Oasl2 (2'-5' oligoadenylate synthetase-like 2) - Rat Genome Database

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Gene: Oasl2 (2'-5' oligoadenylate synthetase-like 2) Mus musculus
Analyze
Symbol: Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
RGD ID: 1316499
MGI Page MGI
Description: Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in interleukin-27-mediated signaling pathway and purine nucleotide biosynthetic process. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in central nervous system; retina; right atrium; and thymus primordium. Orthologous to human OASL2P (2'-5' oligoadenylate synthetase like 2, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2; M1204; Mmu-; Mmu-OASL; Oasl; p54 OASL; p54OASL
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,034,995 - 115,050,306 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,034,997 - 115,050,295 (+)EnsemblGRCm39 Ensembl
GRCm385114,896,926 - 114,912,245 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,896,936 - 114,912,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,346,943 - 115,362,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,157,933 - 115,173,226 (+)NCBIMGSCv36mm8
Celera5111,989,345 - 112,005,767 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
membrane  (IBA)
nucleoplasm  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10395668   PMID:10779534   PMID:11042159   PMID:11076861   PMID:12396720   PMID:12477932   PMID:12799444   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:21142819   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24931123   PMID:26633895   PMID:27721430   PMID:30635239   PMID:30973865   PMID:32270034   PMID:32277054   PMID:33706013  
PMID:38355793  


Genomics

Comparative Map Data
Oasl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,034,995 - 115,050,306 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,034,997 - 115,050,295 (+)EnsemblGRCm39 Ensembl
GRCm385114,896,926 - 114,912,245 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,896,936 - 114,912,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,346,943 - 115,362,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,157,933 - 115,173,226 (+)NCBIMGSCv36mm8
Celera5111,989,345 - 112,005,767 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
OASL2P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,053,732 - 121,059,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,053,732 - 121,059,670 (-)EnsemblGRCh38hg38GRCh38
GRCh3712121,491,535 - 121,497,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.31NCBI
T2T-CHM13v2.012121,044,406 - 121,050,354 (-)NCBIT2T-CHM13v2.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1695
Count of miRNA genes:658
Interacting mature miRNAs:809
Transcripts:ENSMUST00000031542, ENSMUST00000124716, ENSMUST00000129707, ENSMUST00000137828, ENSMUST00000144064, ENSMUST00000146072, ENSMUST00000150361
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031542   ⟹   ENSMUSP00000031542
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,034,997 - 115,050,295 (+)Ensembl
GRCm38.p6 Ensembl5114,896,936 - 114,912,234 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124716   ⟹   ENSMUSP00000115070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,039,414 - 115,049,281 (+)Ensembl
GRCm38.p6 Ensembl5114,901,353 - 114,911,220 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,042,491 - 115,044,784 (+)Ensembl
GRCm38.p6 Ensembl5114,904,430 - 114,906,723 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,035,637 - 115,038,344 (+)Ensembl
GRCm38.p6 Ensembl5114,897,576 - 114,900,283 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144064   ⟹   ENSMUSP00000117876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,035,803 - 115,050,287 (+)Ensembl
GRCm38.p6 Ensembl5114,897,742 - 114,912,226 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146072   ⟹   ENSMUSP00000117795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,035,062 - 115,037,907 (+)Ensembl
GRCm38.p6 Ensembl5114,897,001 - 114,899,846 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150361   ⟹   ENSMUSP00000119042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,035,091 - 115,038,032 (+)Ensembl
GRCm38.p6 Ensembl5114,897,030 - 114,899,971 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201445
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,039,895 - 115,042,002 (+)Ensembl
GRCm38.p6 Ensembl5114,901,834 - 114,903,941 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5115,035,593 - 115,036,411 (+)Ensembl
GRCm38.p6 Ensembl5114,897,532 - 114,898,350 (+)Ensembl
RefSeq Acc Id: NM_001359181   ⟹   NP_001346110
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,034,995 - 115,050,306 (+)NCBI
GRCm385114,896,934 - 114,912,245 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011854   ⟹   NP_035984
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,034,995 - 115,050,306 (+)NCBI
GRCm385114,896,934 - 114,912,245 (+)ENTREZGENE
MGSCv375115,346,943 - 115,362,254 (+)RGD
Celera5111,989,345 - 112,005,767 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530314   ⟹   XP_006530377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,035,020 - 115,050,291 (+)NCBI
GRCm385114,896,926 - 114,912,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530315   ⟹   XP_006530378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,035,020 - 115,050,291 (+)NCBI
GRCm385114,896,931 - 114,912,232 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035984   ⟸   NM_011854
- Peptide Label: isoform 1
- UniProtKB: Q9D6S2 (UniProtKB/Swiss-Prot),   Q9Z2F2 (UniProtKB/Swiss-Prot),   Q8K234 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530378   ⟸   XM_006530315
- Peptide Label: isoform X1
- UniProtKB: Q9D6S2 (UniProtKB/Swiss-Prot),   Q9Z2F2 (UniProtKB/Swiss-Prot),   Q8K234 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530377   ⟸   XM_006530314
- Peptide Label: isoform X1
- UniProtKB: Q9D6S2 (UniProtKB/Swiss-Prot),   Q9Z2F2 (UniProtKB/Swiss-Prot),   Q8K234 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001346110   ⟸   NM_001359181
- Peptide Label: isoform 2
- UniProtKB: F6VMV6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000119042   ⟸   ENSMUST00000150361
Ensembl Acc Id: ENSMUSP00000117876   ⟸   ENSMUST00000144064
Ensembl Acc Id: ENSMUSP00000115070   ⟸   ENSMUST00000124716
Ensembl Acc Id: ENSMUSP00000031542   ⟸   ENSMUST00000031542
Ensembl Acc Id: ENSMUSP00000117795   ⟸   ENSMUST00000146072
Protein Domains
2'-5'-oligoadenylate synthetase   Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2F2-F1-model_v2 AlphaFold Q9Z2F2 1-508 view protein structure

