KIR2DS3 (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3) - Rat Genome Database

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Gene: KIR2DS3 (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3) Homo sapiens
Analyze
No known orthologs.
Symbol: KIR2DS3
Name: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3
RGD ID: 1350757
HGNC Page HGNC:6335
Description: Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: killer cell immunoglobulin-like receptor 2DS3; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3; MHC class I NK cell receptor; natural killer cell inhibitory receptor; natural killer-associated transcript 7; NKAT-7; NKAT7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: only annotated on alternate loci and patches unit in reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map19q13.4NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bortezomib  (EXP)
CGP 52608  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
Additional References at PubMed
PMID:7749980   PMID:8662091   PMID:8765026   PMID:9430220   PMID:9430221   PMID:11237011   PMID:12559621   PMID:15496913   PMID:15896204   PMID:16403292   PMID:16508981   PMID:16829306  
PMID:17462498   PMID:17498266   PMID:17868255   PMID:17882223   PMID:18074414   PMID:18340360   PMID:18480828   PMID:18571006   PMID:18643961   PMID:18668235   PMID:18681957   PMID:18687225  
PMID:18764809   PMID:18778326   PMID:18830515   PMID:18848853   PMID:19000141   PMID:19005473   PMID:19032228   PMID:19046302   PMID:19120281   PMID:19169284   PMID:19181658   PMID:19218127  
PMID:19279038   PMID:19309280   PMID:19326408   PMID:19410616   PMID:19421224   PMID:19450876   PMID:19489269   PMID:19493232   PMID:19500138   PMID:19527230   PMID:19630074   PMID:19664392  
PMID:19683555   PMID:19761533   PMID:19846535   PMID:19850842   PMID:19861144   PMID:19875891   PMID:19897003   PMID:19926642   PMID:19934297   PMID:19936734   PMID:19968064   PMID:20082482  
PMID:20082646   PMID:20137308   PMID:20173784   PMID:20173792   PMID:20193031   PMID:20200544   PMID:20207982   PMID:20210918   PMID:20210919   PMID:20331834   PMID:20356536   PMID:20371502  
PMID:20371915   PMID:20426625   PMID:20483367   PMID:20492596   PMID:20519398   PMID:20528243   PMID:20580654   PMID:20600442   PMID:20643584   PMID:20650299   PMID:20652381   PMID:20670355  
PMID:20878400   PMID:21206914   PMID:21402922   PMID:21873635   PMID:22219647   PMID:22653583   PMID:23394822   PMID:23826153   PMID:24929143   PMID:26472014   PMID:27490240   PMID:27631728  
PMID:28993188   PMID:33961781   PMID:35537400  


Genomics

Markers in Region
RH69059  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3719145,111 - 145,237UniSTSGRCh37
GRCh371955,359,389 - 55,359,515UniSTSGRCh37
GRCh3719112,471 - 112,597UniSTSGRCh37
GRCh371984,118 - 84,244UniSTSGRCh37
GRCh3719128,931 - 129,057UniSTSGRCh37
Build 361960,051,201 - 60,051,327RGDNCBI36
Celera1952,399,992 - 52,400,118RGD
Cytogenetic Map19q13.4UniSTS
HuRef1951,682,072 - 51,682,198UniSTS
GeneMap99-GB4 RH Map19281.76UniSTS
RH76182  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map19q13.4UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_005994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF022047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM851002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY320039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU459006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU182359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX008031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KI270882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KI270885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KI270886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP420440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU645196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L76670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Sequences
Protein RefSeqs NP_036445 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189411 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB36598 (Get FASTA)   NCBI Sequence Viewer  
  AAB95320 (Get FASTA)   NCBI Sequence Viewer  
  AAX23108 (Get FASTA)   NCBI Sequence Viewer  
  ADJ94516 (Get FASTA)   NCBI Sequence Viewer  
  ADJ94582 (Get FASTA)   NCBI Sequence Viewer  
  ADJ94615 (Get FASTA)   NCBI Sequence Viewer  
  ADJ94627 (Get FASTA)   NCBI Sequence Viewer  
  ADJ94680 (Get FASTA)   NCBI Sequence Viewer  
  AFV74774 (Get FASTA)   NCBI Sequence Viewer  
  AJI81003 (Get FASTA)   NCBI Sequence Viewer  
  ANJ04794 (Get FASTA)   NCBI Sequence Viewer  
  CAA65870 (Get FASTA)   NCBI Sequence Viewer  
  CAO98983 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000477925.1
  ENSP00000478314.1
  ENSP00000479108.1
  ENSP00000479929.1
  ENSP00000480340.1
  ENSP00000480969.1
  ENSP00000482047.1
  ENSP00000483315.1
  ENSP00000483518.1
  ENSP00000484057.1
  ENSP00000484937.1
  ENSP00000490994.1
  ENSP00000491988.1
  ENSP00000492688.1
  ENSP00000493528.1
  ENSP00000494304.1
  ENSP00000494430.1
  ENSP00000495002.1
  ENSP00000496718.1
  ENSP00000500030.1
  ENSP00000500091.1
  ENSP00000500348.1
  ENSP00000500428.1
  ENSP00000500568.1
  ENSP00000500575.1
  ENSP00000500689.1
  ENSP00000500722.1
GenBank Protein Q14952 (Get FASTA)   NCBI Sequence Viewer  
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14952-F1-model_v2 AlphaFold Q14952 1-304 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6335 AgrOrtholog
COSMIC KIR2DS3 COSMIC
Ensembl Genes ENSG00000275500 UniProtKB/TrEMBL
  ENSG00000275599 UniProtKB/TrEMBL
  ENSG00000276177 UniProtKB/TrEMBL
  ENSG00000276392 UniProtKB/TrEMBL
  ENSG00000276686 UniProtKB/TrEMBL
  ENSG00000277163 UniProtKB/Swiss-Prot
  ENSG00000277193 UniProtKB/TrEMBL
  ENSG00000277657 UniProtKB/Swiss-Prot
  ENSG00000278086 UniProtKB/TrEMBL
  ENSG00000278116 UniProtKB/TrEMBL
  ENSG00000278306 UniProtKB/Swiss-Prot
  ENSG00000288206 UniProtKB/TrEMBL
  ENSG00000288357 UniProtKB/TrEMBL
  ENSG00000288381 UniProtKB/TrEMBL
  ENSG00000288487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000611193.2 UniProtKB/Swiss-Prot
  ENST00000613265.1 UniProtKB/Swiss-Prot
  ENST00000614513.1 UniProtKB/TrEMBL
  ENST00000614725.2 UniProtKB/Swiss-Prot
  ENST00000617330.1 UniProtKB/TrEMBL
  ENST00000617974.1 UniProtKB/TrEMBL
  ENST00000618755.2 UniProtKB/TrEMBL
  ENST00000620545.1 UniProtKB/TrEMBL
  ENST00000620638.1 UniProtKB/TrEMBL
  ENST00000621273.1 UniProtKB/TrEMBL
  ENST00000621304.1 UniProtKB/TrEMBL
  ENST00000638381.1 UniProtKB/TrEMBL
  ENST00000639063.1 UniProtKB/TrEMBL
  ENST00000640609.1 UniProtKB/Swiss-Prot
  ENST00000642705.1 UniProtKB/TrEMBL
  ENST00000644091.1 UniProtKB/TrEMBL
  ENST00000645003.1 UniProtKB/Swiss-Prot
  ENST00000645169.1 UniProtKB/TrEMBL
  ENST00000646732.1 UniProtKB/TrEMBL
  ENST00000671758.1 UniProtKB/TrEMBL
  ENST00000672440.1 UniProtKB/TrEMBL
  ENST00000672516.1 UniProtKB/TrEMBL
  ENST00000672609.1 UniProtKB/TrEMBL
  ENST00000672626.1 UniProtKB/TrEMBL
  ENST00000672702.1 UniProtKB/TrEMBL
  ENST00000673237.1 UniProtKB/TrEMBL
  ENST00000673371.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000275500 GTEx
  ENSG00000275599 GTEx
  ENSG00000276177 GTEx
  ENSG00000276392 GTEx
  ENSG00000276686 GTEx
  ENSG00000277163 GTEx
  ENSG00000277193 GTEx
  ENSG00000277657 GTEx
  ENSG00000278086 GTEx
  ENSG00000278116 GTEx
  ENSG00000278306 GTEx
  ENSG00000288206 GTEx
  ENSG00000288357 GTEx
  ENSG00000288381 GTEx
  ENSG00000288487 GTEx
HGNC ID HGNC:6335 ENTREZGENE
Human Proteome Map KIR2DS3 Human Proteome Map
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3808 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3808 ENTREZGENE
OMIM 604954 OMIM
PANTHER KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED UniProtKB/TrEMBL
  MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLATELET GLYCOPROTEIN VI UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30120 PharmGKB
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A376A8X2_HUMAN UniProtKB/TrEMBL
  A0A8H2NLG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NLG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NLH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NLJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NM07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NMJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NNC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NND1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2NVJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2RGV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2RNX6_HUMAN UniProtKB/TrEMBL
  A0A8H2RQ18 ENTREZGENE, UniProtKB/TrEMBL
  A0A8H2RRD4 ENTREZGENE, UniProtKB/TrEMBL
  B0L652_HUMAN UniProtKB/TrEMBL
  B6CAV4_HUMAN UniProtKB/TrEMBL
  B6CAV9_HUMAN UniProtKB/TrEMBL
  B7SEW2_HUMAN UniProtKB/TrEMBL
  K7QT50 ENTREZGENE, UniProtKB/TrEMBL
  K7RE56_HUMAN UniProtKB/TrEMBL
  KI2S3_HUMAN UniProtKB/Swiss-Prot
  O00644 ENTREZGENE
  Q14952 ENTREZGENE
  Q32WD8_HUMAN UniProtKB/TrEMBL
UniProt Secondary O00644 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 KIR2DS3  killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3  KIR2DS3  killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3  Symbol and/or name change 5135510 APPROVED