Enkur (enkurin, TRPC channel interacting protein) - Rat Genome Database

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Gene: Enkur (enkurin, TRPC channel interacting protein) Mus musculus
Analyze
Symbol: Enkur
Name: enkurin, TRPC channel interacting protein
RGD ID: 1320398
MGI Page MGI
Description: Enables calmodulin binding activity. Involved in flagellated sperm motility. Acts upstream of or within establishment of left/right asymmetry. Located in 9+0 motile cilium; acrosomal vesicle; and sperm principal piece. Is active in axonemal B tubule inner sheath. Is expressed in lung; node; testis; and trachea. Orthologous to human ENKUR (enkurin, TRPC channel interacting protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933434I06Rik; AU016229; enkurin; MGC117794
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39221,185,542 - 21,210,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl221,185,542 - 21,210,176 (-)EnsemblGRCm39 Ensembl
GRCm38221,180,731 - 21,205,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl221,180,731 - 21,205,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv37221,102,358 - 21,126,992 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36221,098,485 - 21,123,119 (-)NCBIMGSCv36mm8
Celera221,062,063 - 21,086,735 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map214.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15385169   PMID:16141072   PMID:16141073   PMID:17971504   PMID:21677750   PMID:21873635   PMID:29257953  
PMID:29733335   PMID:37295417   PMID:37865089   PMID:37989994   PMID:38355793  


Genomics

Comparative Map Data
Enkur
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39221,185,542 - 21,210,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl221,185,542 - 21,210,176 (-)EnsemblGRCm39 Ensembl
GRCm38221,180,731 - 21,205,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl221,180,731 - 21,205,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv37221,102,358 - 21,126,992 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36221,098,485 - 21,123,119 (-)NCBIMGSCv36mm8
Celera221,062,063 - 21,086,735 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map214.82NCBI
ENKUR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381024,981,985 - 25,062,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1024,981,979 - 25,062,279 (-)EnsemblGRCh38hg38GRCh38
GRCh371025,270,914 - 25,351,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361025,310,923 - 25,345,036 (-)NCBINCBI36Build 36hg18NCBI36
Build 341025,310,922 - 25,345,036NCBI
Celera1024,971,786 - 25,006,443 (-)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1024,931,919 - 25,012,056 (-)NCBIHuRef
CHM1_11025,271,433 - 25,351,929 (-)NCBICHM1_1
T2T-CHM13v2.01025,000,242 - 25,080,555 (-)NCBIT2T-CHM13v2.0
Enkur
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,599,057 - 88,622,668 (-)NCBIGRCr8
mRatBN7.21783,690,105 - 83,714,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,690,797 - 83,714,408 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1787,163,349 - 87,186,973 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01790,998,723 - 91,022,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01785,015,657 - 85,039,281 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01788,071,794 - 88,095,444 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,071,757 - 88,095,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01789,759,584 - 89,782,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41795,178,267 - 95,201,846 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11795,189,321 - 95,212,473 (-)NCBI
Celera1782,943,601 - 82,967,089 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Enkur
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554294,182,715 - 4,204,077 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554294,182,507 - 4,203,275 (+)NCBIChiLan1.0ChiLan1.0
ENKUR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2837,680,559 - 37,714,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11037,685,888 - 37,720,082 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01025,156,234 - 25,236,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11025,526,548 - 25,606,817 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1025,526,548 - 25,606,709 (-)Ensemblpanpan1.1panPan2
ENKUR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128,497,252 - 8,522,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28,497,726 - 8,522,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha27,191,779 - 7,216,813 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026,696,396 - 6,721,436 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26,696,892 - 6,721,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126,066,321 - 6,091,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026,144,423 - 6,169,486 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026,311,130 - 6,336,653 (+)NCBIUU_Cfam_GSD_1.0
Enkur
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934424,512,670 - 24,535,805 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936484677,833 - 701,038 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936484679,541 - 700,898 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENKUR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1050,310,984 - 50,341,238 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11050,310,497 - 50,364,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,747,194 - 55,759,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENKUR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1924,710,588 - 24,740,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl924,707,109 - 24,740,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605130,669,028 - 30,700,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enkur
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247963,961,538 - 3,980,952 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247963,961,148 - 3,980,197 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Enkur
1310 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:181
Interacting mature miRNAs:202
Transcripts:ENSMUST00000027992, ENSMUST00000147793, ENSMUST00000156248
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
10045633Heal15_mwound healing/regeneration 15 (mouse)Not determined2121989642Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
UniSTS:234333  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38221,180,834 - 21,181,047UniSTSGRCm38
MGSCv37221,102,461 - 21,102,674UniSTSGRCm37
Celera221,062,166 - 21,062,379UniSTS
Cytogenetic Map2A3UniSTS
AU016229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38221,180,931 - 21,181,079UniSTSGRCm38
MGSCv37221,102,558 - 21,102,706UniSTSGRCm37
Celera221,062,263 - 21,062,411UniSTS
Cytogenetic Map2A3UniSTS
Whitehead/MRC_RH2377.67UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027992   ⟹   ENSMUSP00000027992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl221,185,542 - 21,210,176 (-)Ensembl
GRCm38.p6 Ensembl221,180,731 - 21,205,365 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl221,198,916 - 21,210,050 (-)Ensembl
GRCm38.p6 Ensembl221,194,105 - 21,205,239 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156248
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl221,201,269 - 21,210,163 (-)Ensembl
GRCm38.p6 Ensembl221,196,458 - 21,205,352 (-)Ensembl
RefSeq Acc Id: NM_027728   ⟹   NP_082004
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39221,185,542 - 21,210,176 (-)NCBI
GRCm38221,180,731 - 21,205,365 (-)ENTREZGENE
MGSCv37221,102,358 - 21,126,992 (-)RGD
Celera221,062,063 - 21,086,735 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_082004 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99519 (Get FASTA)   NCBI Sequence Viewer  
  AAI32426 (Get FASTA)   NCBI Sequence Viewer  
  AAI32452 (Get FASTA)   NCBI Sequence Viewer  
  AAS45167 (Get FASTA)   NCBI Sequence Viewer  
  EDL08129 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027992
  ENSMUSP00000027992.3
GenBank Protein Q6SP97 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082004   ⟸   NM_027728
- UniProtKB: Q6SP97 (UniProtKB/Swiss-Prot),   Q4KL11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027992   ⟸   ENSMUST00000027992
Protein Domains
Enkurin   IQ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SP97-F1-model_v2 AlphaFold Q6SP97 1-255 view protein structure

Promoters
RGD ID:6832980
Promoter ID:MM_KWN:27973
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001001297,   NM_027728,   NM_177588,   OTTMUST00000027312,   OTTMUST00000027313,   OTTMUST00000027318,   OTTMUST00000027319,   UC008IND.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36221,127,164 - 21,127,664 (+)MPROMDB
RGD ID:6876466
Promoter ID:EPDNEW_M1684
Type:initiation region
Name:Enkur_1
Description:Mus musculus enkurin, TRPC channel interacting protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38221,205,361 - 21,205,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918483 AgrOrtholog
Ensembl Genes ENSMUSG00000026679 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027992 ENTREZGENE
  ENSMUST00000027992.3 UniProtKB/Swiss-Prot
InterPro Enkurin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enkurin_domain-protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1918483 ENTREZGENE
NCBI Gene 71233 ENTREZGENE
PANTHER PTHR21490:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Enkurin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enkur PhenoGen
PROSITE ENKURIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ENKUR_MOUSE UniProtKB/Swiss-Prot
  Q4KL11 ENTREZGENE, UniProtKB/TrEMBL
  Q6SP97 ENTREZGENE