Promoters
RGD ID:6887704
Promoter ID:EPDNEW_M7303
Type:initiation region
Name:Oasl2_2
Description:Mus musculus 2'-5' oligoadenylate synthetase-like 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7304  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385114,896,984 - 114,897,044EPDNEW
RGD ID:6887706
Promoter ID:EPDNEW_M7304
Type:initiation region
Name:Oasl2_1
Description:Mus musculus 2'-5' oligoadenylate synthetase-like 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7303  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385114,897,569 - 114,897,629EPDNEW
RGD ID:6837983
Promoter ID:MM_KWN:43608
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung
Transcripts:NM_011854,   OTTMUST00000034640,   OTTMUST00000034641,   OTTMUST00000034642,   OTTMUST00000040921
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,347,241 - 115,347,772 (+)MPROMDB
RGD ID:6837984
Promoter ID:MM_KWN:43609
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000034643
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,350,791 - 115,351,577 (+)MPROMDB
RGD ID:6837985
Promoter ID:MM_KWN:43610
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000034644
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,354,371 - 115,354,992 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344390 AgrOrtholog
Ensembl Genes ENSMUSG00000029561 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031542 ENTREZGENE
  ENSMUST00000031542.13 UniProtKB/Swiss-Prot
  ENSMUST00000124716.3 UniProtKB/TrEMBL
  ENSMUST00000144064.5 UniProtKB/TrEMBL
  ENSMUST00000146072.8 UniProtKB/TrEMBL
  ENSMUST00000150361.2 UniProtKB/TrEMBL
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2-5-oligoadenylate_synth_CS UniProtKB/Swiss-Prot
  2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-5OAS_C_CS UniProtKB/TrEMBL
  2-5OAS_N_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/Swiss-Prot
KEGG Report mmu:23962 UniProtKB/Swiss-Prot
MGD MGI:1344390 ENTREZGENE
NCBI Gene 23962 ENTREZGENE
PANTHER 2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OAS1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ubiquitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oasl2 PhenoGen
PROSITE 25A_SYNTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART UBQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z324_MOUSE UniProtKB/TrEMBL
  D3Z352_MOUSE UniProtKB/TrEMBL
  F6VMV6 ENTREZGENE, UniProtKB/TrEMBL
  F6Y3A6_MOUSE UniProtKB/TrEMBL
  OASL2_MOUSE UniProtKB/Swiss-Prot
  Q3UDH2_MOUSE UniProtKB/TrEMBL
  Q8K234 ENTREZGENE, UniProtKB/TrEMBL
  Q9D6S2 ENTREZGENE
  Q9Z2F2 ENTREZGENE
UniProt Secondary Q9D6S2 UniProtKB/Swiss-Prot