Gkap1 (G kinase anchoring protein 1) - Rat Genome Database

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Gene: Gkap1 (G kinase anchoring protein 1) Rattus norvegicus
Analyze
Symbol: Gkap1
Name: G kinase anchoring protein 1
RGD ID: 1306955
Description: Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of insulin receptor signaling pathway and signal transduction. Predicted to be located in Golgi apparatus. Orthologous to human GKAP1 (G kinase anchoring protein 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G kinase-anchoring protein 1; LOC361202
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,389,377 - 6,429,091 (+)NCBIGRCr8
mRatBN7.2176,383,963 - 6,423,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,383,963 - 6,423,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,407,259 - 6,447,000 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,939,428 - 7,978,942 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,403,641 - 6,443,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,785,428 - 6,825,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,785,428 - 6,825,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,989,135 - 9,028,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,315,255 - 12,355,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11712,315,254 - 12,355,039 (+)NCBI
Celera176,493,506 - 6,533,164 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10671526   PMID:12477932   PMID:25416956   PMID:25586176   PMID:25931508  


Genomics

Comparative Map Data
Gkap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,389,377 - 6,429,091 (+)NCBIGRCr8
mRatBN7.2176,383,963 - 6,423,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,383,963 - 6,423,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,407,259 - 6,447,000 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,939,428 - 7,978,942 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,403,641 - 6,443,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,785,428 - 6,825,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,785,428 - 6,825,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,989,135 - 9,028,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,315,255 - 12,355,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11712,315,254 - 12,355,039 (+)NCBI
Celera176,493,506 - 6,533,164 (+)NCBICelera
Cytogenetic Map17p14NCBI
GKAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38983,739,425 - 83,817,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl983,739,425 - 83,829,516 (-)EnsemblGRCh38hg38GRCh38
GRCh37986,354,340 - 86,432,684 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36985,544,156 - 85,622,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 34983,583,891 - 83,662,211NCBI
Celera956,924,338 - 57,002,769 (-)NCBICelera
Cytogenetic Map9q21.32NCBI
HuRef956,179,648 - 56,258,053 (-)NCBIHuRef
CHM1_1986,501,068 - 86,579,457 (-)NCBICHM1_1
T2T-CHM13v2.0995,889,113 - 95,967,455 (-)NCBIT2T-CHM13v2.0
Gkap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,381,160 - 58,422,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,381,160 - 58,423,513 (-)EnsemblGRCm39 Ensembl
GRCm381358,233,346 - 58,274,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,233,346 - 58,275,699 (-)EnsemblGRCm38mm10GRCm38
MGSCv371358,334,712 - 58,375,549 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,242,974 - 58,283,811 (-)NCBIMGSCv36mm8
Celera1359,295,562 - 59,336,387 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.97NCBI
Gkap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554323,459,103 - 3,532,889 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554323,459,100 - 3,532,889 (+)NCBIChiLan1.0ChiLan1.0
GKAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21182,897,567 - 82,976,538 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1982,903,510 - 82,982,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0941,061,159 - 41,140,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1982,675,689 - 82,753,519 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl982,654,660 - 82,753,525 (-)Ensemblpanpan1.1panPan2
GKAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1175,662,369 - 75,732,663 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl175,674,901 - 75,732,661 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,311,647 - 76,382,444 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0175,963,323 - 76,034,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl175,976,368 - 76,063,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1175,776,653 - 75,847,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0175,541,756 - 75,612,771 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,242,855 - 76,313,645 (+)NCBIUU_Cfam_GSD_1.0
Gkap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947122,338,311 - 122,395,961 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936828628,840 - 686,921 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936828632,729 - 686,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1031,141,847 - 31,246,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11031,141,799 - 31,230,967 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21035,228,961 - 35,317,629 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GKAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11294,552,603 - 94,633,035 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1294,552,382 - 94,632,344 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603882,966,312 - 83,047,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gkap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248096,566,640 - 6,628,908 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248096,566,640 - 6,628,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gkap1
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:162
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000026070
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 2 43 56 41 18 41 8 10 74 35 40 11 8
Low 1 1 1 1
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000026070   ⟹   ENSRNOP00000026070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,383,963 - 6,423,679 (+)Ensembl
Rnor_6.0 Ensembl176,785,428 - 6,825,140 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083408   ⟹   ENSRNOP00000075132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,383,963 - 6,423,679 (+)Ensembl
Rnor_6.0 Ensembl176,786,348 - 6,825,144 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111759   ⟹   ENSRNOP00000083360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,384,252 - 6,423,679 (+)Ensembl
RefSeq Acc Id: NM_001012160   ⟹   NP_001012160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,389,377 - 6,429,091 (+)NCBI
mRatBN7.2176,383,963 - 6,423,680 (+)NCBI
Rnor_6.0176,785,428 - 6,825,141 (+)NCBI
Rnor_5.0178,989,135 - 9,028,904 (+)NCBI
RGSC_v3.41712,315,255 - 12,355,040 (+)RGD
Celera176,493,506 - 6,533,164 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276552   ⟹   XP_063132622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,390,395 - 6,429,091 (+)NCBI
RefSeq Acc Id: XM_063276553   ⟹   XP_063132623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,390,395 - 6,429,091 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012160 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132622 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132623 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83717 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026070.6
  ENSRNOP00000075132.2
  ENSRNOP00000083360.1
GenBank Protein Q5XIG5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012160   ⟸   NM_001012160
- UniProtKB: Q5XIG5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026070   ⟸   ENSRNOT00000026070
Ensembl Acc Id: ENSRNOP00000075132   ⟸   ENSRNOT00000083408
Ensembl Acc Id: ENSRNOP00000083360   ⟸   ENSRNOT00000111759
RefSeq Acc Id: XP_063132622   ⟸   XM_063276552
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132623   ⟸   XM_063276553
- Peptide Label: isoform X2
- UniProtKB: A0A8L2RA95 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIG5-F1-model_v2 AlphaFold Q5XIG5 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700282
Promoter ID:EPDNEW_R10805
Type:multiple initiation site
Name:Gkap1_1
Description:G kinase anchoring protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0176,785,421 - 6,785,481EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306955 AgrOrtholog
BioCyc Gene G2FUF-10338 BioCyc
Ensembl Genes ENSRNOG00000019272 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026070.7 UniProtKB/TrEMBL
  ENSRNOT00000083408.2 UniProtKB/TrEMBL
  ENSRNOT00000111759.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190699 IMAGE-MGC_LOAD
InterPro GKAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361202 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94608 IMAGE-MGC_LOAD
NCBI Gene 361202 ENTREZGENE
PANTHER G KINASE-ANCHORING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gkap1 PhenoGen
PRINTS GKINASEAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019272 RatGTEx
UniProt A0A8I5ZVX4_RAT UniProtKB/TrEMBL
  A0A8L2QDT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RA95 ENTREZGENE, UniProtKB/TrEMBL
  GKAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Gkap1  G kinase anchoring protein 1  Gkap1_predicted  G kinase anchoring protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gkap1_predicted  G kinase anchoring protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED