Neurod2 (neuronal differentiation 2)

Advanced Search (OLGA)

Gene: Neurod2 (neuronal differentiation 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Neurod2

Name:

neuronal differentiation 2

RGD ID:

12541558

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN associative learning (ortholog); behavioral fear response (ortholog); neuron development (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 72 (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neurogenic differentiation factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	22,271,242 - 22,273,510 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	14,802,275 - 14,803,423 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	14,801,636 - 14,803,437 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 72 (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

associative learning (IEA,ISO)

axon development (IEA)

behavioral fear response (IEA,ISO)

cell differentiation (IEA)

cellular response to calcium ion (IEA)

cellular response to electrical stimulus (IEA)

central nervous system development (IEA)

cerebellar cortex development (IEA)

negative regulation of synapse maturation (IEA)

nervous system development (IEA)

neuron development (IEA,ISO)

positive regulation of calcium-mediated signaling (IEA)

positive regulation of DNA-binding transcription factor activity (ISO)

positive regulation of neuron differentiation (IEA)

positive regulation of synapse maturation (IEA)

positive regulation of synaptic plasticity (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

protein ubiquitination (IEA)

regulation of DNA-templated transcription (IEA)

sensory organ development (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

E-box binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

protein heterodimerization activity (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Neurod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	22,271,242 - 22,273,510 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	14,802,275 - 14,803,423 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	14,801,636 - 14,803,437 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEUROD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	39,603,768 - 39,607,920 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	39,603,536 - 39,609,777 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	37,760,021 - 37,764,173 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	35,013,547 - 35,017,701 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	35,014,574 - 35,017,699	NCBI
Celera	17	34,419,756 - 34,423,910 (-)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	33,553,760 - 33,557,911 (-)	NCBI		HuRef
CHM1_1	17	37,995,843 - 37,999,997 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	40,467,334 - 40,471,484 (-)	NCBI		T2T-CHM13v2.0

Neurod2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	98,216,241 - 98,220,471 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	98,216,241 - 98,220,474 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	98,325,415 - 98,329,645 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	98,325,415 - 98,329,648 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	98,186,731 - 98,190,959 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	98,142,680 - 98,145,735 (-)	NCBI		MGSCv36	mm8
Celera	11	107,979,699 - 107,983,919 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	61.75	NCBI

Neurod2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	83,820,092 - 83,824,277 (-)	NCBI		GRCr8
mRatBN7.2	10	83,323,801 - 83,327,986 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,324,442 - 83,327,986 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	88,268,712 - 88,272,256 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	87,766,799 - 87,770,343 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	83,159,451 - 83,162,995 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	86,280,865 - 86,282,681 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,280,892 - 86,282,693 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	86,077,165 - 86,091,687 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	87,097,850 - 87,111,300 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	87,112,219 - 87,114,038 (-)	NCBI
Celera	10	82,073,679 - 82,075,495 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Neurod2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	14,368,605 - 14,370,544 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEUROD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	25,346,953 - 25,351,602 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	27,241,742 - 27,246,400 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	17,680,415 - 17,685,053 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	17,899,078 - 17,900,592 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NEUROD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	22,864,708 - 22,869,044 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	22,866,212 - 22,867,360 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	22,336,643 - 22,340,973 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	23,657,923 - 23,662,258 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	23,659,425 - 23,660,573 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	22,430,480 - 22,434,810 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	22,691,526 - 22,695,854 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	22,816,657 - 22,820,987 (+)	NCBI		UU_Cfam_GSD_1.0

NEUROD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	22,709,609 - 22,713,778 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	22,709,473 - 22,713,785 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	23,162,856 - 23,166,874 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEUROD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	66,557,831 - 66,563,757 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	66,560,957 - 66,562,105 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	37,471,013 - 37,474,358 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Neurod2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	3,453,591 - 3,457,625 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	3,453,525 - 3,457,618 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005321777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000023013 ⟹ ENSSTOP00000019143

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936490	14,802,275 - 14,803,423 (-)	Ensembl

RefSeq Acc Id:

XM_005321777 ⟹ XP_005321834

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	22,271,242 - 22,273,510 (+)	NCBI
SpeTri2.0	NW_004936490	14,801,636 - 14,803,437 (-)	NCBI

