human)	3.59	0.000241	Lipid level	LDL cholesterol	19	31907594	57907594	Human
1331657	COPD9_H	Chronic obstructive pulmonary disease QTL 9 (human)	1.94		Chronic airflow obstruction	post-bronchodilator FEV1	19	31021760	57021760	Human

Markers in Region

RH91819

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	55,995,727 - 55,995,851	UniSTS	GRCh37
Build 36	19	60,687,539 - 60,687,663	RGD	NCBI36
Celera	19	53,035,657 - 53,035,781	RGD
Cytogenetic Map	19	q13.42	UniSTS
HuRef	19	52,308,910 - 52,309,034	UniSTS
GeneMap99-GB4 RH Map	19	284.08	UniSTS

G42907

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	55,998,787 - 55,998,912	UniSTS	GRCh37
Build 36	19	60,690,599 - 60,690,724	RGD	NCBI36
Celera	19	53,038,717 - 53,038,842	RGD
Cytogenetic Map	19	q13.42	UniSTS
HuRef	19	52,311,970 - 52,312,095	UniSTS

RH77907

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	55,998,467 - 55,998,617	UniSTS	GRCh37
Build 36	19	60,690,279 - 60,690,429	RGD	NCBI36
Celera	19	53,038,397 - 53,038,547	RGD
Cytogenetic Map	19	q13.42	UniSTS
HuRef	19	52,311,650 - 52,311,800	UniSTS
GeneMap99-GB4 RH Map	19	289.56	UniSTS
NCBI RH Map	19	599.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2252	4973	1726	2351	6	623	1949	465	2269	7305	6471	53	3734	1	852	1744	1617	174	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_027671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_020378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB038651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB055059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC008735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF086533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC019079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM785191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU730663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000205194 ⟹ ENSP00000205194

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	55,485,188 - 55,487,566 (+)	Ensembl

Ensembl Acc Id:

ENST00000587400 ⟹ ENSP00000472383

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	55,485,234 - 55,487,566 (+)	Ensembl

Ensembl Acc Id:

ENST00000588985 ⟹ ENSP00000471807

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	55,486,422 - 55,487,568 (+)	Ensembl

Ensembl Acc Id:

ENST00000591590 ⟹ ENSP00000470543

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	55,485,195 - 55,486,607 (+)	Ensembl

Ensembl Acc Id:

ENST00000592719

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	55,485,223 - 55,487,568 (+)	Ensembl

RefSeq Acc Id:

NM_020378 ⟹ NP_065111

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	55,485,188 - 55,487,566 (+)	NCBI
GRCh37	19	55,996,557 - 55,998,935 (+)	ENTREZGENE
Build 36	19	60,688,406 - 60,690,747 (+)	NCBI Archive
Celera	19	53,036,524 - 53,038,865 (+)	RGD
HuRef	19	52,309,740 - 52,312,118 (+)	ENTREZGENE
CHM1_1	19	55,990,597 - 55,992,975 (+)	NCBI
T2T-CHM13v2.0	19	58,581,461 - 58,583,839 (+)	NCBI

Sequence:

show sequence

ACTTCCGCCCGCGACCCCCTTCCAGACCCGCTCCCGAAACCTTGTCGAAGGACCAAAGGCGACC
GGTGCAGGTGCACGACGCCAGCTCCCTTCTGGGGGGCCGGGGCCTGGGGGTTGCCATGGCCCCC
AGCCACCTGTCAGTGCGGGAGATGAGGGAAGATGAGAAGCCCCTGGTGCTGGAGATGCTGAAGG
CCGGCGTGAAGGACACGGAAAACCGCGTGGCCCTCCATGCCTTGACACGGCCGCCGGCCCTGCT
CCTCCTGGCGGCGGCCAGCAGCGGCCTGCGCTTTGTCCTGGCTTCCTTCGCCCTGGCCCTCCTC
CTGCCGGTGTTCCTGGCTGTGGCCGCCGTGAAGCTGGGCCTGCGGGCCCGATGGGGCTCGCTGC
CTCCGCCGGGTGGCCTGGGGGGCCCCTGGGTGGCCGTGCGGGGCTCCGGTGACGTGTGTGGGGT
CCTGGCTCTGGCCCCTGGCACAAATGCAGGGGACGGGGCCCGGGTCACCCGCCTGTCTGTCTCT
CGCTGGCACCGCCGCCGGGGCGTGGGCAGGAGGCTGCTGGCCTTCGCGGAGGCCCGGGCTCGGG
CCTGGGCTGGGGGCATGGGGGAGCCCCGGGCCCGGCTCGTGGTCCCCGTGGCTGTGGCCGCCTG
GGGGGTGGGAGGGATGCTGGAGGGCTGTGGCTACCAGGCCGAGGGGGGCTGGGGCTGCCTGGGC
TACACGCTGGTGAGGGAATTCAGCAAAGACCTGTGAAGCTACAGACTGACAGCCAGGGCAGGGG
AGGAGGGAGGGGCGCCAGCACCTGATGATCGCCTACTGTCTGCGGGTTCTTTTACCTGCTCTCC
CTCAGTGAGTCCTCAACCACCCTGGGCCCAGAAACAGAGGCCTGCCGAGGGGAGGAGCCTGGCC
TCTGTCCACCCGTCAGCAGTGTGAAGTCTGTTGTGTTTGAGCTTCTCAGAGTGGAATGACTCCT
TTTCCTTCCTGGCCCTCGGGGGCCTCTCGAGGTCAGCCTCTCCAACCCCTACCTCAGCTCCTGT
CTGCACTGAGAAACCTCCCCGGGTGATGTCTGCAAAGTCTGTGCTGTCCGTGCCCCAGGCTGGG
AGAGCTATCTGGGGAGGGGGAGAGGAGGCCGAGCAGAATACACCCCAGAGTTAGGGTTTGCGAC
TCCGCCTCCCTGGGACCTGGATTGGGTCAGATGCCTGTCCTTGGAGGGGACAAGGTTGACTGCT
TAGGAGGCGCGACGCACAGGGCTGCCAGGCCTGGCCCCTCTCTGGGAAGGTTGAGAGCTGAGAC
GGGCAGCCCTGTCCCTTCCTCCAGATCCGTCTGGTTTTTTACACCGTTTGTTAATAAAGCCTGA
AACCGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_065111	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH19079	(Get FASTA)	NCBI Sequence Viewer
	BAB03716	(Get FASTA)	NCBI Sequence Viewer
	BAB85857	(Get FASTA)	NCBI Sequence Viewer
	EAW72385	(Get FASTA)	NCBI Sequence Viewer
	EAW72386	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000205194
	ENSP00000205194.3
	ENSP00000470543.1
	ENSP00000471807.1
	ENSP00000472383.1
GenBank Protein	Q8WUY8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_065111 ⟸ NM_020378

- UniProtKB:

Q8TDY7 (UniProtKB/Swiss-Prot), Q9NS72 (UniProtKB/Swiss-Prot), Q8WUY8 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPALLLLAAASSGLRFVLASFAL
ALLLPVFLAVAAVKLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPGTNAGDGARVTRL
SVSRWHRRRGVGRRLLAFAEARARAWAGGMGEPRARLVVPVAVAAWGVGGMLEGCGYQAEGGWG
CLGYTLVREFSKDL

hide sequence

Ensembl Acc Id:

ENSP00000205194 ⟸ ENST00000205194

Ensembl Acc Id:

ENSP00000472383 ⟸ ENST00000587400

Ensembl Acc Id:

ENSP00000471807 ⟸ ENST00000588985

Ensembl Acc Id:

ENSP00000470543 ⟸ ENST00000591590

Protein Domains

N-acetyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8WUY8-F1-model_v2	AlphaFold	Q8WUY8	1-206	view protein structure

Promoters

RGD ID:

13205751

Promoter ID:

EPDNEW_H26456

Type:

initiation region

Name:

NAT14_2

Description:

N-acetyltransferase 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H26457 EPDNEW_H26458

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	55,476,621 - 55,476,681	EPDNEW

RGD ID:

13205753

Promoter ID:

EPDNEW_H26457

Type:

initiation region

Name:

NAT14_3

Description:

N-acetyltransferase 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H26456 EPDNEW_H26458

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	55,484,975 - 55,485,035	EPDNEW

RGD ID:

13205755

Promoter ID:

EPDNEW_H26458

Type:

initiation region

Name:

NAT14_1

Description:

N-acetyltransferase 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H26456 EPDNEW_H26457

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	55,485,188 - 55,485,248	EPDNEW

RGD ID:

6795835

Promoter ID:

HG_KWN:31063

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_020378

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	19	60,687,954 - 60,688,454 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:28918	AgrOrtholog
COSMIC	NAT14	COSMIC
Ensembl Genes	ENSG00000090971	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000205194	ENTREZGENE
	ENST00000205194.5	UniProtKB/Swiss-Prot
	ENST00000587400.1	UniProtKB/TrEMBL
	ENST00000588985.1	UniProtKB/TrEMBL
	ENST00000591590.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.630.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000090971	GTEx
HGNC ID	HGNC:28918	ENTREZGENE
Human Proteome Map	NAT14	Human Proteome Map
InterPro	Acyl_CoA_acyltransferase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Camello_NAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GNAT_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:57106	UniProtKB/Swiss-Prot
NCBI Gene	57106	ENTREZGENE
PANTHER	GNAT FAMILY N-ACETYLTRANSFERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	N-ACETYLTRANSFERASE 14-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Acetyltransf_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA162396977	PharmGKB
PROSITE	GNAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55729	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	M0QZH3_HUMAN	UniProtKB/TrEMBL
	M0R1E3_HUMAN	UniProtKB/TrEMBL
	M0R284_HUMAN	UniProtKB/TrEMBL
	NAT14_HUMAN	UniProtKB/Swiss-Prot
	Q8TDY7	ENTREZGENE
	Q8WUY8	ENTREZGENE
	Q9NS72	ENTREZGENE
UniProt Secondary	Q8TDY7	UniProtKB/Swiss-Prot
	Q9NS72	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-16	NAT14	N-acetyltransferase 14 (putative)		N-acetyltransferase 14 (GCN5-related, putative)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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