Serpina1fl2 (serpin family A member 1F like 2) - Rat Genome Database

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Gene: Serpina1fl2 (serpin family A member 1F like 2) Rattus norvegicus
Analyze
Symbol: Serpina1fl2
Name: serpin family A member 1F like 2
RGD ID: 1597377
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in response to cytokine. Predicted to be located in extracellular space.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1-antitrypsin-like protein CM55-MM; alpha-1-antitrypsin-related protein-like; LOC690311; similar to Alpha-1-antitrypsin-related protein precursor
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,590,388 - 128,599,849 (-)NCBIGRCr8
mRatBN7.26122,825,598 - 122,835,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,830,395 - 122,835,059 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06127,569,502 - 127,582,204 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06136,788,274 - 136,797,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,961,972 - 127,966,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline

Genomics

Variants

.
Variants in Serpina1fl2
19 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006240513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000096399   ⟹   ENSRNOP00000076607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,830,395 - 122,831,958 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102489   ⟹   ENSRNOP00000081246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,830,395 - 122,835,059 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107005   ⟹   ENSRNOP00000077347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,831,285 - 122,835,059 (-)Ensembl
RefSeq Acc Id: XM_006240513   ⟹   XP_006240575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,590,388 - 128,599,849 (-)NCBI
mRatBN7.26122,825,598 - 122,835,059 (-)NCBI
Rnor_6.06127,569,502 - 127,582,204 (-)NCBI
Rnor_5.06136,788,274 - 136,797,735 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006240575 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076607.1
  ENSRNOP00000077347.1
  ENSRNOP00000081246.1
RefSeq Acc Id: XP_006240575   ⟸   XM_006240513
- UniProtKB: A0A8I5XW19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076607   ⟸   ENSRNOT00000096399
Ensembl Acc Id: ENSRNOP00000077347   ⟸   ENSRNOT00000107005
Ensembl Acc Id: ENSRNOP00000081246   ⟸   ENSRNOT00000102489
Protein Domains
SERPIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-36403 BioCyc
Ensembl Genes ENSRNOG00000064752 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096399.1 UniProtKB/TrEMBL
  ENSRNOT00000102489.1 UniProtKB/TrEMBL
  ENSRNOT00000107005.1 UniProtKB/TrEMBL
Gene3D-CATH Alpha-1-antitrypsin, domain 1 UniProtKB/TrEMBL
  Antithrombin, subunit I, domain 2 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene 690311 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR, SERPIN UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina1fl2 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000064752 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Serpins UniProtKB/TrEMBL
UniProt A0A8I5XW19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5E3_RAT UniProtKB/TrEMBL
  A0A8I5ZRU6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Serpina1fl2  serpin family A member 1F like 2  LOC690311  similar to Alpha-1-antitrypsin-related protein precursor  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC690311  similar to Alpha-1-antitrypsin-related protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL