TRIM64 (tripartite motif containing 64) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: TRIM64 (tripartite motif containing 64) Homo sapiens
Analyze
Symbol: TRIM64
Name: tripartite motif containing 64
RGD ID: 1349864
HGNC Page HGNC:14663
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C11orf28; TRIM64A; tripartite motif-containing 64; tripartite motif-containing protein 64
RGD Orthologs
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,966,037 - 89,974,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,966,037 - 89,974,072 (+)EnsemblGRCh38hg38GRCh38
GRCh371189,699,205 - 89,707,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361189,341,320 - 89,346,888 (+)NCBINCBI36Build 36hg18NCBI36
Celera1186,951,536 - 86,956,174 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,900,198 - 85,900,608 (-)NCBIHuRef
CHM1_11189,486,999 - 89,492,587 (-)NCBICHM1_1
T2T-CHM13v2.01189,886,173 - 89,894,223 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
CGP 52608  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References
Additional References at PubMed
PMID:16554811   PMID:21873635   PMID:22144910   PMID:36229750  


Genomics

Comparative Map Data
TRIM64
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,966,037 - 89,974,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,966,037 - 89,974,072 (+)EnsemblGRCh38hg38GRCh38
GRCh371189,699,205 - 89,707,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361189,341,320 - 89,346,888 (+)NCBINCBI36Build 36hg18NCBI36
Celera1186,951,536 - 86,956,174 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,900,198 - 85,900,608 (-)NCBIHuRef
CHM1_11189,486,999 - 89,492,587 (-)NCBICHM1_1
T2T-CHM13v2.01189,886,173 - 89,894,223 (+)NCBIT2T-CHM13v2.0
LOC100524034
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1923,009,082 - 23,015,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,572,372 - 25,578,578 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in TRIM64
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1		 pathogenic
GRCh38/hg38 11q14.3(chr11:89650515-90084741)x1 copy number loss See cases [RCV000137458] Chr11:89650515..90084741 [GRCh38]
Chr11:89383683..89817909 [GRCh37]
Chr11:89023331..89457557 [NCBI36]
Chr11:11q14.3		 pathogenic|likely benign
GRCh38/hg38 11q14.3(chr11:89727372-89972044)x3 copy number gain See cases [RCV000139678] Chr11:89727372..89972044 [GRCh38]
Chr11:89460540..89705212 [GRCh37]
Chr11:89100188..89344860 [NCBI36]
Chr11:11q14.3		 likely benign
GRCh38/hg38 11q14.3(chr11:89425778-90689442)x1 copy number loss See cases [RCV000141934] Chr11:89425778..90689442 [GRCh38]
Chr11:89158946..90422610 [GRCh37]
Chr11:88798594..90062258 [NCBI36]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.1-21(chr11:80318996-96116221)x1 copy number loss See cases [RCV000446395] Chr11:80318996..96116221 [GRCh37]
Chr11:11q14.1-21		 pathogenic
GRCh37/hg19 11q14.3(chr11:89540275-89956475)x3 copy number gain See cases [RCV000448705] Chr11:89540275..89956475 [GRCh37]
Chr11:11q14.3		 benign
GRCh37/hg19 11q14.3(chr11:89514122-92745981)x1 copy number loss See cases [RCV000448827] Chr11:89514122..92745981 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.2-14.3(chr11:87099219-91921385) copy number loss Abnormal esophagus morphology [RCV000416734] Chr11:87099219..91921385 [GRCh37]
Chr11:11q14.2-14.3		 likely benign
GRCh37/hg19 11q14.1-21(chr11:84924674-93574799)x1 copy number loss See cases [RCV000448436] Chr11:84924674..93574799 [GRCh37]
Chr11:11q14.1-21		 likely pathogenic
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11q14.1-14.3(chr11:81771852-90851187) copy number loss Intellectual disability [RCV000721939] Chr11:81771852..90851187 [GRCh37]
Chr11:11q14.1-14.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2		 pathogenic
GRCh37/hg19 11q14.1-21(chr11:83179196-94716998)x3 copy number gain not provided [RCV000750120] Chr11:83179196..94716998 [GRCh37]
Chr11:11q14.1-21		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787372] Chr11:89482692..90933956 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.3(chr11:89659554-90697895)x3 copy number gain not provided [RCV001006433] Chr11:89659554..90697895 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.1-14.3(chr11:84830143-92029933)x3 copy number gain not provided [RCV001006426] Chr11:84830143..92029933 [GRCh37]
Chr11:11q14.1-14.3		 pathogenic
GRCh37/hg19 11q14.3(chr11:89062443-89762600)x3 copy number gain not provided [RCV001006431] Chr11:89062443..89762600 [GRCh37]
Chr11:11q14.3		 likely benign
NM_001136486.2(TRIM64):c.362T>A (p.Met121Lys) single nucleotide variant not specified [RCV004684797] Chr11:89968865 [GRCh38]
Chr11:89702033 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.1-21(chr11:80318996-96116221) copy number loss not specified [RCV002052941] Chr11:80318996..96116221 [GRCh37]
Chr11:11q14.1-21		 pathogenic
GRCh37/hg19 11q14.1-21(chr11:84924674-93574799) copy number loss not specified [RCV002052942] Chr11:84924674..93574799 [GRCh37]
Chr11:11q14.1-21		 likely pathogenic
GRCh37/hg19 11q14.3(chr11:89514122-92745981) copy number loss not specified [RCV002052946] Chr11:89514122..92745981 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3		 uncertain significance
GRCh37/hg19 11q14.1-22.1(chr11:77855209-98002445) copy number loss not specified [RCV002052940] Chr11:77855209..98002445 [GRCh37]
Chr11:11q14.1-22.1		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11q14.3(chr11:89474818-89887082)x1 copy number loss not provided [RCV002474964] Chr11:89474818..89887082 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.1-22.3(chr11:81478509-104667040)x1 copy number loss not provided [RCV002475722] Chr11:81478509..104667040 [GRCh37]
Chr11:11q14.1-22.3		 pathogenic
NM_001136486.2(TRIM64):c.278T>C (p.Val93Ala) single nucleotide variant not specified [RCV004162435] Chr11:89968781 [GRCh38]
Chr11:89701949 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.68T>A (p.Ile23Lys) single nucleotide variant not specified [RCV004184287] Chr11:89968571 [GRCh38]
Chr11:89701739 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.202G>C (p.Val68Leu) single nucleotide variant not specified [RCV004184150] Chr11:89968705 [GRCh38]
Chr11:89701873 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.1214A>G (p.Gln405Arg) single nucleotide variant not specified [RCV004186360] Chr11:89973753 [GRCh38]
Chr11:89706921 [GRCh37]
Chr11:11q14.3		 likely benign
NM_001136486.2(TRIM64):c.1052A>G (p.Asn351Ser) single nucleotide variant not specified [RCV004108874] Chr11:89973591 [GRCh38]
Chr11:89706759 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.388T>A (p.Trp130Arg) single nucleotide variant not specified [RCV004189218] Chr11:89968891 [GRCh38]
Chr11:89702059 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.930T>G (p.Phe310Leu) single nucleotide variant not specified [RCV004272616] Chr11:89973469 [GRCh38]
Chr11:89706637 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.914T>G (p.Val305Gly) single nucleotide variant not specified [RCV004275682] Chr11:89973453 [GRCh38]
Chr11:89706621 [GRCh37]
Chr11:11q14.3		 uncertain significance
GRCh37/hg19 11q14.3(chr11:89602560-90979365)x3 copy number gain not provided [RCV003484848] Chr11:89602560..90979365 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.109C>T (p.Pro37Ser) single nucleotide variant not specified [RCV004476058] Chr11:89968612 [GRCh38]
Chr11:89701780 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.1229T>C (p.Leu410Pro) single nucleotide variant not specified [RCV004476059] Chr11:89973768 [GRCh38]
Chr11:89706936 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.334G>A (p.Gly112Arg) single nucleotide variant not specified [RCV004476060] Chr11:89968837 [GRCh38]
Chr11:89702005 [GRCh37]
Chr11:11q14.3		 uncertain significance
NM_001136486.2(TRIM64):c.359A>C (p.His120Pro) single nucleotide variant not specified [RCV004476061] Chr11:89968862 [GRCh38]
Chr11:89702030 [GRCh37]
Chr11:11q14.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:109
Interacting mature miRNAs:109
Transcripts:ENST00000332157, ENST00000533122
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH93993  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q14.3UniSTS
GeneMap99-GB4 RH Map11309.41UniSTS
RH75742  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q14.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 16 52 26 130 12 10 11 50 49 59 96 1 96 10

Sequence


Ensembl Acc Id: ENST00000533122   ⟹   ENSP00000483764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1189,966,037 - 89,974,072 (+)Ensembl
RefSeq Acc Id: NM_001136486   ⟹   NP_001129958
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381189,966,037 - 89,974,072 (+)NCBI
GRCh371189,701,672 - 89,707,240 (+)RGD
Celera1186,951,536 - 86,956,174 (+)RGD
HuRef1185,900,198 - 85,900,608 (-)ENTREZGENE
CHM1_11189,486,999 - 89,492,587 (-)NCBI
T2T-CHM13v2.01189,886,173 - 89,894,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054367645   ⟹   XP_054223620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01189,889,261 - 89,894,223 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001129958 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NGJ6 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000483764
  ENSP00000483764.1
RefSeq Acc Id: NP_001129958   ⟸   NM_001136486
- UniProtKB: A6NGJ6 (UniProtKB/Swiss-Prot),   I1YAQ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000483764   ⟸   ENST00000533122
RefSeq Acc Id: XP_054223620   ⟸   XM_054367645
- Peptide Label: isoform X1
Protein Domains
B box-type   B30.2/SPRY   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6NGJ6-F1-model_v2 AlphaFold A6NGJ6 1-449 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14663 AgrOrtholog
COSMIC TRIM64 COSMIC
Ensembl Genes ENSG00000204450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000533122 ENTREZGENE
  ENST00000533122.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/TrEMBL
GTEx ENSG00000204450 GTEx
HGNC ID HGNC:14663 ENTREZGENE
Human Proteome Map TRIM64 Human Proteome Map
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIM/RBCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:120146 UniProtKB/Swiss-Prot
NCBI Gene TRIM64 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIPARTITE MOTIF-CONTAINING PROTEIN 64-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25492 PharmGKB
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Concanavalin A-like lectins/glucanases UniProtKB/TrEMBL
  RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot
UniProt A6NGJ6 ENTREZGENE
  I1YAQ0 ENTREZGENE, UniProtKB/TrEMBL
  TRI64_HUMAN UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 TRIM64  tripartite motif containing 64  TRIM64  tripartite motif-containing 64  Symbol and/or name change 5135510 APPROVED