Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Plcd3 | Mouse | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PLCD3 mRNA | CTD | PMID:22206623 | Plcd3 | Mouse | 17beta-estradiol | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PLCD3 mRNA | CTD | PMID:21185374 | Plcd3 | Mouse | 17beta-estradiol | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of PLCD3 mRNA | CTD | PMID:30165855 | Plcd3 | Mouse | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Plcd3 | Mouse | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Plcd3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLCD3 mRNA | CTD | PMID:21570461 | Plcd3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLCD3 mRNA | CTD | PMID:33387578 | Plcd3 | Mouse | 2-hydroxypropanoic acid | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PLCD3 mRNA | CTD | PMID:30851411 | Plcd3 | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLCD3 mRNA | CTD | PMID:28628672 | Plcd3 | Mouse | 4,4'-sulfonyldiphenol | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of PLCD3 gene | CTD | PMID:31601247 | Plcd3 | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of PLCD3 mRNA | CTD | PMID:28973697 | Plcd3 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of PLCD3 mRNA | CTD | PMID:24780913 | Plcd3 | Mouse | acrylamide | decreases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of PLCD3 mRNA | CTD | PMID:28959563 | Plcd3 | Mouse | amphetamine | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Amphetamine results in increased expression of PLCD3 mRNA | CTD | PMID:30779732 | Plcd3 | Mouse | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLCD3 mRNA] | CTD | PMID:22228805 | Plcd3 | Mouse | benzo[a]pyrene | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PLCD3 mRNA | CTD | PMID:32234424 | Plcd3 | Mouse | benzo[a]pyrene | increases methylation | ISO | PLCD3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PLCD3 3' UTR | CTD | PMID:27901495 | Plcd3 | Mouse | benzo[e]pyrene | increases methylation | ISO | PLCD3 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of PLCD3 exon | CTD | PMID:30157460 | Plcd3 | Mouse | beta-lapachone | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of PLCD3 mRNA | CTD | PMID:38218311 | Plcd3 | Mouse | bisphenol A | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PLCD3 mRNA | CTD | PMID:25181051 and PMID:35192832 | Plcd3 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PLCD3 mRNA | CTD | PMID:32156529 | Plcd3 | Mouse | bisphenol A | decreases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PLCD3 mRNA | CTD | PMID:32145629 | Plcd3 | Mouse | bisphenol A | affects expression | ISO | PLCD3 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PLCD3 mRNA | CTD | PMID:30903817 | Plcd3 | Mouse | bisphenol A | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PLCD3 mRNA | CTD | PMID:29275510 | Plcd3 | Mouse | bisphenol A | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLCD3 mRNA | CTD | PMID:28628672 | Plcd3 | Mouse | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of PLCD3 promoter | CTD | PMID:27312807 | Plcd3 | Mouse | bisphenol A | increases methylation | ISO | Plcd3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of PLCD3 gene | CTD | PMID:28505145 | Plcd3 | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of PLCD3 mRNA | CTD | PMID:38685157 | Plcd3 | Mouse | Brodifacoum | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | bromfenacoum results in increased expression of PLCD3 protein | CTD | PMID:28903499 | Plcd3 | Mouse | cadmium dichloride | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PLCD3 mRNA | CTD | PMID:38568856 | Plcd3 | Mouse | caffeine | increases phosphorylation | ISO | PLCD3 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of PLCD3 protein | CTD | PMID:35688186 | Plcd3 | Mouse | calcitriol | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLCD3 mRNA | CTD | PMID:21592394 | Plcd3 | Mouse | calcitriol | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PLCD3 mRNA | CTD | PMID:21592394 | Plcd3 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD3 mRNA | CTD | PMID:20938992 | Plcd3 | Mouse | cisplatin | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PLCD3 mRNA | CTD | PMID:27392435 | Plcd3 | Mouse | clothianidin | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | clothianidin results in decreased expression of PLCD3 mRNA | CTD | PMID:31626844 | Plcd3 | Mouse | copper(II) sulfate | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PLCD3 mRNA | CTD | PMID:19549813 | Plcd3 | Mouse | coumarin | increases phosphorylation | ISO | PLCD3 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PLCD3 protein | CTD | PMID:35688186 | Plcd3 | Mouse | crocidolite asbestos | decreases methylation | ISO | PLCD3 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of PLCD3 gene | CTD | PMID:29523930 | Plcd3 | Mouse | cyclosporin A | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PLCD3 mRNA | CTD | PMID:25562108 | Plcd3 | Mouse | cyclosporin A | decreases methylation | ISO | PLCD3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased methylation of PLCD3 promoter | CTD | PMID:27989131 | Plcd3 | Mouse | dexamethasone | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Dexamethasone results in increased expression of PLCD3 mRNA | CTD | PMID:20032058 | Plcd3 | Mouse | dexamethasone | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLCD3 mRNA | CTD | PMID:28628672 | Plcd3 | Mouse | dexamethasone | multiple interactions | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of PLCD3 mRNA] | CTD | PMID:20032058 | Plcd3 | Mouse | dioxygen | increases expression | EXP | | 6480464 | Oxygen deficiency results in increased expression of PLCD3 mRNA | CTD | PMID:24205000 | Plcd3 | Mouse | dioxygen | affects methylation | EXP | | 6480464 | Oxygen deficiency affects the methylation of PLCD3 promoter | CTD | PMID:24205000 | Plcd3 | Mouse | fluoranthene | multiple interactions | EXP | | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of PLCD3 mRNA | CTD | PMID:28329830 | Plcd3 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD3 mRNA | CTD | PMID:20938992 | Plcd3 | Mouse | FR900359 | increases phosphorylation | ISO | PLCD3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PLCD3 protein | CTD | PMID:37730182 | Plcd3 | Mouse | fulvestrant | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of PLCD3 gene | CTD | PMID:31601247 | Plcd3 | Mouse | furan | increases methylation | ISO | Plcd3 (Rattus norvegicus) | 6480464 | furan results in increased methylation of PLCD3 gene | CTD | PMID:22079235 | Plcd3 | Mouse | gentamycin | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PLCD3 mRNA | CTD | PMID:33387578 | Plcd3 | Mouse | indometacin | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLCD3 mRNA | CTD | PMID:28628672 | Plcd3 | Mouse | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of PLCD3 mRNA | CTD | PMID:36331819 | Plcd3 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD3 mRNA | CTD | PMID:20938992 | Plcd3 | Mouse | lead(0) | affects expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Lead affects the expression of PLCD3 mRNA | CTD | PMID:28903495 | Plcd3 | Mouse | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of PLCD3 mRNA | CTD | PMID:26307267 | Plcd3 | Mouse | methapyrilene | increases methylation | ISO | PLCD3 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of PLCD3 exon | CTD | PMID:30157460 | Plcd3 | Mouse | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PLCD3 mRNA | CTD | PMID:22776087 | Plcd3 | Mouse | ozone | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PLCD3 mRNA | CTD | PMID:35430440 | Plcd3 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PLCD3 mRNA | CTD | PMID:17562736 | Plcd3 | Mouse | paracetamol | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLCD3 mRNA | CTD | PMID:29067470 | Plcd3 | Mouse | paracetamol | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PLCD3 mRNA | CTD | PMID:26690555 | Plcd3 | Mouse | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Plcd3 | Mouse | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of PLCD3 mRNA | CTD | PMID:37995155 | Plcd3 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of PLCD3 mRNA | CTD | PMID:36331819 | Plcd3 | Mouse | perfluorooctanoic acid | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of PLCD3 mRNA | CTD | PMID:36326898 | Plcd3 | Mouse | potassium dichromate | increases expression | EXP | | 6480464 | Potassium Dichromate results in increased expression of PLCD3 mRNA | CTD | PMID:23608068 | Plcd3 | Mouse | quercetin | decreases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Quercetin results in decreased expression of PLCD3 mRNA | CTD | PMID:18095365 | Plcd3 | Mouse | rac-lactic acid | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PLCD3 mRNA | CTD | PMID:30851411 | Plcd3 | Mouse | resveratrol | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of PLCD3 mRNA | CTD | PMID:23557933 | Plcd3 | Mouse | sodium arsenite | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PLCD3 mRNA | CTD | PMID:38568856 | Plcd3 | Mouse | Soman | increases expression | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Soman results in increased expression of PLCD3 mRNA | CTD | PMID:19281266 | Plcd3 | Mouse | sunitinib | decreases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PLCD3 mRNA | CTD | PMID:31533062 | Plcd3 | Mouse | testosterone | multiple interactions | ISO | PLCD3 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLCD3 mRNA | CTD | PMID:21592394 | Plcd3 | Mouse | testosterone | multiple interactions | ISO | Plcd3 (Rattus norvegicus) | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of PLCD3 mRNA] | CTD | PMID:20032058 | Plcd3 | Mouse | testosterone | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PLCD3 mRNA | CTD | PMID:21592394 | Plcd3 | Mouse | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of PLCD3 protein | CTD | PMID:24648495 | Plcd3 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of PLCD3 gene | CTD | PMID:35295148 | Plcd3 | Mouse | triphenyl phosphate | affects expression | ISO | PLCD3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PLCD3 mRNA | CTD | PMID:37042841 | Plcd3 | Mouse | tris(2-butoxyethyl) phosphate | affects expression | ISO | PLCD3 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of PLCD3 mRNA | CTD | PMID:29024780 | Plcd3 | Mouse | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of PLCD3 mRNA | CTD | PMID:30912803 | Plcd3 | Mouse | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of PLCD3 mRNA | CTD | PMID:21427059 | Plcd3 | Mouse | valproic acid | increases expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLCD3 mRNA | CTD | PMID:23179753 | Plcd3 | Mouse | valproic acid | affects expression | ISO | PLCD3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PLCD3 mRNA | CTD | PMID:25979313 | |