Slc6a20b (solute carrier family 6 member 20b) - Rat Genome Database

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Gene: Slc6a20b (solute carrier family 6 member 20b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc6a20b (Ensembl: Slc6a20a)
Name: solute carrier family 6 member 20b (Ensembl:solute carrier family 6 member 20a)
RGD ID: 1566368
Description: Enables L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and amino-acid betaine transport. Predicted to be located in apical plasma membrane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC301083; RGD1566368; similar to Solute carrier family 6 (neurotransmitter transporter), member 20; sodium- and chloride-dependent transporter XTRP3; sodium- and chloride-dependent transporter XTRP3B
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,108,481 - 132,158,422 (-)NCBIGRCr8
mRatBN7.28123,234,731 - 123,278,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,234,714 - 123,278,680 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08132,663,281 - 132,709,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08131,815,415 - 131,862,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,362,272 - 128,408,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8122,342,351 - 122,386,695 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a20bRatamino acid import across plasma membrane involved_inIDA 8554670PMID:15632147ARUK-UCL 
Slc6a20bRatamino acid transport involved_inIDA 8554670PMID:15632147UniProt 
Slc6a20bRatamino acid transport involved_inIEAUniProtKB-KW:KW-00291600115GO_REF:0000043UniProtGO_REF:0000043
Slc6a20bRatamino-acid betaine transport involved_inIMP 30309905PMID:26028423ARUK-UCL 
Slc6a20bRatglycine import across plasma membrane involved_inISSUniProtKB:Q9NP911600115GO_REF:0000024UniProtGO_REF:0000024
Slc6a20bRatglycine import across plasma membrane involved_inIBAMGI:2143217 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc6a20bRatL-proline import across plasma membrane involved_inIDA 8554670PMID:15632147ARUK-UCL 
Slc6a20bRatL-proline import across plasma membrane involved_inIBAMGI:2143217 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc6a20bRatsodium ion transmembrane transport involved_inIBAPANTHER:PTN000177662 and UniProtKB:P305311600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc6a20bRattransmembrane transport involved_inIEAGO:00152931600115GO_REF:0000108GOCGO_REF:0000108
1 to 10 of 10 rows

Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc6a20bRatapical plasma membrane located_inISSUniProtKB:Q8VDB91600115GO_REF:0000024UniProtGO_REF:0000024
Slc6a20bRatapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Slc6a20bRatapical plasma membrane is_active_inIBAMGI:1336891 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc6a20bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Slc6a20bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Slc6a20bRatmembrane located_inIEAInterPro:IPR0001751600115GO_REF:0000002InterProGO_REF:0000002
Slc6a20bRatplasma membrane is_active_inIBAFB:FBgn0011603 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc6a20bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Slc6a20bRatplasma membrane located_inIEAInterPro:IPR0024381600115GO_REF:0000002InterProGO_REF:0000002
1 to 9 of 9 rows

Molecular Function
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1 to 10 of 10 rows


#
Reference Title
Reference Citation
1. Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium. Cano M, etal., Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2172-9. doi: 10.1016/j.bbamem.2015.05.020. Epub 2015 May 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. Takanaga H, etal., J Biol Chem. 2005 Mar 11;280(10):8974-84. Epub 2005 Jan 4.


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Variants in Slc6a20b
227 total Variants

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000008172
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat

BI281911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,234,947 - 123,235,159 (+)MAPPERmRatBN7.2
Rnor_6.08132,666,041 - 132,666,252NCBIRnor6.0
Rnor_5.08131,818,741 - 131,818,952UniSTSRnor5.0
RGSC_v3.48128,362,489 - 128,362,700UniSTSRGSC3.4
Celera8122,345,111 - 122,345,322UniSTS
RH 3.4 Map81276.89UniSTS
Cytogenetic Map8q32UniSTS







Ensembl Acc Id: ENSRNOT00000008172   ⟹   ENSRNOP00000008172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,234,714 - 123,266,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108032   ⟹   ENSRNOP00000093413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,234,714 - 123,278,680 (-)Ensembl
RefSeq Acc Id: XM_002729986   ⟹   XP_002730032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,108,481 - 132,156,039 (-)NCBI
mRatBN7.28123,234,731 - 123,278,306 (-)NCBI
Rnor_6.08132,663,281 - 132,709,243 (-)NCBI
Rnor_5.08131,815,415 - 131,862,081 (-)NCBI
RGSC_v3.48128,362,272 - 128,408,149 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266353   ⟹   XP_063122423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,108,481 - 132,158,422 (-)NCBI
Protein RefSeqs XP_002730032 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122423 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008172
  ENSRNOP00000008172.7
  ENSRNOP00000093413.1
RefSeq Acc Id: XP_002730032   ⟸   XM_002729986
- Peptide Label: isoform X1
- UniProtKB: Q64093 (UniProtKB/Swiss-Prot),   A0A8I6AX01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000093413   ⟸   ENSRNOT00000108032
Ensembl Acc Id: ENSRNOP00000008172   ⟸   ENSRNOT00000008172
RefSeq Acc Id: XP_063122423   ⟸   XM_063266353
- Peptide Label: isoform X2
- UniProtKB: F1LZT7 (UniProtKB/TrEMBL)


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28611 BioCyc
Ensembl Genes ENSRNOG00000006010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008172 ENTREZGENE
  ENSRNOT00000008172.8 UniProtKB/TrEMBL
  ENSRNOT00000108032.1 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Neutral_aa_SLC6 UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
KEGG Report rno:301083 UniProtKB/TrEMBL
NCBI Gene 301083 ENTREZGENE
PANTHER PTHR11616 UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3 UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PhenoGen Slc6a20b PhenoGen
PRINTS NANEUSMPORT UniProtKB/TrEMBL
  ORPHTRNSPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006010 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/TrEMBL
UniProt A0A8I6AX01 ENTREZGENE, UniProtKB/TrEMBL
  F1LZT7 ENTREZGENE, UniProtKB/TrEMBL
  Q64093 ENTREZGENE
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-03 Slc6a20b  solute carrier family 6 member 20b  RGD1566368  similar to Solute carrier family 6 (neurotransmitter transporter), member 20  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1566368  similar to Solute carrier family 6 (neurotransmitter transporter), member 20   RGD1566368_predicted  similar to Solute carrier family 6 (neurotransmitter transporter), member 20 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566368_predicted  similar to Solute carrier family 6 (neurotransmitter transporter), member 20 (predicted)  LOC301083  similar to Solute carrier family 6 (neurotransmitter transporter), member 20  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC301083  similar to Solute carrier family 6 (neurotransmitter transporter), member 20      Symbol and Name status set to provisional 70820 PROVISIONAL