Eola2 (endothelium and lymphocyte associated ASCH domain 2) - Rat Genome Database

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Gene: Eola2 (endothelium and lymphocyte associated ASCH domain 2) Rattus norvegicus
Analyze
Symbol: Eola2
Name: endothelium and lymphocyte associated ASCH domain 2
RGD ID: 1562747
Description: Orthologous to several human genes including EOLA2 (endothelium and lymphocyte associated ASCH domain 2); INTERACTS WITH bisphenol A; dibutyl phthalate; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC292328; LOC292328; RGD1562747; similar to RIKEN cDNA 1110012L19; uncharacterized protein LOC292328
RGD Orthologs
Human
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,108,628 - 154,113,426 (+)NCBIGRCr8
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX149,064,041 - 149,068,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX151,258,277 - 151,261,793 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X154,792,460 - 154,795,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X152,334,022 - 152,337,538 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,484,134 - 69,488,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,484,174 - 69,489,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0869,192,972 - 69,197,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X156,620,142 - 156,623,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1132,341,858 - 132,345,374 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18534126  


Genomics

Comparative Map Data
Eola2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,108,628 - 154,113,426 (+)NCBIGRCr8
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX149,064,041 - 149,068,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX151,258,277 - 151,261,793 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X154,792,460 - 154,795,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X152,334,022 - 152,337,538 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,484,134 - 69,488,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,484,174 - 69,489,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0869,192,972 - 69,197,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X156,620,142 - 156,623,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1132,341,858 - 132,345,374 (-)NCBICelera
Cytogenetic MapXq37NCBI
EOLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X149,929,532 - 149,938,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX149,929,527 - 149,938,700 (-)EnsemblGRCh38hg38GRCh38
GRCh37X149,100,415 - 149,106,709 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X148,851,073 - 148,857,374 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX149,351,614 - 149,351,919 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX137,971,130 - 137,971,438 (-)NCBIHuRef
CHM1_1X148,974,755 - 148,981,056 (-)NCBICHM1_1
T2T-CHM13v2.0X148,191,783 - 148,206,745 (-)NCBIT2T-CHM13v2.0
EOLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X150,060,911 - 150,074,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X150,069,781 - 150,078,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X139,577,979 - 139,587,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X149,508,737 - 149,523,459 (-)NCBIpanpan1.1PanPan1.1panPan2
Eola2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X115,798,966 - 115,809,226 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367142,447,289 - 2,453,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EOLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X124,529,014 - 124,543,153 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606562,220,348 - 62,234,690 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:112
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000056518
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH128792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X149,067,413 - 149,067,563 (+)MAPPERmRatBN7.2
Rnor_6.0869,487,785 - 69,487,934NCBIRnor6.0
Rnor_5.0869,196,485 - 69,196,634UniSTSRnor5.0
RGSC_v3.4X156,620,159 - 156,620,308UniSTSRGSC3.4
Celera1132,341,875 - 132,342,024UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 6 15 2
Low 3 43 55 41 19 41 8 11 65 29 26 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056518   ⟹   ENSRNOP00000053358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl869,484,323 - 69,487,951 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077290   ⟹   ENSRNOP00000071593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl869,484,174 - 69,489,891 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095412   ⟹   ENSRNOP00000093972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX149,064,041 - 149,068,627 (+)Ensembl
RefSeq Acc Id: NM_001106212   ⟹   NP_001099682
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,108,863 - 154,112,379 (+)NCBI
mRatBN7.2X149,064,064 - 149,067,580 (+)NCBI
Rnor_6.0869,484,323 - 69,487,951 (+)NCBI
Rnor_5.0869,192,972 - 69,197,698 (+)NCBI
RGSC_v3.4X156,620,142 - 156,623,658 (-)RGD
Celera1132,341,858 - 132,345,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243225   ⟹   XP_006243287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,108,628 - 154,113,426 (+)NCBI
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBI
Rnor_6.0869,484,134 - 69,488,998 (+)NCBI
Rnor_5.0869,192,972 - 69,197,698 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099682 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84454 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093972
  ENSRNOP00000093972.1
Reference Protein Sequences
RefSeq Acc Id: NP_001099682   ⟸   NM_001106212
- UniProtKB: D3ZPT1 (UniProtKB/TrEMBL),   A6KQ84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243287   ⟸   XM_006243225
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071593   ⟸   ENSRNOT00000077290
RefSeq Acc Id: ENSRNOP00000053358   ⟸   ENSRNOT00000056518
RefSeq Acc Id: ENSRNOP00000093972   ⟸   ENSRNOT00000095412
Protein Domains
ASCH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPT1-F1-model_v2 AlphaFold D3ZPT1 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696066
Promoter ID:EPDNEW_R6591
Type:initiation region
Name:RGD1562747_1
Description:similar to RIKEN cDNA 1110012L19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0869,484,353 - 69,484,413EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562747 AgrOrtholog
BioCyc Gene G2FUF-730 BioCyc
Ensembl Genes ENSRNOG00000037352 Ensembl
  ENSRNOG00000063254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095412 ENTREZGENE
  ENSRNOT00000095412.1 UniProtKB/TrEMBL
Gene3D-CATH Hypothetical protein UniProtKB/TrEMBL
InterPro ASCH_domain UniProtKB/TrEMBL
  CXorf40 UniProtKB/TrEMBL
  PUA-like UniProtKB/TrEMBL
KEGG Report rno:292328 UniProtKB/TrEMBL
NCBI Gene 292328 ENTREZGENE
PANTHER PROTEIN EOLA1-RELATED UniProtKB/TrEMBL
  PTHR31666 UniProtKB/TrEMBL
PhenoGen Eola2 PhenoGen
RatGTEx ENSRNOG00000037352 RatGTEx
  ENSRNOG00000063254 RatGTEx
SMART ASCH UniProtKB/TrEMBL
Superfamily-SCOP PUA-like UniProtKB/TrEMBL
UniProt A0A0G2K0V2 ENTREZGENE
  A6KQ84 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Eola2  endothelium and lymphocyte associated ASCH domain 2  RGD1562747  similar to RIKEN cDNA 1110012L19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562747  similar to RIKEN cDNA 1110012L19   RGD1562747_predicted  similar to RIKEN cDNA 1110012L19 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562747_predicted  similar to RIKEN cDNA 1110012L19 (predicted)  LOC292328  similar to RIKEN cDNA 1110012L19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292328  similar to RIKEN cDNA 1110012L19      Symbol and Name status set to provisional 70820 PROVISIONAL