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Gene: EME2 (essential meiotic structure-specific endonuclease subunit 2) Sus scrofa

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Symbol:

EME2

Name:

essential meiotic structure-specific endonuclease subunit 2

RGD ID:

14286086

Description:

ENCODES a protein that exhibits DNA binding (inferred); endonuclease activity (inferred); nuclease activity (inferred); INVOLVED IN DNA recombination (inferred); DNA repair (inferred); double-strand break repair (inferred); ASSOCIATED WITH combined oxidative phosphorylation deficiency 32 (ortholog); developmental and epileptic encephalopathy 1 (ortholog); epilepsy (ortholog); FOUND IN endodeoxyribonuclease complex (inferred); Holliday junction resolvase complex (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

probable crossover junction endonuclease EME2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	40,186,846 - 40,193,957 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	40,190,545 - 40,193,994 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,654,317 - 41,657,915 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

combined oxidative phosphorylation deficiency 32 (ISO)

developmental and epileptic encephalopathy 1 (ISO)

epilepsy (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy (ISO)

Leigh disease (ISO)

mitochondrial metabolism disease (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA recombination (IEA)

DNA repair (IEA)

double-strand break repair (IBA,IEA)

mitotic intra-S DNA damage checkpoint signaling (IBA)

replication fork processing (IBA,IEA)

resolution of meiotic recombination intermediates (IBA)

Cellular Component

endodeoxyribonuclease complex (IEA)

Holliday junction resolvase complex (IBA,IEA)

nucleus (IEA)

Molecular Function

crossover junction DNA endonuclease activity (IBA)

DNA binding (IEA)

endonuclease activity (IEA)

nuclease activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

EME2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	40,186,846 - 40,193,957 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	40,190,545 - 40,193,994 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,654,317 - 41,657,915 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EME2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	1,772,810 - 1,781,702 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	1,772,810 - 1,781,708 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	1,822,811 - 1,831,703 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	1,763,230 - 1,766,240 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	1,763,229 - 1,766,239	NCBI
Celera	16	2,035,508 - 2,038,518 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	1,746,125 - 1,749,135 (+)	NCBI		HuRef
CHM1_1	16	1,823,177 - 1,826,187 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	1,788,644 - 1,797,538 (+)	NCBI		T2T-CHM13v2.0

Eme2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,111,126 - 25,114,061 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,107,460 - 25,114,061 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	24,892,152 - 24,895,087 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	24,888,486 - 24,895,087 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,029,097 - 25,032,032 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	17	25,418,842 - 25,421,778 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.53	NCBI

Eme2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,413,661 - 14,420,489 (-)	NCBI		GRCr8
mRatBN7.2	10	13,913,216 - 13,915,991 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,913,221 - 13,915,968 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	18,660,326 - 18,663,080 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	18,149,186 - 18,151,940 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	13,648,403 - 13,651,157 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	14,253,552 - 14,257,017 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,254,252 - 14,256,930 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,069,599 - 14,073,012 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,140,925 - 14,144,052 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	14,141,303 - 14,144,070 (-)	NCBI
Celera	10	13,591,783 - 13,595,248 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Eme2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,493,911 - 15,496,620 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	15,492,925 - 15,496,639 (-)	NCBI	ChiLan1.0	ChiLan1.0

EME2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	2,039,846 - 2,048,366 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	5,821,300 - 5,827,294 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	395,571 - 403,233 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	1,825,548 - 1,831,870 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	1,825,622 - 1,829,557 (+)	Ensembl	panpan1.1		panPan2

EME2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,127,433 - 39,129,487 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,366,095 - 40,369,289 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	39,443,616 - 39,446,146 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	39,120,323 - 39,123,517 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,092,905 - 39,096,098 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	39,571,350 - 39,573,880 (-)	NCBI		UU_Cfam_GSD_1.0

Eme2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,488,946 - 104,492,111 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	2,217,811 - 2,220,432 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	2,217,352 - 2,220,556 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EME2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	1,682,232 - 1,685,863 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	1,682,249 - 1,685,260 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	29,396,356 - 29,404,408 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eme2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624913	475,618 - 478,959 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in EME2
35 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005655136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01094541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000028167 ⟹ ENSSSCP00000022345

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	40,186,846 - 40,193,957 (-)	Ensembl

RefSeq Acc Id:

XM_005655136 ⟹ XP_005655193

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	40,190,545 - 40,193,994 (-)	NCBI

Sequence:

show sequence

GGGCGCGGCCGGAAGCGCAGAAGAGGCCGGGCGGGCCATGGCCGACGCTGGAGCTGGGAGGGCC
GGGGGCTCGCGCCGGGGCCGGGGCCGGGGACCGCGGAGGCCCCCGACCTGGGAGATCTCGGACT
CGGACGCCGAGGGTTCCGCCGGCNGCGAGGCCGCCGCGACCGTCCGGGACCCGGCGGAGGAGCG
CAGGGCGGCGGCCAAGGCACTGCGGCGGCTGCGACCCGAGCGGGCCGTGCGGCGCCTGGCGGTG
CTCGTGGACCCAGCCATCCTGGAAGATGCTGCTGCCGACATCCTGATGGAGGCCTTGGACACCC
TGAGCTGTGAGTACCGTGTGGAGCCCCAGCGCCCTGCCCGGAGCCTCAGGTGGAGCAGAGTGAA
GCCAGATCCTTGCCCTCCCGGTGTGCCTCCTGAGGTGTGGGCTGCAGATGAGCAGGACCTGCTG
CTGCTGCTGGAGCCCCAGGAGTTTCTGCAGGGCGTTGGCCAGCTGATCCAGAGCAGTGGCCCAA
CCTGTTCTGTGCCCTGGATCTGTCCTGAGAGCCCTGCCCGCCCCCACCTGGCTGTCATCGGGTT
GGATGCTTACCTCTGGTCTCACCAGCCCAGCACCCAGGAGATGCAGCAGCCAGAGAATCCAGTG
GTGGCCCGTGCCAAGGTGGCAGTCGGCTGGCCCGAGGTGGAGGAGGCGCTGGTGCTCCTACAGC
TCTGGGCAAACGTGGATGTGCTGCTGGTGGCCTCCTGGCAGGAACTGAGTCAACACGTGTGCGC
ATTCACCAAGGCCCTTGCCCAGCGCCCCTTCAAGCAGTCCCGGGAGCCGAGGGCCTTCTCCTTC
TGCACCGCAGGGCGCTGGGCAGCAGGAGAGCAAGTGGCAAGAGGTGGCACAGGGCTGCGGGCGG
CCTGGCGGTGGCAGATCCAGCAGTTCAACCGCGTCAGCCCAGCCGTGGCCGATGCTGTCGTCGC
CGCCTTCCCCTCTCCCCGGCTTCTGCAACAGGCGTACGTGACCTGCAGCACGGAGCAGGAGCGC
CTGGTCCTCCTGGCTGGCCTGCCTGTGAAGACGGGCGAGGGTGCGCGGCCCCACAGGGTGGGGC
CTGACCTTTCCCGCCGCCTCTGCCTCCTCCTAACCGCCACCAACCCCGACCTCCTGCTGGACCT
GGGCTGCTGACCACGCCATGGGCCTGCCGCTGGCAGATTTGACGCAGCCGCCGCAGGCACTGAC
CAGAAACCAGAGGGAGTGGGGGGCAGGAGGGCAAGCCACGCGGAACAGCCAGTTCTAGGGCTCT
CGGCCAGTTCTGCCCCCAGGGGGTGGAGGGAAGCAGGGAAAGTTCTCATGTAACTGGGATGGGC
AGGAGAGGAGATTCTTGTCTGGCCAGGAGATGTGAGCCGGCTGGAAAGTCTGGAGAAGCAGGGG
CAGCATTCAGGTGCCCTGGGCCCTGCACAGCCTGGAGGAGGGGGTGGAAGCCACCCAGGACAGT
CGGGAAGGGCTGGGGAGCACCTCAGGCAGGTGCCCAGGGCACACGCCAGTCCCCTGGAGGCTTG
GCATTGGCTCTGGAGAGGAAGAGCTGTAAGGAAGCTCTGAGGGAAGAAGAGAAGCAGGCCACCG
CCTCCCGAGGGTGTGCGACACCCCAACGGGAGCTGGGCTGTGCGCCCCAGCCTTGGCCCGGCCC
C

hide sequence

Protein Sequences


Protein RefSeqs	XP_005655193	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000022345
	ENSSSCP00000022345.3
	ENSSSCP00025011006.1
	ENSSSCP00030022605.1
	ENSSSCP00035028110.1
	ENSSSCP00045046907.1
	ENSSSCP00050047950.1
	ENSSSCP00055049458.1
	ENSSSCP00060038449.1
	ENSSSCP00065025857.1
	ENSSSCP00070046884.1

RefSeq Acc Id:

XP_005655193 ⟸ XM_005655136

- UniProtKB:

A0A4X1VXV3 (UniProtKB/TrEMBL), I3LE59 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADAGAGRAGGSRRGRGRGPRRPPTWEISDSDAEGSAGXEAAATVRDPAEERRAAAKALRRLRP
ERAVRRLAVLVDPAILEDAAADILMEALDTLSCEYRVEPQRPARSLRWSRVKPDPCPPGVPPEV
WAADEQDLLLLLEPQEFLQGVGQLIQSSGPTCSVPWICPESPARPHLAVIGLDAYLWSHQPSTQ
EMQQPENPVVARAKVAVGWPEVEEALVLLQLWANVDVLLVASWQELSQHVCAFTKALAQRPFKQ
SREPRAFSFCTAGRWAAGEQVARGGTGLRAAWRWQIQQFNRVSPAVADAVVAAFPSPRLLQQAY
VTCSTEQERLVLLAGLPVKTGEGARPHRVGPDLSRRLCLLLTATNPDLLLDLGC

hide sequence

Ensembl Acc Id:

ENSSSCP00000022345 ⟸ ENSSSCT00000028167

Protein Domains

ERCC4

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000021467	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00025019219	UniProtKB/TrEMBL
	ENSSSCG00030035877	UniProtKB/TrEMBL
	ENSSSCG00035052029	UniProtKB/TrEMBL
	ENSSSCG00045038219	UniProtKB/TrEMBL
	ENSSSCG00050078526	UniProtKB/TrEMBL
	ENSSSCG00055030872	UniProtKB/TrEMBL
	ENSSSCG00060065075	UniProtKB/TrEMBL
	ENSSSCG00065043551	UniProtKB/TrEMBL
	ENSSSCG00070027552	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000028167	ENTREZGENE
	ENSSSCT00000028167.3	UniProtKB/TrEMBL
	ENSSSCT00025026071.1	UniProtKB/TrEMBL
	ENSSSCT00030049803.1	UniProtKB/TrEMBL
	ENSSSCT00035069360.1	UniProtKB/TrEMBL
	ENSSSCT00045066189.1	UniProtKB/TrEMBL
	ENSSSCT00050108210.1	UniProtKB/TrEMBL
	ENSSSCT00055061614.1	UniProtKB/TrEMBL
	ENSSSCT00060088848.1	UniProtKB/TrEMBL
	ENSSSCT00065059596.1	UniProtKB/TrEMBL
	ENSSSCT00070055240.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.670	UniProtKB/TrEMBL
	3.40.50.10130	UniProtKB/TrEMBL
InterPro	EME1/EME2_C	UniProtKB/TrEMBL
	ERCC4_domain	UniProtKB/TrEMBL
	Mms4/EME1/EME2	UniProtKB/TrEMBL
NCBI Gene	EME2	ENTREZGENE
PANTHER	CROSSOVER JUNCTION ENDONUCLEASE EME2-RELATED	UniProtKB/TrEMBL
	PTHR21077	UniProtKB/TrEMBL
Pfam	EME1-MUS81_C	UniProtKB/TrEMBL
	ERCC4	UniProtKB/TrEMBL
SMART	ERCC4	UniProtKB/TrEMBL
UniProt	A0A4X1VXV3	ENTREZGENE, UniProtKB/TrEMBL
	I3LE59	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:87677	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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