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Gene: BC051665 (cDNA sequence BC051665) Mus musculus

Analyze

No known orthologs.

Symbol:

BC051665

Name:

cDNA sequence BC051665

RGD ID:

1318704

MGI Page

MGI

Description:

Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cathepsin L-like; hypothetical protein LOC218275; MGC60730; uncharacterized protein LOC218275

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	CTSL (cathepsin L)	HGNC	Panther, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Cts7l2 (cathepsin 7 like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Ctsll3 (cathepsin L-like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ctsla (cathepsin La)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	zgc:174154	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	zgc:174154	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:dkey-269i1.4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:dkey-239j18.2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:dkey-239j18.3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ctslb (cathepsin Lb)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	zgc:174153	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ctsll (cathepsin L, like)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Cp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cpl-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ctsv	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	60,929,701 - 60,934,178 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	60,929,701 - 60,934,178 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	60,781,887 - 60,786,364 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	60,781,887 - 60,786,364 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	60,883,248 - 60,887,725 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	60,791,510 - 60,795,972 (-)	NCBI		MGSCv36	mm8
Celera	13	61,841,836 - 61,846,314 (-)	NCBI		Celera
Cytogenetic Map	13	B2	NCBI
cM Map	13	32.53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis involved in protein catabolic process (IBA)

Cellular Component

extracellular space (IBA)

lysosome (IBA)

Molecular Function

cysteine-type endopeptidase activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:16141072	PMID:16141073	PMID:21677750	PMID:21873635

Genomics

Variants

Variants in BC051665
147 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	139
Count of miRNA genes:	129
Interacting mature miRNAs:	135
Transcripts:	ENSMUST00000026078
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300561	Heal7_m	wound healing/regeneration 7 (mouse)			Not determined		13	36144820	70144904	Mouse
4142331	Bxs6_m	BXSB/MpJ autoimmune nephritis 6 (mouse)			Not determined			45210442	83744746	Mouse
12738439	Twq4_m	testis weight QTL 4 (mouse)					13	31129110	65129110	Mouse
4142009	Pregq3_m	pregnancy QTL 3 (mouse)			Not determined		13	20615512	72385189	Mouse
1357587	Pfat3_m	predicted fat percentage 3 (mouse)			Not determined		13	36101530	70101640	Mouse
10401111	Pgia40_m	proteoglycan induced arthritis 40 (mouse)			Not determined		13	27918469	61918560	Mouse
1300573	Elsgp2_m	elevated serum gp70 2 (mouse)			Not determined		13	50616828	84617027	Mouse
10412109	Bxs7_m	BXSB/MpJ autoimmune nephritis 7 (mouse)			Not determined		13	45210442	83744746	Mouse
10412235	Scgq5_m	spontaneous crescentic glomerulonephritis QTL 5 (mouse)			Not determined		13	36060908	96239162	Mouse
4142314	Tailaq3_m	tail length adjusted QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
1558850	Sgp3_m	serum gp70 production 3 (mouse)			Not determined		13	56470456	76971314	Mouse
4141992	W6q16_m	weight 6 weeks QTL 16 (mouse)			Not determined			55720354	112431103	Mouse
10755517	Chol15_m	cholesterol 15 (mouse)					13	30969467	64969467	Mouse
4142372	Moo2_m	modifier of Odc2 (mouse)			Not determined		X	50318411	84318559	Mouse
15039353	Nmrs35_m	NAFLD-associated magnetic resonance shift 35 (mouse)					13	40588253	74588253	Mouse
10412163	Wra1_m	wheel running activity 1 (mouse)			Not determined		13	59132600	93132738	Mouse
1302157	Bwem2_m	body weight day 30 males 2 (mouse)			Not determined		13	39629249	73629397	Mouse
4142241	Tailq3_m	tail length QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
1301299	Sluc23_m	susceptibility to lung cancer 23 (mouse)			Not determined		13	34921943	68922081	Mouse
4140959	W10q17_m	weight 10 weeks QTL 17 (mouse)			Not determined			55720354	112431103	Mouse
1357553	Cia28_m	collagen induced arthritis 28 (mouse)			Not determined		13	56629249	96239162	Mouse
10755533	Chol18_m	cholesterol 18 (mouse)					13	30969467	64969467	Mouse
1300985	Bmd13_m	bone mineral density 13 (mouse)			Not determined		13	39629249	73629397	Mouse
1302073	Pgct1_m	primordial germ cell tumor locus 1 (mouse)			Not determined		13	53820783	87820897	Mouse
10045621	Heal21_m	wound healing/regeneration 21 (mouse)			Not determined		13	28217379	62217515	Mouse
1300862	Cfbw5_m	cystic fibrosis body weight 5 (mouse)			Not determined		13	38720358	72720517	Mouse
1300668	Pas10_m	pulmonary adenoma susceptibility 10 (mouse)			Not determined		13	41489042	75489158	Mouse
1357563	Bmch6_m	bone mechanical trait 6 (mouse)			Not determined		13	55384980	89385140	Mouse
10402414	Sgp5_m	serum gp70 production 5 (mouse)			Not determined		13	56470456	105422186	Mouse
1301666	Eae13_m	susceptibility to experimental allergic encephalomyelitis 13 (mouse)			Not determined		13	50318411	84318559	Mouse
26884393	Humsd7_m	humerus midshaft diameter 7, 16 week (mouse)					13	3950000	76048119	Mouse
1300710	Pcd4ts2_m	p-glycoprotein positive CD4 T cell subset 2 (mouse)			Not determined		13	28210442	62210544	Mouse
1301734	Acsns2_m	Angiostrongylus costaricensis nematode susceptibility 2 (mouse)			Not determined		13	36101530	70101640	Mouse
26884396	Humsd4_m	humerus midshaft diameter 4, 10 week (mouse)					13	47853476	73148119	Mouse
14696729	Kidlq2_m	kidney weight, left QTL 2 (mouse)					13	31344736	65344736	Mouse
1301801	Cpfd5_m	cerebellum pattern fissures (mouse)			Not determined		13	39629249	73629397	Mouse
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
1357802	Vtbt15_m	vertebral trabecular bone trait 15 (mouse)			Not determined		13	28217379	62217515	Mouse
14746975	Manh74_m	mandible shape 74 (mouse)					13	52477269	86477269	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK145559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC051665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ076391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT010498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000026078 ⟹ ENSMUSP00000026078

