Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A) - Rat Genome Database

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Gene: Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A) Mus musculus
Analyze
No known orthologs.
Symbol: Cmtm2a
Name: CKLF-like MARVEL transmembrane domain containing 2A
RGD ID: 1552714
MGI Page MGI
Description: Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700001K04Rik; 1700041N15Rik; 1700063K20Rik; AI449770; AR; ARR19; C32; chemokine-like factor super family 2A; chemokine-like factor superfamily 2-1b; chemokine-like factor superfamily member 2A; Ckl; Cklf; CKLF-like MARVEL transmembrane domain-containing protein 2A; Cklf1; CKLF3; CKLF4; CKLF5; Cklfs; Cklfsf2-1b; Cklfsf2a; UCK-1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,007,674 - 105,019,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,007,674 - 105,019,813 (-)EnsemblGRCm39 Ensembl
GRCm388104,281,042 - 104,293,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,281,042 - 104,293,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv378106,804,942 - 106,817,081 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,170,171 - 107,182,303 (-)NCBIMGSCv36mm8
Celera8108,512,498 - 108,524,606 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2aMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of CMTM2A mRNACTDPMID:22206623
Cmtm2aMouseacetohydrazide decreases expressionEXP 6480464acetylhydrazine results in decreased expression of CMTM2A mRNACTDPMID:15282401
Cmtm2aMousebis(2-ethylhexyl) phthalate increases expressionEXP 6480464Diethylhexyl Phthalate results in increased expression of CMTM2A mRNACTDPMID:34319233
Cmtm2aMousebisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of CMTM2A promoterCTDPMID:27312807
Cmtm2aMousebisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CMTM2A mRNACTDPMID:32156529
Cmtm2aMousebisphenol A decreases methylationEXP 6480464bisphenol A results in decreased methylation of CMTM2A promoterCTDPMID:27312807
Cmtm2aMousecarbon nanotube increases expressionEXP 6480464Nanotubes more ...CTDPMID:25554681
Cmtm2aMousecholine multiple interactionsEXP 6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CMTM2A mRNACTDPMID:20938992
Cmtm2aMousefolic acid multiple interactionsEXP 6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CMTM2A mRNACTDPMID:20938992
Cmtm2aMouseL-methionine multiple interactionsEXP 6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CMTM2A mRNACTDPMID:20938992

1 to 10 of 10 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2aMousechemotaxis involved_inIEAUniProtKB-KW:KW-01452290270 UniProtGO_REF:0000043
Cmtm2aMousenegative regulation of DNA-templated transcription acts_upstream_of_or_withinIDA 2290270 PMID:14576337MGIPMID:14576337
Cmtm2aMouseregulation of testosterone biosynthetic process acts_upstream_of_or_withinIDA 2290270 PMID:19398553MGIPMID:19398553
Cmtm2aMousesignal transduction involved_inIEAGO:00051252290270 GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2aMousecytoplasm located_inIDA 2290270 PMID:14576337MGIPMID:14576337
Cmtm2aMouseextracellular space located_inIEAUniProtKB-KW:KW-02022290270 UniProtGO_REF:0000043
Cmtm2aMousemembrane located_inIEAUniProtKB-SubCell:SL-01622290270 UniProtGO_REF:0000044
Cmtm2aMousemembrane is_active_inIBAPANTHER:PTN001103553 more ...2290270 GO_CentralGO_REF:0000033
Cmtm2aMousenucleus located_inIPIPR:P190912290270 PMID:14576337MGIPMID:14576337

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2aMousecytokine activity enablesIEAUniProtKB-KW:KW-02022290270 UniProtGO_REF:0000043
Cmtm2aMouseprotein binding enablesIPIPR:P19091 and PR:Q6NZM92290270 PMID:14576337MGIPMID:14576337
Cmtm2aMousetranscription corepressor activity enablesIDA 2290270 PMID:14576337MGIPMID:14576337


#
Reference Title
Reference Citation
1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Han W, etal., Genomics 2003 Jun;81(6):609-17.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12183067   PMID:12477932   PMID:14576337   PMID:14672409   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16343975   PMID:19398553  
PMID:20472563   PMID:20562862   PMID:21873635   PMID:22587964   PMID:26260329   PMID:30209135   PMID:30982091   PMID:31455729   PMID:37098609  



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Variants in Cmtm2a
858 total Variants

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:97
Interacting mature miRNAs:99
Transcripts:ENSMUST00000034344
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse

1 to 10 of 34 rows
AI449770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,281,332 - 104,281,478UniSTSGRCm38
GRCm388104,257,304 - 104,257,450UniSTSGRCm38
MGSCv378106,805,232 - 106,805,378UniSTSGRCm37
MGSCv378106,781,204 - 106,781,350UniSTSGRCm37
Celera8108,512,788 - 108,512,934UniSTS
Celera8108,488,760 - 108,488,906UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map8D1UniSTS
Whitehead/MRC_RH81217.16UniSTS







Ensembl Acc Id: ENSMUST00000034344   ⟹   ENSMUSP00000034344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,007,674 - 105,019,810 (-)Ensembl
GRCm38.p6 Ensembl8104,281,042 - 104,293,178 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212487   ⟹   ENSMUSP00000148812
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,017,745 - 105,019,813 (-)Ensembl
GRCm38.p6 Ensembl8104,291,113 - 104,293,181 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212492   ⟹   ENSMUSP00000148378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,007,931 - 105,019,806 (-)Ensembl
GRCm38.p6 Ensembl8104,281,299 - 104,293,174 (-)Ensembl
RefSeq Acc Id: NM_027022   ⟹   NP_081298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,007,674 - 105,019,813 (-)NCBI
GRCm388104,281,042 - 104,293,181 (-)NCBI
MGSCv378106,804,942 - 106,817,081 (-)RGD
Celera8108,512,498 - 108,524,606 (-)RGD
cM Map8 ENTREZGENE
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_081298 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH49747 (Get FASTA)   NCBI Sequence Viewer  
  AAO17718 (Get FASTA)   NCBI Sequence Viewer  
  AAO34102 (Get FASTA)   NCBI Sequence Viewer  
  AAP33493 (Get FASTA)   NCBI Sequence Viewer  
  BAB24146 (Get FASTA)   NCBI Sequence Viewer  
  BAB24775 (Get FASTA)   NCBI Sequence Viewer  
  EDL11207 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034344
  ENSMUSP00000034344.10
GenBank Protein Q9DAR1 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_081298   ⟸   NM_027022
- UniProtKB: Q811V3 (UniProtKB/Swiss-Prot),   Q9CVR4 (UniProtKB/Swiss-Prot),   Q9DAR1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034344   ⟸   ENSMUST00000034344
Ensembl Acc Id: ENSMUSP00000148378   ⟸   ENSMUST00000212492
Ensembl Acc Id: ENSMUSP00000148812   ⟸   ENSMUST00000212487
MARVEL

Name Modeler Protein Id AA Range Protein Structure
AF-Q9DAR1-F1-model_v2 AlphaFold Q9DAR1 1-169 view protein structure

RGD ID:8668003
Promoter ID:EPDNEW_M12032
Type:initiation region
Name:Cmtm2a_1
Description:Mus musculus CKLF-like MARVEL transmembrane domain containing2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388104,293,174 - 104,293,234EPDNEW


1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000074127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034344 ENTREZGENE
  ENSMUST00000034344.10 UniProtKB/Swiss-Prot
InterPro Marvel UniProtKB/Swiss-Prot
KEGG Report mmu:73381 UniProtKB/Swiss-Prot
MGD MGI:2447160 ENTREZGENE
NCBI Gene 73381 ENTREZGENE
PhenoGen Cmtm2a PhenoGen
PROSITE MARVEL UniProtKB/Swiss-Prot
UniProt A0A1D5RLI2_MOUSE UniProtKB/TrEMBL
  A0A1D5RMK3_MOUSE UniProtKB/TrEMBL
  CLF2A_MOUSE UniProtKB/Swiss-Prot
  Q811V3 ENTREZGENE
  Q9CVR4 ENTREZGENE
  Q9DAR1 ENTREZGENE
UniProt Secondary Q811V3 UniProtKB/Swiss-Prot
  Q9CVR4 UniProtKB/Swiss-Prot
1 to 17 of 17 rows