KCTD2 (potassium channel tetramerization domain containing 2) - Rat Genome Database

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Gene: KCTD2 (potassium channel tetramerization domain containing 2) Sus scrofa
Analyze
Symbol: KCTD2
Name: potassium channel tetramerization domain containing 2
RGD ID: 14028165
Description: ENCODES a protein that exhibits cullin family protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein homooligomerization (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BTB/POZ domain-containing protein KCTD2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,226,376 - 6,241,318 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,226,380 - 6,241,363 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,238,863 - 6,253,256 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCTD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,226,376 - 6,241,318 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,226,380 - 6,241,363 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,238,863 - 6,253,256 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,032,571 - 75,065,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,032,575 - 75,065,889 (+)EnsemblGRCh38hg38GRCh38
GRCh371773,028,666 - 73,061,981 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,554,874 - 70,573,576 (+)NCBINCBI36Build 36hg18NCBI36
Build 341770,554,873 - 70,573,574NCBI
Celera1769,636,216 - 69,648,576 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,453,047 - 68,471,555 (+)NCBIHuRef
CHM1_11773,107,758 - 73,126,460 (+)NCBICHM1_1
T2T-CHM13v2.01775,924,318 - 75,957,335 (+)NCBIT2T-CHM13v2.0
Kctd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,310,915 - 115,322,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,310,954 - 115,322,100 (+)EnsemblGRCm39 Ensembl
GRCm3811115,420,094 - 115,431,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,420,128 - 115,431,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,281,440 - 115,292,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,236,240 - 115,247,362 (+)NCBIMGSCv36mm8
Celera11127,169,969 - 127,197,343 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.84NCBI
Kctd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,162,091 - 101,173,721 (+)NCBIGRCr8
mRatBN7.210100,663,013 - 100,674,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,662,884 - 100,674,336 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.010103,972,700 - 103,984,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,972,888 - 103,984,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,294,907 - 104,306,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,499,682 - 105,510,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1099,238,524 - 99,249,880 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Kctd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,899,534 - 1,917,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,899,533 - 1,918,534 (+)NCBIChiLan1.0ChiLan1.0
KCTD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,085,869 - 91,104,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,908,907 - 95,927,729 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,994,314 - 69,012,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,549,728 - 74,568,358 (+)NCBIpanpan1.1PanPan1.1panPan2
KCTD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,417,352 - 5,432,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,419,966 - 5,444,470 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,096,207 - 6,111,427 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,087,644 - 6,103,110 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,087,644 - 6,115,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,125,515 - 6,140,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,235,864 - 6,251,080 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,295,990 - 6,311,454 (-)NCBIUU_Cfam_GSD_1.0
Kctd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,040,141 - 6,052,103 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594302,366 - 370,878 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594359,856 - 373,499 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,606,832 - 46,625,366 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,609,675 - 46,625,289 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,392,424 - 17,410,766 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,863,232 - 4,878,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,863,312 - 4,877,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCTD2
292 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 1 1 20
Low 10 4 4 1 3 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000048742   ⟹   ENSSSCP00000037764
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,226,376 - 6,241,318 (-)Ensembl
RefSeq Acc Id: XM_021066666   ⟹   XP_020922325
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,226,380 - 6,241,363 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020922325   ⟸   XM_021066666
- UniProtKB: A0A4X1V0J7 (UniProtKB/TrEMBL),   A0A287A214 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000037764   ⟸   ENSSSCT00000048742
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031958 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025028828 UniProtKB/TrEMBL
  ENSSSCG00030003687 UniProtKB/TrEMBL
  ENSSSCG00035071765 UniProtKB/TrEMBL
  ENSSSCG00040059712 UniProtKB/TrEMBL
  ENSSSCG00045037152 UniProtKB/TrEMBL
  ENSSSCG00050078916 UniProtKB/TrEMBL
  ENSSSCG00055020403 UniProtKB/TrEMBL
  ENSSSCG00060004789 UniProtKB/TrEMBL
  ENSSSCG00065071157 UniProtKB/TrEMBL
  ENSSSCG00070021641 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048742 ENTREZGENE
  ENSSSCT00000048742.3 UniProtKB/TrEMBL
  ENSSSCT00025039148.1 UniProtKB/TrEMBL
  ENSSSCT00030004805.1 UniProtKB/TrEMBL
  ENSSSCT00030004821.1 UniProtKB/TrEMBL
  ENSSSCT00035097056.1 UniProtKB/TrEMBL
  ENSSSCT00040081180.1 UniProtKB/TrEMBL
  ENSSSCT00045064074.1 UniProtKB/TrEMBL
  ENSSSCT00045064103.1 UniProtKB/TrEMBL
  ENSSSCT00050108890.1 UniProtKB/TrEMBL
  ENSSSCT00050108891.1 UniProtKB/TrEMBL
  ENSSSCT00055040059.1 UniProtKB/TrEMBL
  ENSSSCT00055040145.1 UniProtKB/TrEMBL
  ENSSSCT00060005952.1 UniProtKB/TrEMBL
  ENSSSCT00060005955.1 UniProtKB/TrEMBL
  ENSSSCT00065097779.1 UniProtKB/TrEMBL
  ENSSSCT00070042990.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.2000 UniProtKB/TrEMBL
  6.10.140.750 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
NCBI Gene KCTD2 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD2 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A287A214 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V0J7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1JFN6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89398 ENTREZGENE