MUL1 (mitochondrial E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: MUL1 (mitochondrial E3 ubiquitin protein ligase 1) Sus scrofa
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Symbol: MUL1
Name: mitochondrial E3 ubiquitin protein ligase 1
RGD ID: 14172544
Description: ENCODES a protein that exhibits identical protein binding (inferred); ligase activity (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of cysteine-type endopeptidase activity (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); congenital disorder of glycosylation Ir (ortholog); hyperprolinemia type 2 (ortholog); FOUND IN axon (inferred); mitochondrial outer membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitochondrial ubiquitin ligase activator of NFKB 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,747,650 - 78,758,812 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,747,687 - 78,758,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,940,825 - 72,951,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MUL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,747,650 - 78,758,812 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,747,687 - 78,758,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,940,825 - 72,951,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,499,448 - 20,508,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,499,448 - 20,508,151 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,825,941 - 20,834,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,698,530 - 20,707,241 (-)NCBINCBI36Build 36hg18NCBI36
Celera119,150,266 - 19,158,998 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,072,017 - 19,080,749 (-)NCBIHuRef
CHM1_1120,936,341 - 20,945,071 (-)NCBICHM1_1
T2T-CHM13v2.0120,324,399 - 20,333,109 (-)NCBIT2T-CHM13v2.0
Mul1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,160,239 - 138,169,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,161,982 - 138,169,576 (+)EnsemblGRCm39 Ensembl
GRCm384138,434,660 - 138,442,265 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,434,671 - 138,442,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv374137,990,587 - 137,998,180 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,706,748 - 137,714,341 (+)NCBIMGSCv36mm8
Celera4140,222,392 - 140,230,021 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.28NCBI
Mul1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,936,112 - 155,945,163 (+)NCBIGRCr8
mRatBN7.25150,652,812 - 150,661,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,652,812 - 150,661,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,349,485 - 153,358,544 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,123,776 - 155,132,836 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,105,793 - 155,114,844 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,855,105 - 156,864,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,850,206 - 156,864,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,603,318 - 160,612,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,213,350 - 157,222,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,223,470 - 157,229,347 (+)NCBI
Celera5149,044,144 - 149,053,195 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mul1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,058,930 - 1,066,096 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,059,168 - 1,066,096 (-)NCBIChiLan1.0ChiLan1.0
MUL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,610,504 - 206,619,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,727,347 - 205,736,078 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,454,792 - 19,463,527 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,496,356 - 20,505,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,496,356 - 20,505,281 (-)Ensemblpanpan1.1panPan2
MUL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,394,013 - 78,402,032 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,394,040 - 78,425,482 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,908,052 - 74,916,067 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,960,900 - 78,968,926 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,926,527 - 78,968,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,779,474 - 75,787,475 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,791,322 - 76,799,325 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,794,850 - 77,802,859 (+)NCBIUU_Cfam_GSD_1.0
Mul1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,654,858 - 40,661,194 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,477,504 - 6,486,660 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,479,640 - 6,486,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,042,777 - 112,051,866 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,042,481 - 112,052,168 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,165,474 - 4,175,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mul1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,557,560 - 5,586,964 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,560,071 - 5,566,763 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MUL1
348 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000027632   ⟹   ENSSSCP00000023363
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl678,747,650 - 78,758,812 (-)Ensembl
RefSeq Acc Id: XM_003356176   ⟹   XP_003356224
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1678,747,687 - 78,758,821 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003356224   ⟸   XM_003356176
- UniProtKB: A0A480L4S7 (UniProtKB/TrEMBL),   A0A8D1VB19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000023363   ⟸   ENSSSCT00000027632

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028045 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005013098 UniProtKB/TrEMBL
  ENSSSCG00015010023 UniProtKB/TrEMBL
  ENSSSCG00030048542 UniProtKB/TrEMBL
  ENSSSCG00035081204 UniProtKB/TrEMBL
  ENSSSCG00040051128 UniProtKB/TrEMBL
  ENSSSCG00045015407 UniProtKB/TrEMBL
  ENSSSCG00050078965 UniProtKB/TrEMBL
  ENSSSCG00055013039 UniProtKB/TrEMBL
  ENSSSCG00060037594 UniProtKB/TrEMBL
  ENSSSCG00065027353 UniProtKB/TrEMBL
  ENSSSCG00070028870 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027632 ENTREZGENE
  ENSSSCT00000027632.4 UniProtKB/TrEMBL
  ENSSSCT00005020551.1 UniProtKB/TrEMBL
  ENSSSCT00005020587.1 UniProtKB/TrEMBL
  ENSSSCT00015013163.1 UniProtKB/TrEMBL
  ENSSSCT00015013200.1 UniProtKB/TrEMBL
  ENSSSCT00030067761.1 UniProtKB/TrEMBL
  ENSSSCT00030067798.1 UniProtKB/TrEMBL
  ENSSSCT00035111676.1 UniProtKB/TrEMBL
  ENSSSCT00035111677.1 UniProtKB/TrEMBL
  ENSSSCT00040069050.1 UniProtKB/TrEMBL
  ENSSSCT00040069121.1 UniProtKB/TrEMBL
  ENSSSCT00040069168.1 UniProtKB/TrEMBL
  ENSSSCT00045026100.1 UniProtKB/TrEMBL
  ENSSSCT00045026133.1 UniProtKB/TrEMBL
  ENSSSCT00050108996.1 UniProtKB/TrEMBL
  ENSSSCT00050108997.1 UniProtKB/TrEMBL
  ENSSSCT00055025646.1 UniProtKB/TrEMBL
  ENSSSCT00055025686.1 UniProtKB/TrEMBL
  ENSSSCT00060050869.1 UniProtKB/TrEMBL
  ENSSSCT00060050873.1 UniProtKB/TrEMBL
  ENSSSCT00065036835.1 UniProtKB/TrEMBL
  ENSSSCT00065036840.1 UniProtKB/TrEMBL
  ENSSSCT00070057918.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro GIDE UniProtKB/TrEMBL
  MDM2_MDM4_MUL1 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report ssc:100514904 UniProtKB/TrEMBL
NCBI Gene MUL1 ENTREZGENE
PANTHER MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 UniProtKB/TrEMBL
  MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 UniProtKB/TrEMBL
Pfam GIDE UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A480L4S7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W528_PIG UniProtKB/TrEMBL
  A0A8D0II35_PIG UniProtKB/TrEMBL
  A0A8D0X4K9_PIG UniProtKB/TrEMBL
  A0A8D1EZH9_PIG UniProtKB/TrEMBL
  A0A8D1F113_PIG UniProtKB/TrEMBL
  A0A8D1F139_PIG UniProtKB/TrEMBL
  A0A8D1KX19_PIG UniProtKB/TrEMBL
  A0A8D1PAX9_PIG UniProtKB/TrEMBL
  A0A8D1QE21_PIG UniProtKB/TrEMBL
  A0A8D1VB19 ENTREZGENE, UniProtKB/TrEMBL
  I3LH19_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90484 ENTREZGENE