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Gene: Sp5 (Sp5 transcription factor) Ictidomys tridecemlineatus

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Symbol:

Sp5

Name:

Sp5 transcription factor

RGD ID:

12488415

Description:

ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN bone morphogenesis (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); post-anal tail morphogenesis (ortholog); ASSOCIATED WITH Prostatic Neoplasms (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transcription factor Sp5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	132,523,183 - 132,529,083 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936509	1,077,801 - 1,080,585 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Prostatic Neoplasms (ISO)

split hand-foot malformation 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone morphogenesis (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

post-anal tail morphogenesis (ISO)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Sp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	132,523,183 - 132,529,083 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936509	1,077,801 - 1,080,585 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	170,715,337 - 170,718,078 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	170,715,337 - 170,718,078 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	171,571,847 - 171,574,588 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	171,280,107 - 171,282,743 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	165,188,525 - 165,191,166 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	163,460,993 - 163,463,634 (+)	NCBI		HuRef
CHM1_1	2	171,578,145 - 171,580,786 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	171,192,053 - 171,195,210 (+)	NCBI		T2T-CHM13v2.0

Sp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	70,305,267 - 70,308,070 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	70,305,267 - 70,308,073 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	70,474,923 - 70,477,726 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	70,474,923 - 70,477,729 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	70,312,980 - 70,315,783 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	70,275,762 - 70,278,565 (+)	NCBI		MGSCv36	mm8
Celera	2	72,140,603 - 72,143,373 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	41.49	NCBI

Sp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	75,682,677 - 75,685,479 (+)	NCBI		GRCr8
mRatBN7.2	3	55,274,931 - 55,277,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,274,931 - 55,277,733 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	58,675,413 - 58,678,225 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,259,012 - 67,261,824 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,021,613 - 65,024,433 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	56,766,475 - 56,769,277 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	56,766,475 - 56,769,277 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	63,385,629 - 63,388,430 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	52,694,648 - 52,697,450 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	52,535,681 - 52,593,279 (+)	NCBI
Celera	3	54,831,937 - 54,834,741 (+)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

Sp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	4,076,530 - 4,080,169 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	4,076,872 - 4,079,887 (-)	NCBI	ChiLan1.0	ChiLan1.0

SP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	73,388,840 - 73,391,939 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	73,403,824 - 73,406,912 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	58,000,430 - 58,003,659 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	175,459,656 - 175,462,341 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	15,256,661 - 15,262,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	15,255,960 - 15,258,645 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	15,269,898 - 15,276,764 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	15,381,287 - 15,388,153 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	15,380,435 - 15,383,691 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	15,470,195 - 15,477,057 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	15,458,156 - 15,465,024 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	15,569,425 - 15,576,307 (+)	NCBI		UU_Cfam_GSD_1.0

SP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	76,902,387 - 76,905,022 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	76,900,138 - 76,905,024 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	86,287,246 - 86,289,259 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	56,244,579 - 56,247,770 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	56,245,295 - 56,247,186 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	143,296,852 - 143,299,907 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	8,189,236 - 8,193,232 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	8,189,795 - 8,192,247 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005324575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005324575 ⟹ XP_005324632

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	132,523,183 - 132,529,082 (+)	NCBI
SpeTri2.0	NW_004936509	1,077,801 - 1,080,585 (+)	NCBI

Sequence:

