OR5AL1 (olfactory receptor family 5 subfamily AL member 1 (gene/pseudogene)) - Rat Genome Database

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Gene: OR5AL1 (olfactory receptor family 5 subfamily AL member 1 (gene/pseudogene)) Homo sapiens
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Symbol: OR5AL1
Name: olfactory receptor family 5 subfamily AL member 1 (gene/pseudogene)
RGD ID: 1342502
HGNC Page HGNC:14844
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Olfactory receptor 5AL1; olfactory receptor OR11-184; olfactory receptor, family 5, subfamily AL, member 1 pseudogene; OR5AL1P
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: suggests misassembly; Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,412,696 - 56,413,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,412,696 - 56,413,680 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,180,172 - 56,181,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,936,648 - 55,937,832 (+)NCBINCBI36Build 36hg18NCBI36
Celera1153,527,853 - 53,528,837 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,517,083 - 52,518,069 (+)NCBIHuRef
CHM1_11156,046,454 - 56,047,440 (+)NCBICHM1_1
T2T-CHM13v2.01156,350,611 - 56,351,598 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12213199   PMID:12644552   PMID:12730696   PMID:14983052   PMID:21873635   PMID:22908908  


Genomics

Comparative Map Data
OR5AL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,412,696 - 56,413,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,412,696 - 56,413,680 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,180,172 - 56,181,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,936,648 - 55,937,832 (+)NCBINCBI36Build 36hg18NCBI36
Celera1153,527,853 - 53,528,837 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,517,083 - 52,518,069 (+)NCBIHuRef
CHM1_11156,046,454 - 56,047,440 (+)NCBICHM1_1
T2T-CHM13v2.01156,350,611 - 56,351,598 (+)NCBIT2T-CHM13v2.0
Or5al1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39285,989,689 - 85,990,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl285,987,087 - 85,992,182 (-)EnsemblGRCm39 Ensembl
GRCm38286,159,345 - 86,160,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl286,156,743 - 86,161,838 (-)EnsemblGRCm38mm10GRCm38
MGSCv37285,999,502 - 86,000,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36285,960,266 - 85,961,207 (-)NCBIMGSCv36mm8
Celera287,733,000 - 87,734,096 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.74NCBI
Or5al1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8391,563,871 - 91,564,812 (-)NCBIGRCr8
mRatBN7.2371,157,207 - 71,158,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl371,157,207 - 71,158,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx374,542,154 - 74,543,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0383,140,692 - 83,141,633 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0380,923,857 - 80,924,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0373,474,667 - 73,475,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl373,474,667 - 73,475,608 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0380,043,888 - 80,044,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4369,328,854 - 69,329,795 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1369,225,225 - 69,226,167 (-)NCBI
Celera370,487,372 - 70,488,313 (-)NCBICelera
Cytogenetic Map3q24NCBI
LOC112438846
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2957,574,640 - 57,575,623 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,590,069 - 58,591,052 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,657,747 - 51,658,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OR5AL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11839,515,818 - 39,516,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1839,515,818 - 39,516,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1839,061,525 - 39,062,466 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01840,193,059 - 40,194,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1840,193,059 - 40,194,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11839,797,918 - 39,798,859 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01839,365,180 - 39,366,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,948,250 - 39,949,191 (-)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q11-12.1(chr11:55445689-57114783)x1 copy number loss See cases [RCV000050913] Chr11:55445689..57114783 [GRCh38]
Chr11:55213165..56882257 [GRCh37]
Chr11:54969741..56638833 [NCBI36]
Chr11:11q11-12.1		 benign
GRCh38/hg38 11q12.1(chr11:56149822-56770518)x3 copy number gain See cases [RCV000134767] Chr11:56149822..56770518 [GRCh38]
Chr11:55917298..56537994 [GRCh37]
Chr11:55673874..56294570 [NCBI36]
Chr11:11q12.1		 benign
GRCh38/hg38 11q11-12.1(chr11:55316535-57539457)x3 copy number gain See cases [RCV000141200] Chr11:55316535..57539457 [GRCh38]
Chr11:55084011..57306930 [GRCh37]
Chr11:54840587..57063506 [NCBI36]
Chr11:11q11-12.1		 uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55319519-58998777)x3 copy number gain See cases [RCV000142757] Chr11:55319519..58998777 [GRCh38]
Chr11:55086995..58766250 [GRCh37]
Chr11:54843571..58522826 [NCBI36]
Chr11:11q11-12.1		 pathogenic

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 20 42 23 40 15 20 1 15 1 27 60 58 30 2 47 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001348230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_145506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF399353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK004654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LJII02000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000440231   ⟹   ENSP00000477393
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,412,696 - 56,413,680 (+)Ensembl
RefSeq Acc Id: NR_145506
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,412,696 - 56,413,683 (+)NCBI
T2T-CHM13v2.01156,350,611 - 56,351,598 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001335159 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ALI87566 (Get FASTA)   NCBI Sequence Viewer  
  ALI87819 (Get FASTA)   NCBI Sequence Viewer  
  ALI87820 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000518210.1
GenBank Protein P0C617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSP00000477393   ⟸   ENST00000440231
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C617-F1-model_v2 AlphaFold P0C617 1-329 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14844 AgrOrtholog
COSMIC OR5AL1 COSMIC
Ensembl Genes ENSG00000272987 Ensembl, ENTREZGENE
  ENSG00000292252 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000440231 ENTREZGENE
  ENST00000710330.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000272987 GTEx
  ENSG00000292252 GTEx
HGNC ID HGNC:14844 ENTREZGENE
Human Proteome Map OR5AL1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:79482 UniProtKB/Swiss-Prot
NCBI Gene 79482 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 5AL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32463 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GVW9_HUMAN UniProtKB/TrEMBL
  A0A126GWL2_HUMAN UniProtKB/TrEMBL
  A0A126GWL7 ENTREZGENE, UniProtKB/TrEMBL
  O5AL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR5AL1  olfactory receptor family 5 subfamily AL member 1 (gene/pseudogene)    olfactory receptor, family 5, subfamily AL, member 1 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED