ARFGEF3 (ARFGEF family member 3) - Rat Genome Database

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Gene: ARFGEF3 (ARFGEF family member 3) Sus scrofa
Analyze
Symbol: ARFGEF3
Name: ARFGEF family member 3
RGD ID: 13985778
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN regulation of ARF protein signal transduction (inferred); ASSOCIATED WITH dystonia (ortholog); Familial Behcet-Like Autoinflammatory Syndrome (ortholog); Febrile Seizures (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: brefeldin A-inhibited guanine nucleotide-exchange protein 3; KIAA1244
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,069,337 - 26,256,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,205,357 - 29,262,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
ARFGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,069,337 - 26,256,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,205,357 - 29,262,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARFGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386138,161,939 - 138,344,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6138,161,939 - 138,344,663 (+)EnsemblGRCh38hg38GRCh38
GRCh376138,483,076 - 138,665,800 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,524,917 - 138,701,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 346138,569,923 - 138,701,629NCBI
Celera6139,223,168 - 139,405,937 (+)NCBICelera
Cytogenetic Map6q23.3-q24.1NCBI
HuRef6136,044,516 - 136,227,216 (+)NCBIHuRef
CHM1_16138,745,409 - 138,928,150 (+)NCBICHM1_1
T2T-CHM13v2.06139,350,430 - 139,533,149 (+)NCBIT2T-CHM13v2.0
Arfgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,463,759 - 18,619,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,457,587 - 18,619,697 (-)EnsemblGRCm39 Ensembl
GRCm381018,588,011 - 18,743,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1018,581,839 - 18,743,949 (-)EnsemblGRCm38mm10GRCm38
MGSCv371018,307,817 - 18,463,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361018,277,427 - 18,433,174 (-)NCBIMGSCv36mm8
Celera1018,494,647 - 18,649,063 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.79NCBI
Arfgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,058,574 - 15,223,742 (-)NCBIGRCr8
mRatBN7.2113,245,578 - 13,404,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,244,830 - 13,404,084 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0113,837,861 - 13,918,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,838,707 - 13,915,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0113,986,480 - 14,064,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0115,548,420 - 15,637,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4113,680,369 - 13,841,423 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1113,680,844 - 13,841,485 (-)NCBI
Celera111,698,155 - 11,856,654 (-)NCBICelera
Cytogenetic Map1p12NCBI
Arfgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,220,743 - 21,366,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,220,743 - 21,366,477 (-)NCBIChiLan1.0ChiLan1.0
ARFGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25158,119,095 - 158,306,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16156,016,706 - 156,204,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,916,799 - 136,100,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16140,010,547 - 140,187,173 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6140,010,542 - 140,179,197 (+)Ensemblpanpan1.1panPan2
ARFGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1130,482,375 - 30,658,706 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,527,870 - 30,652,027 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,361,691 - 31,537,808 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0130,646,268 - 30,822,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl130,646,228 - 30,818,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1130,524,950 - 30,701,101 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,406,541 - 30,583,150 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,715,619 - 30,891,829 (+)NCBIUU_Cfam_GSD_1.0
Arfgef3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,569,562 - 125,721,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,348,791 - 5,500,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,348,786 - 5,501,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARFGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,066,605 - 35,247,749 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,069,082 - 35,247,727 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660407,234,046 - 7,425,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arfgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475315,554,360 - 15,700,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475315,526,452 - 15,700,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARFGEF3
7897 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 21
Low 10 4 3 2 2 2 3 1
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000023062   ⟹   ENSSSCP00000025072
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045479   ⟹   ENSSSCP00000053057
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067431   ⟹   ENSSSCP00000072976
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074802   ⟹   ENSSSCP00000071942
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077365   ⟹   ENSSSCP00000069068
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000100638   ⟹   ENSSSCP00000080040
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)Ensembl
RefSeq Acc Id: XM_021087436   ⟹   XP_020943095
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,255,753 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087441   ⟹   XP_020943100
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,256,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087446   ⟹   XP_020943105
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,233,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087451   ⟹   XP_020943110
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,209,166 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087457   ⟹   XP_020943116
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,209,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087461   ⟹   XP_020943120
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1126,069,337 - 26,196,453 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020943100   ⟸   XM_021087441
- Peptide Label: isoform X2
- UniProtKB: A0A8D1RZV7 (UniProtKB/TrEMBL),   I3LLV2 (UniProtKB/TrEMBL),   A0A8D0T542 (UniProtKB/TrEMBL),   A0A8D1FM11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943095   ⟸   XM_021087436
- Peptide Label: isoform X1
- UniProtKB: A0A287BAG5 (UniProtKB/TrEMBL),   A0A8D1S5Q5 (UniProtKB/TrEMBL),   A0A8D0TEA9 (UniProtKB/TrEMBL),   A0A8D1FN67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943105   ⟸   XM_021087446
- Peptide Label: isoform X3
- UniProtKB: A0A8D0JEM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943110   ⟸   XM_021087451
- Peptide Label: isoform X4
- UniProtKB: A0A8D0JEY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943116   ⟸   XM_021087457
- Peptide Label: isoform X4
- UniProtKB: A0A8D0JEY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943120   ⟸   XM_021087461
- Peptide Label: isoform X4
- UniProtKB: A0A8D0JEY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000071942   ⟸   ENSSSCT00000074802
RefSeq Acc Id: ENSSSCP00000053057   ⟸   ENSSSCT00000045479
RefSeq Acc Id: ENSSSCP00000025072   ⟸   ENSSSCT00000023062
RefSeq Acc Id: ENSSSCP00000069068   ⟸   ENSSSCT00000077365
RefSeq Acc Id: ENSSSCP00000072976   ⟸   ENSSSCT00000067431
RefSeq Acc Id: ENSSSCP00000080040   ⟸   ENSSSCT00000100638
Protein Domains
SEC7


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022968 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005026554 UniProtKB/TrEMBL
  ENSSSCG00025066223 UniProtKB/TrEMBL
  ENSSSCG00035057218 UniProtKB/TrEMBL
  ENSSSCG00040065141 UniProtKB/TrEMBL
  ENSSSCG00045005006 UniProtKB/TrEMBL
  ENSSSCG00055027002 UniProtKB/TrEMBL
  ENSSSCG00065027500 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000023062 ENTREZGENE
  ENSSSCT00000023062.4 UniProtKB/TrEMBL
  ENSSSCT00000045479 ENTREZGENE
  ENSSSCT00000045479.3 UniProtKB/TrEMBL
  ENSSSCT00000067431.2 UniProtKB/TrEMBL
  ENSSSCT00000074802.2 UniProtKB/TrEMBL
  ENSSSCT00000077365.1 UniProtKB/TrEMBL
  ENSSSCT00000100638.1 UniProtKB/TrEMBL
  ENSSSCT00005042683.1 UniProtKB/TrEMBL
  ENSSSCT00005042874.1 UniProtKB/TrEMBL
  ENSSSCT00025091033.1 UniProtKB/TrEMBL
  ENSSSCT00025092322.1 UniProtKB/TrEMBL
  ENSSSCT00035076541.1 UniProtKB/TrEMBL
  ENSSSCT00035076576.1 UniProtKB/TrEMBL
  ENSSSCT00040089045.1 UniProtKB/TrEMBL
  ENSSSCT00040090022.1 UniProtKB/TrEMBL
  ENSSSCT00045008352.1 UniProtKB/TrEMBL
  ENSSSCT00045008368.1 UniProtKB/TrEMBL
  ENSSSCT00055053505.1 UniProtKB/TrEMBL
  ENSSSCT00055053908.1 UniProtKB/TrEMBL
  ENSSSCT00065037056.1 UniProtKB/TrEMBL
  ENSSSCT00065037074.1 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  DCB_dom UniProtKB/TrEMBL
  Sec7/BIG1-like_C UniProtKB/TrEMBL
  Sec7_C UniProtKB/TrEMBL
  Sec7_dom UniProtKB/TrEMBL
NCBI Gene ARFGEF3 ENTREZGENE
PANTHER BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 3 UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
Pfam BIG2_C UniProtKB/TrEMBL
  DCB UniProtKB/TrEMBL
  DUF1981 UniProtKB/TrEMBL
SMART Sec7 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A287BAG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QY49_PIG UniProtKB/TrEMBL
  A0A5G2RCG6_PIG UniProtKB/TrEMBL
  A0A5G2RED7_PIG UniProtKB/TrEMBL
  A0A8D0JEM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JEY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T542 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TEA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FM11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FN67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RZV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S5Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FP07_PIG UniProtKB/TrEMBL
  I3LLV2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85452 ENTREZGENE