FBXW10 (F-box and WD repeat domain containing 10) - Rat Genome Database

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Gene: FBXW10 (F-box and WD repeat domain containing 10) Homo sapiens
Analyze
Symbol: FBXW10
Name: F-box and WD repeat domain containing 10
RGD ID: 1344414
HGNC Page HGNC:1211
Description: Predicted to be located in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and WD-40 domain protein 10; F-box and WD-40 domain-containing protein 10; F-box protein; F-box/WD repeat-containing protein 10; Fbw10; HREP; SM25H2; SM2SH2; testicular tissue protein Li 69; ubiquitin ligase specificity factor; ubiquitin ligase-specificity factor
RGD Orthologs
Mouse
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,744,054 - 18,779,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,744,026 - 18,779,349 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,647,367 - 18,682,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,588,051 - 18,623,387 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,588,063 - 18,623,386NCBI
Cytogenetic Map17p11.2NCBI
HuRef1718,230,526 - 18,264,647 (+)NCBIHuRef
CHM1_11718,656,781 - 18,692,149 (+)NCBICHM1_1
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11230166   PMID:12477932   PMID:15520277   PMID:16344560   PMID:19028597   PMID:20498703   PMID:21145461   PMID:23899520   PMID:26673895   PMID:31400758   PMID:34857952   PMID:36215168  
PMID:36990424   PMID:37277019   PMID:37775405   PMID:38334954  


Genomics

Comparative Map Data
FBXW10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,744,054 - 18,779,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,744,026 - 18,779,349 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,647,367 - 18,682,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,588,051 - 18,623,387 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,588,063 - 18,623,386NCBI
Cytogenetic Map17p11.2NCBI
HuRef1718,230,526 - 18,264,647 (+)NCBIHuRef
CHM1_11718,656,781 - 18,692,149 (+)NCBICHM1_1
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBIT2T-CHM13v2.0
Fbxw10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,737,893 - 62,768,290 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,737,895 - 62,768,291 (+)EnsemblGRCm39 Ensembl
GRCm381162,847,067 - 62,877,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,847,069 - 62,877,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,660,625 - 62,690,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,663,264 - 62,693,660 (+)NCBIMGSCv36mm8
Celera1169,772,318 - 69,802,562 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1138.78NCBI
Fbxw10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81048,012,555 - 48,051,136 (+)NCBIGRCr8
mRatBN7.21047,513,313 - 47,551,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,486,297 - 47,551,907 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01049,259,050 - 49,296,714 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1049,259,194 - 49,296,663 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01049,029,089 - 49,075,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1046,758,482 - 46,795,881 (+)NCBICelera
Cytogenetic Map10q23NCBI
FBXW10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,807,047 - 53,842,562 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11758,428,799 - 58,464,666 (+)NCBINHGRI_mPanPan1

Variants

.
Variants in FBXW10
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p11.2(chr17:16879232-18970941)x3 copy number gain See cases [RCV000050888] Chr17:16879232..18970941 [GRCh38]
Chr17:16782546..18874254 [GRCh37]
Chr17:16723271..18814979 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15776915-18771753)x1 copy number loss See cases [RCV000050513] Chr17:15776915..18771753 [GRCh38]
Chr17:15680229..18675066 [GRCh37]
Chr17:15620954..18615791 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15898032-20620700)x1 copy number loss See cases [RCV000050602] Chr17:15898032..20620700 [GRCh38]
Chr17:15801346..20524013 [GRCh37]
Chr17:15742071..20464605 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16879232-20390725)x3 copy number gain See cases [RCV000050622] Chr17:16879232..20390725 [GRCh38]
Chr17:16782546..20294038 [GRCh37]
Chr17:16723271..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16879232-20390725)x1 copy number loss See cases [RCV000050624] Chr17:16879232..20390725 [GRCh38]
Chr17:16782546..20294038 [GRCh37]
Chr17:16723271..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15259164-20925299)x3 copy number gain See cases [RCV000051852] Chr17:15259164..20925299 [GRCh38]
Chr17:15162481..20828612 [GRCh37]
Chr17:15103206..20769204 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15897832-20620841)x3 copy number gain See cases [RCV000051853] Chr17:15897832..20620841 [GRCh38]
Chr17:15801146..20524154 [GRCh37]
Chr17:15741871..20464746 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16836827-20340442)x3 copy number gain See cases [RCV000051876] Chr17:16836827..20340442 [GRCh38]
Chr17:16740141..20243755 [GRCh37]
Chr17:16680866..20184347 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16656168-20390725)x3 copy number gain See cases [RCV000051855] Chr17:16656168..20390725 [GRCh38]
Chr17:16559482..20294038 [GRCh37]
Chr17:16500207..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16836827-20504849)x3 copy number gain See cases [RCV000051877] Chr17:16836827..20504849 [GRCh38]
Chr17:16740141..20408162 [GRCh37]
Chr17:16680866..20348754 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16919369-20289856)x3 copy number gain See cases [RCV000051879] Chr17:16919369..20289856 [GRCh38]
Chr17:16822683..20193169 [GRCh37]
Chr17:16763408..20133761 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16692462-20390725)x3 copy number gain See cases [RCV000051858] Chr17:16692462..20390725 [GRCh38]
Chr17:16595776..20294038 [GRCh37]
Chr17:16536501..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16713514-20582527)x3 copy number gain See cases [RCV000051860] Chr17:16713514..20582527 [GRCh38]
Chr17:16616828..20485840 [GRCh37]
Chr17:16557553..20426432 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16713515-20340442)x3 copy number gain See cases [RCV000051871] Chr17:16713515..20340442 [GRCh38]
Chr17:16616829..20243755 [GRCh37]
Chr17:16557554..20184347 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15234685-20620700)x3 copy number gain See cases [RCV000051849] Chr17:15234685..20620700 [GRCh38]
Chr17:15138002..20524013 [GRCh37]
Chr17:15078727..20464605 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16760817-20429770)x3 copy number gain See cases [RCV000051872] Chr17:16760817..20429770 [GRCh38]
Chr17:16664131..20333083 [GRCh37]
Chr17:16604856..20273675 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16760818-20504849)x3 copy number gain See cases [RCV000051873] Chr17:16760818..20504849 [GRCh38]
Chr17:16664132..20408162 [GRCh37]
Chr17:16604857..20348754 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:16060129-20620841)x1 copy number loss See cases [RCV000054330] Chr17:16060129..20620841 [GRCh38]
Chr17:15963443..20524154 [GRCh37]
Chr17:15904168..20464746 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16760818-20390725)x1 copy number loss See cases [RCV000054337] Chr17:16760818..20390725 [GRCh38]
Chr17:16664132..20294038 [GRCh37]
Chr17:16604857..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16836827-20465067)x1 copy number loss See cases [RCV000054355] Chr17:16836827..20465067 [GRCh38]
Chr17:16740141..20368380 [GRCh37]
Chr17:16680866..20308972 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16858444-20340442)x1 copy number loss See cases [RCV000054356] Chr17:16858444..20340442 [GRCh38]
Chr17:16761758..20243755 [GRCh37]
Chr17:16702483..20184347 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16858444-20465067)x1 copy number loss See cases [RCV000054357] Chr17:16858444..20465067 [GRCh38]
Chr17:16761758..20368380 [GRCh37]
Chr17:16702483..20308972 [NCBI36]
Chr17:17p11.2		 pathogenic
Single allele complex PMP22-RAI1 contiguous gene duplication syndrome [RCV002280690] Chr17:14876984..22124952 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16879232-20316151)x3 copy number gain See cases [RCV000133695] Chr17:16879232..20316151 [GRCh38]
Chr17:16782546..20219464 [GRCh37]
Chr17:16723271..20160056 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16854250-20492169)x3 copy number gain See cases [RCV000134467] Chr17:16854250..20492169 [GRCh38]
Chr17:16757564..20395482 [GRCh37]
Chr17:16698289..20336074 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:17331511-20022528)x1 copy number loss See cases [RCV000135874] Chr17:17331511..20022528 [GRCh38]
Chr17:17234825..19925841 [GRCh37]
Chr17:17175550..19866433 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:18701974-18954766)x3 copy number gain See cases [RCV000135913] Chr17:18701974..18954766 [GRCh38]
Chr17:18605287..18858079 [GRCh37]
Chr17:18546012..18798804 [NCBI36]
Chr17:17p11.2		 benign
GRCh38/hg38 17p11.2(chr17:16879233-20390697)x1 copy number loss See cases [RCV000135996] Chr17:16879233..20390697 [GRCh38]
Chr17:16782547..20294010 [GRCh37]
Chr17:16723272..20234602 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16734558-20390697)x3 copy number gain See cases [RCV000135997] Chr17:16734558..20390697 [GRCh38]
Chr17:16637872..20294010 [GRCh37]
Chr17:16578597..20234602 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16734558-20390697)x1 copy number loss See cases [RCV000135998] Chr17:16734558..20390697 [GRCh38]
Chr17:16637872..20294010 [GRCh37]
Chr17:16578597..20234602 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16734588-20390725)x1 copy number loss See cases [RCV000136906] Chr17:16734588..20390725 [GRCh38]
Chr17:16637902..20294038 [GRCh37]
Chr17:16578627..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16734588-20316151)x1 copy number loss See cases [RCV000136951] Chr17:16734588..20316151 [GRCh38]
Chr17:16637902..20219464 [GRCh37]
Chr17:16578627..20160056 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16699816-20390725)x1 copy number loss See cases [RCV000137974] Chr17:16699816..20390725 [GRCh38]
Chr17:16603130..20294038 [GRCh37]
Chr17:16543855..20234630 [NCBI36]
Chr17:17p11.2		 pathogenic|likely benign
GRCh38/hg38 17p11.2(chr17:16854250-20492214)x3 copy number gain See cases [RCV000138255] Chr17:16854250..20492214 [GRCh38]
Chr17:16757564..20395527 [GRCh37]
Chr17:16698289..20336119 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:17331511-19017784)x3 copy number gain See cases [RCV000138572] Chr17:17331511..19017784 [GRCh38]
Chr17:17234825..18921097 [GRCh37]
Chr17:17175550..18861822 [NCBI36]
Chr17:17p11.2		 uncertain significance
GRCh38/hg38 17p11.2(chr17:16989087-20370816)x1 copy number loss See cases [RCV000139239] Chr17:16989087..20370816 [GRCh38]
Chr17:16892401..20274129 [GRCh37]
Chr17:16833126..20214721 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16854250-20560048)x3 copy number gain See cases [RCV000139188] Chr17:16854250..20560048 [GRCh38]
Chr17:16757564..20463361 [GRCh37]
Chr17:16698289..20403953 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16699694-20530646)x3 copy number gain See cases [RCV000140217] Chr17:16699694..20530646 [GRCh38]
Chr17:16603008..20433959 [GRCh37]
Chr17:16543733..20374551 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15883037-20620700)x1 copy number loss See cases [RCV000139510] Chr17:15883037..20620700 [GRCh38]
Chr17:15786351..20524013 [GRCh37]
Chr17:15727076..20464605 [NCBI36]
Chr17:17p12-11.2		 pathogenic|likely pathogenic
GRCh38/hg38 17p11.2(chr17:16656162-20390697)x1 copy number loss See cases [RCV000139558] Chr17:16656162..20390697 [GRCh38]
Chr17:16559476..20294010 [GRCh37]
Chr17:16500201..20234602 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:17018951-20148630)x1 copy number loss See cases [RCV000141105] Chr17:17018951..20148630 [GRCh38]
Chr17:16922265..20051943 [GRCh37]
Chr17:16862990..19992535 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16699816-20492214)x3 copy number gain See cases [RCV000140852] Chr17:16699816..20492214 [GRCh38]
Chr17:16603130..20395527 [GRCh37]
Chr17:16543855..20336119 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16838097-20436415)x1 copy number loss See cases [RCV000141975] Chr17:16838097..20436415 [GRCh38]
Chr17:16741411..20339728 [GRCh37]
Chr17:16682136..20280320 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:17067833-19019419)x1 copy number loss See cases [RCV000141729] Chr17:17067833..19019419 [GRCh38]
Chr17:16971147..18922732 [GRCh37]
Chr17:16911872..18863457 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16858500-20570955)x3 copy number gain See cases [RCV000142075] Chr17:16858500..20570955 [GRCh38]
Chr17:16761814..20474268 [GRCh37]
Chr17:16702539..20414860 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15552362-19014200)x3 copy number gain See cases [RCV000142169] Chr17:15552362..19014200 [GRCh38]
Chr17:15455676..18917513 [GRCh37]
Chr17:15396401..18858238 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16734588-18834703)x1 copy number loss See cases [RCV000142986] Chr17:16734588..18834703 [GRCh38]
Chr17:16637902..18738016 [GRCh37]
Chr17:16578627..18678741 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16696708-20492860)x3 copy number gain See cases [RCV000143381] Chr17:16696708..20492860 [GRCh38]
Chr17:16600022..20396173 [GRCh37]
Chr17:16540747..20336765 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16718415-20546210)x3 copy number gain See cases [RCV000143417] Chr17:16718415..20546210 [GRCh38]
Chr17:16621729..20449523 [GRCh37]
Chr17:16562454..20390115 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16858500-20559337)x1 copy number loss See cases [RCV000143210] Chr17:16858500..20559337 [GRCh38]
Chr17:16761814..20462650 [GRCh37]
Chr17:16702539..20403242 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15883037-20658018)x1 copy number loss See cases [RCV000143177] Chr17:15883037..20658018 [GRCh38]
Chr17:15786351..20561331 [GRCh37]
Chr17:15727076..20501923 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16699816-20428292)x1 copy number loss See cases [RCV000143181] Chr17:16699816..20428292 [GRCh38]
Chr17:16603130..20331605 [GRCh37]
Chr17:16543855..20272197 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16426633-20998588)x3 copy number gain See cases [RCV000143715] Chr17:16426633..20998588 [GRCh38]
Chr17:16329947..20901901 [GRCh37]
Chr17:16270672..20842493 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15850859-20649235)x1 copy number loss See cases [RCV000143650] Chr17:15850859..20649235 [GRCh38]
Chr17:15754173..20552548 [GRCh37]
Chr17:15694898..20493140 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh38/hg38 17p11.2(chr17:16853120-20436482)x1 copy number loss See cases [RCV000143596] Chr17:16853120..20436482 [GRCh38]
Chr17:16756434..20339795 [GRCh37]
Chr17:16697159..20280387 [NCBI36]
Chr17:17p11.2		 pathogenic
GRCh38/hg38 17p12-11.2(chr17:15729893-20510251)x1 copy number loss See cases [RCV000143485] Chr17:15729893..20510251 [GRCh38]
Chr17:15633207..20413564 [GRCh37]
Chr17:15573932..20354156 [NCBI36]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16603130-20261191)x1 copy number loss See cases [RCV000449069] Chr17:16603130..20261191 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p12-11.2(chr17:15767020-20261250)x3 copy number gain See cases [RCV000240104] Chr17:15767020..20261250 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:17053390-19893098)x1 copy number loss See cases [RCV000239910] Chr17:17053390..19893098 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16654302-20261250)x1 copy number loss See cases [RCV000240274] Chr17:16654302..20261250 [GRCh37]
Chr17:17p11.2		 pathogenic
arr[hg19]17p11.2(16,757,111-20,219,651)x3 duplication Potocki-Lupski syndrome [RCV000591005] Chr17:16757111..20219651 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16740141-20261191)x3 copy number gain See cases [RCV000449384] Chr17:16740141..20261191 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16651292-18722974)x1 copy number loss See cases [RCV000449355] Chr17:16651292..18722974 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p12-11.2(chr17:10771948-21510992)x1 copy number loss See cases [RCV000447345] Chr17:10771948..21510992 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p12-11.2(chr17:15745315-20261191)x1 copy number loss See cases [RCV000446498] Chr17:15745315..20261191 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16761814-20304295)x1 copy number loss See cases [RCV000446300] Chr17:16761814..20304295 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16637902-20261250)x1 copy number loss See cases [RCV000446465] Chr17:16637902..20261250 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16741771-20430791)x3 copy number gain See cases [RCV000445753] Chr17:16741771..20430791 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16757564-20261191)x1 copy number loss See cases [RCV000448145] Chr17:16757564..20261191 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18465463-19149350)x1 copy number loss See cases [RCV000448508] Chr17:18465463..19149350 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:16741411-20304154)x1 copy number loss See cases [RCV000448636] Chr17:16741411..20304154 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16741411-20449523)x1 copy number loss See cases [RCV000448404] Chr17:16741411..20449523 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16741411-20408379)x1 copy number loss See cases [RCV000447955] Chr17:16741411..20408379 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16761814-20462723)x1 copy number loss See cases [RCV000448752] Chr17:16761814..20462723 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16772264-20433502)x3 copy number gain See cases [RCV000448097] Chr17:16772264..20433502 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16745600-20396173)x1 copy number loss See cases [RCV000510506] Chr17:16745600..20396173 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:17200426-21900910)x1 copy number loss See cases [RCV000510254] Chr17:17200426..21900910 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16761814-20339795)x3 copy number gain See cases [RCV000510267] Chr17:16761814..20339795 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16727264-20413564)x1 copy number loss See cases [RCV000511412] Chr17:16727264..20413564 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16772264-20297091)x1 copy number loss See cases [RCV000511915] Chr17:16772264..20297091 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16741411-20410218)x1 copy number loss See cases [RCV000511460] Chr17:16741411..20410218 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16738161-20338182)x3 copy number gain See cases [RCV000511433] Chr17:16738161..20338182 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p11.2(chr17:16727264-20395889)x1 copy number loss See cases [RCV000511111] Chr17:16727264..20395889 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16651292-20437532)x3 copy number gain See cases [RCV000511042] Chr17:16651292..20437532 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16782546-20294038) copy number loss Sleep abnormality [RCV000626510] Chr17:16782546..20294038 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18465208-18922732)x1 copy number loss See cases [RCV000512184] Chr17:18465208..18922732 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:16591260-20473937)x3 copy number gain See cases [RCV000512356] Chr17:16591260..20473937 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16741411-20489023)x1 copy number loss See cases [RCV000512446] Chr17:16741411..20489023 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p11.2(chr17:16842163-20217777) copy number gain Delayed speech and language development [RCV000626511] Chr17:16842163..20217777 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16727264-20310241)x1 copy number loss not provided [RCV000683897] Chr17:16727264..20310241 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16761814-20292897)x3 copy number gain not provided [RCV000683900] Chr17:16761814..20292897 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16999980-20298979)x1 copy number loss not provided [RCV000683901] Chr17:16999980..20298979 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18615096-18917513)x3 copy number gain not provided [RCV000683906] Chr17:18615096..18917513 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:16741411-20430791)x1 copy number loss not provided [RCV000683898] Chr17:16741411..20430791 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:17021607-20015978)x1 copy number loss not provided [RCV000683902] Chr17:17021607..20015978 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p11.2(chr17:16768248-20391959)x1 copy number loss not provided [RCV000739423] Chr17:16768248..20391959 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18596126-19180190)x3 copy number gain not provided [RCV000739427] Chr17:18596126..19180190 [GRCh37]
Chr17:17p11.2		 benign
Single allele duplication Autism [RCV000754201] Chr17:16770855..20422847 [GRCh38]
Chr17:17p11.2		 pathogenic
NC_000017.11:g.(?_16770855)_(20585863_?)del deletion Autism [RCV000754202] Chr17:16770855..20585863 [GRCh38]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16660721-20417975)x1 copy number loss not provided [RCV000739417] Chr17:16660721..20417975 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p12-11.2(chr17:15796140-20331131)x3 copy number gain not provided [RCV000751941] Chr17:15796140..20331131 [GRCh37]
Chr17:17p12-11.2		 pathogenic
NM_001267585.2(FBXW10):c.824G>T (p.Arg275Leu) single nucleotide variant not provided [RCV000948449] Chr17:18749875 [GRCh38]
Chr17:18653188 [GRCh37]
Chr17:17p11.2		 benign
GRCh37/hg19 17p11.2(chr17:16842991-20217316) copy number loss Smith-Magenis syndrome [RCV000767738] Chr17:16842991..20217316 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18529674-18923470)x1 copy number loss not provided [RCV000848947] Chr17:18529674..18923470 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p12-11.2(chr17:15632431-18726389)x1 copy number loss not provided [RCV001006874] Chr17:15632431..18726389 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16664739-20370783) copy number gain Potocki-Lupski syndrome [RCV003236713] Chr17:16664739..20370783 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18484296-18696073)x3 copy number gain not provided [RCV001006880] Chr17:18484296..18696073 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:18537316-18686905)x3 copy number gain not provided [RCV001006881] Chr17:18537316..18686905 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:18599743-18876835)x3 copy number gain not provided [RCV001259294] Chr17:18599743..18876835 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:16651292-20286898) copy number loss Smith-Magenis syndrome [RCV002280651] Chr17:16651292..20286898 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16761814-20330062)x3 copy number gain not provided [RCV001259290] Chr17:16761814..20330062 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16763370-20395611)x1 copy number loss not provided [RCV001259291] Chr17:16763370..20395611 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18509439-19143976)x3 copy number gain not provided [RCV001259293] Chr17:18509439..19143976 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:17145361-20137943) copy number loss Smith-Magenis syndrome [RCV001352632] Chr17:17145361..20137943 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16601603-20063369) copy number gain Potocki-Lupski syndrome [RCV001352635] Chr17:16601603..20063369 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16829153-20361747)x3 copy number gain Potocki-Lupski syndrome [RCV001801179] Chr17:16829153..20361747 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:17151140-20187953) copy number loss Smith-Magenis syndrome [RCV002280652] Chr17:17151140..20187953 [GRCh37]
Chr17:17p11.2		 pathogenic
NC_000017.10:g.(?_16842861)_(19578885_?)del deletion Immunodeficiency, common variable, 2 [RCV002049406]|Joubert syndrome [RCV002047402] Chr17:16842861..19578885 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16664739-20217378)x1 copy number loss not provided [RCV002211424] Chr17:16664739..20217378 [GRCh37]
Chr17:17p11.2		 pathogenic
NC_000017.10:g.(?_16842861)_(19578885_?)dup duplication Familial aplasia of the vermis [RCV003116613]|Immunodeficiency, common variable, 2 [RCV003116614] Chr17:16842861..19578885 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:16736709-20339460)x3 copy number gain See cases [RCV002292216] Chr17:16736709..20339460 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:17103571-19331028)x3 copy number gain not provided [RCV002474502] Chr17:17103571..19331028 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:18599744-18882395)x3 copy number gain not provided [RCV002473581] Chr17:18599744..18882395 [GRCh37]
Chr17:17p11.2		 uncertain significance
GRCh37/hg19 17p11.2(chr17:17116969-20217378)x1 copy number loss not provided [RCV003222939] Chr17:17116969..20217378 [GRCh37]
Chr17:17p11.2		 pathogenic
Single allele duplication not provided [RCV003448668] Chr17:16757513..18772328 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p11.2(chr17:16651293-20450566)x1 copy number loss not provided [RCV003483315] Chr17:16651293..20450566 [GRCh37]
Chr17:17p11.2		 pathogenic
GRCh37/hg19 17p12-11.2(chr17:15694772-20582794)x1 copy number loss not provided [RCV003483314] Chr17:15694772..20582794 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p11.2-11.1(chr17:18614422-22227823)x3 copy number gain not provided [RCV003485147] Chr17:18614422..22227823 [GRCh37]
Chr17:17p11.2-11.1		 uncertain significance
GRCh37/hg19 17p11.2(chr17:18509272-18917513)x3 copy number gain not provided [RCV003485146] Chr17:18509272..18917513 [GRCh37]
Chr17:17p11.2		 uncertain significance
NM_001267585.2(FBXW10):c.2256G>A (p.Leu752=) single nucleotide variant not provided [RCV003413170] Chr17:18772661 [GRCh38]
Chr17:18675974 [GRCh37]
Chr17:17p11.2		 likely benign
GRCh37/hg19 17p12-11.2(chr17:15759103-20564268)x1 copy number loss not specified [RCV003987246] Chr17:15759103..20564268 [GRCh37]
Chr17:17p12-11.2		 pathogenic
GRCh37/hg19 17p13.3-11.2(chr17:525-21510992)x3 copy number gain not specified [RCV003987215] Chr17:525..21510992 [GRCh37]
Chr17:17p13.3-11.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1644
Count of miRNA genes:836
Interacting mature miRNAs:978
Transcripts:ENST00000301938, ENST00000308799, ENST00000395665, ENST00000395667, ENST00000573605, ENST00000574478
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human
407311311GWAS960287_Hlow density lipoprotein cholesterol measurement QTL GWAS960287 (human)2e-08low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)171877612918776130Human

Markers in Region
RH123806  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,653,452 - 18,653,798UniSTSGRCh37
GRCh371715,516,581 - 15,516,927UniSTSGRCh37
Build 361715,457,306 - 15,457,652RGDNCBI36
Cytogenetic Map17p12UniSTS
HuRef1715,389,282 - 15,389,628UniSTS
TNG Radiation Hybrid Map179148.0UniSTS
D17S1686  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,659,103 - 18,659,322UniSTSGRCh37
Build 361718,599,828 - 18,600,047RGDNCBI36
Cytogenetic Map17p12UniSTS
Whitehead-YAC Contig Map17 UniSTS
FBXW10_9126  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371715,468,614 - 15,469,437UniSTSGRCh37
GRCh371718,682,021 - 18,682,846UniSTSGRCh37
Build 361715,409,339 - 15,410,162RGDNCBI36
HuRef1718,264,006 - 18,264,831UniSTS
D17S725  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,657,151 - 18,657,252UniSTSGRCh37
GRCh371715,513,108 - 15,513,228UniSTSGRCh37
Build 361715,453,833 - 15,453,953RGDNCBI36
Cytogenetic Map17p12UniSTS
HuRef1715,385,809 - 15,385,929UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1152 2255 2653 2054 4598 1656 2160 2 576 857 418 1928 5750 5105 29 3635 697 1627 1490 169

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001267585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001267586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_051988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY729024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI828401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB055860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC006954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000301938   ⟹   ENSP00000306937
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1718,744,075 - 18,779,349 (+)Ensembl
Ensembl Acc Id: ENST00000308799   ⟹   ENSP00000310382
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1718,744,026 - 18,779,349 (+)Ensembl
Ensembl Acc Id: ENST00000395665   ⟹   ENSP00000379025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1718,744,054 - 18,779,349 (+)Ensembl
Ensembl Acc Id: ENST00000573605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1718,769,477 - 18,772,634 (+)Ensembl
Ensembl Acc Id: ENST00000574478   ⟹   ENSP00000463552
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1718,744,072 - 18,779,342 (+)Ensembl
RefSeq Acc Id: NM_001267585   ⟹   NP_001254514
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
GRCh371718,647,326 - 18,682,662 (+)NCBI
HuRef1718,230,526 - 18,264,647 (+)NCBI
CHM1_11718,656,781 - 18,692,149 (+)NCBI
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001267586   ⟹   NP_001254515
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
GRCh371718,647,326 - 18,682,662 (+)NCBI
HuRef1718,230,526 - 18,264,647 (+)NCBI
CHM1_11718,656,781 - 18,692,149 (+)NCBI
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411059   ⟹   NP_001397988
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
RefSeq Acc Id: NR_051988
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
GRCh371718,647,326 - 18,682,662 (+)NCBI
HuRef1718,230,526 - 18,264,647 (+)NCBI
CHM1_11718,656,781 - 18,692,149 (+)NCBI
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011523625   ⟹   XP_011521927
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,778,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024020   ⟹   XP_016879509
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024021   ⟹   XP_016879510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,772,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047435121   ⟹   XP_047291077
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435122   ⟹   XP_047291078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435123   ⟹   XP_047291079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435124   ⟹   XP_047291080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435125   ⟹   XP_047291081
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435126   ⟹   XP_047291082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435127   ⟹   XP_047291083
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435129   ⟹   XP_047291085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435130   ⟹   XP_047291086
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435131   ⟹   XP_047291087
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435132   ⟹   XP_047291088
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_047435133   ⟹   XP_047291089
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,763,471 - 18,779,349 (+)NCBI
RefSeq Acc Id: XM_054314707   ⟹   XP_054170682
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,048 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314708   ⟹   XP_054170683
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,048 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314709   ⟹   XP_054170684
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314710   ⟹   XP_054170685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314711   ⟹   XP_054170686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314712   ⟹   XP_054170687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314713   ⟹   XP_054170688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,049 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314714   ⟹   XP_054170689
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314715   ⟹   XP_054170690
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,048 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314716   ⟹   XP_054170691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,208 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314717   ⟹   XP_054170692
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,047 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314718   ⟹   XP_054170693
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,048 - 18,724,713 (+)NCBI
RefSeq Acc Id: XM_054314719   ⟹   XP_054170694
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,048 - 18,725,498 (+)NCBI
RefSeq Acc Id: XM_054314720   ⟹   XP_054170695
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,690,049 - 18,718,715 (+)NCBI
RefSeq Acc Id: XM_054314721   ⟹   XP_054170696
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01718,709,624 - 18,725,498 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001254514 (Get FASTA)   NCBI Sequence Viewer  
  NP_001254515 (Get FASTA)   NCBI Sequence Viewer  
  NP_001397988 (Get FASTA)   NCBI Sequence Viewer  
  XP_011521927 (Get FASTA)   NCBI Sequence Viewer  
  XP_016879509 (Get FASTA)   NCBI Sequence Viewer  
  XP_016879510 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291077 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291078 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291079 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291080 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291081 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291082 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291083 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291085 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291086 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291087 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291088 (Get FASTA)   NCBI Sequence Viewer  
  XP_047291089 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170682 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170683 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170684 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170685 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170686 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170687 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170688 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170689 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170690 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170691 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170692 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170693 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170694 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170695 (Get FASTA)   NCBI Sequence Viewer  
  XP_054170696 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH28364 (Get FASTA)   NCBI Sequence Viewer  
  AAU43731 (Get FASTA)   NCBI Sequence Viewer  
  AEE60982 (Get FASTA)   NCBI Sequence Viewer  
  CAB66756 (Get FASTA)   NCBI Sequence Viewer  
  CBH19282 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000306937
  ENSP00000306937.4
  ENSP00000310382
  ENSP00000310382.4
  ENSP00000379025
  ENSP00000379025.4
  ENSP00000463552.1
GenBank Protein Q5XX13 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001254514   ⟸   NM_001267585
- Peptide Label: isoform 1
- UniProtKB: Q8TC00 (UniProtKB/Swiss-Prot),   C9JZD7 (UniProtKB/Swiss-Prot),   C9JRY8 (UniProtKB/Swiss-Prot),   Q9H0F0 (UniProtKB/Swiss-Prot),   Q5XX13 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001254515   ⟸   NM_001267586
- Peptide Label: isoform 2
- UniProtKB: Q5XX13 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011521927   ⟸   XM_011523625
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_016879509   ⟸   XM_017024020
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_016879510   ⟸   XM_017024021
- Peptide Label: isoform X13
- Sequence:
Ensembl Acc Id: ENSP00000310382   ⟸   ENST00000308799
Ensembl Acc Id: ENSP00000463552   ⟸   ENST00000574478
Ensembl Acc Id: ENSP00000306937   ⟸   ENST00000301938
Ensembl Acc Id: ENSP00000379025   ⟸   ENST00000395665
RefSeq Acc Id: XP_047291077   ⟸   XM_047435121
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047291078   ⟸   XM_047435122
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047291079   ⟸   XM_047435123
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047291080   ⟸   XM_047435124
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047291081   ⟸   XM_047435125
- Peptide Label: isoform X5
RefSeq Acc Id: XP_047291088   ⟸   XM_047435132
- Peptide Label: isoform X11
RefSeq Acc Id: XP_047291086   ⟸   XM_047435130
- Peptide Label: isoform X9
RefSeq Acc Id: XP_047291083   ⟸   XM_047435127
- Peptide Label: isoform X7
RefSeq Acc Id: XP_047291082   ⟸   XM_047435126
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047291085   ⟸   XM_047435129
- Peptide Label: isoform X8
- UniProtKB: A0A140VJJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047291087   ⟸   XM_047435131
- Peptide Label: isoform X10
RefSeq Acc Id: XP_047291089   ⟸   XM_047435133
- Peptide Label: isoform X14
RefSeq Acc Id: NP_001397988   ⟸   NM_001411059
- Peptide Label: isoform 3
RefSeq Acc Id: XP_054170684   ⟸   XM_054314709
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054170685   ⟸   XM_054314710
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054170686   ⟸   XM_054314711
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054170692   ⟸   XM_054314717
- Peptide Label: isoform X11
RefSeq Acc Id: XP_054170694   ⟸   XM_054314719
- Peptide Label: isoform X12
RefSeq Acc Id: XP_054170682   ⟸   XM_054314707
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054170683   ⟸   XM_054314708
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054170690   ⟸   XM_054314715
- Peptide Label: isoform X9
RefSeq Acc Id: XP_054170693   ⟸   XM_054314718
- Peptide Label: isoform X12
RefSeq Acc Id: XP_054170688   ⟸   XM_054314713
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054170695   ⟸   XM_054314720
- Peptide Label: isoform X13
RefSeq Acc Id: XP_054170687   ⟸   XM_054314712
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054170689   ⟸   XM_054314714
- Peptide Label: isoform X8
- UniProtKB: A0A140VJJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054170691   ⟸   XM_054314716
- Peptide Label: isoform X10
RefSeq Acc Id: XP_054170696   ⟸   XM_054314721
- Peptide Label: isoform X14
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XX13-F1-model_v2 AlphaFold Q5XX13 1-1052 view protein structure

Promoters
RGD ID:7234233
Promoter ID:EPDNEW_H22862
Type:initiation region
Name:FBXW10_1
Description:F-box and WD repeat domain containing 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381718,744,054 - 18,744,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1211 AgrOrtholog
COSMIC FBXW10 COSMIC
Ensembl Genes ENSG00000171931 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000301938 ENTREZGENE
  ENST00000301938.4 UniProtKB/Swiss-Prot
  ENST00000308799 ENTREZGENE
  ENST00000308799.8 UniProtKB/Swiss-Prot
  ENST00000395665 ENTREZGENE
  ENST00000395665.9 UniProtKB/Swiss-Prot
  ENST00000574478 ENTREZGENE
  ENST00000574478.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000171931 GTEx
HGNC ID HGNC:1211 ENTREZGENE
Human Proteome Map FBXW10 Human Proteome Map
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCF_subunit_WD-repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10517 UniProtKB/Swiss-Prot
NCBI Gene 10517 ENTREZGENE
OMIM 611679 OMIM
PANTHER CMT1A DUPLICATED REGION TRANSCRIPT 1 PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25575 PharmGKB
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJJ5 ENTREZGENE, UniProtKB/TrEMBL
  C9JRY8 ENTREZGENE
  C9JZD7 ENTREZGENE
  FBW10_HUMAN UniProtKB/Swiss-Prot
  J3QLH9_HUMAN UniProtKB/TrEMBL
  Q5XX13 ENTREZGENE
  Q8TC00 ENTREZGENE
  Q9H0F0 ENTREZGENE
UniProt Secondary C9JRY8 UniProtKB/Swiss-Prot
  C9JZD7 UniProtKB/Swiss-Prot
  Q8TC00 UniProtKB/Swiss-Prot
  Q9H0F0 UniProtKB/Swiss-Prot