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Gene: Hspb3 (heat shock protein family B (small) member 3) Ictidomys tridecemlineatus

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Symbol:

Hspb3

Name:

heat shock protein family B (small) member 3

RGD ID:

12545869

Description:

ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 4 (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); nuclear speck (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock protein beta-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	204,240,935 - 204,242,322 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	13,178,022 - 13,178,480 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	13,177,430 - 13,178,824 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant distal hereditary motor neuronopathy 4 (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

Neurodevelopmental Disorders (ISO)

spinal muscular atrophy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

nuclear speck (IEA)

nucleus (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Hspb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	204,240,935 - 204,242,322 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	13,178,022 - 13,178,480 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	13,177,430 - 13,178,824 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSPB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	54,455,699 - 54,456,377 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	54,455,699 - 54,456,377 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	53,751,529 - 53,752,207 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	53,787,202 - 53,787,964 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	53,787,201 - 53,787,964	NCBI
Celera	5	50,705,068 - 50,705,830 (+)	NCBI		Celera
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	50,725,404 - 50,726,187 (+)	NCBI		HuRef
CHM1_1	5	53,754,285 - 53,755,068 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	55,283,264 - 55,283,942 (+)	NCBI		T2T-CHM13v2.0

Hspb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	113,799,432 - 113,800,212 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	113,799,432 - 113,800,212 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	113,662,896 - 113,663,676 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	113,662,896 - 113,663,676 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	114,453,104 - 114,453,884 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	114,783,774 - 114,784,537 (-)	NCBI		MGSCv36	mm8
Celera	13	117,987,638 - 117,988,418 (-)	NCBI		Celera
Cytogenetic Map	13	D2.2	NCBI
cM Map	13	64.01	NCBI

Hspb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	47,028,451 - 47,029,165 (-)	NCBI		GRCr8
mRatBN7.2	2	45,295,285 - 45,295,999 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	45,295,053 - 45,296,145 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	52,406,949 - 52,407,663 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	50,465,318 - 50,466,032 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	45,338,460 - 45,339,174 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	45,517,788 - 45,518,502 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	45,517,789 - 45,518,502 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	64,549,281 - 64,549,995 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	45,078,615 - 45,079,329 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	45,006,847 - 45,007,562 (-)	NCBI
Celera	2	41,063,625 - 41,064,339 (-)	NCBI		Celera
Cytogenetic Map	2	q14	NCBI

Hspb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	13,113,984 - 13,114,442 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	13,113,854 - 13,114,599 (-)	NCBI	ChiLan1.0	ChiLan1.0

HSPB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	59,480,184 - 59,480,962 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	57,631,048 - 57,634,586 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	59,566,129 - 59,569,668 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	61,190,450 - 61,191,220 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	61,190,585 - 61,191,037 (-)	Ensembl	panpan1.1		panPan2

HSPB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	60,953,530 - 61,001,912 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	60,985,195 - 60,985,647 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	60,720,671 - 60,825,699 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	61,446,367 - 61,551,465 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	4	61,225,186 - 61,330,105 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	61,352,336 - 61,426,819 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	61,871,138 - 61,976,297 (-)	NCBI		UU_Cfam_GSD_1.0

HSPB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	33,716,626 - 33,719,018 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	33,716,458 - 33,717,402 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	35,787,723 - 35,788,802 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSPB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	50,732,737 - 50,733,744 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	50,733,157 - 50,733,609 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666082	343,576 - 347,073 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hspb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	4,933,197 - 4,933,655 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	4,933,086 - 4,933,828 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002189 ⟹ ENSSTOP00000022795

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936480	13,178,022 - 13,178,480 (-)	Ensembl

RefSeq Acc Id:

XM_005319638 ⟹ XP_005319695

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	204,240,935 - 204,242,322 (-)	NCBI
SpeTri2.0	NW_004936480	13,177,430 - 13,178,824 (-)	NCBI

Sequence:

show sequence

AATGCCCCTTTGGAGTCCCACTTTCTCTTGAAGTAAGCAAGGCAGACACATTTGCCAAGGATAA
CTGAGACTGTAAGAGCAGCCCTTGACTGGGCAGCTTGTGCAGGCTGCTGTGTGGCTAAATGCAA
CTCGGAAACATGCCCTATAAATAGCCCTTCATTGTCAGCCTGTGTGAAAAGACAAGAGTGAGTG
TGCGTGGTCTGATTCAGGCCTAATGAAGTGGTTTCCTCTGGGCAGAGCTATAAACCCAGTAGCT
GCTCTGTCTGGGAATCTAGTCAGAAGGCAACTGCAAGCGTTCACCACTCTCTGAAGGGAAGCTC
TTCCATGCTGGCTTTGCCTCCACTATGGCAAAAATCATTTTGAGGCATCTCATAGAAACTCCAG
TGCGTTACCAGGAGGAGTTTGAAGCTCGGGGTTTGGAAGACTGCAGACTGGATCATGCTCTATA
TGCACTGCCTGGGCCAACCATCGTGGACCTGAGAAAAGTCAGAGCCGTGCCGCAATCTCTTCCA
GTGGACTCAGCAACCACAGAGACGCCACCCCAAGAAGGCAAATCCCGCTTTCAAATTCTGCTGG
ATGTGGTCCAGTTCCTCCCCGAAGATATCATCATTCAGACCTTCGAGGGCTGGCTGCTGATTAA
AGCTCAACATGGAACCAGAATGGATGAGCATGGTTTCATCTCACGAAGCTTCACCCGACAGTAC
AAACTGCCAGATGGCGTTGAAACCAAAGATTTGTCTGCCATCCTCTGTCATGATGGAATTCTGG
TGGTGGAAGTAAAGGATCCGCTTGAGACTAAGTGAAACCTTATCGGGGTTCCTGATCCTAGGAT
ATGAGGAAGATGTTCTATGGATGGTACCACCGGAATTTTTGTGTTACCCACGTTTGAAATAATT
TGCTATGACTTTTATGAAGGTTAAAAATATATACATAGTTCCTGGTATGTTGAAGATGTTTTTA
TTATTCTTATGCCGAAAGAGAAATTGTTAAATATGTTTGTGCAGTTCAAACTAATGGTATTCTT
ACAAGGAAAACATTGAACCTTTAGGAGACTGTACATTGATACTAGAGAAGTCTCAGAATTGTTT
CTTAATGACTCCAACAATGCTAGACAGGCTATGTTTTTATAATTCATGGCAAAGAGTGTTCTCA
CTTAAGGAATCCTTTTCCATTTTGTGAAGATTTTTATACTGCTAAAAAGAGTTGTGATTCCCTT
CACTTGATAGGCTTTTCTTTTCAGTGAATTTTAATTAAAGTGGAGTTTTATAAATATGGAGTGT
GAAAGTTAAAATACAGCACTTGGAAACTGAGTGTGAAATTTATTTATGATTCATGATAGTTGTT
ACTGCCTTAAATATCAGTTGGAAAATCCAAATAAAAGTATTATTCTTAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319695	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022795.1
GenBank Protein	KAG3266692	(Get FASTA)	NCBI Sequence Viewer
	KAG3266693	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005319695 ⟸ XM_005319638
- UniProtKB:	I3NEJ8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAKIILRHLIETPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKVRAVPQSLPVDSATTET PPQEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVET KDLSAILCHDGILVVEVKDPLETK hide sequence

Ensembl Acc Id:

ENSSTOP00000022795 ⟸ ENSSTOT00000002189

Protein Domains

sHSP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002196	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002189.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.790	UniProtKB/TrEMBL
InterPro	A-crystallin/Hsp20_dom	UniProtKB/TrEMBL
	Alpha-crystallin/sHSP_animal	UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/TrEMBL
	HSPB3	UniProtKB/TrEMBL
NCBI Gene	Hspb3	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN BETA-3	UniProtKB/TrEMBL
	PTHR47097	UniProtKB/TrEMBL
Pfam	HSP20	UniProtKB/TrEMBL
PRINTS	ACRYSTALLIN	UniProtKB/TrEMBL
PROSITE	SHSP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49764	UniProtKB/TrEMBL
UniProt	I3NEJ8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM