RHOT2 (ras homolog family member T2) - Rat Genome Database

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Gene: RHOT2 (ras homolog family member T2) Sus scrofa
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Symbol: RHOT2
Name: ras homolog family member T2
RGD ID: 14281922
Description: ENCODES a protein that exhibits calcium ion binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN cellular homeostasis (ortholog); mitochondrial outer membrane permeabilization (ortholog); mitochondrion transport along microtubule (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH epilepsy (ortholog); idiopathic generalized epilepsy (ortholog); short-rib thoracic dysplasia 9 with or without polydactyly (ortholog); FOUND IN mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ARHT2; MIRO-2; mitochondrial Rho GTPase 2; ras homolog gene family, member T2; rho GTPase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,100,879 - 41,106,418 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,100,876 - 41,106,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,369,920 - 41,377,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15218247   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RHOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,100,879 - 41,106,418 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,100,876 - 41,106,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,369,920 - 41,377,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RHOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816668,083 - 674,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16668,100 - 674,174 (+)EnsemblGRCh38hg38GRCh38
GRCh3716718,083 - 724,174 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616658,134 - 664,172 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416658,133 - 664,171NCBI
Celera16918,290 - 924,328 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16639,868 - 645,999 (+)NCBIHuRef
CHM1_116718,057 - 724,148 (+)NCBICHM1_1
T2T-CHM13v2.016672,158 - 678,249 (+)NCBIT2T-CHM13v2.0
Rhot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,057,431 - 26,063,499 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,057,431 - 26,063,825 (-)EnsemblGRCm39 Ensembl
GRCm381725,838,457 - 25,844,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,838,457 - 25,844,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,975,783 - 25,981,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,566,438 - 25,572,451 (-)NCBIMGSCv36mm8
Celera1726,371,660 - 26,377,674 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.93NCBI
Rhot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,363,467 - 15,369,263 (-)NCBIGRCr8
mRatBN7.21014,858,954 - 14,864,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,858,956 - 14,864,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,597,937 - 19,603,746 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,086,813 - 19,092,622 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,587,109 - 14,592,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,205,943 - 15,211,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,205,534 - 15,211,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,018,888 - 15,024,682 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,104,341 - 15,110,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,104,340 - 15,110,135 (-)NCBI
Celera1014,527,898 - 14,533,692 (-)NCBICelera
Cytogenetic Map10q12NCBI
Rhot2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544216,528,886 - 16,534,856 (-)NCBIChiLan1.0ChiLan1.0
RHOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218909,491 - 915,456 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,693,381 - 4,699,289 (+)NCBINHGRI_mPanPan1
PanPan1.116682,471 - 688,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16682,588 - 687,861 (+)Ensemblpanpan1.1panPan2
RHOT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,900,889 - 39,905,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,901,062 - 39,922,320 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,164,862 - 41,169,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,243,392 - 40,248,230 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,931,949 - 39,936,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,892,169 - 39,897,003 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,371,301 - 40,376,139 (-)NCBIUU_Cfam_GSD_1.0
Rhot2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,238,646 - 112,244,207 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936501336,506 - 341,671 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15587,888 - 593,740 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5586,539 - 595,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,543,364 - 30,549,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhot2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249131,480,569 - 1,486,502 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RHOT2
45 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSSCT00000091761   ⟹   ENSSSCP00000079315
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl341,100,879 - 41,106,418 (-)Ensembl
RefSeq Acc Id: NM_214325   ⟹   NP_999490
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1341,100,876 - 41,106,370 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999490   ⟸   NM_214325
- UniProtKB: A0A4X1SRH8 (UniProtKB/TrEMBL),   A0A8D0RR14 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000079315   ⟸   ENSSSCT00000091761
Protein Domains
EF-hand   Miro


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000062928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025029306 UniProtKB/TrEMBL
  ENSSSCG00030061708 UniProtKB/TrEMBL
  ENSSSCG00035075270 UniProtKB/TrEMBL
  ENSSSCG00055004627 UniProtKB/TrEMBL
  ENSSSCG00065018243 UniProtKB/TrEMBL
  ENSSSCG00070003339 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000091761 ENTREZGENE
  ENSSSCT00000091761.1 UniProtKB/TrEMBL
  ENSSSCT00025039841.1 UniProtKB/TrEMBL
  ENSSSCT00030086265.1 UniProtKB/TrEMBL
  ENSSSCT00035102290.1 UniProtKB/TrEMBL
  ENSSSCT00055009210.1 UniProtKB/TrEMBL
  ENSSSCT00065024272.1 UniProtKB/TrEMBL
  ENSSSCT00070006581.1 UniProtKB/TrEMBL
  ENSSSCT00070006608.1 UniProtKB/TrEMBL
  ENSSSCT00070006622.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_assoc_1 UniProtKB/TrEMBL
  EF_hand_assoc_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Miro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIRO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397596 UniProtKB/Swiss-Prot
NCBI Gene RHOT2 ENTREZGENE
PANTHER MITOCHONDRIAL RHO GTPASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF_assoc_1 UniProtKB/TrEMBL
  EF_assoc_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Mt_Rho_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SRH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SRK4_PIG UniProtKB/TrEMBL
  A0A4X1ST67_PIG UniProtKB/TrEMBL
  A0A8D0RR14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FJB5_PIG UniProtKB/TrEMBL
  MIRO2_PIG UniProtKB/Swiss-Prot, ENTREZGENE