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Gene: Dbx2 (developing brain homeobox 2) Ictidomys tridecemlineatus

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Symbol:

Dbx2

Name:

developing brain homeobox 2

RGD ID:

12585074

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); G2/M transition of mitotic cell cycle (ortholog); gene expression (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein DBX2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	69,788,219 - 69,823,531 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	3,345,549 - 3,376,577 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	3,345,334 - 3,376,721 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epidermal growth factor receptor signaling pathway (ISO)

G2/M transition of mitotic cell cycle (ISO)

gene expression (ISO)

neural precursor cell proliferation (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	69,788,219 - 69,823,531 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	3,345,549 - 3,376,577 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	3,345,334 - 3,376,721 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DBX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	45,014,672 - 45,051,099 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	45,014,672 - 45,051,099 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	45,408,455 - 45,444,882 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	43,694,806 - 43,731,149 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	44,211,912 - 44,248,577 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI
HuRef	12	42,436,496 - 42,473,246 (-)	NCBI		HuRef
CHM1_1	12	45,373,560 - 45,409,894 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	44,973,282 - 45,009,708 (-)	NCBI		T2T-CHM13v2.0

Dbx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	95,521,444 - 95,552,838 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	95,521,444 - 95,553,841 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	95,623,563 - 95,654,771 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	95,623,563 - 95,655,960 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	95,453,994 - 95,485,202 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	95,453,994 - 95,485,202 (-)	NCBI		MGSCv36	mm8
Celera	15	97,769,717 - 97,800,856 (-)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	50.47	NCBI

Dbx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	128,651,603 - 128,681,886 (-)	NCBI		GRCr8
mRatBN7.2	7	126,772,389 - 126,802,625 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	126,772,227 - 126,802,564 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	136,966,879 - 136,997,104 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	136,967,200 - 136,997,050 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	136,606,113 - 136,636,311 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	134,212,949 - 134,243,282 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	134,289,385 - 134,297,367 (-)	NCBI
Celera	7	123,282,070 - 123,312,294 (-)	NCBI		Celera
Cytogenetic Map	7	q35	NCBI

Dbx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955500	4,213,183 - 4,231,844 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955500	4,212,848 - 4,238,727 (-)	NCBI	ChiLan1.0	ChiLan1.0

DBX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	49,126,883 - 49,167,284 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	49,123,668 - 49,164,042 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	43,688,140 - 43,728,531 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	44,556,961 - 44,593,152 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	44,556,531 - 44,593,152 (+)	Ensembl	panpan1.1		panPan2

DBX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	9,232,489 - 9,255,666 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	9,119,535 - 9,251,354 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	37,057,992 - 37,095,951 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	9,407,774 - 9,444,849 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	9,407,808 - 9,443,351 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	9,214,034 - 9,251,972 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	9,253,744 - 9,290,746 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	37,296,100 - 37,334,062 (-)	NCBI		UU_Cfam_GSD_1.0

DBX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	75,945,871 - 75,980,496 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	75,945,866 - 75,983,466 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	78,874,750 - 78,875,486 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DBX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	41,190,840 - 41,230,057 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	205,228,432 - 205,268,945 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dbx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	7,285,920 - 7,318,461 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	7,285,905 - 7,323,265 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005324854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000000231 ⟹ ENSSTOP00000000204

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936512	3,345,549 - 3,376,577 (-)	Ensembl

RefSeq Acc Id:

XM_005324854 ⟹ XP_005324911

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	69,788,219 - 69,823,531 (+)	NCBI
SpeTri2.0	NW_004936512	3,345,334 - 3,376,721 (-)	NCBI