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	60,929,701 - 60,934,178 (-)	Ensembl
GRCm38.p6 Ensembl	13	60,781,887 - 60,786,364 (-)	Ensembl

RefSeq Acc Id:

NM_199148 ⟹ NP_954599

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	60,929,701 - 60,934,178 (-)	NCBI
GRCm38	13	60,781,887 - 60,786,364 (-)	ENTREZGENE
MGSCv37	13	60,883,248 - 60,887,725 (-)	RGD
Celera	13	61,841,836 - 61,846,314 (-)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

GTCACAGCCTGGGACCTCAGCAACCTCTGAAGACCTGAGACTCTGAAGCCCACCTGCCCAGCTA
TGTACATCCCAGGGTTTGGAAGTATGACTCCAGTTTTCCTCCTGGCCACCCTGTGCTTAGGGGT
GGTCTCAGCTGCTCCAGCACACGATCCCAGTTTGGATGCTGTATGGGAGGAATGGAAGACAAAA
CACAGGAAAACATACAACATGAATGAAGAAGCACAGAAGAGAGCAGTGTGGGAGAATAACATGA
AGATGATCGGCCTGCACAACGAGGACTATCTGAAGGGGAAGCATGGCTTCAACTTGGAGATGAA
CGCCTTTGGTGATTTGACCAATACAGAATTCAGAGAATTGATGACTGGCTTTCAAAGCATGGGG
CACAAGGAGATGACCATCTTCCAGGAGCCCTTGCTGGGTGATGTCCCCAAGTCTGTTGATTGGA
GAGATCATGGCTATGTGACTCCTGTGAAAGACCAGGGTCATTGTGGATCTTGTTGGGCTTTTAG
TGCAGTTGGTTCCTTGGAAGGACAAATATTCAGAAAAACAGGCAAACTGGTCCCTCTGAGTGAA
CAGAACCTAATGGACTGCTCCTGGTCCTATGGCAACGTAGGTTGTAATGGTGGCTTGATGGAAC
TAGCCTTCCAGTATGTGAAGGAAAACAGAGGCCTGGACACAAGGGAGTCCTACGCATATGAAGC
CTGGGATGGACCCTGCAGGTACGATCCTAAGTACTCTGCAGTTAACATCACAGGCTTTGTGAAA
GTCCCATTGAGCGAAGATGCCCTGATGAATGCCGTGGCCAGTGTGGGGCCCGTCTCAGTTGGAA
TTGACACTCATCACCACTCCTTCAGGTTCTACAGAGGTGGTACGTACTATGAGCCAGACTGTAG
CAGCACTAATCTGGATCATGCTGTCCTGGTAGTTGGCTATGGTGAAGAATCAGATGGCAGGAAG
TACTGGCTGGTCAAGAACAGCTGGGGTGAAGACTGGGGCATGGATGGCTACATAAAGATGGCCA
AAGACAGGGACAACAACTGTGGGATTGCTACCTATGCCATCTACCCCACCGTGTGAGCTGCCCG
GACAGCAAGGAAGGAATGAGCTGCATGTACAGAGGAGGGCGTCCCCCTTCACAGACCAGCCAGC
CTCTGCTCTGTGGGGAATGGTAGCTGAGTCACTGAAGGTCCATTTTTTGGTGTGCATTCTGGAA
CATTTTACTCCAGCTAAATGTGACTGCCAATCTGCTGCCGTGAGCAGCTTTGTATCAGTGAGTT
CTGAATTTTAATTGTTTTTTTTTTTTTACAAGATGTACAGAATTTCTATAAAACCTGCGTTTAA
AAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_954599	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH51665	(Get FASTA)	NCBI Sequence Viewer
	BAE26509	(Get FASTA)	NCBI Sequence Viewer
	EDL41301	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000026078
	ENSMUSP00000026078.9

RefSeq Acc Id:	NP_954599 ⟸ NM_199148
- Peptide Label:	precursor
- UniProtKB:	E9Q623 (UniProtKB/TrEMBL), Q80X23 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTPVFLLATLCLGVVSAAPAHDPSLDAVWEEWKTKHRKTYNMNEEAQKRAVWENNMKMIGLHNE DYLKGKHGFNLEMNAFGDLTNTEFRELMTGFQSMGHKEMTIFQEPLLGDVPKSVDWRDHGYVTP VKDQGHCGSCWAFSAVGSLEGQIFRKTGKLVPLSEQNLMDCSWSYGNVGCNGGLMELAFQYVKE NRGLDTRESYAYEAWDGPCRYDPKYSAVNITGFVKVPLSEDALMNAVASVGPVSVGIDTHHHSF RFYRGGTYYEPDCSSTNLDHAVLVVGYGEESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCG IATYAIYPTV hide sequence

Ensembl Acc Id:

ENSMUSP00000026078 ⟸ ENSMUST00000026078

Protein Domains

Cathepsin propeptide inhibitor Peptidase C1A papain C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9Q623-F1-model_v2	AlphaFold	E9Q623	1-330	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2682300	AgrOrtholog
Ensembl Genes	ENSMUSG00000042243	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000026078	ENTREZGENE
	ENSMUST00000026078.10	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Pept_cys_AS	UniProtKB/TrEMBL
	Pept_his_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Peptidase_C1A_papain-like	UniProtKB/TrEMBL
	Prot_inhib_I29	UniProtKB/TrEMBL
KEGG Report	mmu:218275	UniProtKB/TrEMBL
MGD	MGI:2682300	ENTREZGENE
NCBI Gene	218275	ENTREZGENE
PANTHER	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
Pfam	Inhibitor_I29	UniProtKB/TrEMBL
	Peptidase_C1	UniProtKB/TrEMBL
PhenoGen	BC051665	PhenoGen
PRINTS	PAPAIN	UniProtKB/TrEMBL
PROSITE	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
	THIOL_PROTEASE_CYS	UniProtKB/TrEMBL
	THIOL_PROTEASE_HIS	UniProtKB/TrEMBL
SMART	Inhibitor_I29	UniProtKB/TrEMBL
	Pept_C1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	E9Q623	ENTREZGENE, UniProtKB/TrEMBL
	Q3ULD9_MOUSE	UniProtKB/TrEMBL
	Q80X23	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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