show sequence

CTTCGGGTGTCCATGCCTCGGCGGTGGCGCCCCGCTCCACAGCGAGCGGCCTCCAAGCTGTAGC
CATGGCCGCCGTGGCTGTCCTCCGGAACGACTCGCTGCAGGCCTTCCTCCAGGACCGCACCCCC
AGCGCCTCCCCGGACCTGGGCAAGCACTCGCCCCTGGCGCTGCTGGCCGCCACCTGTAGCCGGA
TCGGCCAGCCAGGCACGGCAGCGGCCCCGGACTTCCTGCAGGTGCCCTACGACCCAGCGCTGGG
CTCACCCTCCAGGCTCTTCCACCCCTGGACCGCGGACATGCCGGCGCATTCACCGGGCGCGCTG
CCTCCCCCGCATCCCAGCCTTGGGCTGACGCCACAGAAAACGCACCTGCAGCCTTCTTTTGGGG
CTGCACACGAGCTACCACTCACACCCCCAGCTGACCCCTCGTATCCTTACGAGTTCTCGCCGGT
CAAGATGCTGCCCTCGAGCATGGCAGGTCTGCCTGCCAGCTGTGCACCGGCCTACGTGCCCTAC
GCTACGCAGGCTGCCCTACCGCCAGGGTACTCCAATCTCCTACCCCCGCCGCCGCCACCGCCTC
CGCCGCCCACCTGCCGCCAGTTGTCCCCCAACCCGGCCCCCGACGACCTCCCGTGGTGGAGCAT
TCCTCAGTCGGGCGCTGGGCCAGGGGCCTCTGCGGTTCCGGGGGGCGGCCTCTCCAGCGCCTGT
GCCGGGCCCCCCCATGCTCCGCGCTTCCCTTCCTCTGCTGCCGCTGCCGCTGCTGCGGCCGCCG
CCTTGCAAAGGGGCCTGGTGTTAGGCCCGTCGGACTTTGCGCAGTACCAGAGCCAGATCGCCGC
GTTGTTGCAGACCAAGGCCCCCCTGGCGGCCACGGCCAGGAGGTGCCGCCGCTGCCGTTGCCCC
AACTGCCAGGCGGCGGGCGGCGCCCCTGAGGCGGAGCCGGGCAAGAAGAAGCAACACGTGTGCC
ACGTGCCGGGCTGCGGCAAGGTGTACGGGAAGACGTCGCATCTGAAAGCGCATCTGCGTTGGCA
CACGGGTGAGCGGCCCTTCGTGTGCAACTGGCTTTTTTGCGGCAAGAGCTTTACGCGCTCAGAC
GAGTTGCAGCGGCACCTGCGGACTCACACCGGCGAGAAACGCTTCGCCTGTCCCGAGTGTGGCA
AGCGCTTCATGCGGAGCGACCACCTTGCCAAGCACGTCAAGACGCACCAAAATAAGAAGCTCAA
AGTTGCTGAGACCGGGGTTAAGCGGGAGAACCCGCGGGACTTGTGAGCCCATCCTGGCGTGCCC
CGAGGTCACTCCCGCCTCAGACCCCCTTCTCAGTACCTCTTGCGGAGGTCCCGGGGTCTGTGGG
CAGCAGACTTAGTAGATGAACTTCAGTTGTCCGCCTCTCAAAGTAGAGCCGGGCTCCCACTTTC
CTTAGCCCTAGAATAGAGGGACGGTTGGGATCTGGGACTTGTTGGGTCATGGTTGGGATCTTGA
GTTACCCCAGGAGTGGTTCTAAACTTTGAATCATTTCCACCATCTGGGAGACCTACAGTTGGGA
CGTAACACCCAGAGCTGGCCTTGTATATAGGAAACGCTGCTGAATGAAAGCGAAAGGACCTTGG
GAGATTCTAAATATTGCTCGGGTTTTCGCTAGGATCCATTCGGACTTTGTACAGATTATTTAAT
AGCTTTGTTAAAGAATAATTATAATAATTATAACATTAATAAAATGTTTTCTTTGTCCTCAGCT
ACACGCAGAGCTACAGCATGATATGTCTCTGTAAAGCGACCAGCAGTTGCAGCGTGAAAATAAA
TACATTAGGGTCACCTTAGGAAGACCCCGCAGAGTAGATCTCATTTGATCTTTTCTTCTTCCGG
GAGGCTTTACAAAGCGGTCAGGTTTCACTGGGAATTTGATGGCTCCTGTGTGCTGCATGTGTCG
GCGGCTTCTTTGGCTTGCGAAGTCATGGCAAGCATTGGGTGCATGGATAGAAGTAGGGCAAGGT
CAGATTTGTAGTAGAGGCTAGGGTAAGATTTTCCCGTCAGTTTGAGTTTGTCCTGCGGCTTTAG
GACTTCACTGTCAGGGTTGTGTTTGCAGAAACCTTTGCAAATAACA

hide sequence

RefSeq Acc Id:

XM_040294450 ⟹ XP_040150384

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	132,523,184 - 132,529,083 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005324632	(Get FASTA)	NCBI Sequence Viewer
	XP_040150384	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015225.1
	ENSSTOP00000030963.1
GenBank Protein	KAG3274679	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005324632 ⟸ XM_005324575
- Peptide Label:	isoform X1
- UniProtKB:	I3MSY0 (UniProtKB/TrEMBL), A0A287DBP7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGTAAAPDFLQVPYDPALG SPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPV KMLPSSMAGLPASCAPAYVPYATQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSI PQSGAGPGASAVPGGGLSSACAGPPHAPRFPSSAAAAAAAAAALQRGLVLGPSDFAQYQSQIAA LLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWH TGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLK VAETGVKRENPRDL hide sequence

RefSeq Acc Id:	XP_040150384 ⟸ XM_040294450
- Peptide Label:	isoform X2
- UniProtKB:	A0A287DBP7 (UniProtKB/TrEMBL)

Protein Domains

C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008099	UniProtKB/TrEMBL
	ENSSTOG00000029574	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008086.3	UniProtKB/TrEMBL
	ENSSTOT00000039386.1	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	Sp5	ENTREZGENE
PANTHER	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR SP5	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A287DBP7	ENTREZGENE, UniProtKB/TrEMBL
	I3MSY0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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