SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2) - Rat Genome Database

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Gene: SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2) Sus scrofa
Analyze
Symbol: SDR42E2
Name: short chain dehydrogenase/reductase family 42E, member 2
RGD ID: 14070649
Description: ENCODES a protein that exhibits 3-beta-hydroxy-delta5-steroid dehydrogenase activity (inferred); INVOLVED IN steroid biosynthetic process (inferred); ASSOCIATED WITH autistic disorder (ortholog); chromosome 16p12.1 deletion syndrome (ortholog); schizophrenia (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: putative short-chain dehydrogenase/reductase family 42E member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl323,990,242 - 24,023,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1323,989,671 - 24,026,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2324,421,757 - 24,449,903 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SDR42E2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl323,990,242 - 24,023,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1323,989,671 - 24,026,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2324,421,757 - 24,449,903 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDR42E2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381622,162,506 - 22,191,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1622,162,492 - 22,192,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371622,173,827 - 22,203,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1620,956,809 - 20,981,602 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1620,421,642 - 20,446,458 (+)NCBIHuRef
CHM1_11622,189,562 - 22,217,474 (-)NCBICHM1_1
T2T-CHM13v2.01622,025,463 - 22,054,707 (-)NCBIT2T-CHM13v2.0
Sdr42e2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397120,408,853 - 120,431,122 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7120,411,588 - 120,430,416 (+)EnsemblGRCm39 Ensembl
GRCm387120,809,630 - 120,831,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,812,365 - 120,831,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv377127,955,879 - 127,974,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367120,600,559 - 120,622,342 (+)NCBIMGSCv36mm8
Celera7120,725,132 - 120,743,883 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.92NCBI
Sdr42e2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,788,773 - 184,814,064 (+)NCBIGRCr8
mRatBN7.21175,361,630 - 175,382,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1175,362,150 - 175,382,050 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01190,756,747 - 190,769,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01197,674,382 - 197,693,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,660,219 - 179,682,374 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1173,092,377 - 173,114,247 (+)NCBICelera
Cytogenetic Map1q36NCBI
Sdr42e2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955493834,582 - 849,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955493834,582 - 849,058 (+)NCBIChiLan1.0ChiLan1.0
SDR42E2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21823,001,719 - 23,037,208 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11627,527,813 - 27,557,620 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01616,540,166 - 16,569,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11622,477,440 - 22,502,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1622,477,440 - 22,502,105 (+)Ensemblpanpan1.1panPan2
SDR42E2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1623,452,730 - 23,469,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha624,944,773 - 24,964,677 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0623,589,112 - 23,609,017 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl623,589,129 - 23,607,052 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1623,390,866 - 23,410,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0623,297,001 - 23,316,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0623,681,924 - 23,701,845 (-)NCBIUU_Cfam_GSD_1.0
Sdr42e2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344119,013,271 - 119,030,162 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365017,111,563 - 7,126,490 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365017,111,563 - 7,126,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDR42E2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1519,831,523 - 19,862,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606810,011,816 - 10,044,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdr42e2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247827,576,994 - 7,593,084 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247827,577,918 - 7,593,084 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SDR42E2
1399 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system reproductive system
High
Medium
Low 1 3 17
Below cutoff 4 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008592   ⟹   ENSSSCP00000008371
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl323,990,242 - 24,023,024 (-)Ensembl
RefSeq Acc Id: XM_021086483   ⟹   XP_020942142
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1323,989,671 - 24,026,548 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020942142 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000008371.4
Reference Protein Sequences
RefSeq Acc Id: XP_020942142   ⟸   XM_021086483
- Sequence:
RefSeq Acc Id: ENSSSCP00000008371   ⟸   ENSSSCT00000008592
Protein Domains
3-beta hydroxysteroid dehydrogenase/isomerase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007842 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008592.5 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene SDR42E2 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/TrEMBL
  SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2 UniProtKB/TrEMBL
Pfam 3Beta_HSD UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt F1RPD6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92663 ENTREZGENE