Lime1 (Lck interacting transmembrane adaptor 1)

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Gene: Lime1 (Lck interacting transmembrane adaptor 1) Rattus norvegicus

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Symbol:

Lime1

Name:

Lck interacting transmembrane adaptor 1

RGD ID:

1562795

Description:

Predicted to enable protein kinase binding activity. Predicted to be involved in B cell receptor signaling pathway. Predicted to act upstream of or within several processes, including regulation of MAP kinase activity; regulation of intracellular signal transduction; and regulation of release of sequestered calcium ion into cytosol. Predicted to be part of B cell receptor complex. Orthologous to human LIME1 (Lck interacting transmembrane adaptor 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

lck-interacting transmembrane adapter 1; LOC362289; RGD1562795; similar to Lck-interacting transmembrane adaptor protein LIME

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	188,868,338 - 188,870,661 (+)	NCBI		GRCr8
mRatBN7.2	3	168,490,535 - 168,496,627 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,490,074 - 168,493,127 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	172,871,356 - 172,873,679 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,830,457 - 181,832,780 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	178,491,737 - 178,494,060 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	176,881,881 - 176,888,230 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,882,027 - 176,884,350 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,591,825 - 180,598,362 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,522,420 - 170,524,743 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	164,093,412 - 164,095,735 (-)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

benign familial infantile seizures 6 (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 33 (ISO)

early infantile epileptic encephalopathy (ISO)

neuronal ceroid lipofuscinosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

amitrole (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

dioxygen (ISO)

elemental selenium (ISO)

fipronil (EXP)

folic acid (ISO)

methamphetamine (ISO)

methimazole (EXP)

obeticholic acid (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

tetraphene (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triptonide (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell receptor signaling pathway (IBA,ISO)

regulation of canonical NF-kappaB signal transduction (ISO)

regulation of MAP kinase activity (ISO)

regulation of non-canonical NF-kappaB signal transduction (ISO)

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

regulation of release of sequestered calcium ion into cytosol (ISO)

regulation of transcription by RNA polymerase II (ISO)

T cell receptor signaling pathway (IEA)

Cellular Component

B cell receptor complex (IBA,ISO)

Molecular Function

protein binding (ISO)

protein kinase binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16249387	PMID:22664934

Genomics

Comparative Map Data

Lime1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	188,868,338 - 188,870,661 (+)	NCBI		GRCr8
mRatBN7.2	3	168,490,535 - 168,496,627 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,490,074 - 168,493,127 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	172,871,356 - 172,873,679 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,830,457 - 181,832,780 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	178,491,737 - 178,494,060 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	176,881,881 - 176,888,230 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,882,027 - 176,884,350 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,591,825 - 180,598,362 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,522,420 - 170,524,743 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	164,093,412 - 164,095,735 (-)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

LIME1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,735,701 - 63,739,103 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	63,736,283 - 63,739,103 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	62,367,053 - 62,370,456 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,838,422 - 61,840,904 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	59,052,243 - 59,054,730 (+)	NCBI		Celera
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	59,100,311 - 59,102,798 (+)	NCBI		HuRef
CHM1_1	20	62,269,861 - 62,272,348 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,555,977 - 65,559,374 (+)	NCBI		T2T-CHM13v2.0

Lime1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	181,023,028 - 181,025,421 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	181,021,871 - 181,025,421 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	181,381,235 - 181,383,628 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	181,380,078 - 181,383,628 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	181,115,940 - 181,118,333 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	181,310,642 - 181,313,035 (+)	NCBI		MGSCv36	mm8
Celera	2	185,463,534 - 185,465,927 (+)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	103.63	NCBI

Lime1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	490,471 - 491,688 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955528	490,319 - 492,943 (-)	NCBI	ChiLan1.0	ChiLan1.0

LIME1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	69,542,309 - 69,545,450 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	69,534,316 - 69,537,455 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	20	61,659,672 - 61,662,970 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	61,661,427 - 61,662,767 (+)	Ensembl	panpan1.1		panPan2

LIME1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	47,269,922 - 47,272,288 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	46,403,833 - 46,406,303 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	48,408,800 - 48,411,270 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	24	47,253,687 - 47,256,157 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	47,378,552 - 47,381,021 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	48,116,648 - 48,119,118 (+)	NCBI		UU_Cfam_GSD_1.0

Lime1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	195,526,421 - 195,529,680 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936514	10,980,136 - 10,983,323 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIME1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	62,652,996 - 62,655,336 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	62,652,618 - 62,655,342 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LIME1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	491,618 - 494,446 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	491,096 - 493,147 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	48,045,313 - 48,048,117 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lime1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624741	29,390,743 - 29,393,457 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lime1
15 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	29
Count of miRNA genes:	28
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000019545
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
1300161	Rf10	Renal function QTL 10	3.57		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	3	161192952	169034231	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat

Markers in Region

RH128332

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,490,188 - 168,490,340 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,881,412 - 176,881,563	NCBI	Rnor6.0
Rnor_5.0	3	180,591,544 - 180,591,695	UniSTS	Rnor5.0
RGSC_v3.4	3	170,521,805 - 170,521,956	UniSTS	RGSC3.4
Celera	3	164,096,199 - 164,096,350	UniSTS
Cytogenetic Map	3	q43	UniSTS

RH136770

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,492,923 - 168,493,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,884,147 - 176,884,274	NCBI	Rnor6.0
Rnor_5.0	3	180,594,279 - 180,594,406	UniSTS	Rnor5.0
RGSC_v3.4	3	170,524,540 - 170,524,667	UniSTS	RGSC3.4
Celera	3	164,093,488 - 164,093,615	UniSTS
RH 3.4 Map	3	1547.6	UniSTS
Cytogenetic Map	3	q43	UniSTS

RH139532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,492,855 - 168,493,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,884,079 - 176,884,274	NCBI	Rnor6.0
Rnor_5.0	3	180,594,211 - 180,594,406	UniSTS	Rnor5.0
RGSC_v3.4	3	170,524,472 - 170,524,667	UniSTS	RGSC3.4
Celera	3	164,093,488 - 164,093,683	UniSTS
RH 3.4 Map	3	1547.3	UniSTS
Cytogenetic Map	3	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019545 ⟹ ENSRNOP00000019545

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	168,490,804 - 168,493,127 (+)	Ensembl
Rnor_6.0 Ensembl	3	176,882,027 - 176,884,350 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103427 ⟹ ENSRNOP00000081724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	168,490,074 - 168,493,121 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119792 ⟹ ENSRNOP00000091376

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	168,490,074 - 168,492,803 (+)	Ensembl

RefSeq Acc Id:

NM_001108614 ⟹ NP_001102084

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	188,868,338 - 188,870,661 (+)	NCBI
mRatBN7.2	3	168,490,804 - 168,493,127 (+)	NCBI
Rnor_6.0	3	176,882,027 - 176,884,350 (+)	NCBI
Rnor_5.0	3	180,591,825 - 180,598,362 (+)	NCBI
RGSC_v3.4	3	170,522,420 - 170,524,743 (+)	RGD
Celera	3	164,093,412 - 164,095,735 (-)	RGD

Sequence:

show sequence

GAGGCGAGCAGAGGCTGTGGGAGCAGCTGCGCAGGAGCTGTGTGGCTGCTGGGAGGTGCTGAGA
AACACAGGAAGTGAGGTGAGGCGTCACCAGCAGCCCACAAAGACCTTCCTGGCTGCCCTAGACA
GGGCCAAGCAGCAAACCCCCGGTGGCCTTGGTAAGTGCTCCCCCATCCTCTATCCTGGGCCAGT
CCCCAACCTCTCCATGCCCTGGGGTCTGGGAGGGTTAGTCCCTGCCTGGCTAGGCCTTTGATAA
CTTGGCTGTAGCCAAGTTAGTCAGCTTGGGCCCACTCTGTATAAGAAGCCTATACTCCAGGCCT
GGACAGGCAGGCCCTCACCCTGATTTTATTCACCCTGAACTCATGGGCAAGACCCTAATCAGCT
CTACTAAGGGCAACTCCAGGAAAGGCAGGAACCCTGGGAAGGGAAGAGTGGGGTGGGAGTACAT
GGCCCTCATAGCAGCTCCCCTGTTCATTGACCCCCAACTGCTTAACTTGCGTTGTGAGTAATCT
AGGAACAGTGCTTGACACAAGGGGTCACTCCTTGGGCATTGGTGGCCAGAGGTGAGATCTGTGG
TCTGTGGCTCAACGTCAGTGATGTCAGAGACTTCCCCAGGTGATGGGCTTGAGCTAGAGATGCA
GCTTTGTTCAGTGAGGTCATAACTCCTGGCCGTGCTCCTGCATCTCCACTCCTGATAACTAAAG
GGGTAGGCAGAGCCCTTCTCACTAGGATCCTTAGCTAGAGAAGGAAGGTGGGTCCCCAGGGCAG
GGCAAAAATGCAAGGCTGGGGGTTTCCGGTGTGCTGAGTCAACCAGGGAGAAGGAACCCACTGC
TGGGCCAGATCTGCAAGTAGGCTGCAGCTGTACACTGGTCCCACAGCCAGCCAGCCCCCAGTGC
TCATCTCTTCTGTCCCCAGGTCTCCCTTCCCTGCTTGACAGGATGAGGCCACCAGTGCCTTCAG
CCCCACTAGCTCTCTGGGTCCTGGGCTGCTTCTCCCTGCTCCTTTGGCTATGGGCACTGTGCAC
AGCCTGCCACAGGAAGAGAGCTCAGAGGCAGCAAACTGGGCTGCAGGGCAGTTTGATGCCAGTG
GAAGTGCCACTGCTGAGACAGGCCCACCTCTGCTCCCTCAGCAAGTCTGACACCAGACTGCATG
AGCTGCACCGAGGCCAACGCTCCACCATAGCCCCACGGCCTGCTAGCATGGATCTTCTGCATCC
ACGCTGGCTAGAGTTATCCAGGGGCAGCACCAGGTCTCAGGTACCCAACTCTGCCTTCCCACCA
CGGCAACTGCCCAGGGCCCCTCCTGCTGCCCCTGCAACTCCGCCTTCTACTAGCCCTGAGGCCA
CTTACTCCAATGTGGGGCTGGCTGCAATTCCCAGGGCCAGCCTGGCTGCTAGCCCTGTGGTGTG
GCCTGGAAGACAGCTGACCATTAGCTGTACCAGGCTTGGTCCTGGGGCCGAGTATGCCTGCATC
CAGAAGCACAAAGGGACAGAGCAGGGCTGCCAAGAATCACAACAGAAGGCTAAGGTGACCCCAG
CTACTCAGATGGATGTCTTATACTCTAGGGTCTGCAAGCCTAAAAGAAGAGACCCAAGACCTGA
CACAGACCAGCTGAACCTCCAGGATGGGAGAACAATTCTGGCCCTTGGGAATGATGTGAAATAT
GAGGCTATCACTCTCAGGGGCCAGGATATGAAGCAAGGAACCTTAGAAAATGTATATGAAAGCA
TCAAGGAGATGGGCCTCTGAGCAGCTGAGCCCTCACCTCCTGTCTGCTTCTGCTTCAGGAGGGT
TTGATGTGCAGGTCCTTCTGTGTCCTTCACCTCCACAGCTGACAGCACAAAGCTCAGGTCCAGT
CCTTGTGGCCTAATTAAATCTCTGTTCAGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102084	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL88721	(Get FASTA)	NCBI Sequence Viewer
	EDL88722	(Get FASTA)	NCBI Sequence Viewer
	EDL88723	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019545.4
	ENSRNOP00000081724.1
	ENSRNOP00000091376.1

RefSeq Acc Id:	NP_001102084 ⟸ NM_001108614
- Peptide Label:	precursor
- UniProtKB:	D4A1E8 (UniProtKB/TrEMBL), A6KM14 (UniProtKB/TrEMBL), A6KM15 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPPVPSAPLALWVLGCFSLLLWLWALCTACHRKRAQRQQTGLQGSLMPVEVPLLRQAHLCSLS KSDTRLHELHRGQRSTIAPRPASMDLLHPRWLELSRGSTRSQVPNSAFPPRQLPRAPPAAPATP PSTSPEATYSNVGLAAIPRASLAASPVVWPGRQLTISCTRLGPGAEYACIQKHKGTEQGCQESQ QKAKVTPATQMDVLYSRVCKPKRRDPRPDTDQLNLQDGRTILALGNDVKYEAITLRGQDMKQGT LENVYESIKEMGL hide sequence

Ensembl Acc Id:

ENSRNOP00000019545 ⟸ ENSRNOT00000019545

Ensembl Acc Id:

ENSRNOP00000091376 ⟸ ENSRNOT00000119792

Ensembl Acc Id:

ENSRNOP00000081724 ⟸ ENSRNOT00000103427

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A1E8-F1-model_v2	AlphaFold	D4A1E8	1-269	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692755

Promoter ID:

EPDNEW_R3280

Type:

single initiation site

Name:

Lime1_1

Description:

Lck interacting transmembrane adaptor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	176,882,020 - 176,882,080	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562795	AgrOrtholog
BioCyc Gene	G2FUF-46288	BioCyc
Ensembl Genes	ENSRNOG00000049336	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019545.6	UniProtKB/TrEMBL
	ENSRNOT00000103427.1	UniProtKB/TrEMBL
	ENSRNOT00000119792.1	UniProtKB/TrEMBL
InterPro	Lime1	UniProtKB/TrEMBL
KEGG Report	rno:362289	UniProtKB/TrEMBL
NCBI Gene	362289	ENTREZGENE
PANTHER	LCK-INTERACTING TRANSMEMBRANE ADAPTER 1	UniProtKB/TrEMBL
	PTHR47740	UniProtKB/TrEMBL
Pfam	LIME1	UniProtKB/TrEMBL
PhenoGen	Lime1	PhenoGen
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000049336	RatGTEx
UniProt	A0A8I5ZS90_RAT	UniProtKB/TrEMBL
	A0A8I6AG03_RAT	UniProtKB/TrEMBL
	A6KM14	ENTREZGENE, UniProtKB/TrEMBL
	A6KM15	ENTREZGENE, UniProtKB/TrEMBL
	D4A1E8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-29	Lime1	Lck interacting transmembrane adaptor 1	RGD1562795_predicted	similar to Lck-interacting transmembrane adaptor protein LIME (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1562795_predicted	similar to Lck-interacting transmembrane adaptor protein LIME (predicted)	LOC362289	similar to Lck-interacting transmembrane adaptor protein LIME	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC362289	similar to Lck-interacting transmembrane adaptor protein LIME			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar