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Gene: Rnf212 (ring finger protein 212) Rattus norvegicus

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Symbol:

Rnf212

Name:

ring finger protein 212

RGD ID:

1588767

Description:

Predicted to enable SUMO transferase activity. Predicted to be involved in chiasma assembly and meiotic gene conversion. Predicted to be active in synaptonemal complex. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to human RNF212 (ring finger protein 212); INTERACTS WITH tributylstannane; (+)-catechin (ortholog); 1,2-dimethylhydrazine (ortholog).

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC689721; probable E3 SUMO-protein ligase RNF212; similar to D1081.9

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF212 (ring finger protein 212)	HGNC	Ensembl, HomoloGene, NCBI
Mus musculus (house mouse):	Rnf212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf212 (ring finger protein 212)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RNF212 (ring finger protein 212)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf212 (ring finger protein 212)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf212 (ring finger protein 212)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12200	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	zhp-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31053	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	zhp-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,090,752 - 1,132,242 (+)	NCBI		GRCr8
mRatBN7.2	14	949,397 - 988,377 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	949,448 - 987,831 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	14	1,959,148 - 1,998,077 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	1,959,610 - 1,998,102 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	1,954,917 - 2,001,683 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,490,056 - 1,528,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	987,670 - 1,027,260 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	breast ductal carcinoma		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Ductal breast carcinoma	ClinVar
Rnf212	Rat	cherubism		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Fibrous dysplasia of jaw	ClinVar	PMID:28492532
Rnf212	Rat	Down syndrome		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Down syndrome	ClinVar
Rnf212	Rat	invasive ductal carcinoma		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Breast cancer and invasive ductal	ClinVar
Rnf212	Rat	spermatogenic failure 3		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Non-obstructive azoospermia	ClinVar	PMID:25741868
Rnf212	Rat	spermatogenic failure 62		ISO	RNF212 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Spermatogenic failure 62	ClinVar	PMID:31125047

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	spermatogenic failure 62		ISO	RNF212 (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	(+)-catechin	multiple interactions	ISO	RNF212 (Homo sapiens)	6480464	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of RNF212 mRNA	CTD	PMID:24763279
Rnf212	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Rnf212 (Mus musculus)	6480464	Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of RNF212 mRNA]	CTD	PMID:22206623
Rnf212	Rat	1,2-dimethylhydrazine	decreases expression	ISO	Rnf212 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of RNF212 mRNA	CTD	PMID:22206623
Rnf212	Rat	amiodarone	increases expression	ISO	RNF212 (Homo sapiens)	6480464	Amiodarone results in increased expression of RNF212 mRNA	CTD	PMID:19774075
Rnf212	Rat	benzo[a]pyrene	increases methylation	ISO	RNF212 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of RNF212 exon and Benzo(a)pyrene results in increased methylation of RNF212 promoter	CTD	PMID:27901495
Rnf212	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RNF212 (Homo sapiens)	6480464	Diethylhexyl Phthalate results in decreased expression of RNF212 mRNA	CTD	PMID:31163220
Rnf212	Rat	bisphenol A	decreases methylation	ISO	RNF212 (Homo sapiens)	6480464	bisphenol A results in decreased methylation of RNF212 gene	CTD	PMID:31601247
Rnf212	Rat	bisphenol AF	affects expression	ISO	Rnf212 (Mus musculus)	6480464	bisphenol AF affects the expression of RNF212 mRNA	CTD	PMID:36464114
Rnf212	Rat	butanal	increases expression	ISO	RNF212 (Homo sapiens)	6480464	butyraldehyde results in increased expression of RNF212 mRNA	CTD	PMID:26079696
Rnf212	Rat	cadmium atom	multiple interactions	ISO	RNF212 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of RNF212 mRNA	CTD	PMID:35301059
Rnf212	Rat	cadmium dichloride	multiple interactions	ISO	RNF212 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of RNF212 mRNA	CTD	PMID:35301059
Rnf212	Rat	chromium(6+)	multiple interactions	ISO	RNF212 (Homo sapiens)	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of RNF212 mRNA	CTD	PMID:38479592
Rnf212	Rat	entinostat	increases expression	ISO	RNF212 (Homo sapiens)	6480464	entinostat results in increased expression of RNF212 mRNA	CTD	PMID:27188386
Rnf212	Rat	epoxiconazole	decreases expression	ISO	Rnf212 (Mus musculus)	6480464	epoxiconazole results in decreased expression of RNF212 mRNA	CTD	PMID:35436446
Rnf212	Rat	folic acid	multiple interactions	ISO	Rnf212 (Mus musculus)	6480464	Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of RNF212 mRNA]	CTD	PMID:22206623
Rnf212	Rat	pentanal	increases expression	ISO	RNF212 (Homo sapiens)	6480464	pentanal results in increased expression of RNF212 mRNA	CTD	PMID:26079696
Rnf212	Rat	propanal	increases expression	ISO	RNF212 (Homo sapiens)	6480464	propionaldehyde results in increased expression of RNF212 mRNA	CTD	PMID:26079696
Rnf212	Rat	silicon dioxide	increases expression	ISO	RNF212 (Homo sapiens)	6480464	Silicon Dioxide results in increased expression of RNF212 mRNA	CTD	PMID:34973136
Rnf212	Rat	sodium arsenite	decreases expression	ISO	Rnf212 (Mus musculus)	6480464	sodium arsenite results in decreased expression of RNF212 mRNA	CTD	PMID:37682722
Rnf212	Rat	tributylstannane	increases expression	EXP		6480464	tributyltin results in increased expression of RNF212 mRNA	CTD	PMID:31129395
Rnf212	Rat	valproic acid	affects expression	ISO	RNF212 (Homo sapiens)	6480464	Valproic Acid affects the expression of RNF212 mRNA	CTD	PMID:25979313
Rnf212	Rat	valproic acid	increases methylation	ISO	RNF212 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of RNF212 gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	chiasma assembly	involved_in	ISO	Rnf212 (Mus musculus)	1624291	PMID:24390283	RGD	PMID:24390283
Rnf212	Rat	homologous chromosome pairing at meiosis	involved_in	IBA	MGI:3642276 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Rnf212	Rat	meiotic cell cycle	involved_in	IEA	UniProtKB-KW:KW-0469	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Rnf212	Rat	meiotic gene conversion	involved_in	ISO	Rnf212 (Mus musculus)	1624291	PMID:23396135 and PMID:24390283	RGD	PMID:23396135 and PMID:24390283
Rnf212	Rat	reciprocal meiotic recombination	involved_in	ISO	Rnf212 (Mus musculus)	1624291	PMID:23396135 and PMID:24390283	RGD	PMID:23396135 and PMID:24390283
Rnf212	Rat	reciprocal meiotic recombination	involved_in	IEA	InterPro:IPR042123	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	synaptonemal complex	located_in	ISO	Rnf212 (Mus musculus)	1624291	PMID:23396135 and PMID:24390283	RGD	PMID:23396135 and PMID:24390283
Rnf212	Rat	synaptonemal complex	is_active_in	IBA	FB:FBgn0283545 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Rnf212	Rat	synaptonemal complex	located_in	IEA	InterPro:IPR042123	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Rnf212	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Rnf212	Rat	SUMO transferase activity	enables	IEA	InterPro:IPR042123	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Rnf212	Rat	SUMO transferase activity	enables	IBA	PANTHER:PTN001099470 and SGD:S000004386	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Rnf212	Rat	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:23396135	PMID:24390283

Rnf212
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,090,752 - 1,132,242 (+)	NCBI		GRCr8
mRatBN7.2	14	949,397 - 988,377 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	949,448 - 987,831 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	14	1,959,148 - 1,998,077 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	1,959,610 - 1,998,102 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	1,954,917 - 2,001,683 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,490,056 - 1,528,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	987,670 - 1,027,260 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

RNF212
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	1,056,251 - 1,113,710 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	1,056,250 - 1,113,564 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	1,050,039 - 1,107,352 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	1,055,269 - 1,097,350 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	1,001,205 - 1,042,016 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	1,035,618 - 1,077,091 (-)	NCBI		HuRef
CHM1_1	4	1,064,436 - 1,107,142 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	1,055,136 - 1,112,433 (-)	NCBI		T2T-CHM13v2.0

Rnf212
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,875,971 - 108,922,933 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,877,156 - 108,922,848 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	108,728,105 - 108,775,067 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,729,290 - 108,774,982 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	108,969,610 - 108,990,875 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	109,156,644 - 109,204,001 (-)	NCBI		MGSCv36	mm8
Celera	5	105,852,176 - 105,871,271 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	53.24	NCBI

Rnf212
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	525,085 - 559,153 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	525,430 - 559,037 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF212
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	1,380,303 - 1,446,980 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	1,346,898 - 1,413,522 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	1,167,176 - 1,259,080 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	1,087,252 - 1,146,172 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	1,102,342 - 1,146,153 (-)	Ensembl	panpan1.1		panPan2

RNF212
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	91,453,856 - 91,483,674 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	91,453,367 - 91,474,547 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	93,919,190 - 93,949,001 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	92,450,675 - 92,480,516 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	92,450,161 - 92,480,515 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	91,624,032 - 91,654,085 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	91,677,071 - 91,706,907 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	92,060,979 - 92,090,807 (+)	NCBI		UU_Cfam_GSD_1.0

Rnf212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	68,421,143 - 68,455,264 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936477	22,122,854 - 22,173,324 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF212
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	399,715 - 413,896 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	393,707 - 413,952 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RNF212
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	47,665,652 - 47,705,754 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666051	4,043,749 - 4,104,384 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf212
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	26,082,378 - 26,120,655 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	26,081,943 - 26,120,967 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Rnf212
163 total Variants

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat

D14Arb2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	1,097,310 - 1,097,415 (+)	Marker Load Pipeline
mRatBN7.2	14	952,901 - 953,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	1,963,159 - 1,963,263	NCBI	Rnor6.0
Rnor_5.0	14	1,958,885 - 1,958,989	UniSTS	Rnor5.0
RGSC_v3.4	14	1,493,147 - 1,493,252	RGD	RGSC3.4
RGSC_v3.4	14	1,493,148 - 1,493,252	UniSTS	RGSC3.4
RGSC_v3.1	14	1,493,147 - 1,493,252	RGD
Celera	14	992,348 - 992,452	UniSTS
SHRSP x BN Map	14	0.0	RGD
SHRSP x BN Map	14	0.0	UniSTS
FHH x ACI Map	14	1.33	RGD
Cytogenetic Map	14	p22	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	XM_003751319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003752700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000085898 ⟹ ENSRNOP00000070745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	949,448 - 987,830 (+)	Ensembl
Rnor_6.0 Ensembl	14	1,959,610 - 1,998,102 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096364 ⟹ ENSRNOP00000077915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	973,858 - 987,831 (+)	Ensembl

RefSeq Acc Id:

XM_003751319 ⟹ XP_003751367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,090,752 - 1,132,242 (+)	NCBI
mRatBN7.2	14	949,438 - 987,831 (+)	NCBI
Rnor_6.0	14	1,959,149 - 1,998,077 (+)	NCBI
Rnor_5.0	14	1,954,917 - 2,001,683 (+)	NCBI

Sequence:

show sequence

TGAAATTAGTTTAATATCGTCAGAAATTACCCCCTTCCACGATCTGTTAAGTGGGGAATGATCTTCCATAAAGATCACTGAACACAGTGGCAAGCGGGGATCTCTGTCCTGCCCTGATTCACTTCTGT
CCGATGTTCTAATGGAATCCCTCCCGACCATTCCATTCTTCACTGGGTACTTCTAGTCCCCTAGCCTGGTCCATAACCACAGCCCACCCCCACCCTCCTGGTAGACCTTCCTCCAACCCTGCTAGGAA
TCTATGGTTCTTCTTGCTTTCAATGGCTCCCGGTTTTTCTCTCCTCTGCATTATGGTGTGTACAAATGTCCCTGGGCCTAGCTCTACCCTGAGGGCCGATCCACTCAGACTCCCTCAATATCCACTAC
CACAGCCCAGTTTCACCCAAGAAGCCACTGTGCCTGCCCACATCGCCAAGTTTTCCTCCACCGCCAAGAAGGCCTTTTCTCGACTCAGTACTTTCCGCCCTGGCTTCTTCCTCCGGGGTTGGTTCCGT
GTCGGTTTGTGCGGCCTTGTGCGCATGCGCTGGAATGAGCGCAGGCGCAGAGCTGCCTTTCTAAGCTGTGCCTGGTACTGAGGGGAGGGTCTGTATCTCTCTGTGCCCTCGCTGGCCTCGCGCGAATC
CCACGTGGGTCCTCCGTCATGGCCAGCTGGGTGTTCTGTAATCGCTGTTTCCAGCCGCCGCACAGGAAGTCGTCCTTCAGCCTGACCAGCTGTGGGCACGTGTTCTGCGATTCCTGCATCCTGAAAGG
TAAAAAGAATGAATGCATGATCTGTGAAGTCCCTTGTCAGACAGTTTTACTCTCAAAACATACTAACTCCAATGTCCAGACGTTCTTTCTGGACATAGATGGTCTGTGCAAGAAGTATTCCCAGGAGA
TCTCTCAGATTTCGGAATTTCAAGAAAAACACAGGAGGAGGTTAGTGACTTTCTACCGAGAAAAGATTTCTCAGTTGGAAGAGTCCCTCAGAAAGTCAGTACTACAAATCAAGCAACTACAAAGTATG
AGGTCATCACAACAACCAGCTTTCAACACAATCAAAAATTCAGTTTCAACAAAGCCAAATGGATATATCTTTCTACCACCCAACTCTTCACTCCCTGACAGAATAGAGTCGATGGATATTGACCTGAC
TTCTCCAGCAAGAAAGCCTGAGACAGCAGCAGGCCCTTCAAGAATTTCTCTGATTAGTCCGCCTCAGGATGGACGCATGGGCAGTGTCTCCTGCCGGGGACCCCAGCATCTCAGCTTGACACCAAGCC
ATGCAAGCACAGCAAAGGCTTTCAGAGTACCACCATTGCAGGTGCCCTACAAGGAACTGTCACCACTTCCAGCATCACAGCTATCCAGCAGAGCAACACAAGCTCCTTCCCCCAGCATTAGCAGTTCA
TGGACAGGACCACCTCGGCAGCCCATCAGTATCTCAGGCCTGCTGCAGAGACAGAGTGCAGGGTCAGCGTCCCCTAGGGGGATGAACACTGAGAAAATGAGCCCATTCTTGCCTTCCACGCCTGCAAA
TCTACGCTCTGTAGCCAGCCCCTGGCAAGTGTGTGTTCATCGGTAAATATCACTGTACAGTTCATTCTAGAGAGATGATGTAACTAAATAAAGTAGCTTTCTGATAAAGCA

hide sequence

RefSeq Acc Id:

XM_017599407 ⟹ XP_017454896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,090,752 - 1,132,242 (+)	NCBI
mRatBN7.2	14	949,397 - 988,377 (+)	NCBI
Rnor_6.0	14	1,959,148 - 1,998,074 (+)	NCBI

Sequence:

show sequence

TTGAAATTAGTTTAATATCGTCAGAAATTACCCCCTTCCACGATCTGTTAAGTGGGGAATGATCTTCCATAAAGATCACTGAACACAGTGGCAAGCGGGGATCTCTGTCCTGCCCTGATTCACTTCTG
TCCGATGTTCTAATGGAATCCCTCCCGACCATTCCATTCTTCACTGGGTACTTCTAGTCCCCTAGCCTGGTCCATAACCACAGCCCACCCCCACCCTCCTGGTAGACCTTCCTCCAACCCTGCTAGGA
ATCTATGGTTCTTCTTGCTTTCAATGGCTCCCGGTTTTTCTCTCCTCTGCATTATGGTGTGTACAAATGTCCCTGGGCCTAGCTCTACCCTGAGGGCCGATCCACTCAGACTCCCTCAATATCCACTA
CCACAGCCCAGTTTCACCCAAGAAGCCACTGTGCCTGCCCACATCGCCAAGTTTTCCTCCACCGCCAAGAAGGCCTTTTCTCGACTCAGTACTTTCCGCCCTGGCTTCTTCCTCCGGGGTTGGTTCCG
TGTCGGTTTGTGCGGCCTTGTGCGCATGCGCTGGAATGAGCGCAGGCGCAGAGCTGCCTTTCTAAGCTGTGCCTGGTACTGAGGGGAGGGTCTGTATCTCTCTGTGCCCTCGCTGGCCTCGCGCGAAT
CCCACGTGGGTCCTCCGTCATGGCCAGCTGGGTGTTCTGTAATCGCTGTTTCCAGCCGCCGCACAGGAAGTCGTCCTTCAGCCTGACCAGCTGTGGGCACGTGTTCTGCGATTCCTGCATCCTGAAAG
GTAAAAAGAATGAATGCATGATCTGTGAAGTCCCTTGTCAGACAGTTTTACTCTCAAAACATACTAACTCCAATGTCCAGACGTTCTTTCTGGACATAGATGGTCTGTGCAAGAAGTATTCCCAGGAG
ATCTCTCAGATTTCGGAATTTCAAGAAAAACACAGGAGGAGGTTAGTGACTTTCTACCGAGAAAAGATTTCTCAGTTGGAAGAGTCCCTCAGAAAGTCAGTACTACAAATCAAGCAACTACAAAGTAT
GAGGTCATCACAACAACCAGCTTTCAACACAATCAAAAATTCAGTTTCAACAAAGCCAAATGGATATATCTTTCTACCACCCAACTCTTCACTCCCTGACAGAATAGAGTCGATGGATATTGACCTGA
CTTCTCCAGCAAGAAAGCCTGAGACAGCAGCAGGCCCTTCAAGAATTTCTCTGATTAGTCCGCCTCAGGATGGACGCATGGGCAGTGTCTCCTGCCGGGGACCCCAGCATCTCAGCTTGACACCAAGC
CATGCAAGCACAGCAAAGGCTTTCAGGGTCAGCGTCCCCTAGGGGGATGAACACTGAGAAAATGAGCCCATTCTTGCCTTCCACGCCTGCAAATCTACGCTCTGTAGCCAGCCCCTGGCAAGTGTGTG
TTCATCGGTAAATATCACTGTACAGTTCATTCTAGAGAGATGATGTAACTAAATAAAGTAGCTTTCTGATAAA

hide sequence

RefSeq Acc Id:

XM_039092606 ⟹ XP_038948534

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,093,989 - 1,132,242 (+)	NCBI
mRatBN7.2	14	949,582 - 987,831 (+)	NCBI


Protein RefSeqs	XP_003751367	(Get FASTA)	NCBI Sequence Viewer
	XP_017454896	(Get FASTA)	NCBI Sequence Viewer
	XP_038948534	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070745.2
	ENSRNOP00000077915.1
	ENSRNOP00000099102

RefSeq Acc Id:	XP_003751367 ⟸ XM_003751319
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYP9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASWVFCNRCFQPPHRKSSFSLTSCGHVFCDSCILKGKKNECMICEVPCQTVLLSKHTNSNVQTFFLDIDGLCKKYSQEISQISEFQEKHRRRLVTFYREKISQLEESLRKSVLQIKQLQSMRSSQQP AFNTIKNSVSTKPNGYIFLPPNSSLPDRIESMDIDLTSPARKPETAAGPSRISLISPPQDGRMGSVSCRGPQHLSLTPSHASTAKAFRVPPLQVPYKELSPLPASQLSSRATQAPSPSISSSWTGPPR QPISISGLLQRQSAGSASPRGMNTEKMSPFLPSTPANLRSVASPWQVCVHR hide sequence

RefSeq Acc Id:

XP_017454896 ⟸ XM_017599407

- Peptide Label:

isoform X2

- Sequence:

show sequence

MASWVFCNRCFQPPHRKSSFSLTSCGHVFCDSCILKGKKNECMICEVPCQTVLLSKHTNSNVQT
FFLDIDGLCKKYSQEISQISEFQEKHRRRLVTFYREKISQLEESLRKSVLQIKQLQSMRSSQQPAFNTIKNSVSTKPNGYIFLPPNSSLPDRIESMDIDLTSPARKPETAAGPSRISLISPPQDGRMG
SVSCRGPQHLSLTPSHASTAKAFRVSVP

hide sequence

Ensembl Acc Id:

ENSRNOP00000070745 ⟸ ENSRNOT00000085898

RefSeq Acc Id:	XP_038948534 ⟸ XM_039092606
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000077915 ⟸ ENSRNOT00000096364

Protein Domains

RING-type

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JYP9-F1-model_v2	AlphaFold	A0A0G2JYP9	1-307	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-16687	BioCyc
Ensembl Genes	ENSRNOG00000059010	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000085898.2	UniProtKB/TrEMBL
	ENSRNOT00000096364.1	UniProtKB/TrEMBL
	ENSRNOT00000172376	ENTREZGENE
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
InterPro	Vilya/Cst9/RNF212	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
NCBI Gene	689721	ENTREZGENE
PANTHER	E3 SUMO-PROTEIN LIGASE RNF212-RELATED	UniProtKB/TrEMBL
	PTHR22663	UniProtKB/TrEMBL
Pfam	zf-RING_5	UniProtKB/TrEMBL
PhenoGen	Rnf212	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000059010	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A0G2JYP9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5XWM3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-02	Rnf212	ring finger protein 212	LOC689721	similar to D1081.9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC689721	similar to D1081.9	LOC682124	similar to D1081.9	Data merged from RGD:1586961	1643240	APPROVED
2006-11-19	LOC689721	similar to D1081.9			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682124	similar to D1081.9			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar

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