Wdr55 (WD repeat domain 55) - Rat Genome Database

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Gene: Wdr55 (WD repeat domain 55) Mus musculus
Analyze
Symbol: Wdr55
Name: WD repeat domain 55
RGD ID: 1551404
MGI Page MGI
Description: Involved in rRNA processing. Located in cytoplasm and nucleolus. Is expressed in liver and testis. Orthologous to human WDR55 (WD repeat domain 55).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410080P20Rik; C80692; WD repeat-containing protein 55
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm13700  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,893,275 - 36,896,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,893,273 - 36,896,863 (+)EnsemblGRCm39 Ensembl
GRCm381836,760,222 - 36,763,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,760,220 - 36,763,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv371836,919,893 - 36,923,362 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,886,213 - 36,889,682 (+)NCBIMGSCv36mm8
Celera1837,212,303 - 37,215,772 (+)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IMP)
nucleolus  (IMP,ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Youngren KK, etal., Nature 2005 May 19;435(7040):360-4.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18769712   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:32968282  


Genomics

Comparative Map Data
Wdr55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,893,275 - 36,896,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,893,273 - 36,896,863 (+)EnsemblGRCm39 Ensembl
GRCm381836,760,222 - 36,763,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,760,220 - 36,763,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv371836,919,893 - 36,923,362 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,886,213 - 36,889,682 (+)NCBIMGSCv36mm8
Celera1837,212,303 - 37,215,772 (+)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
WDR55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,664,904 - 140,672,345 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,664,868 - 140,674,124 (+)EnsemblGRCh38hg38GRCh38
GRCh375140,044,489 - 140,051,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,024,568 - 140,030,737 (+)NCBINCBI36Build 36hg18NCBI36
Celera5136,121,131 - 136,127,300 (+)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,189,624 - 135,195,794 (+)NCBIHuRef
CHM1_15139,477,633 - 139,483,802 (+)NCBICHM1_1
T2T-CHM13v2.05141,190,300 - 141,197,742 (+)NCBIT2T-CHM13v2.0
Wdr55
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541833,648 - 37,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541833,237 - 37,676 (-)NCBIChiLan1.0ChiLan1.0
WDR55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24135,922,502 - 135,930,185 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15134,061,857 - 134,068,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,029,221 - 136,037,015 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,145,749 - 142,152,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,145,749 - 142,152,992 (+)Ensemblpanpan1.1panPan2
WDR55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,820,082 - 35,825,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,820,116 - 35,825,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,859,066 - 32,864,304 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,275,685 - 36,280,927 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,275,721 - 36,280,922 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,328,029 - 33,333,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,195,807 - 34,201,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,948,519 - 34,953,756 (+)NCBIUU_Cfam_GSD_1.0
Wdr55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,003,907 - 152,008,110 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,603,229 - 9,608,444 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365319,603,391 - 9,607,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,378,462 - 142,384,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,378,467 - 142,384,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,322,646 - 148,328,865 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12343,298,165 - 43,304,644 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,297,967 - 43,303,355 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,578,517 - 34,586,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474333,415,984 - 33,422,107 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,416,212 - 33,421,861 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wdr55
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:103
Interacting mature miRNAs:104
Transcripts:ENSMUST00000049323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse

Markers in Region
Wdr55  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B2UniSTS
cM Map18 UniSTS
C80692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381836,763,342 - 36,763,463UniSTSGRCm38
MGSCv371836,922,996 - 36,923,117UniSTSGRCm37
Celera1837,215,406 - 37,215,527UniSTS
Cytogenetic Map18B2UniSTS
cM Map1820.0UniSTS
Whitehead/MRC_RH18522.05UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049323   ⟹   ENSMUSP00000039010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1836,893,273 - 36,896,863 (+)Ensembl
GRCm38.p6 Ensembl1836,760,220 - 36,763,810 (+)Ensembl
RefSeq Acc Id: ENSMUST00000235748   ⟹   ENSMUSP00000157945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1836,895,711 - 36,896,196 (+)Ensembl
GRCm38.p6 Ensembl1836,762,658 - 36,763,143 (+)Ensembl
RefSeq Acc Id: ENSMUST00000236324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1836,895,027 - 36,895,992 (+)Ensembl
GRCm38.p6 Ensembl1836,761,974 - 36,762,939 (+)Ensembl
RefSeq Acc Id: NM_026464   ⟹   NP_080740
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391836,893,275 - 36,896,761 (+)NCBI
GRCm381836,760,222 - 36,763,708 (+)NCBI
MGSCv371836,919,893 - 36,923,362 (+)RGD
Celera1837,212,303 - 37,215,772 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_154585
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391836,893,275 - 36,896,761 (+)NCBI
GRCm381836,760,222 - 36,763,708 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080740   ⟸   NM_026464
- UniProtKB: A2RS10 (UniProtKB/Swiss-Prot),   Q9CX97 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039010   ⟸   ENSMUST00000049323
RefSeq Acc Id: ENSMUSP00000157945   ⟸   ENSMUST00000235748

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CX97-F1-model_v2 AlphaFold Q9CX97 1-388 view protein structure

Promoters
RGD ID:13677488
Promoter ID:EPDNEW_M22893
Type:initiation region
Name:Wdr55_1
Description:Mus musculus WD repeat domain 55 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381836,760,231 - 36,760,291EPDNEW
RGD ID:6829611
Promoter ID:MM_KWN:24988
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026464
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361836,919,071 - 36,920,017 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915186 AgrOrtholog
Ensembl Genes ENSMUSG00000042660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049323 ENTREZGENE
  ENSMUST00000049323.9 UniProtKB/Swiss-Prot
  ENSMUST00000235748.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apc4_WD40_dom UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WDR55 UniProtKB/Swiss-Prot
KEGG Report mmu:67936 UniProtKB/Swiss-Prot
MGD MGI:1915186 ENTREZGENE
NCBI Gene 67936 ENTREZGENE
PANTHER WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/Swiss-Prot
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/Swiss-Prot
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/TrEMBL
Pfam ANAPC4_WD40 UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wdr55 PhenoGen
PIRSF WD_repeat_p55 UniProtKB/Swiss-Prot
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BA55_MOUSE UniProtKB/TrEMBL
  A2RS10 ENTREZGENE
  Q91X61_MOUSE UniProtKB/TrEMBL
  Q9CX97 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2RS10 UniProtKB/Swiss-Prot