Wfikkn2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Wfikkn2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2) Ictidomys tridecemlineatus
Analyze
Symbol: Wfikkn2
Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
RGD ID: 12472401
Description: ENCODES a protein that exhibits enzyme inhibitor activity (inferred); peptidase inhibitor activity (inferred); receptor antagonist activity (inferred); INVOLVED IN muscle cell development (ortholog); roof of mouth development (ortholog); skeletal system development (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560226,171,465 - 26,177,752 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649010,897,292 - 10,903,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649010,897,390 - 10,903,605 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wfikkn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560226,171,465 - 26,177,752 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649010,897,292 - 10,903,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649010,897,390 - 10,903,605 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WFIKKN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,834,584 - 50,842,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,834,650 - 50,842,353 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,911,945 - 48,919,714 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,267,604 - 46,274,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,267,838 - 46,274,706NCBI
Celera1745,373,930 - 45,381,027 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,279,935 - 44,287,032 (+)NCBIHuRef
CHM1_11748,976,713 - 48,983,810 (+)NCBICHM1_1
T2T-CHM13v2.01751,701,726 - 51,709,488 (+)NCBIT2T-CHM13v2.0
Wfikkn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,126,777 - 94,138,613 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,126,782 - 94,136,831 (-)EnsemblGRCm39 Ensembl
GRCm381194,235,951 - 94,247,793 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,235,956 - 94,246,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,097,266 - 94,103,893 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,053,688 - 94,058,639 (-)NCBIMGSCv36mm8
Celera11103,853,093 - 103,859,772 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Wfikkn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,682,459 - 79,688,553 (-)NCBIGRCr8
mRatBN7.21079,185,563 - 79,191,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,186,647 - 79,191,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,790,637 - 83,796,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,288,759 - 83,294,849 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,803,077 - 78,809,171 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,936,156 - 81,943,142 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,936,444 - 81,942,188 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,770,066 - 81,776,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,875,905 - 82,880,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11082,890,432 - 82,895,216 (-)NCBI
Celera1077,974,533 - 77,977,705 (-)NCBICelera
Cytogenetic Map10q26NCBI
Wfikkn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545110,976,700 - 10,982,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545110,976,748 - 10,982,482 (-)NCBIChiLan1.0ChiLan1.0
WFIKKN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21967,022,496 - 67,030,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,829,550 - 71,837,231 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,924,892 - 44,932,578 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,796,740 - 49,804,166 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,797,334 - 49,805,569 (+)Ensemblpanpan1.1panPan2
WFIKKN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,711,470 - 26,717,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,711,959 - 26,716,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0927,504,998 - 27,511,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,505,641 - 27,511,624 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,271,858 - 26,278,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,530,696 - 26,537,340 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,661,168 - 26,667,806 (+)NCBIUU_Cfam_GSD_1.0
WFIKKN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1227,093,679 - 27,100,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11227,093,241 - 27,100,423 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,281,710 - 27,288,914 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFIKKN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,503,547 - 42,513,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,504,880 - 42,509,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,216,922 - 13,225,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wfikkn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,669,926 - 6,675,318 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,669,114 - 6,675,254 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005321625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000027226   ⟹   ENSSTOP00000015503
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649010,897,292 - 10,903,765 (-)Ensembl
RefSeq Acc Id: XM_005321625   ⟹   XP_005321682
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560226,171,465 - 26,177,752 (+)NCBI
SpeTri2.0NW_00493649010,897,390 - 10,903,605 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321682 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015503.2
GenBank Protein KAG3269269 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005321682   ⟸   XM_005321625
- UniProtKB: I3MTQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000015503   ⟸   ENSSTOT00000027226
Protein Domains
BPTI/Kunitz inhibitor   Ig-like   Kazal-like   NTR   WAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021096 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027226.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
  WAP_dom UniProtKB/TrEMBL
  WFIKKN1/2 UniProtKB/TrEMBL
NCBI Gene Wfikkn2 ENTREZGENE
PANTHER ACP24A4-RELATED UniProtKB/TrEMBL
  WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00131 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF50242 UniProtKB/TrEMBL
  SSF57256 UniProtKB/TrEMBL
  SSF57362 UniProtKB/TrEMBL
UniProt I3MTQ8 ENTREZGENE, UniProtKB/TrEMBL