Gfral (GDNF family receptor alpha like)

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Gene: Gfral (GDNF family receptor alpha like) Ictidomys tridecemlineatus

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Symbol:

Gfral

Name:

GDNF family receptor alpha like

RGD ID:

12605863

Description:

ENCODES a protein that exhibits glial cell-derived neurotrophic factor receptor activity (inferred); receptor tyrosine kinase binding (inferred); signaling receptor activity (inferred); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); negative regulation of neuron apoptotic process (ortholog); stress-activated protein kinase signaling cascade (ortholog); FOUND IN actin cytoskeleton (inferred); external side of plasma membrane (inferred); focal adhesion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GDNF family receptor alpha-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	58,142,126 - 58,200,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	5,759,739 - 5,817,766 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	5,759,739 - 5,817,766 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

GDF15-GFRAL signaling pathway (IEA)

negative regulation of appetite (IEA)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,ISO)

nervous system development (IEA)

positive regulation of MAPK cascade (IEA)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

reduction of food intake in response to dietary excess (IEA)

response to metformin (IEA)

stress-activated protein kinase signaling cascade (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA)

external side of plasma membrane (IEA)

focal adhesion (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

receptor complex (IEA)

Molecular Function

glial cell-derived neurotrophic factor receptor activity (IEA)

protein binding (ISO)

receptor tyrosine kinase binding (IEA)

signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Gfral
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	58,142,126 - 58,200,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	5,759,739 - 5,817,766 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	5,759,739 - 5,817,766 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFRAL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	55,327,469 - 55,402,493 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	55,327,469 - 55,402,493 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	55,192,267 - 55,267,291 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	55,300,226 - 55,375,250 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	56,853,801 - 56,928,807 (+)	NCBI		Celera
Cytogenetic Map	6	p12.1	NCBI
HuRef	6	55,027,047 - 55,102,043 (+)	NCBI		HuRef
CHM1_1	6	55,195,111 - 55,270,112 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	55,167,078 - 55,242,077 (+)	NCBI		T2T-CHM13v2.0

Gfral
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	76,071,389 - 76,120,939 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	76,071,384 - 76,120,939 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	76,164,102 - 76,213,657 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	76,164,102 - 76,213,657 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	76,011,909 - 76,061,464 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	75,950,011 - 75,999,566 (-)	NCBI		MGSCv36	mm8
Celera	9	73,328,203 - 73,377,755 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	42.48	NCBI

Gfral
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	85,798,337 - 85,843,705 (-)	NCBI		GRCr8
mRatBN7.2	8	76,917,894 - 76,963,258 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	76,918,657 - 76,959,425 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	82,419,396 - 82,464,788 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	80,690,290 - 80,735,679 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	78,518,750 - 78,564,135 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	83,235,647 - 83,282,635 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	83,236,103 - 83,280,888 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	82,811,145 - 82,856,620 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	80,996,846 - 81,041,527 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	76,704,509 - 76,748,832 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Gfral
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	903,061 - 952,750 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	903,001 - 952,750 (-)	NCBI	ChiLan1.0	ChiLan1.0

GFRAL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	69,794,682 - 69,863,335 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	65,671,198 - 65,739,873 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	54,878,072 - 54,946,716 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	56,512,880 - 56,581,527 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	56,512,880 - 56,581,527 (+)	Ensembl	panpan1.1		panPan2

GFRAL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	22,646,015 - 22,702,428 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	22,646,374 - 22,702,545 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	22,536,780 - 22,592,921 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	23,143,717 - 23,199,868 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	23,143,750 - 23,199,935 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	22,634,384 - 22,696,904 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	22,744,315 - 22,800,438 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	22,876,403 - 22,932,522 (+)	NCBI		UU_Cfam_GSD_1.0

GFRAL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	25,750,184 - 25,808,637 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	25,749,608 - 25,806,844 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	30,218,618 - 30,274,488 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GFRAL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	16,154,054 - 16,221,616 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	16,155,423 - 16,216,101 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	22,315,979 - 22,398,387 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfral
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	2,811,103 - 2,876,909 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624850	2,811,103 - 2,876,909 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040282830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000006846 ⟹ ENSSTOP00000006119

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936476	5,759,739 - 5,817,766 (-)	Ensembl

RefSeq Acc Id:

XM_005318849 ⟹ XP_005318906

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	58,142,126 - 58,200,906 (+)	NCBI
SpeTri2.0	NW_004936476	5,759,739 - 5,817,766 (-)	NCBI

Sequence:

show sequence

ATGATAGTGCTCATTTTACTGGCTATGAGACTAAGCTCAGAAAATGGATCTGCTTCCCACACCA
ATGTTTGTGCATATTTAAGAGAGCAATGCTTAAGTGATGCACATGGATGCAAACCTGCATGGAG
AATAATGGAAGATGCCTGCAATGTTTCAGATCCAGGTGACCCCTGCAAGATAAGTAATTTGTCA
CACTGTAACCTGAGAATCCAGTCCTTCGTGGACAGCAATTTCCAGTTTAAAGAGTGTCTCTGCA
CAGATGACCTGTACTGTACTGTGAACAAGTTTCTTGGAAAAGAATGTGTCAATAAATCAGATAA
CATGAATGAGGATGATACATTCAATTGGAATATAACTACTCCTTCCTATCATGGATTCAATGGG
ATCCAGTCCTGTTTGGAAGTGACAGAGGCGTGTGTAGGGGATGTGGTGTGTAATGCACAGTTGG
CCCCTTACCTTAAAGCATGCTCAACAAATGGAGATCTGTGTGATGTGAAACACTGCCAAACAGC
CATACGGTTCTTCTATCAAAATATGCCTTTTAACGTTGCCCAGATGTTGGCTTTTTGTGACTGT
GCTCAATCTGATATACCTTGTCAGCAGTCCAAAGAAGCTCTTCACAGCAAGCCATGTGCAGTGA
ACATAATTCCACCCCCTACTTGCCTCAATGTAATTCACAGCTGCCGAAATGATGAATTATGCAG
GAGACGCTATAGAACATTTCAGTCCAAATGCTGGCCTCGGGTAACTGGAAAGTGCCATGAAGAT
GAAACCTGCATCAGCATGTTGGGCAAACAGGACCTCACTTGCTCAGGAAGTGATGACTGCAAAG
CAGCGTACTTGGGCACCCTTGGGACTGTTCTTCAAGCACAGTGCACCTGCAGAAGTGTCACACA
AAGTGAAGAGTCTTTGTGCAAGATTTTTGAGCACATGCTTCATAGAAAATCATGTTTTAATTAC
CCAATGCTGTCTAATTTCAAGGGCATTGCATTGTATAAAAGAAAACATGCCAAGGAAATTACTC
TAACTGGATTTCATTCCTCCTTCAATGGGCAAGTCATCTATGCTGTGATGTGCATGACAGTCAC
CTGTGGAATCCTTCTCTTGGTTATGCTCAAGTTGAGACTGTCCAGAATATCAAGTCAAACAAGA
GATTCTCCACCAATCCAAATACCTGGAGGAGTCATCATTCATTGA

hide sequence

RefSeq Acc Id:

XM_040282830 ⟹ XP_040138764

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	58,154,287 - 58,200,906 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005318906	(Get FASTA)	NCBI Sequence Viewer
	XP_040138764	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006119.3
GenBank Protein	KAG3289662	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005318906 ⟸ XM_005318849
- Peptide Label:	isoform X2
- UniProtKB:	I3M8M7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIVLILLAMRLSSENGSASHTNVCAYLREQCLSDAHGCKPAWRIMEDACNVSDPGDPCKISNLS HCNLRIQSFVDSNFQFKECLCTDDLYCTVNKFLGKECVNKSDNMNEDDTFNWNITTPSYHGFNG IQSCLEVTEACVGDVVCNAQLAPYLKACSTNGDLCDVKHCQTAIRFFYQNMPFNVAQMLAFCDC AQSDIPCQQSKEALHSKPCAVNIIPPPTCLNVIHSCRNDELCRRRYRTFQSKCWPRVTGKCHED ETCISMLGKQDLTCSGSDDCKAAYLGTLGTVLQAQCTCRSVTQSEESLCKIFEHMLHRKSCFNY PMLSNFKGIALYKRKHAKEITLTGFHSSFNGQVIYAVMCMTVTCGILLLVMLKLRLSRISSQTR DSPPIQIPGGVIIH hide sequence

RefSeq Acc Id:	XP_040138764 ⟸ XM_040282830
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSSTOP00000006119 ⟸ ENSSTOT00000006846

Protein Domains

GDNF/GAS1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006853	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006846.3	UniProtKB/TrEMBL
InterPro	GDNF/GAS1	UniProtKB/TrEMBL
	GDNF_alpha	UniProtKB/TrEMBL
	GDNF_rcpt	UniProtKB/TrEMBL
NCBI Gene	Gfral	ENTREZGENE
PANTHER	GDNF FAMILY RECEPTOR ALPHA-LIKE	UniProtKB/TrEMBL
	PTHR10269	UniProtKB/TrEMBL
Pfam	GDNF	UniProtKB/TrEMBL
SMART	GDNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF110035	UniProtKB/TrEMBL
UniProt	I3M8M7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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