Fbxo4 (F-box protein 4) - Rat Genome Database

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Gene: Fbxo4 (F-box protein 4) Mus musculus
Analyze
Symbol: Fbxo4
Name: F-box protein 4
RGD ID: 1316857
MGI Page MGI
Description: Enables ubiquitin protein ligase activity and ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; protein destabilization; and regulation of DNA damage checkpoint. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700096C12Rik; AI851261; AW494535; F-box only protein 4; Fbx4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,993,046 - 4,009,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,994,927 - 4,009,055 (-)EnsemblGRCm39 Ensembl
GRCm38153,963,564 - 3,979,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,965,445 - 3,979,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,913,564 - 3,929,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,915,461 - 3,929,573 (-)NCBIMGSCv36mm8
Celera153,825,238 - 3,841,215 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, etal., Genes Dev 2004 Nov 1;18(21):2573-80.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17081987   PMID:19767775   PMID:21242966   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:21911473   PMID:22124152   PMID:24019069   PMID:25801820   PMID:27977682   PMID:29142209   PMID:29925002   PMID:32325033   PMID:32554809  


Genomics

Comparative Map Data
Fbxo4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,993,046 - 4,009,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,994,927 - 4,009,055 (-)EnsemblGRCm39 Ensembl
GRCm38153,963,564 - 3,979,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,965,445 - 3,979,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,913,564 - 3,929,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,915,461 - 3,929,573 (-)NCBIMGSCv36mm8
Celera153,825,238 - 3,841,215 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.84NCBI
FBXO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38541,925,281 - 42,040,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl541,925,254 - 41,941,743 (+)EnsemblGRCh38hg38GRCh38
GRCh37541,925,383 - 41,941,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36541,961,113 - 41,977,429 (+)NCBINCBI36Build 36hg18NCBI36
Build 34541,961,112 - 41,970,940NCBI
Celera541,813,649 - 41,829,966 (+)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef541,878,053 - 41,894,370 (+)NCBIHuRef
CHM1_1541,927,215 - 41,943,529 (+)NCBICHM1_1
T2T-CHM13v2.0542,181,685 - 42,298,494 (+)NCBIT2T-CHM13v2.0
Fbxo4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8254,902,394 - 54,915,388 (-)NCBIGRCr8
mRatBN7.2253,174,798 - 53,187,792 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl253,174,798 - 53,187,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx260,273,074 - 60,286,042 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0258,331,816 - 58,344,784 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0253,363,530 - 53,376,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0253,797,954 - 53,811,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,797,954 - 53,811,134 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0272,830,881 - 72,844,061 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4253,871,746 - 53,884,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1253,800,345 - 53,812,541 (-)NCBI
Celera248,852,920 - 48,865,913 (-)NCBICelera
Cytogenetic Map2q16NCBI
Fbxo4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542626,046,742 - 26,063,388 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542626,046,742 - 26,066,747 (+)NCBIChiLan1.0ChiLan1.0
FBXO4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2468,209,415 - 68,425,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1566,441,446 - 66,579,338 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0568,336,673 - 68,474,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1573,500,841 - 73,517,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl573,500,850 - 73,517,051 (-)Ensemblpanpan1.1panPan2
FBXO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1467,620,947 - 67,664,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl467,651,275 - 67,664,915 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha467,304,401 - 67,348,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0468,132,595 - 68,177,003 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl468,149,420 - 68,176,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1467,874,636 - 67,918,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,005,389 - 68,049,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0468,544,850 - 68,589,223 (-)NCBIUU_Cfam_GSD_1.0
Fbxo4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213230,497,928 - 230,516,528 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936518854,721 - 874,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936518855,304 - 873,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1626,707,470 - 26,752,024 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11626,707,470 - 26,751,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21627,971,745 - 27,988,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1440,682,063 - 40,698,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl440,682,333 - 40,698,370 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607131,118,629 - 31,134,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,017,815 - 13,046,883 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,019,929 - 13,047,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo4
481 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:704
Count of miRNA genes:396
Interacting mature miRNAs:443
Transcripts:ENSMUST00000022791, ENSMUST00000148169, ENSMUST00000148817
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218736Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15324016724388176Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120489829Mouse
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120489829Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120489829Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120489829Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120489829Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346465237464652Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101390Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120489829Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120489829Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273195Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse

Markers in Region
AI851261  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,965,642 - 3,965,756UniSTSGRCm38
MGSCv37153,915,642 - 3,915,756UniSTSGRCm37
Celera153,827,317 - 3,827,431UniSTS
Cytogenetic Map15A1UniSTS
Whitehead/MRC_RH1514.19UniSTS
Whitehead/MRC_RH1515.37UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000022791   ⟹   ENSMUSP00000022791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl153,994,927 - 4,009,055 (-)Ensembl
GRCm38.p6 Ensembl153,965,445 - 3,979,573 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl154,000,766 - 4,001,464 (-)Ensembl
GRCm38.p6 Ensembl153,971,284 - 3,971,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148817
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl153,998,520 - 4,002,342 (-)Ensembl
GRCm38.p6 Ensembl153,969,038 - 3,972,860 (-)Ensembl
RefSeq Acc Id: NM_134099   ⟹   NP_598860
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39153,993,046 - 4,009,055 (-)NCBI
GRCm38153,963,564 - 3,979,573 (-)ENTREZGENE
MGSCv37153,913,564 - 3,929,573 (-)RGD
Celera153,825,238 - 3,841,215 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_598860 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH40086 (Get FASTA)   NCBI Sequence Viewer  
  CAC36404 (Get FASTA)   NCBI Sequence Viewer  
  EDL03400 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000022791
  ENSMUSP00000022791.9
GenBank Protein Q8CHQ0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598860   ⟸   NM_134099
- UniProtKB: E9QPM9 (UniProtKB/Swiss-Prot),   Q99JG8 (UniProtKB/Swiss-Prot),   Q8CHQ0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000022791   ⟸   ENSMUST00000022791
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHQ0-F1-model_v2 AlphaFold Q8CHQ0 1-385 view protein structure

Promoters
RGD ID:6826010
Promoter ID:MM_KWN:17910
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:OTTMUST00000069279
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36153,922,001 - 3,922,501 (-)MPROMDB
RGD ID:6826009
Promoter ID:MM_KWN:17912
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_134099
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36153,929,166 - 3,929,737 (-)MPROMDB
RGD ID:8683306
Promoter ID:EPDNEW_M19683
Type:initiation region
Name:Fbxo4_1
Description:Mus musculus F-box protein 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38153,979,511 - 3,979,571EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2146220 AgrOrtholog
Ensembl Genes ENSMUSG00000022184 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022791 ENTREZGENE
  ENSMUST00000022791.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  FBXO4 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:106052 UniProtKB/Swiss-Prot
MGD MGI:2146220 ENTREZGENE
NCBI Gene 106052 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 4 UniProtKB/Swiss-Prot
  PTHR16008 UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot
PhenoGen Fbxo4 PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot
SMART FBOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81383 UniProtKB/Swiss-Prot
UniProt E9QPM9 ENTREZGENE
  FBX4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99JG8 ENTREZGENE
UniProt Secondary E9QPM9 UniProtKB/Swiss-Prot
  Q99JG8 UniProtKB/Swiss-Prot