C4h12orf60 (similar to human chromosome 12 open reading frame 60) - Rat Genome Database

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Gene: C4h12orf60 (similar to human chromosome 12 open reading frame 60) Rattus norvegicus
Analyze
Symbol: C4h12orf60 (Ensembl: LOC500354)
Name: similar to human chromosome 12 open reading frame 60 (Ensembl:similar to C030030A07Rik protein)
RGD ID: 1563896
Description: Orthologous to human C12orf60 (chromosome 12 open reading frame 60); INTERACTS WITH bisphenol A; 2-palmitoylglycerol (ortholog); acrylamide (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500354; LOC500354; MGC114375; similar to C030030A07Rik protein; uncharacterized protein C12orf60 homolog
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,450,603 - 171,462,735 (+)NCBIGRCr8
mRatBN7.24169,716,821 - 169,731,532 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,716,030 - 169,734,237 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,014,134 - 176,026,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,795,867 - 171,807,999 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,419,797 - 170,431,896 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,807,633 - 170,822,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,820,594 - 170,821,995 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,067,929 - 235,079,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,862,352 - 173,874,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4158,302,929 - 158,315,061 (+)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
C4h12orf60
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,450,603 - 171,462,735 (+)NCBIGRCr8
mRatBN7.24169,716,821 - 169,731,532 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,716,030 - 169,734,237 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,014,134 - 176,026,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,795,867 - 171,807,999 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,419,797 - 170,431,896 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,807,633 - 170,822,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,820,594 - 170,821,995 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,067,929 - 235,079,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,862,352 - 173,874,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4158,302,929 - 158,315,061 (+)NCBICelera
Cytogenetic Map4q43NCBI
C12orf60
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,803,670 - 14,824,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,803,666 - 14,906,586 (+)EnsemblGRCh38hg38GRCh38
GRCh371214,956,604 - 14,977,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,847,773 - 14,868,059 (+)NCBINCBI36Build 36hg18NCBI36
Celera1220,101,493 - 20,121,778 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,725,963 - 14,746,251 (+)NCBIHuRef
CHM1_11214,922,599 - 14,942,885 (+)NCBICHM1_1
T2T-CHM13v2.01214,680,940 - 14,701,780 (+)NCBIT2T-CHM13v2.0
BC049715
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,805,158 - 136,818,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,804,624 - 136,817,660 (+)EnsemblGRCm39 Ensembl
GRCm386136,828,160 - 136,841,920 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,827,626 - 136,840,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv376136,777,364 - 136,789,075 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,792,637 - 136,804,858 (+)NCBIMGSCv36mm8
Celera6139,838,338 - 139,873,089 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.72NCBI
C10H12orf60
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,274,332 - 20,275,298 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,270,604 - 20,271,990 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,828,266 - 14,830,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,225,226 - 15,227,584 (+)NCBIpanpan1.1PanPan1.1panPan2
C27H12orf60
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,774,850 - 31,805,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,792,007 - 31,792,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,643,151 - 14,657,088 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,098,407 - 32,112,354 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,097,434 - 32,103,970 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,970,874 - 32,002,078 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,946,479 - 31,960,407 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,375,054 - 14,406,334 (+)NCBIUU_Cfam_GSD_1.0
CUNH12orf60
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,923,566 - 92,945,348 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365872,650,860 - 2,651,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C5H12orf60
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,734,665 - 57,735,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,734,455 - 57,735,612 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,123,758 - 61,139,304 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH12orf60
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,704,531 - 14,724,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,723,155 - 14,723,889 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,586,179 - 20,587,408 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH12orf60
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475223,198,069 - 23,198,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C4h12orf60
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:189
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000032568
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat

Markers in Region
BE097368  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04235,068,490 - 235,068,700NCBIRnor5.0
Rnor_5.04234,453,424 - 234,453,634NCBIRnor5.0
Rnor_5.04234,387,724 - 234,387,934NCBIRnor5.0
Rnor_5.04234,363,247 - 234,363,457NCBIRnor5.0
RGSC_v3.44173,862,914 - 173,863,123UniSTSRGSC3.4
Celera4158,303,491 - 158,303,700UniSTS
RH 3.4 Map41027.2UniSTS
Cytogenetic Map4q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 20 89 58 57 26 25 26 6 137 68 69 26 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000032568   ⟹   ENSRNOP00000033325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,719,481 - 169,731,586 (+)Ensembl
Rnor_6.0 Ensembl4170,820,594 - 170,821,995 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102803   ⟹   ENSRNOP00000096597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,716,030 - 169,734,237 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114428   ⟹   ENSRNOP00000082720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,716,954 - 169,734,237 (+)Ensembl
RefSeq Acc Id: NM_001037797   ⟹   NP_001032886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,450,603 - 171,462,735 (+)NCBI
mRatBN7.24169,719,400 - 169,731,532 (+)NCBI
Rnor_6.04170,810,582 - 170,822,037 (+)NCBI
Rnor_5.04235,067,929 - 235,079,384 (+)NCBI
RGSC_v3.44173,862,352 - 173,874,481 (+)RGD
Celera4158,302,929 - 158,315,061 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419525   ⟹   NP_001406454
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,450,733 - 171,462,735 (+)NCBI
mRatBN7.24169,719,530 - 169,731,532 (+)NCBI
RefSeq Acc Id: NP_001032886   ⟸   NM_001037797
- UniProtKB: Q4KLZ4 (UniProtKB/Swiss-Prot),   A6IMI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033325   ⟸   ENSRNOT00000032568
Ensembl Acc Id: ENSRNOP00000096597   ⟸   ENSRNOT00000102803
Ensembl Acc Id: ENSRNOP00000082720   ⟸   ENSRNOT00000114428
RefSeq Acc Id: NP_001406454   ⟸   NM_001419525
- UniProtKB: Q4KLZ4 (UniProtKB/Swiss-Prot),   A6IMI8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLZ4-F1-model_v2 AlphaFold Q4KLZ4 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563896 AgrOrtholog
BioCyc Gene G2FUF-42594 BioCyc
Ensembl Genes ENSRNOG00000027979 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025811 UniProtKB/Swiss-Prot
  ENSRNOG00060008853 UniProtKB/Swiss-Prot
  ENSRNOG00065011806 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032568.4 UniProtKB/Swiss-Prot
  ENSRNOT00000102803.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114428.1 UniProtKB/Swiss-Prot
  ENSRNOT00055044506 UniProtKB/Swiss-Prot
  ENSRNOT00055044515 UniProtKB/Swiss-Prot
  ENSRNOT00055044517 UniProtKB/Swiss-Prot
  ENSRNOT00060014833 UniProtKB/Swiss-Prot
  ENSRNOT00060014841 UniProtKB/Swiss-Prot
  ENSRNOT00060014850 UniProtKB/Swiss-Prot
  ENSRNOT00065019180 UniProtKB/Swiss-Prot
  ENSRNOT00065019183 UniProtKB/Swiss-Prot
  ENSRNOT00065019185 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133030 IMAGE-MGC_LOAD
InterPro DUF4533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500354 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114375 IMAGE-MGC_LOAD
NCBI Gene 500354 ENTREZGENE
PANTHER CHROMOSOME 12 OPEN READING FRAME 60 UniProtKB/Swiss-Prot
  CHROMOSOME 12 OPEN READING FRAME 60 UniProtKB/Swiss-Prot
  CHROMOSOME 12 OPEN READING FRAME 60 UniProtKB/TrEMBL
  CHROMOSOME 12 OPEN READING FRAME 60 UniProtKB/TrEMBL
Pfam DUF4533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C4h12orf60 PhenoGen
RatGTEx ENSRNOG00000027979 RatGTEx
  ENSRNOG00055025811 RatGTEx
  ENSRNOG00060008853 RatGTEx
  ENSRNOG00065011806 RatGTEx
UniProt A6IMI8 ENTREZGENE, UniProtKB/TrEMBL
  CL060_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C4h12orf60  similar to human chromosome 12 open reading frame 60  LOC500354  similar to C030030A07Rik protein  Symbol and Name Changed 1299863 APPROVED
2006-02-09 LOC500354  similar to C030030A07Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL