Pgc (progastricsin) - Rat Genome Database

Name: Pgc
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Pgc (progastricsin) Ictidomys tridecemlineatus

Analyze

Symbol:

Pgc

Name:

progastricsin

RGD ID:

12720566

Description:

ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); endopeptidase activity (inferred); INVOLVED IN positive regulation of antibacterial peptide production (ortholog); ASSOCIATED WITH infantile Refsum disease (ortholog); Zellweger syndrome (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

gastricsin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PGC (progastricsin)	NCBI	Ortholog
Mus musculus (house mouse):	Pgc (progastricsin (pepsinogen C))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pgc (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pgc (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PGC (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PGC (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PGC (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PGC (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pgc (progastricsin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	45,913,605 - 45,920,575 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936476	18,039,709 - 18,046,510 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

infantile Refsum disease (ISO)

Zellweger syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

digestion (IEA)

positive regulation of antibacterial peptide production (ISO)

proteolysis (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

aspartic-type endopeptidase activity (IEA)

endopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pgc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	45,913,605 - 45,920,575 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936476	18,039,709 - 18,046,510 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	41,736,711 - 41,747,397 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	41,736,711 - 41,754,109 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	41,704,449 - 41,715,135 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	41,812,430 - 41,823,099 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	41,812,429 - 41,823,099	NCBI
Celera	6	43,257,886 - 43,268,464 (-)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	41,423,279 - 41,433,946 (-)	NCBI		HuRef
CHM1_1	6	41,707,932 - 41,718,508 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	41,565,267 - 41,576,000 (-)	NCBI		T2T-CHM13v2.0

Pgc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	48,037,767 - 48,045,403 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	48,037,767 - 48,045,407 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	47,726,842 - 47,734,478 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	47,726,842 - 47,734,482 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	47,863,791 - 47,871,427 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	47,190,033 - 47,197,669 (+)	NCBI		MGSCv36	mm8
Celera	17	51,163,923 - 51,171,529 (+)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	23.98	NCBI

Pgc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	20,755,002 - 20,763,220 (-)	NCBI		GRCr8
mRatBN7.2	9	13,257,462 - 13,265,682 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	13,257,462 - 13,265,682 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	21,837,988 - 21,845,673 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	26,902,067 - 26,909,766 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	25,201,385 - 25,209,079 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	15,266,699 - 15,274,917 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	15,266,699 - 15,274,917 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	14,191,145 - 14,199,127 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	8,723,620 - 8,731,837 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	8,722,923 - 8,731,141 (-)	NCBI
Celera	9	11,009,766 - 11,018,396 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Pgc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	8,142,661 - 8,151,339 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	8,142,523 - 8,153,044 (-)	NCBI	ChiLan1.0	ChiLan1.0

PGC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	56,229,793 - 56,240,297 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	52,099,801 - 52,110,296 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	41,321,932 - 41,330,494 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	42,627,385 - 42,637,514 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	42,627,222 - 42,637,514 (-)	Ensembl	panpan1.1		panPan2

PGC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	10,425,137 - 10,435,129 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	10,454,837 - 10,463,787 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	10,905,543 - 10,914,475 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	12	10,436,269 - 10,445,194 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	10,519,705 - 10,528,842 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	10,613,396 - 10,622,545 (-)	NCBI		UU_Cfam_GSD_1.0

PGC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	36,922,271 - 36,951,349 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	36,922,269 - 36,951,380 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	42,257,163 - 42,286,645 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	30,414,769 - 30,424,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	30,415,124 - 30,424,766 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	41,732,945 - 41,743,040 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pgc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	17,311,644 - 17,319,764 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	17,311,743 - 17,319,675 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005318703 ⟹ XP_005318760

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	45,913,605 - 45,920,575 (-)	NCBI
SpeTri2.0	NW_004936476	18,039,709 - 18,046,510 (+)	NCBI

Sequence:

show sequence

GTGCGACTGTGGATCTCAGAGTGGCGCTTGCTCTGTGACCAGCTGGGAATCGGCATCATGAAGT
GGATGGTGGTGGCCTTGGTCTGCCTCCTGGCCTTGGAGGCATCGACTACAATTGTCAAGGTCCC
CCTGAGGAAAATGAAGACTATGCGTCAGACCATGAGGGAAAAGGGCTTGCTGGGGGACTTCCTG
AGGACCCACAAGTACGACCCAGCTCAGAAGTACCGCTTCAGCGACTTCAGCGTGCTCTATGAGC
CCATGAGCTACATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTT
CCTGGTCCTGTTTGACACTGGCTCCTCCAACCTGTGGGTGCCCTCGGTCTACTGCCAGAGCCAG
GCCTGCACCACACACCCTCGCTTCAACCCCAGCAAGTCCTCCACCTTCTCCACCAACGGGCAGA
CCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACAGGCTTCTTCGGCTATGACACCCTGACTGT
CCAGAGCATCCAGGTCCCCAACCAGGAGTTTGGCCTGAGTGAGCAAGAGCCGGGAACCAATTTT
GTCTATGCACAGTTCGATGGCATCATGGGCCTGGCCTACCCTGCCCTGTCCTCAGGAGGTGCCA
CCACAGCCCTGCAGGGCATGCTGCAGGTGGACGCCCTGTCCAGCCCCATGTTCAGCGTCTACCT
CAGCAACCAAGGGGGATCTGAGGATGGAGGAGCGGTCATCTTTGGAGGTGTGGACGAGAGCCTG
TACACAGGGCAGATCTTCTGGGCTCCTGTTACCCGGGAGCTCTACTGGCAGATCGGCATCCAGG
AGTTCTATGTTGGGGAAGAGGCTTCTGGCTGGTGCTCCCAGGGCTGCCAGGCCATGGTGGACAC
AGGAACCTCTCTGCTCACCGTGCCCCAGCAGTACCTGAGCTCCCTTCTGCAAGCTATAGGGGCC
CAGGAGGATGAGTATGGACAGTTTTTCGTGAACTGTAATAACGTCCAGAACCTGCCCACCTTCA
CCTTCGTCATCAACGGGGTGCAGTTCCCTCTGCCGCCCTCAGCCTACATCCTCAACGAGAATGG
CTACTGCTCGGTTGGACTGGAAGCCACCTACGTGTCCTCAGGAAATGGCCAGCCCTTTTGGATT
CTTGGGGACGTCTTCCTCAGGTCCTACTATTCCGTCTTTGACATGGCCAACAACAGGGTGGGCT
TTGCCACTGCCGCCTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005318760	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005854.2
	ENSSTOP00000030819.1
GenBank Protein	KAG3289444	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318760 ⟸ XM_005318703

- UniProtKB:

I3M846 (UniProtKB/TrEMBL), A0A287DBB6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKWMVVALVCLLALEASTTIVKVPLRKMKTMRQTMREKGLLGDFLRTHKYDPAQKYRFSDFSVL
YEPMSYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTTHPRFNPSKSSTFSTN
GQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSEQEPGTNFVYAQFDGIMGLAYPALSSG
GATTALQGMLQVDALSSPMFSVYLSNQGGSEDGGAVIFGGVDESLYTGQIFWAPVTRELYWQIG
IQEFYVGEEASGWCSQGCQAMVDTGTSLLTVPQQYLSSLLQAIGAQEDEYGQFFVNCNNVQNLP
TFTFVINGVQFPLPPSAYILNENGYCSVGLEATYVSSGNGQPFWILGDVFLRSYYSVFDMANNR
VGFATAA

hide sequence

Protein Domains

Peptidase A1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006547	UniProtKB/TrEMBL
	ENSSTOG00000022561	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006546.3	UniProtKB/TrEMBL
	ENSSTOT00000041891.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.70.10	UniProtKB/TrEMBL
	6.10.140.60	UniProtKB/TrEMBL
InterPro	Aspartic_peptidase_A1	UniProtKB/TrEMBL
	Aspartic_peptidase_AS	UniProtKB/TrEMBL
	Aspartic_peptidase_N	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
	Peptidase_aspartic_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Pgc	ENTREZGENE
PANTHER	BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED	UniProtKB/TrEMBL
	GASTRICSIN	UniProtKB/TrEMBL
Pfam	A1_Propeptide	UniProtKB/TrEMBL
	Asp	UniProtKB/TrEMBL
PRINTS	PEPSIN	UniProtKB/TrEMBL
PROSITE	ASP_PROTEASE	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50630	UniProtKB/TrEMBL
UniProt	A0A287DBB6	ENTREZGENE, UniProtKB/TrEMBL
	I3M846	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar