Or2a25 (olfactory receptor family 2 subfamily A member 25) - Rat Genome Database

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Gene: Or2a25 (olfactory receptor family 2 subfamily A member 25) Mus musculus
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Symbol: Or2a25
Name: olfactory receptor family 2 subfamily A member 25
RGD ID: 1550998
MGI Page MGI
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR2A25 (olfactory receptor family 2 subfamily A member 25).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GA_x6K02T2P3E9-4647978-4647046; MGC129177; MOR261; MOR261-1; olfactory receptor 447; olfactory receptor MOR261-1; Olfr447
RGD Orthologs
Human
Rat
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,888,459 - 42,889,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,885,812 - 42,891,207 (+)EnsemblGRCm39 Ensembl
GRCm38642,911,525 - 42,912,457 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,908,878 - 42,914,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,861,524 - 42,862,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,841,132 - 42,842,064 (+)NCBIMGSCv36mm8
Celera642,857,870 - 42,858,802 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11802173   PMID:11875048   PMID:12477932   PMID:14611657   PMID:21873635   PMID:32295537  


Genomics

Comparative Map Data
Or2a25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,888,459 - 42,889,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,885,812 - 42,891,207 (+)EnsemblGRCm39 Ensembl
GRCm38642,911,525 - 42,912,457 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,908,878 - 42,914,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,861,524 - 42,862,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,841,132 - 42,842,064 (+)NCBIMGSCv36mm8
Celera642,857,870 - 42,858,802 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.97NCBI
OR2A25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387144,069,811 - 144,075,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7144,069,811 - 144,075,870 (+)EnsemblGRCh38hg38GRCh38
GRCh377143,766,904 - 143,772,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,402,246 - 143,403,178 (+)NCBINCBI36Build 36hg18NCBI36
Build 347143,208,960 - 143,209,893NCBI
Celera7138,404,581 - 138,405,513 (+)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7137,970,845 - 137,971,777 (+)NCBIHuRef
CHM1_17143,708,683 - 143,709,615 (+)NCBICHM1_1
T2T-CHM13v2.07145,350,304 - 145,356,363 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27143,109,535 - 143,110,467 (+)NCBI
Or2a25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,878,588 - 72,879,529 (+)NCBIGRCr8
mRatBN7.2471,878,578 - 71,879,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,878,578 - 71,879,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,864,269 - 76,865,210 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,777,495 - 72,778,436 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0471,171,693 - 71,172,634 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0472,502,935 - 72,503,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,502,935 - 72,503,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,200,767 - 137,201,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,817,740 - 70,818,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1471,093,869 - 71,094,811 (+)NCBI
Celera466,828,260 - 66,829,201 (+)NCBICelera
Cytogenetic Map4q24NCBI
OR2A25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,826,033 - 5,827,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,826,282 - 5,827,214 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0165,680,133 - 5,681,065 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,680,133 - 5,681,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,620,052 - 5,620,984 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,477,915 - 5,478,847 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,547,455 - 5,548,387 (-)NCBIUU_Cfam_GSD_1.0
LOC103227152
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,811,214 - 112,813,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,811,981 - 112,812,913 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,582,606 - 9,583,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or2a25
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSMUST00000055763
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
UniSTS:489486  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,911,525 - 42,912,457UniSTSGRCm38
MGSCv37642,861,524 - 42,862,456UniSTSGRCm37
Celera642,857,870 - 42,858,802UniSTS
Cytogenetic Map6B2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000055763   ⟹   ENSMUSP00000052312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,888,459 - 42,889,391 (+)Ensembl
GRCm38.p6 Ensembl642,911,525 - 42,912,457 (+)Ensembl
Ensembl Acc Id: ENSMUST00000216408   ⟹   ENSMUSP00000149325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,885,812 - 42,891,207 (+)Ensembl
GRCm38.p6 Ensembl642,908,878 - 42,914,273 (+)Ensembl
RefSeq Acc Id: NM_146988   ⟹   NP_667199
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,888,459 - 42,889,391 (+)NCBI
GRCm38642,911,525 - 42,912,457 (+)ENTREZGENE
MGSCv37642,861,524 - 42,862,456 (+)RGD
Celera642,857,870 - 42,858,802 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_667199   ⟸   NM_146988
- UniProtKB: Q8VGP6 (UniProtKB/TrEMBL),   Q3MI36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000149325   ⟸   ENSMUST00000216408
Ensembl Acc Id: ENSMUSP00000052312   ⟸   ENSMUST00000055763
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VGP6-F1-model_v2 AlphaFold Q8VGP6 1-310 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3030281 AgrOrtholog
Ensembl Genes ENSMUSG00000045708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000055763 ENTREZGENE
  ENSMUST00000055763.4 UniProtKB/TrEMBL
  ENSMUST00000216408.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report mmu:258990 UniProtKB/TrEMBL
MGD MGI:3030281 ENTREZGENE
NCBI Gene 258990 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or2a25 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt Q3MI36 ENTREZGENE, UniProtKB/TrEMBL
  Q8VGP6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-24 Or2a25  olfactory receptor family 2 subfamily A member 25  Olfr447  olfactory receptor 447  Symbol and/or name change 5135510 APPROVED