Sequence:

show sequence

CGCCCTCAGGCACCATGCTGACCCGCCTGTTCAGCGAGCCCGGCCTCCTCTCGGACGTGCCCAA
ATTCGCCAGCTGGGGCGACGGCGACGACGACGAGCCGAGAAGCGACAAGGGCGACGCGCCGCCG
CAGCCGCCGCCTGCGCCCGGGCCGGGGGCTCCGGGGCCCGCCCGGGCGGCCAAACCAGTCCCCC
TGCGTGGAGAAGAGGTACCAGAGGCCACGTTGGCGGAGGTCAAGGAGGAAGGCGAGCTGGGGGG
CGAGGAGGAGGAGGAAGAGGAGGAGGAAGAAGGACTGGACGAGGCAGAGGGCGAACGGCCCAAG
AAGCGAGGTCCCAAGAAACGCAAGATGACCAAGGCGCGCCTGGAGCGCTCCAAGCTGCGGCGGC
AGAAGGCGAACGCGCGGGAGCGCAACCGCATGCACGACCTGAACGCAGCGCTGGACAACCTGCG
GAAGGTGGTGCCCTGCTACTCCAAGACGCAAAAGCTGTCCAAGATCGAGACGCTGCGCCTAGCC
AAGAACTACATCTGGGCGCTCTCGGAGATCCTGCGCTCCGGAAAGCGGCCGGATCTGGTGTCCT
ACGTGCAGACTCTGTGCAAGGGTCTGTCGCAGCCCACCACCAATCTGGTGGCTGGCTGCCTGCA
GCTCAACTCCCGCAACTTCCTCACGGAGCAGGGCGCCGACGGCACGGGCCGCTTCCACGGCTCT
GGCGGCCCATTCGCCATGCACCCCTACCCTTACCCGTGCTCGCGCCTGGCGGGCGCACAGTGCC
AGGCAGCCGGCGGCCTGGGCAGCGGTGCGGCGCACGCCCTGCGGACCCACGGCTACTGCGCCGC
CTACGAGACGCTGTATGCAGCGGCCGGAGGTGGTGGCGCGAGCCCGGACTACAACAGCTCCGAA
TACGAGGGCCCGCTCAGTCCCCCGCTGTGTCTCAATGGCAACTTCTCACTCAAGCAGGACTCGT
CGCCCGACCACGAGAAGAGCTACCACTACTCTATGCACTACTCGGCGCTGCCCGGCTCTCGGCC
CACCGGCCACGGGCTGGTCTTCGGCTCGTCGGCTGTGCGCGGGGGCGTACACTCGGAGAATCTC
TTGTCTTACGATATGCACCTTCACCACGACCGGGGCCCCATGTATGAGGAGCTCAATGCGTTTT
TCCATAACTGAGACCTCGCGCCAGTCCTTTTCTTTTTCTTTTGCCTTTGCCCGTCCCCCTGCCC
CAGCCCCGCTCCGATCGCAGGGGCACCCTCACCCACCCCGGCGGCGCCGGGTGCAGGGAGCGGG
CTGCCGGTCCTGCCGCTCTTCTGGGCAGAGCCGTCTCTTGCCTATAGGTGGCCCGTCCCAGGGG
CCTCGCTTTCCCCAGGGGACTCGCCTTCTCTTTCCCCAAAGGGTTCCCTCCCTCTCTCTCCTAG
GGAGTGCTTCTCCAGGGACCACTCTCCGGGTCCTCCCTGGAGACCCCCAACTCCCAATAACTTC
ACTTACATTTTCTCCTCCCCCTCCTCCCTGCAGGCCCAAAGGAGTTGGTCAGGGGGCAGCTGAG
CTGTGGGACGCGGTTTTCCCCTGTCATCATTATTATTTTAAAAACAGACACCAAGCTGCCGAGG
CCCGAAAGGAGCTGGGCGCCCCCTCTTTCTGGAAGAGGGCAGAAGTCAGGGCGCCTTCACCTCC
AACCCCGAATCTCCGCGTTTTGTAATTTTAATTTTGGCGGGAGGGGATGTGGATTGAGAGGAAA
GAGAGAGGCCAAGACAATTTGTAACTAGAATCCAGTTTTCCCTTTTCCTTTTTTAAAAACACAA
ACATACAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005321834	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019143.1
GenBank Protein	KAG3269083	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005321834 ⟸ XM_005321777

- UniProtKB:

I3N447 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAPGPGAPGPARAAKPVPLRGEE
VPEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANA
RERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTL
CKGLSQPTTNLVAGCLQLNSRNFLTEQGADGTGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGG
LGSGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHE
KSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN

hide sequence

Ensembl Acc Id:

ENSSTOP00000019143 ⟸ ENSSTOT00000023013

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020820	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023013.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	bHLH_transcription_factors	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Neurogenic_DUF	UniProtKB/TrEMBL
	TF_bHLH_NeuroD	UniProtKB/TrEMBL
NCBI Gene	Neurod2	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED	UniProtKB/TrEMBL
	PTHR19290:SF83	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
	Neuro_bHLH	UniProtKB/TrEMBL
PIRSF	bHLH_NeuroD	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	I3N447	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM