IMPA2 (inositol monophosphatase 2)

Advanced Search (OLGA)

Gene: IMPA2 (inositol monophosphatase 2) Sus scrofa

Analyze

Symbol:

IMPA2

Name:

inositol monophosphatase 2

RGD ID:

13968325

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); inositol monophosphate 1-phosphatase activity (inferred); inositol monophosphate phosphatase activity (inferred); INVOLVED IN inositol biosynthetic process (inferred); phosphatidylinositol phosphate biosynthetic process (inferred); response to lithium ion (inferred); ASSOCIATED WITH bipolar disorder (ortholog); chromosome 18p deletion syndrome (ortholog); dystonia (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

inositol(myo)-1(or 4)-monophosphatase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IMPA2 (inositol monophosphatase 2)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Impa2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Impa2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Impa2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IMPA2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IMPA2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Impa2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IMPA2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Impa2 (inositol monophosphatase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	97,280,010 - 97,309,745 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	97,280,008 - 97,309,729 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	90,736,855 - 90,768,966 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bipolar disorder (ISO)

chromosome 18p deletion syndrome (ISO)

dystonia (ISO)

endometriosis (ISO)

Febrile Seizures (ISO)

intellectual disability (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inositol biosynthetic process (IEA)

phosphatidylinositol phosphate biosynthetic process (IEA)

response to lithium ion (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

hydrolase activity (IEA)

inositol monophosphate 1-phosphatase activity (IEA)

inositol monophosphate phosphatase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IMPA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	97,280,010 - 97,309,745 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	97,280,008 - 97,309,729 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	90,736,855 - 90,768,966 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IMPA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	11,981,507 - 12,030,877 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	11,981,025 - 12,030,877 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	11,981,506 - 12,030,876 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	11,971,455 - 12,020,876 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	11,971,454 - 12,020,876	NCBI
Celera	18	11,863,626 - 11,913,083 (+)	NCBI		Celera
Cytogenetic Map	18	p11.21	NCBI
HuRef	18	11,936,022 - 11,985,517 (+)	NCBI		HuRef
CHM1_1	18	11,981,069 - 12,030,550 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	12,144,221 - 12,193,612 (+)	NCBI		T2T-CHM13v2.0

Impa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	67,422,246 - 67,454,375 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	67,422,256 - 67,455,542 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	67,289,247 - 67,319,216 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	67,289,186 - 67,322,472 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	67,448,877 - 67,478,495 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	67,414,592 - 67,444,210 (+)	NCBI		MGSCv36	mm8
Celera	18	68,557,223 - 68,589,548 (+)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	39.92	NCBI

Impa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	63,104,113 - 63,135,232 (+)	NCBI		GRCr8
mRatBN7.2	18	60,834,206 - 60,867,575 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	60,834,246 - 60,865,641 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	62,905,859 - 62,936,953 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	63,604,635 - 63,635,729 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	61,454,773 - 61,485,968 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	63,016,577 - 63,050,123 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	63,016,577 - 63,047,781 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	62,201,776 - 62,233,111 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	63,809,336 - 63,840,069 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	63,882,536 - 63,913,270 (+)	NCBI
Celera	18	58,940,928 - 58,971,996 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

Impa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	1,121,838 - 1,143,507 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	1,119,376 - 1,143,589 (-)	NCBI	ChiLan1.0	ChiLan1.0

IMPA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	26,011,624 - 26,062,252 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	11,704,221 - 11,754,841 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	2,293,788 - 2,344,422 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	4,557,280 - 4,608,985 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	4,557,280 - 4,608,991 (-)	Ensembl	panpan1.1		panPan2

IMPA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	77,604,620 - 77,648,416 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	77,597,888 - 77,648,218 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	77,004,188 - 77,049,429 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	77,661,002 - 77,706,180 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	77,655,833 - 77,706,173 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	77,357,733 - 77,402,884 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	77,404,338 - 77,449,508 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	77,691,372 - 77,736,712 (+)	NCBI		UU_Cfam_GSD_1.0

Impa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	1,041,717 - 1,083,030 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936626	268,727 - 310,787 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936626	268,788 - 310,781 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IMPA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	69,389,414 - 69,436,128 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	69,389,606 - 69,436,191 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	44,380,657 - 44,431,073 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Impa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	19,526,446 - 19,548,386 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	19,526,796 - 19,549,113 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in IMPA2
858 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021096044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01028861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000022557 ⟹ ENSSSCP00000023877

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	97,280,010 - 97,309,745 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000089709 ⟹ ENSSSCP00000074545

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	97,280,012 - 97,309,745 (-)	Ensembl

RefSeq Acc Id:

XM_021096044 ⟹ XP_020951703

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	97,280,008 - 97,309,729 (-)	NCBI

Sequence:

show sequence

GCAAGGCTGCGGGCAGGCGCGGCCCAGCCGCTGAGCAGCAGGAGGTGCGAGGCGATCGCGCAGC
CTGGCGTCCGGGCGGGGGGCGCCGGCGGGCCCAGAGGCCGCTATGAAGCCAAGCGGCGAGGATA
GGGCGGCGAGGGCCGGGGGCCCGTGGGAGGAGTGCTTCGAAGCGGCGGTGCAGCTCGCGCTGCG
GGCAGGACAGATCATCAGAAAAGCCCTTTCTGAGGAAAAACGTGTGTCAACGAAAACGTCAGCC
GTGGACCTGGTGACAGAAACGGACCAGGCAGTGGAGGCCTTGATCCTGTCCGAGCTGCAGGAGC
GCTTCCCCTCGCACAGGTTCATCGCAGAAGAGGCTGCGGCCGCCGGGGCTAAGTGTGTGCTCAC
CCCCAGCCCCACGTGGATCGTCGACCCCATTGACGGCACCTGCAACTTCGTGCACAGATTCCCG
ACCGTGGCAGTGAGCATCGGGTTTGCTGTGAACCAGGAGCTGGAGTTCGGGGTGATCTACCACT
GCACAGAGGAGCGGCTGTACACGGGCCAGAGGGGCCGCGGTGCCTTCTGCAATGGCCAGCAGCT
GCAGGTTTCAGGGAGACAGGTGGGCCATGCTCCATTCACTGACCTCTCCAAGGCCCTGGTCTTG
ACGGAAATCGGTCCCAGGCGCGACCCCGCGACTCTGAAGCTGTTCCTGAGCAACATGGAGAGGC
TGCTTCGCACTGGGGCGCACGGCGTCCGAGTCATCGGCAGCTCCACCTTGGCGCTCTGCCACCT
GGCCTCAGGCGCTGCAGATGCCTACTACCAGTTTGGCCTGCACTGCTGGGACCTGGCCGCTGCC
ACTGTGATCATCCGAGAAGCAGGCGGCATTGTGATGGACACGTCAGGCGGCCCCCTCGACCTCA
TGGCTTGCAGAGTGGTTGCTGCGGGTACCCGGGAGATGGCAACCCTCGTTGCTCAGGCCCTACA
AACGATTAACTATGGGAGGGACGACGAGAGGTGAGGGGAGCAGACGACAAGGACACGCCCCAGG
AGCTGGTGAGGTCCCCAAGGTCAAGTGTCTCTGTATGAGGCCACATCTCAGCCTCAGCGGGAAC
CTCTCTGTAATCTCAGTAGCCTTGTTCAGGTCAGTCCAGCCCTTACTGGGCCGAGACCCAGCTC
TCATAGGACGCGTGTATTGATGATGTAAATCTCAGGTAATAAGGCTTTAAAACTGCTGTTCAGG
CAGACTTGTTCTCAGCGACAGCCCCAGGGCACTTCAGAATGCAATAAATCAAACAATGATGCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_020951703	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000023877
	ENSSSCP00000023877.3
	ENSSSCP00000074545.1
	ENSSSCP00040019446.1

RefSeq Acc Id:

XP_020951703 ⟸ XM_021096044

- UniProtKB:

A0A8D1EAF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKPSGEDRAARAGGPWEECFEAAVQLALRAGQIIRKALSEEKRVSTKTSAVDLVTETDQAVEAL
ILSELQERFPSHRFIAEEAAAAGAKCVLTPSPTWIVDPIDGTCNFVHRFPTVAVSIGFAVNQEL
EFGVIYHCTEERLYTGQRGRGAFCNGQQLQVSGRQVGHAPFTDLSKALVLTEIGPRRDPATLKL
FLSNMERLLRTGAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVMDT
SGGPLDLMACRVVAAGTREMATLVAQALQTINYGRDDER

hide sequence

Ensembl Acc Id:

ENSSSCP00000074545 ⟸ ENSSSCT00000089709

Ensembl Acc Id:

ENSSSCP00000023877 ⟸ ENSSSCT00000022557

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000024162	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00040034353	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000022557	ENTREZGENE
	ENSSSCT00000022557.4	UniProtKB/TrEMBL
	ENSSSCT00000089709.2	UniProtKB/TrEMBL
	ENSSSCT00040046371.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.190.80	UniProtKB/TrEMBL
	Fructose-1,6-Bisphosphatase, subunit A, domain 1	UniProtKB/TrEMBL
InterPro	IMPase	UniProtKB/TrEMBL
	Inositol_monoP_metal-BS	UniProtKB/TrEMBL
	Inositol_monoPase_Li-sen	UniProtKB/TrEMBL
	Inositol_monophosphatase-like	UniProtKB/TrEMBL
	Inositol_monophosphatase_CS	UniProtKB/TrEMBL
NCBI Gene	IMPA2	ENTREZGENE
PANTHER	INOSITOL MONOPHOSPHATASE	UniProtKB/TrEMBL
	INOSITOL MONOPHOSPHATASE 2	UniProtKB/TrEMBL
Pfam	Inositol_P	UniProtKB/TrEMBL
PRINTS	IMPHPHTASES	UniProtKB/TrEMBL
	LIIMPHPHTASE	UniProtKB/TrEMBL
PROSITE	IMP_1	UniProtKB/TrEMBL
	IMP_2	UniProtKB/TrEMBL
Superfamily-SCOP	Carbohydrate phosphatase	UniProtKB/TrEMBL
UniProt	A0A5G2RB34_PIG	UniProtKB/TrEMBL
	A0A8D1EAF2	ENTREZGENE, UniProtKB/TrEMBL
	I3LIH2_PIG	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD