HCST (hematopoietic cell signal transducer) - Rat Genome Database

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Gene: HCST (hematopoietic cell signal transducer) Homo sapiens
Analyze
Symbol: HCST
Name: hematopoietic cell signal transducer
RGD ID: 1350033
HGNC Page HGNC:16977
Description: Enables phosphatidylinositol 3-kinase binding activity and signaling receptor binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cell surface.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DAP10; DKFZP586C1522; DNAX-activation protein 10; KAP10; kinase assoc pro of ~10kDa; kinase assoc protein; membrane protein DAP10; phosphoinositide-3-kinase adaptor protein; PIK3AP; transmembrane adapter protein KAP10
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,902,529 - 35,904,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,902,529 - 35,904,377 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,393,431 - 36,395,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,085,222 - 41,087,013 (+)NCBINCBI36Build 36hg18NCBI36
Build 341941,085,221 - 41,087,013NCBI
Celera1933,107,573 - 33,109,364 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,898,627 - 32,900,418 (+)NCBIHuRef
CHM1_11936,394,675 - 36,396,466 (+)NCBICHM1_1
T2T-CHM13v2.01938,448,294 - 38,450,142 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA)
membrane  (IEA)
plasma membrane  (IDA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10426994   PMID:10528161   PMID:11015446   PMID:11239445   PMID:11398969   PMID:12426564   PMID:12426565   PMID:12477932   PMID:12740575   PMID:12975309   PMID:15048706   PMID:15294961  
PMID:16339517   PMID:19075187   PMID:19322201   PMID:19329438   PMID:21263069   PMID:21706044   PMID:21789015   PMID:21816829   PMID:21873635   PMID:22438812   PMID:25002577   PMID:26221034  
PMID:26439863   PMID:26508790   PMID:31235500   PMID:32296183   PMID:32513696   PMID:32814053   PMID:33153411   PMID:33961781  


Genomics

Comparative Map Data
HCST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,902,529 - 35,904,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,902,529 - 35,904,377 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,393,431 - 36,395,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,085,222 - 41,087,013 (+)NCBINCBI36Build 36hg18NCBI36
Build 341941,085,221 - 41,087,013NCBI
Celera1933,107,573 - 33,109,364 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,898,627 - 32,900,418 (+)NCBIHuRef
CHM1_11936,394,675 - 36,396,466 (+)NCBICHM1_1
T2T-CHM13v2.01938,448,294 - 38,450,142 (+)NCBIT2T-CHM13v2.0
Hcst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,117,137 - 30,119,279 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,117,137 - 30,119,279 (-)EnsemblGRCm39 Ensembl
GRCm38730,417,712 - 30,419,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,417,712 - 30,419,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,202,731 - 31,204,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,126,566 - 30,128,506 (-)NCBIMGSCv36mm8
Celera725,009,424 - 25,011,566 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.45NCBI
Hcst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,804,429 - 94,806,661 (-)NCBIGRCr8
mRatBN7.2185,676,976 - 85,679,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,676,979 - 85,679,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,092,795 - 91,094,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,560,032 - 99,562,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,851,060 - 92,853,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,879,425 - 88,881,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,879,428 - 88,881,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,035,099 - 90,037,271 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,369,349 - 85,371,383 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,447,460 - 85,449,494 (-)NCBI
Celera180,049,152 - 80,051,187 (-)NCBICelera
Cytogenetic Map1q21NCBI
HCST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,897,740 - 41,902,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,884,029 - 43,887,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,817,826 - 32,821,149 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,567,234 - 41,570,544 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,568,739 - 41,570,544 (+)Ensemblpanpan1.1panPan2
HCST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,760,605 - 116,763,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,760,714 - 116,762,024 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,166,169 - 116,169,228 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,363,784 - 117,366,843 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,363,893 - 117,365,203 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,927,340 - 116,930,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,550,872 - 116,553,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,606,637 - 117,609,694 (-)NCBIUU_Cfam_GSD_1.0
Hcst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,181,369 - 11,185,007 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570460,986 - 462,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570460,890 - 462,354 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1645,304,744 - 45,309,048 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,707,447 - 40,711,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
HCST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,810,874 - 30,816,547 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660738,605,509 - 8,609,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in HCST
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29661858-38114723)x1 copy number loss See cases [RCV000135879] Chr19:29661858..38114723 [GRCh38]
Chr19:30152765..38605363 [GRCh37]
Chr19:34844605..43297203 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29671324-37902990)x1 copy number loss See cases [RCV000136794] Chr19:29671324..37902990 [GRCh38]
Chr19:30162231..38393630 [GRCh37]
Chr19:34854071..43085470 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh37/hg19 19q13.12(chr19:36147111-37249653)x1 copy number loss See cases [RCV000511504] Chr19:36147111..37249653 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.11-13.12(chr19:35111811-37744992) copy number loss Generalized epilepsy with febrile seizures plus, type 1 [RCV000767768] Chr19:35111811..37744992 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NC_000019.9:g.(?_33167170)_(36643309_?)dup duplication Hereditary spastic paraplegia 75 [RCV003107659] Chr19:33167170..36643309 [GRCh37]
Chr19:19q13.11-13.12		 uncertain significance
NM_014266.4(HCST):c.*202dup duplication not provided [RCV001638648] Chr19:35904357..35904358 [GRCh38]
Chr19:36395259..36395260 [GRCh37]
Chr19:19q13.12		 benign
GRCh37/hg19 19q13.12(chr19:36019064-36516110)x3 copy number gain not provided [RCV001833065] Chr19:36019064..36516110 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NC_000019.9:g.(?_35521725)_(36643309_?)del deletion Brugada syndrome 5 [RCV001910265] Chr19:35521725..36643309 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_014266.4(HCST):c.124T>C (p.Cys42Arg) single nucleotide variant Inborn genetic diseases [RCV002969106] Chr19:35903786 [GRCh38]
Chr19:36394688 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_014266.4(HCST):c.125G>A (p.Cys42Tyr) single nucleotide variant Inborn genetic diseases [RCV003206420] Chr19:35903787 [GRCh38]
Chr19:36394689 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36312941-36751702)x3 copy number gain not provided [RCV003485199] Chr19:36312941..36751702 [GRCh37]
Chr19:19q13.12		 uncertain significance
Single allele deletion not provided [RCV003448708] Chr19:35225414..37357598 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:444
Count of miRNA genes:277
Interacting mature miRNAs:283
Transcripts:ENST00000246551, ENST00000437550
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D19S844E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,395,329 - 36,395,421UniSTSGRCh37
Build 361941,087,169 - 41,087,261RGDNCBI36
Celera1933,109,520 - 33,109,612RGD
Cytogenetic Map19q13.1UniSTS
HuRef1932,900,574 - 32,900,666UniSTS
A006G29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,395,313 - 36,395,490UniSTSGRCh37
Build 361941,087,153 - 41,087,330RGDNCBI36
Celera1933,109,504 - 33,109,681RGD
Cytogenetic Map19q13.1UniSTS
HuRef1932,900,558 - 32,900,735UniSTS
GeneMap99-GB4 RH Map19214.34UniSTS
G32347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,395,313 - 36,395,490UniSTSGRCh37
Celera1933,109,504 - 33,109,681UniSTS
Cytogenetic Map19q13.1UniSTS
HuRef1932,900,558 - 32,900,735UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 1
Medium 336 1282 320 145 1693 130 1141 33 822 171 295 778 15 808 636 1
Low 2038 1642 1391 468 237 323 2891 1855 2825 220 1108 740 154 1 396 1902 2 2
Below cutoff 47 64 13 9 14 10 278 283 80 23 44 64 4 227 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001007469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054319594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054319595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AD000864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF122904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF172929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF285447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000246551   ⟹   ENSP00000246551
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,902,529 - 35,904,377 (+)Ensembl
RefSeq Acc Id: ENST00000437550   ⟹   ENSP00000400516
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,902,538 - 35,904,270 (+)Ensembl
RefSeq Acc Id: NM_001007469   ⟹   NP_001007470
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,529 - 35,904,271 (+)NCBI
GRCh371936,393,382 - 36,395,173 (+)ENTREZGENE
Build 361941,085,222 - 41,087,013 (+)NCBI Archive
HuRef1932,898,627 - 32,900,418 (+)ENTREZGENE
CHM1_11936,394,675 - 36,396,466 (+)NCBI
T2T-CHM13v2.01938,448,294 - 38,450,036 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014266   ⟹   NP_055081
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,529 - 35,904,377 (+)NCBI
GRCh371936,393,382 - 36,395,173 (+)ENTREZGENE
Build 361941,085,222 - 41,087,013 (+)NCBI Archive
HuRef1932,898,627 - 32,900,418 (+)ENTREZGENE
CHM1_11936,394,675 - 36,396,466 (+)NCBI
T2T-CHM13v2.01938,448,294 - 38,450,142 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026193   ⟹   XP_016881682
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,529 - 35,904,377 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047438090   ⟹   XP_047294046
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,529 - 35,904,271 (+)NCBI
RefSeq Acc Id: XM_054319594   ⟹   XP_054175569
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01938,448,294 - 38,450,142 (+)NCBI
RefSeq Acc Id: XM_054319595   ⟹   XP_054175570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01938,448,294 - 38,450,036 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_055081   ⟸   NM_014266
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UBS1 (UniProtKB/Swiss-Prot),   Q9Y3Y0 (UniProtKB/Swiss-Prot),   Q9UBK5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001007470   ⟸   NM_001007469
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UBK5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016881682   ⟸   XM_017026193
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000246551   ⟸   ENST00000246551
RefSeq Acc Id: ENSP00000400516   ⟸   ENST00000437550
RefSeq Acc Id: XP_047294046   ⟸   XM_047438090
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054175569   ⟸   XM_054319594
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054175570   ⟸   XM_054319595
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UBK5-F1-model_v2 AlphaFold Q9UBK5 1-93 view protein structure

Promoters
RGD ID:7239607
Promoter ID:EPDNEW_H25549
Type:initiation region
Name:HCST_5
Description:hematopoietic cell signal transducer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25550  EPDNEW_H25552  EPDNEW_H25553  EPDNEW_H25554  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,899,017 - 35,899,077EPDNEW
RGD ID:7239609
Promoter ID:EPDNEW_H25550
Type:initiation region
Name:HCST_2
Description:hematopoietic cell signal transducer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25549  EPDNEW_H25552  EPDNEW_H25553  EPDNEW_H25554  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,899,863 - 35,899,923EPDNEW
RGD ID:7239613
Promoter ID:EPDNEW_H25552
Type:initiation region
Name:HCST_4
Description:hematopoietic cell signal transducer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25549  EPDNEW_H25550  EPDNEW_H25553  EPDNEW_H25554  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,900,623 - 35,900,683EPDNEW
RGD ID:7239615
Promoter ID:EPDNEW_H25553
Type:initiation region
Name:HCST_3
Description:hematopoietic cell signal transducer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25549  EPDNEW_H25550  EPDNEW_H25552  EPDNEW_H25554  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,365 - 35,902,425EPDNEW
RGD ID:7239617
Promoter ID:EPDNEW_H25554
Type:initiation region
Name:HCST_1
Description:hematopoietic cell signal transducer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25549  EPDNEW_H25550  EPDNEW_H25552  EPDNEW_H25553  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,902,529 - 35,902,589EPDNEW
RGD ID:6795856
Promoter ID:HG_KWN:29699
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000246551,   ENST00000352614,   NM_001007469
Position:
Human AssemblyChrPosition (strand)Source
Build 361941,084,786 - 41,085,302 (-)MPROMDB
RGD ID:6814640
Promoter ID:HG_XEF:4028
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour
Transcripts:NM_001005900
Position:
Human AssemblyChrPosition (strand)Source
Build 361941,086,351 - 41,086,851 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16977 AgrOrtholog
COSMIC HCST COSMIC
Ensembl Genes ENSG00000126264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000246551 ENTREZGENE
  ENST00000246551.9 UniProtKB/Swiss-Prot
  ENST00000437550 ENTREZGENE
  ENST00000437550.2 UniProtKB/Swiss-Prot
GTEx ENSG00000126264 GTEx
HGNC ID HGNC:16977 ENTREZGENE
Human Proteome Map HCST Human Proteome Map
InterPro HCST UniProtKB/Swiss-Prot
KEGG Report hsa:10870 UniProtKB/Swiss-Prot
NCBI Gene 10870 ENTREZGENE
OMIM 604089 OMIM
PANTHER HEMATOPOIETIC CELL SIGNAL TRANSDUCER UniProtKB/Swiss-Prot
  PTHR21409 UniProtKB/Swiss-Prot
Pfam DAP10 UniProtKB/Swiss-Prot
PharmGKB PA134956649 PharmGKB
UniProt HCST_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9UBS1 ENTREZGENE
  Q9Y3Y0 ENTREZGENE
UniProt Secondary Q9UBS1 UniProtKB/Swiss-Prot
  Q9Y3Y0 UniProtKB/Swiss-Prot