Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A) - Rat Genome Database

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Gene: Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A) Mus musculus
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Symbol: Cmtm2a
Name: CKLF-like MARVEL transmembrane domain containing 2A
RGD ID: 1552714
MGI Page MGI
Description: Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2); INTERACTS WITH 1,2-dimethylhydrazine; acetohydrazide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700001K04Rik; 1700041N15Rik; 1700063K20Rik; AI449770; AR; ARR19; C32; chemokine-like factor super family 2A; chemokine-like factor superfamily 2-1b; chemokine-like factor superfamily member 2A; Ckl; Cklf; CKLF-like MARVEL transmembrane domain-containing protein 2A; Cklf1; CKLF3; CKLF4; CKLF5; Cklfs; Cklfsf2-1b; Cklfsf2a; UCK-1
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,007,674 - 105,019,813 (-)NCBIGRCm39mm39
GRCm39 Ensembl8105,007,674 - 105,019,813 (-)Ensembl
GRCm388104,281,042 - 104,293,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,281,042 - 104,293,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv378106,804,942 - 106,817,081 (-)NCBIGRCm37mm9NCBIm37
MGSCv368107,170,171 - 107,182,303 (-)NCBImm8
Celera8108,512,498 - 108,524,606 (-)NCBICelera
Cytogenetic Map8D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12183067   PMID:12477932   PMID:14576337   PMID:14672409   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16343975   PMID:19398553  
PMID:20472563   PMID:20562862   PMID:21873635   PMID:22587964   PMID:26260329   PMID:30209135   PMID:30982091   PMID:31455729  


Genomics

Comparative Map Data
Cmtm2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,007,674 - 105,019,813 (-)NCBIGRCm39mm39
GRCm39 Ensembl8105,007,674 - 105,019,813 (-)Ensembl
GRCm388104,281,042 - 104,293,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,281,042 - 104,293,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv378106,804,942 - 106,817,081 (-)NCBIGRCm37mm9NCBIm37
MGSCv368107,170,171 - 107,182,303 (-)NCBImm8
Celera8108,512,498 - 108,524,606 (-)NCBICelera
Cytogenetic Map8D3NCBI
Cmtm2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.219671,719 - 678,839 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl19671,719 - 678,837 (+)Ensembl
Rnor_6.019880,024 - 887,144 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19880,024 - 887,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019878,307 - 885,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419629,381 - 636,501 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119629,380 - 636,501 (+)NCBI
Celera19667,618 - 674,738 (+)NCBICelera
Cytogenetic Map19p14NCBI

Position Markers
AI449770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,281,332 - 104,281,478UniSTSGRCm38
GRCm388104,257,304 - 104,257,450UniSTSGRCm38
MGSCv378106,805,232 - 106,805,378UniSTSGRCm37
MGSCv378106,781,204 - 106,781,350UniSTSGRCm37
Celera8108,512,788 - 108,512,934UniSTS
Celera8108,488,760 - 108,488,906UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map8D1UniSTS
Whitehead/MRC_RH81217.16UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8101759576110923404Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8101759576115298718Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:97
Interacting mature miRNAs:99
Transcripts:ENSMUST00000034344
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034344   ⟹   ENSMUSP00000034344
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,007,674 - 105,019,810 (-)Ensembl
GRCm38.p6 Ensembl8104,281,042 - 104,293,178 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212487   ⟹   ENSMUSP00000148812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,017,745 - 105,019,813 (-)Ensembl
GRCm38.p6 Ensembl8104,291,113 - 104,293,181 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212492   ⟹   ENSMUSP00000148378
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,007,931 - 105,019,806 (-)Ensembl
GRCm38.p6 Ensembl8104,281,299 - 104,293,174 (-)Ensembl
RefSeq Acc Id: NM_027022   ⟹   NP_081298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,007,674 - 105,019,813 (-)NCBI
GRCm388104,281,042 - 104,293,181 (-)NCBI
MGSCv378106,804,942 - 106,817,081 (-)RGD
Celera8108,512,498 - 108,524,606 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081298   ⟸   NM_027022
- UniProtKB: Q9DAR1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034344   ⟸   ENSMUST00000034344
RefSeq Acc Id: ENSMUSP00000148378   ⟸   ENSMUST00000212492
RefSeq Acc Id: ENSMUSP00000148812   ⟸   ENSMUST00000212487
Protein Domains
MARVEL

Promoters
RGD ID:8668003
Promoter ID:EPDNEW_M12032
Type:initiation region
Name:Cmtm2a_1
Description:Mus musculus CKLF-like MARVEL transmembrane domain containing2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388104,293,174 - 104,293,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2447160 AgrOrtholog
Ensembl Genes ENSMUSG00000074127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034344 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148378 UniProtKB/TrEMBL
  ENSMUSP00000148812 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034344 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212487 UniProtKB/TrEMBL
  ENSMUST00000212492 UniProtKB/TrEMBL
InterPro Marvel UniProtKB/Swiss-Prot
KEGG Report mmu:73381 UniProtKB/Swiss-Prot
MGD MGI:2447160 ENTREZGENE
NCBI Gene 73381 ENTREZGENE
PhenoGen Cmtm2a PhenoGen
PROSITE MARVEL UniProtKB/Swiss-Prot
UniProt A0A1D5RLI2_MOUSE UniProtKB/TrEMBL
  A0A1D5RMK3_MOUSE UniProtKB/TrEMBL
  CLF2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q811V3 UniProtKB/Swiss-Prot
  Q9CVR4 UniProtKB/Swiss-Prot