Entpd8 (ectonucleoside triphosphate diphosphohydrolase 8) - Rat Genome Database

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Gene: Entpd8 (ectonucleoside triphosphate diphosphohydrolase 8) Rattus norvegicus
Analyze
Symbol: Entpd8
Name: ectonucleoside triphosphate diphosphohydrolase 8
RGD ID: 1561793
Description: Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E-NTPDase 8; NTPDase 8; NTPDase8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,283,392 - 28,295,686 (+)NCBIGRCr8
mRatBN7.237,885,277 - 7,895,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,889,909 - 7,895,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,995,425 - 11,000,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,581,652 - 19,586,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,771,499 - 17,776,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,286,363 - 2,299,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,288,667 - 2,302,782 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,267,798 - 2,281,078 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,229,747 - 5,258,064 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,718,457 - 2,723,116 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (ISO)
plasma membrane  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15122917   PMID:16752921   PMID:17095758   PMID:18404504  


Genomics

Comparative Map Data
Entpd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,283,392 - 28,295,686 (+)NCBIGRCr8
mRatBN7.237,885,277 - 7,895,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,889,909 - 7,895,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,995,425 - 11,000,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,581,652 - 19,586,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,771,499 - 17,776,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,286,363 - 2,299,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,288,667 - 2,302,782 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,267,798 - 2,281,078 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,229,747 - 5,258,064 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,718,457 - 2,723,116 (+)NCBICelera
Cytogenetic Map3p13NCBI
ENTPD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,434,364 - 137,441,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,434,364 - 137,441,816 (-)EnsemblGRCh38hg38GRCh38
GRCh379140,328,816 - 140,335,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,448,637 - 139,455,722 (-)NCBINCBI36Build 36hg18NCBI36
Celera9110,854,994 - 110,862,292 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,793,335 - 109,797,279 (-)NCBIHuRef
CHM1_19140,477,526 - 140,484,325 (-)NCBICHM1_1
T2T-CHM13v2.09149,684,986 - 149,691,908 (-)NCBIT2T-CHM13v2.0
Entpd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,969,308 - 24,975,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,970,316 - 24,975,728 (+)EnsemblGRCm39 Ensembl
GRCm38225,079,296 - 25,085,719 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,080,304 - 25,085,716 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,935,843 - 24,941,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,902,331 - 24,907,735 (+)NCBIMGSCv36mm8
Celera224,807,501 - 24,812,897 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.97NCBI
Entpd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,353,229 - 5,356,019 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,352,843 - 5,357,671 (-)NCBIChiLan1.0ChiLan1.0
ENTPD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,951,005 - 1,955,579 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,953,502 - 1,957,912 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,503,511 - 108,511,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,468,154 - 137,472,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,468,154 - 137,472,092 (-)Ensemblpanpan1.1panPan2
ENTPD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,301,499 - 48,306,210 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,303,206 - 48,305,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,488,660 - 47,493,285 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,163,572 - 49,168,197 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,165,208 - 49,168,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,939,941 - 47,944,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,238,919 - 48,243,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,285,415 - 48,290,040 (+)NCBIUU_Cfam_GSD_1.0
Entpd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,742,160 - 202,760,164 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669615,375 - 634,309 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669629,400 - 632,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENTPD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,007,959 - 314,012,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENTPD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112752,258 - 758,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12752,774 - 757,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,588,947 - 4,594,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Entpd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760599,156 - 603,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760597,580 - 603,523 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Entpd8
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:113
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000012289
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 6 6
Low 17 17 2 17 11 7 11
Below cutoff 8 30 14 17 14 8 8 13 16 15 8

Sequence


Ensembl Acc Id: ENSRNOT00000012289   ⟹   ENSRNOP00000012289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,889,909 - 7,895,296 (+)Ensembl
Rnor_6.0 Ensembl32,288,667 - 2,302,782 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109534   ⟹   ENSRNOP00000095185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,889,909 - 7,895,296 (+)Ensembl
RefSeq Acc Id: NM_001033565   ⟹   NP_001028737
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,288,080 - 28,293,459 (+)NCBI
mRatBN7.237,889,909 - 7,895,289 (+)NCBI
Rnor_6.032,290,304 - 2,299,492 (+)NCBI
Rnor_5.032,267,798 - 2,281,078 (+)NCBI
RGSC_v3.435,229,747 - 5,258,064 (+)RGD
Celera32,718,457 - 2,723,116 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233639   ⟹   XP_006233701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,397 - 28,295,686 (+)NCBI
mRatBN7.237,885,280 - 7,895,517 (+)NCBI
Rnor_6.032,288,898 - 2,299,720 (+)NCBI
Rnor_5.032,267,798 - 2,281,078 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105775   ⟹   XP_038961703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,397 - 28,295,686 (+)NCBI
mRatBN7.237,887,276 - 7,895,517 (+)NCBI
RefSeq Acc Id: XM_063284479   ⟹   XP_063140549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,396 - 28,295,686 (+)NCBI
RefSeq Acc Id: XM_063284480   ⟹   XP_063140550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,401 - 28,295,686 (+)NCBI
RefSeq Acc Id: XM_063284481   ⟹   XP_063140551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,400 - 28,295,686 (+)NCBI
RefSeq Acc Id: XM_063284482   ⟹   XP_063140552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,400 - 28,295,686 (+)NCBI
RefSeq Acc Id: XM_063284483   ⟹   XP_063140553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,392 - 28,295,686 (+)NCBI
RefSeq Acc Id: XM_063284484   ⟹   XP_063140554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,283,396 - 28,295,686 (+)NCBI
RefSeq Acc Id: NP_001028737   ⟸   NM_001033565
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233701   ⟸   XM_006233639
- Peptide Label: isoform X1
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012289   ⟸   ENSRNOT00000012289
RefSeq Acc Id: XP_038961703   ⟸   XM_039105775
- Peptide Label: isoform X1
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000095185   ⟸   ENSRNOT00000109534
RefSeq Acc Id: XP_063140553   ⟸   XM_063284483
- Peptide Label: isoform X3
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140554   ⟸   XM_063284484
- Peptide Label: isoform X4
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140549   ⟸   XM_063284479
- Peptide Label: isoform X1
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140551   ⟸   XM_063284481
- Peptide Label: isoform X2
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140552   ⟸   XM_063284482
- Peptide Label: isoform X2
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140550   ⟸   XM_063284480
- Peptide Label: isoform X2
- UniProtKB: Q5DRK1 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5DRK1-F1-model_v2 AlphaFold Q5DRK1 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561793 AgrOrtholog
BioCyc Gene G2FUF-50487 BioCyc
Ensembl Genes ENSRNOG00000009239 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012289.8 UniProtKB/TrEMBL
  ENSRNOT00000109534.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exopolyphosphatase. Domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GDA1_CD39_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:613267 UniProtKB/Swiss-Prot
NCBI Gene 613267 ENTREZGENE
PANTHER ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDA1_CD39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Entpd8 PhenoGen
PROSITE GDA1_CD39_NTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009239 RatGTEx
UniProt A0A8I6AN09_RAT UniProtKB/TrEMBL
  A6JT07_RAT UniProtKB/TrEMBL
  A6JT08_RAT UniProtKB/TrEMBL
  ENTP8_RAT UniProtKB/Swiss-Prot
  F1LPV1_RAT UniProtKB/TrEMBL
  Q5DRK1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Entpd8  ectonucleoside triphosphate diphosphohydrolase 8      Symbol and Name status set to provisional 70820 PROVISIONAL