MIR10393 (microRNA 10393) - Rat Genome Database

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Gene: MIR10393 (microRNA 10393) Homo sapiens
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Symbol: MIR10393
Name: microRNA 10393
RGD ID: 14398515
HGNC Page HGNC:54002
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381544,717,844 - 44,717,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,010,042 - 45,010,091 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map15q21.1NCBI
T2T-CHM13v2.01542,525,820 - 42,525,869 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:25723320  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000015.10:g.44330225_44821972dup duplication See cases [RCV003313908] Chr15:44330225..44821972 [GRCh38]
Chr15:15q15.3-21.1		 uncertain significance

QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
1643273BW330_HBody Weight QTL 330 (human)1.050.014Body weightbody mass index152686671952866719Human
2289430BMD7_HBone mineral density QTL 7 (human)3.320.0001Bone mineral density151998012945980129Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
1643523BW284_HBody Weight QTL 284 (human)1.950.0013Body weight152179288947792889Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
2289420BW314_HBody weight QTL 314 (human)2.720.0003Body weightlean mass151998012945980129Human


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NR_162102
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381544,717,844 - 44,717,893 (+)NCBI
T2T-CHM13v2.01542,525,820 - 42,525,869 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR10393 COSMIC
GTEx MIR10393 GTEx
HGNC ID HGNC:54002 ENTREZGENE
Human Proteome Map MIR10393 Human Proteome Map
miRBase MI0033417 ENTREZGENE
NCBI Gene MIR10393 ENTREZGENE
RNAcentral URS0000D50193 RNACentral
  URS0000D50F76 RNACentral
  URS0000D535D5 RNACentral