Omg (oligodendrocyte myelin glycoprotein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Omg (oligodendrocyte myelin glycoprotein) Mus musculus
Analyze
Symbol: Omg
Name: oligodendrocyte myelin glycoprotein
RGD ID: 1550981
MGI Page MGI
Description: Enables identical protein binding activity. Acts upstream of or within neuron projection regeneration and regulation of collateral sprouting of intact axon in response to injury. Predicted to be located in myelin sheath and plasma membrane. Is expressed in brain and spinal cord. Orthologous to human OMG (oligodendrocyte myelin glycoprotein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: oligodendrocyte-myelin glycoprotein
RGD Orthologs
Human
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,391,808 - 79,394,908 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,391,808 - 79,394,910 (-)EnsemblGRCm39 Ensembl
GRCm381179,500,982 - 79,504,082 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,500,982 - 79,504,084 (-)EnsemblGRCm38mm10GRCm38
MGSCv371179,314,484 - 79,317,584 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,317,547 - 79,320,214 (-)NCBIMGSCv36mm8
Celera1189,133,664 - 89,136,764 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. Amiguet P, etal., J Neurochem 1992 May;58(5):1676-82.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Pham-Dinh D, etal., Proc Natl Acad Sci U S A 1993 Sep 1;90(17):7990-4.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2434274   PMID:7737302   PMID:7829100   PMID:8244377   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11746780   PMID:12068310   PMID:12466851   PMID:12477932  
PMID:12696059   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18692574   PMID:19672953   PMID:19892785   PMID:20484625   PMID:20547125   PMID:20980605   PMID:21352918  
PMID:21873635   PMID:22406547   PMID:22411787   PMID:24192035   PMID:28634551   PMID:32325033   PMID:33942723   PMID:37142655  


Genomics

Comparative Map Data
Omg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,391,808 - 79,394,908 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,391,808 - 79,394,910 (-)EnsemblGRCm39 Ensembl
GRCm381179,500,982 - 79,504,082 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,500,982 - 79,504,084 (-)EnsemblGRCm38mm10GRCm38
MGSCv371179,314,484 - 79,317,584 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,317,547 - 79,320,214 (-)NCBIMGSCv36mm8
Celera1189,133,664 - 89,136,764 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.79NCBI
OMG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,294,647 - 31,297,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,272,013 - 31,297,539 (-)EnsemblGRCh38hg38GRCh38
GRCh371729,621,665 - 29,624,257 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q11.2NCBI
HuRef1725,832,271 - 25,834,983 (-)NCBIHuRef
CHM1_11729,684,851 - 29,687,563 (-)NCBICHM1_1
T2T-CHM13v2.01732,240,332 - 32,242,924 (-)NCBIT2T-CHM13v2.0
Omg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81064,959,316 - 64,962,050 (-)NCBIGRCr8
mRatBN7.21064,461,350 - 64,464,084 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,461,350 - 64,464,084 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1069,087,722 - 69,090,430 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01068,593,099 - 68,595,807 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01064,062,695 - 64,065,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01066,845,654 - 66,848,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1066,845,654 - 66,848,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,800,318 - 64,803,052 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,688,749 - 65,691,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,702,377 - 65,704,972 (-)NCBI
Celera1063,432,253 - 63,434,919 (-)NCBICelera
Cytogenetic Map10q25NCBI
OMG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1941,545,724 - 41,548,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl941,546,736 - 41,548,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha940,707,663 - 40,710,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0942,366,798 - 42,369,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl942,366,806 - 42,369,511 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1941,149,969 - 41,152,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0941,444,991 - 41,447,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0941,521,009 - 41,523,725 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Omg
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:172
Interacting mature miRNAs:191
Transcripts:ENSMUST00000164465
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
Omg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,501,742 - 79,501,980UniSTSGRCm38
MGSCv371179,315,244 - 79,315,482UniSTSGRCm37
Celera1189,134,424 - 89,134,662UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map11B4-5UniSTS
cM Map1146.07UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000164465   ⟹   ENSMUSP00000132918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,391,808 - 79,394,910 (-)Ensembl
GRCm38.p6 Ensembl1179,500,982 - 79,504,084 (-)Ensembl
RefSeq Acc Id: NM_019409   ⟹   NP_062282
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391179,391,808 - 79,394,908 (-)NCBI
GRCm381179,500,982 - 79,504,082 (-)ENTREZGENE
MGSCv371179,314,484 - 79,317,584 (-)RGD
Celera1189,133,664 - 89,136,764 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_062282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB28991 (Get FASTA)   NCBI Sequence Viewer  
  AAH24757 (Get FASTA)   NCBI Sequence Viewer  
  BAC30251 (Get FASTA)   NCBI Sequence Viewer  
  BAE23166 (Get FASTA)   NCBI Sequence Viewer  
  EDL15608 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000132918
  ENSMUSP00000132918.3
GenBank Protein Q63912 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062282   ⟸   NM_019409
- Peptide Label: precursor
- UniProtKB: Q63912 (UniProtKB/Swiss-Prot),   G3XA53 (UniProtKB/TrEMBL),   Q3UVV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000132918   ⟸   ENSMUST00000164465
Protein Domains
LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63912-F1-model_v2 AlphaFold Q63912 1-440 view protein structure

Promoters
RGD ID:6821477
Promoter ID:MM_KWN:8757
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000056559,   NM_019409
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361179,317,331 - 79,317,831 (-)MPROMDB
RGD ID:8675766
Promoter ID:EPDNEW_M15914
Type:initiation region
Name:Omg_1
Description:Mus musculus oligodendrocyte myelin glycoprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381179,504,031 - 79,504,091EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106586 AgrOrtholog
Ensembl Genes ENSMUSG00000049612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164465 ENTREZGENE
  ENSMUST00000164465.3 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR-bact_E3_ubiq_ligases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:106586 ENTREZGENE
NCBI Gene 18377 ENTREZGENE
PANTHER OLIGODENDROCYTE-MYELIN GLYCOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Omg PhenoGen
PRINTS LEURICHRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3XA53 ENTREZGENE, UniProtKB/TrEMBL
  OMGP_MOUSE UniProtKB/Swiss-Prot
  Q3UVV3 ENTREZGENE, UniProtKB/TrEMBL
  Q63912 ENTREZGENE
  Q8CAB4_MOUSE UniProtKB/TrEMBL