Rnase12 (ribonuclease, RNase A family, 12 (non-active)) - Rat Genome Database

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Gene: Rnase12 (ribonuclease, RNase A family, 12 (non-active)) Mus musculus
Analyze
Symbol: Rnase12
Name: ribonuclease, RNase A family, 12 (non-active)
RGD ID: 1558278
MGI Page MGI
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Orthologous to human RNASE12 (ribonuclease A family member 12 (inactive)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: probable inactive ribonuclease-like protein 12; Rai1; ribonuclease 12; ribonuclease A i1; ribonuclease-like protein 12
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,294,155 - 51,294,699 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,294,155 - 51,295,118 (-)EnsemblGRCm39 Ensembl
GRCm381451,056,698 - 51,057,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,056,698 - 51,057,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,676,458 - 51,676,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,978,734 - 49,979,171 (-)NCBIMGSCv36mm8
Celera1447,334,352 - 47,334,789 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Cho S, etal., Genomics. 2005 Feb;85(2):208-20.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14610273   PMID:16602821   PMID:21267068   PMID:21873635   PMID:24337645   PMID:38355793  


Genomics

Comparative Map Data
Rnase12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,294,155 - 51,294,699 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,294,155 - 51,295,118 (-)EnsemblGRCm39 Ensembl
GRCm381451,056,698 - 51,057,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,056,698 - 51,057,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,676,458 - 51,676,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,978,734 - 49,979,171 (-)NCBIMGSCv36mm8
Celera1447,334,352 - 47,334,789 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.36NCBI
RNASE12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,590,073 - 20,591,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,590,073 - 20,591,376 (-)EnsemblGRCh38hg38GRCh38
GRCh371421,058,232 - 21,059,535 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,128,279 - 20,128,722 (-)NCBINCBI36Build 36hg18NCBI36
Celera14919,115 - 919,858 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,179,194 - 1,179,937 (-)NCBIHuRef
CHM1_11421,060,260 - 21,061,003 (-)NCBICHM1_1
T2T-CHM13v2.01414,787,199 - 14,788,502 (-)NCBIT2T-CHM13v2.0
Rnase12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,749,291 - 26,761,261 (-)NCBIGRCr8
mRatBN7.21524,275,767 - 24,286,843 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,275,774 - 24,276,702 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,046,933 - 27,047,968 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,006,347 - 28,007,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,255,488 - 26,256,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,981,044 - 27,993,044 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,981,226 - 27,981,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,813,813 - 31,814,848 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,035,657 - 27,036,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,051,357 - 27,051,794 (-)NCBI
Celera1524,595,824 - 24,596,261 (-)NCBICelera
Cytogenetic Map15p14NCBI
Rnase12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,399,335 - 1,400,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,399,335 - 1,400,310 (-)NCBIChiLan1.0ChiLan1.0
RNASE12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,090,010 - 22,091,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,306,497 - 21,307,711 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,455,095 - 1,455,777 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,512,240 - 19,512,971 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,512,434 - 19,512,877 (-)Ensemblpanpan1.1panPan2
RNASE12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,903,824 - 17,906,219 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,903,983 - 17,906,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,386,238 - 18,388,665 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,160,555 - 18,162,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,160,721 - 18,162,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,842,557 - 17,844,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,898,192 - 17,900,629 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,026,824 - 18,029,255 (-)NCBIUU_Cfam_GSD_1.0
RNASE12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,340,268 - 78,340,705 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,333,025 - 78,340,906 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,359,308 - 83,367,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNASE12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,112,741 - 21,131,991 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,112,948 - 21,113,391 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,316,253 - 25,317,185 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnase12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,584,782 - 4,585,219 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,584,114 - 4,585,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnase12
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:170
Interacting mature miRNAs:179
Transcripts:ENSMUST00000089798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000089798   ⟹   ENSMUSP00000087231
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,294,155 - 51,294,699 (-)Ensembl
GRCm38.p6 Ensembl1451,056,698 - 51,057,242 (-)Ensembl
Ensembl Acc Id: ENSMUST00000227764   ⟹   ENSMUSP00000154201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,294,155 - 51,295,118 (-)Ensembl
GRCm38.p6 Ensembl1451,056,698 - 51,057,661 (-)Ensembl
RefSeq Acc Id: NM_001011875   ⟹   NP_001011875
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,294,155 - 51,294,699 (-)NCBI
GRCm381451,056,698 - 51,057,242 (-)NCBI
MGSCv371451,676,458 - 51,676,895 (-)RGD
Celera1447,334,267 - 47,334,811 (-)NCBI
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001011875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI46015 (Get FASTA)   NCBI Sequence Viewer  
  AAI46017 (Get FASTA)   NCBI Sequence Viewer  
  AAV87191 (Get FASTA)   NCBI Sequence Viewer  
  CDG32027 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000087231
  ENSMUSP00000087231.3
  ENSMUSP00000154201.2
GenBank Protein Q5GAM8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011875   ⟸   NM_001011875
- Peptide Label: precursor
- UniProtKB: Q5GAM8 (UniProtKB/Swiss-Prot),   W0UUY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000154201   ⟸   ENSMUST00000227764
Ensembl Acc Id: ENSMUSP00000087231   ⟸   ENSMUST00000089798
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAM8-F1-model_v2 AlphaFold Q5GAM8 1-145 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3528588 AgrOrtholog
Ensembl Genes ENSMUSG00000068407 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089798 ENTREZGENE
  ENSMUST00000089798.3 UniProtKB/Swiss-Prot
  ENSMUST00000227764.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:497106 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3528588 ENTREZGENE
NCBI Gene 497106 ENTREZGENE
PANTHER PTHR11437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11437:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnase12 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q5GAM8 ENTREZGENE, UniProtKB/Swiss-Prot
  W0UUY1 ENTREZGENE, UniProtKB/TrEMBL