Zfp654 (zinc finger protein 654) - Rat Genome Database

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Gene: Zfp654 (zinc finger protein 654) Mus musculus
Analyze
Symbol: Zfp654
Name: zinc finger protein 654
RGD ID: 1551594
MGI Page MGI
Description: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZNF654 (zinc finger protein 654).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600021C16Rik; 1810008K20Rik; 433036; Gm5488; predicted gene 5488; Znf654
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391664,600,710 - 64,672,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1664,600,710 - 64,672,015 (-)EnsemblGRCm39 Ensembl
GRCm381664,780,347 - 64,851,937 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1664,780,347 - 64,851,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv371664,780,173 - 64,786,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361664,722,549 - 64,728,523 (-)NCBIMGSCv36mm8
Celera1665,074,987 - 65,080,961 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1637.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 48 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp654Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of ZFP654 mRNACTDPMID:22206623
Zfp654Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13083216480464Tetrachlorodibenzodioxin results in decreased expression of ZFP654 mRNACTDPMID:21215274
Zfp654Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13453606480464Tetrachlorodibenzodioxin results in decreased expression of ZNF654 mRNACTDPMID:29704546
Zfp654Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ZFP654 mRNACTDPMID:21570461
Zfp654Mouse2-hydroxypropanoic acid decreases expressionISORGD:13453606480464Lactic Acid results in decreased expression of ZNF654 mRNACTDPMID:30851411
Zfp654Mouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of ZFP654 mRNACTDPMID:39298647
Zfp654Mouse6-propyl-2-thiouracil decreases expressionISORGD:13083216480464Propylthiouracil results in decreased expression of ZFP654 mRNACTDPMID:30047161
Zfp654Mouseaflatoxin B1 increases methylationISORGD:13453606480464Aflatoxin B1 results in increased methylation of ZNF654 geneCTDPMID:28458013
Zfp654Mouseaflatoxin M1 decreases expressionISORGD:13453606480464Aflatoxin M1 results in decreased expression of ZNF654 mRNACTDPMID:30928695
Zfp654Mouseall-trans-retinoic acid increases expressionISORGD:13453606480464Tretinoin results in increased expression of ZNF654 mRNACTDPMID:33167477
Zfp654Mouseamitrole decreases expressionISORGD:13083216480464Amitrole results in decreased expression of ZFP654 mRNACTDPMID:30047161
Zfp654Mousearistolochic acid A decreases expressionISORGD:13453606480464aristolochic acid I results in decreased expression of ZNF654 mRNACTDPMID:33212167
Zfp654Mousearsane multiple interactionsISORGD:13453606480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ZNF654 more ...CTDPMID:39836092
Zfp654Mousearsenic atom multiple interactionsISORGD:13453606480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ZNF654 more ...CTDPMID:39836092
Zfp654Mouseatrazine increases expressionISORGD:13453606480464Atrazine results in increased expression of ZNF654 mRNACTDPMID:22378314
Zfp654Mousebenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of ZFP654 mRNACTDPMID:22228805
Zfp654Mousebenzo[a]pyrene decreases methylationISORGD:13453606480464Benzo(a)pyrene results in decreased methylation of ZNF654 5' UTRCTDPMID:27901495
Zfp654Mousebisphenol A multiple interactionsISORGD:13083216480464[bisphenol A co-treated with Testosterone] results in increased expression of ZFP654 mRNACTDPMID:26496021
Zfp654Mousecadmium dichloride decreases expressionISORGD:13453606480464Cadmium Chloride results in decreased expression of ZNF654 mRNACTDPMID:38568856
Zfp654Mousecobalt dichloride increases expressionISORGD:13083216480464cobaltous chloride results in increased expression of ZFP654 mRNACTDPMID:24386269

1 to 20 of 48 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp654Mouseregulation of transcription by RNA polymerase II involved_inIBAPANTHER:PTN002694189|MGI:1924705|RGD:619312290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp654Mousenucleus is_active_inIBAPANTHER:PTN002694189|RGD:619312290270 GO_CentralGO_REF:0000033
Zfp654Mousenucleus located_inIEAUniProtKB-SubCell:SL-01912290270 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp654MouseDNA binding enablesIBAPANTHER:PTN002694189|RGD:61931|MGI:19247052290270 GO_CentralGO_REF:0000033
Zfp654MouseDNA binding enablesIEAUniProtKB-KW:KW-02382290270 UniProtGO_REF:0000043
Zfp654MouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN002694189|RGD:619312290270 GO_CentralGO_REF:0000033
Zfp654Mousezinc ion binding enablesIEAUniProtKB-KW:KW-08632290270 UniProtGO_REF:0000043

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp654Mouseincreased bone mineral content  IEA 5509061 MGI 
Zfp654Mousepreweaning lethality, complete penetrance  IEA 5509061 MGI 
Zfp654Mousepreweaning lethality, incomplete penetrance  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15618518   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20059953  
PMID:20412781   PMID:21267068   PMID:21873635   PMID:38355793  



Zfp654
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391664,600,710 - 64,672,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1664,600,710 - 64,672,015 (-)EnsemblGRCm39 Ensembl
GRCm381664,780,347 - 64,851,937 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1664,780,347 - 64,851,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv371664,780,173 - 64,786,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361664,722,549 - 64,728,523 (-)NCBIMGSCv36mm8
Celera1665,074,987 - 65,080,961 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1637.1NCBI
ZNF654
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38388,059,255 - 88,144,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl388,059,255 - 88,144,660 (+)EnsemblGRCh38hg38GRCh38
GRCh37388,108,405 - 88,193,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36388,270,952 - 88,276,504 (+)NCBINCBI36Build 36hg18NCBI36
Build 34388,271,164 - 88,273,912NCBI
Celera388,942,131 - 88,947,592 (+)NCBICelera
Cytogenetic Map3p11.1NCBI
HuRef388,201,768 - 88,207,323 (+)NCBIHuRef
CHM1_1388,141,379 - 88,146,934 (+)NCBICHM1_1
T2T-CHM13v2.0388,135,096 - 88,220,495 (+)NCBIT2T-CHM13v2.0
Zfp654
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81115,947,425 - 16,011,957 (-)NCBIGRCr8
mRatBN7.2112,500,892 - 2,565,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,503,508 - 2,565,637 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0111,831,378 - 1,895,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl111,835,185 - 1,836,897 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0111,811,954 - 1,876,664 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,120,729 - 2,123,544 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,120,489 - 2,182,377 (-)NCBI
Celera112,482,441 - 2,547,648 (-)NCBICelera
Cytogenetic Map11p12NCBI
ZNF654
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2288,216,425 - 88,302,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1388,221,235 - 88,306,796 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0388,197,558 - 88,283,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1390,309,186 - 90,395,198 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl390,309,186 - 90,395,198 (+)Ensemblpanpan1.1panPan2
ZNF654
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131114,287 - 207,313 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31117,435 - 247,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha31157,349 - 250,290 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03197,631 - 190,614 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3198,938 - 230,942 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13177,668 - 170,327 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031124,661 - 217,597 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031429,341 - 522,297 (-)NCBIUU_Cfam_GSD_1.0
Znf654
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049711,604,587 - 1,683,015 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366101,604,575 - 1,683,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366101,604,591 - 1,683,009 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF654
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13167,807,263 - 167,895,736 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113167,807,705 - 167,895,783 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZNF654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12288,782,957 - 88,864,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2288,782,940 - 88,799,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604177,850,024 - 77,932,500 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf654
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247894,449,045 - 4,525,664 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247894,448,957 - 4,528,641 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Zfp654
2303 total Variants

Predicted Target Of
Summary Value
Count of predictions:615
Count of miRNA genes:403
Interacting mature miRNAs:459
Transcripts:ENSMUST00000052588
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse

1 to 10 of 23 rows
RH125452  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381664,852,802 - 64,852,882UniSTSGRCm38
MGSCv371664,852,628 - 64,852,708UniSTSGRCm37
Celera1665,147,232 - 65,147,312UniSTS
Cytogenetic Map16C1.3UniSTS
AW045841  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381664,852,875 - 64,852,956UniSTSGRCm38
MGSCv371664,852,701 - 64,852,782UniSTSGRCm37
Celera1665,147,305 - 65,147,386UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16767.95UniSTS
UniSTS:486248  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381664,784,795 - 64,786,170UniSTSGRCm38
MGSCv371664,784,621 - 64,785,996UniSTSGRCm37
Celera1665,079,435 - 65,080,810UniSTS
Cytogenetic Map16C1.3UniSTS







Ensembl Acc Id: ENSMUST00000052588   ⟹   ENSMUSP00000052946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1664,600,714 - 64,606,684 (-)Ensembl
GRCm38.p6 Ensembl1664,780,351 - 64,786,321 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207826   ⟹   ENSMUSP00000146656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1664,600,710 - 64,672,015 (-)Ensembl
GRCm38.p6 Ensembl1664,780,347 - 64,851,652 (-)Ensembl
RefSeq Acc Id: NM_001347245   ⟹   NP_001334174
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391664,600,710 - 64,672,086 (-)NCBI
GRCm381664,780,347 - 64,851,723 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246018   ⟹   XP_011244320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391664,600,710 - 64,672,300 (-)NCBI
GRCm381664,780,347 - 64,851,937 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003951833
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391664,600,710 - 64,672,240 (-)NCBI
GRCm381664,780,347 - 64,851,877 (-)NCBI
Sequence:
Protein RefSeqs NP_001334174 (Get FASTA)   NCBI Sequence Viewer  
  XP_011244320 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH27760 (Get FASTA)   NCBI Sequence Viewer  
  AAH68018 (Get FASTA)   NCBI Sequence Viewer  
  BAB24088 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000146656
  ENSMUSP00000146656.2
GenBank Protein Q9DAU9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_011244320   ⟸   XM_011246018
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001334174   ⟸   NM_001347245
- UniProtKB: Q8K390 (UniProtKB/Swiss-Prot),   Q9DAU9 (UniProtKB/Swiss-Prot),   A0A140LI34 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000052946   ⟸   ENSMUST00000052588
Ensembl Acc Id: ENSMUSP00000146656   ⟸   ENSMUST00000207826
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q9DAU9-F1-model_v2 AlphaFold Q9DAU9 1-1112 view protein structure

RGD ID:13674218
Promoter ID:EPDNEW_M21258
Type:initiation region
Name:Zfp654_1
Description:Mus musculus zinc finger protein 654 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381664,851,730 - 64,851,790EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000047141 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000207826 ENTREZGENE
  ENSMUST00000207826.2 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro GH-ZnFinger_Regulators UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:72020 UniProtKB/Swiss-Prot
MGD MGI:1919270 ENTREZGENE
NCBI Gene 72020 ENTREZGENE
PANTHER ZINC FINGER PROTEIN 654 UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN RLF UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Zfp654 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A140LI34 ENTREZGENE
  A0A8I4P2L4_MOUSE UniProtKB/TrEMBL
  Q8K390 ENTREZGENE
  Q9DAU9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A140LI34 UniProtKB/Swiss-Prot
  Q8K390 UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-22 Zfp654  zinc finger protein 654  Gm5488  predicted gene 5488  Data merged from RGD:2308249 737654 PROVISIONAL