Sequence:

show sequence

GCCTGCGGCGTCCTCGGTGCCCTCTCCTCCACGCTGGGCTCAGCGCACTCCAGCCCGGGGGAGG
CGGCGGTGAGAAGCGGTGGCCAGGTCCGGCGCGGGGCGCGGGCTAGAGGCGGGTGCAACTGGCC
CAGCGGGCGCCGCACTATGCTCCCCAGCGCCGTGGCAGCGGGCGCGTACTGGGACGTGGTGGCT
TCCTCCGCGCTCCTCAACCTCCCCGCAGCGCCGGGCTTTGGCAACCTGGGCAAGAGTTTCCTGA
TCGAGAACTTGCTGCGGGTCGGAGGCTCCCCAGTCCACGGGCTGCAGCCACCCCCACCCCACGG
CCCCGCGGCCTCCCTAGTCACAGCTGGGGGCGCGCAGCTCCGGCCCCTGCCCGCCAGCCCCGTT
CCCCTCAAGCTGTGCCCAACAGCCGAGCAAGTCGGCCCCGCCGGGGCACCCTACGGCACGCGGT
GGGCATTTCAAGTGCTCAGCCCCTCGGCGGACGGCAGCCTCGCGCCGGGCCGGGCTCCGGAGGA
CCGAGACTGTGCTTTCCAGCCTTCTGCCCCAGGGCCTCCCAAACCTTTTCTTCTGAGTGCTCCA
GCATTCTACTCTGCGTGCTGTGGTGGGTCCTGTCGGCGCCCTGCATCCCCCTCTGCTTTTCCAA
GAGAAGAGAGTGTGCTGCCTTTGCTGACCCAGGACTCTAATTCCAAAGCTCGGAGGGGCATTTT
AAGAAGAGCTGTATTTTCCGAAGACCAGAGAAAGGCTCTGGAGAAAATGTTTCAGAAGCAAAAA
TACATCAGCAAAACAGATCGAAAGAAACTTGCCATCAACTTGGGACTAAAGGAGTCACAGGTGA
AAATTTGGTTTCAAAACAGAAGGATGAAATGGCGGAATTCCAAAGAAAAGGAAGTGCTTTCCAA
TAGGTGCATCCAAGATGTAAGCCTTCAAGAGGATCCTCTTTCACAATCTGCTCTGGGTTTCTCT
TCTCCATGTCCTTCAATATGGGAAGTCTCCCAACAGCACTCAAGTCCAAGATGGAGGGAGAATT
CTCCAGAACCTTCAGAAAAACTAATCCAGGAGAGTTCAGGGGCACCACCCCCAGAAGCAAATTC
ACTGCATGGTGCCTTGTATTTGTCTTCTGAGGAAGAAGCTGGAGACAAGGGTGCACTTACTAGG
GCCATATGAATGGAAGCATTCCTCCATGTTAATTTATAAGAACACTTAACCAACAACATTTGAA
ATCTAAAGCCAATTAGCTTGTGCCTCATCATTGCCTAAAACCTAACACCTTCAGAATGATGCAT
GAACTAATGCTTTAGAAAAATCCACTCCAGTGTTCTCTTATTTAGCCCTATACTCAGACTTAAC
TTGTAAGTGGAATAGAATCTTCCAGGACAGAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005324911	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000204.2
GenBank Protein	KAG3292124	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005324911 ⟸ XM_005324854

- UniProtKB:

I3LW72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPSAVAAGAYWDVVASSALLNLPAAPGFGNLGKSFLIENLLRVGGSPVHGLQPPPPHGPAASL
VTAGGAQLRPLPASPVPLKLCPTAEQVGPAGAPYGTRWAFQVLSPSADGSLAPGRAPEDRDCAF
QPSAPGPPKPFLLSAPAFYSACCGGSCRRPASPSAFPREESVLPLLTQDSNSKARRGILRRAVF
SEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCIQD
VSLQEDPLSQSALGFSSPCPSIWEVSQQHSSPRWRENSPEPSEKLIQESSGAPPPEANSLHGAL
YLSSEEEAGDKGALTRAI

hide sequence

Ensembl Acc Id:

ENSSTOP00000000204 ⟸ ENSSTOT00000000231

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000232	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000231.3	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	H2.0_Homeobox_NeuralPatt	UniProtKB/TrEMBL
	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	HTH_motif	UniProtKB/TrEMBL
NCBI Gene	Dbx2	ENTREZGENE
PANTHER	DBX	UniProtKB/TrEMBL
	HOMEOBOX PROTEIN DBX2	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
	HTHREPRESSR	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	I3LW72	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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