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Gene: Hsf2 (heat shock transcription factor 2) Ictidomys tridecemlineatus

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Symbol:

Hsf2

Name:

heat shock transcription factor 2

RGD ID:

12463109

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); epilepsy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock factor protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	112,680,808 - 112,706,663 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936802	1,369,956 - 1,394,033 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936802	1,369,232 - 1,396,722 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

spermatogenesis (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA)

identical protein binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Hsf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	112,680,808 - 112,706,663 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936802	1,369,956 - 1,394,033 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936802	1,369,232 - 1,396,722 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	122,399,551 - 122,433,119 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	122,399,551 - 122,433,119 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	122,720,696 - 122,754,264 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	122,762,494 - 122,795,810 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	122,762,493 - 122,795,810	NCBI
Celera	6	123,464,983 - 123,498,552 (+)	NCBI		Celera
Cytogenetic Map	6	q22.31	NCBI
HuRef	6	120,297,677 - 120,331,266 (+)	NCBI		HuRef
CHM1_1	6	122,984,511 - 123,018,082 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	123,587,813 - 123,621,398 (+)	NCBI		T2T-CHM13v2.0

Hsf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	57,359,862 - 57,389,239 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	57,362,481 - 57,389,231 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	57,483,766 - 57,513,143 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	57,486,385 - 57,513,135 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	57,206,191 - 57,232,949 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	57,174,901 - 57,201,550 (+)	NCBI		MGSCv36	mm8
Celera	10	58,304,915 - 58,331,733 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	29.19	NCBI

Hsf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	37,366,301 - 37,393,922 (+)	NCBI		GRCr8
mRatBN7.2	20	36,819,864 - 36,847,490 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	36,819,864 - 36,850,174 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	37,839,384 - 37,867,393 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	37,230,068 - 37,258,090 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	37,957,121 - 37,985,145 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	38,935,820 - 38,963,444 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	38,935,820 - 38,963,309 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	40,673,635 - 40,701,259 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	36,520,685 - 36,538,506 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	36,534,484 - 36,552,286 (+)	NCBI
Celera	20	38,134,605 - 38,162,082 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

Hsf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	4,387,495 - 4,408,497 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	4,387,498 - 4,406,719 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	142,393,458 - 142,427,008 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	140,292,704 - 140,326,257 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	120,187,898 - 120,221,391 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	124,312,458 - 124,345,913 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	124,312,353 - 124,348,628 (+)	Ensembl	panpan1.1		panPan2

HSF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	61,777,297 - 61,809,208 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	61,789,720 - 61,808,793 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	62,586,078 - 62,626,997 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	61,980,494 - 62,021,429 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	61,980,455 - 62,022,669 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	61,915,228 - 61,956,121 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	61,702,424 - 61,743,310 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	62,351,349 - 62,392,345 (+)	NCBI		UU_Cfam_GSD_1.0

HSF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	40,147,164 - 40,180,297 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	40,147,267 - 40,180,308 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	44,452,505 - 44,545,206 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	51,363,650 - 51,401,765 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	51,364,389 - 51,401,640 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	23,663,584 - 23,701,505 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	8,647,893 - 8,674,082 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624798	8,646,936 - 8,674,181 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000007465 ⟹ ENSSTOP00000006670

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936802	1,369,956 - 1,394,033 (-)	Ensembl

RefSeq Acc Id:

XM_021720378 ⟹ XP_021576053

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	112,680,808 - 112,706,663 (+)	NCBI
SpeTri2.0	NW_004936802	1,369,232 - 1,396,722 (-)	NCBI

Sequence:

show sequence

ATGCCGCCAATTTATGCTTCTTTTTCTTCTTTTAAGTACATATCTATAACAGGAATTGCTGGAT
ATTATAGTGATTGTTTTAATTTTTTGAGGAACTACTATACTCTTTCCATAGTAGCCACACTTTT
ATATTCCATTGGCAATTCACACGAGTTCAAATTTCTCCACATCTTCATCAATACTTATTTTTTG
TTTTTTGCTCTTGACCATCTTAATGGCTACGAAGTAAATGGCCAAAGTTTTCTGGTCTTGGATG
AACAAAGATTTGCAAAAGAAATTCTTCCAAAATACTTCAAGCACAATAACATGGCAAGCTTTGT
AAGGCAACTAAATATGTATGGTTTCCGTAAAGTAGTACATATTGACTCTGGAATAGTAAAGCAG
GAAAGAGATGGTCCTGTTGAATTTCAGCATCCTTACTTCAAACAAGGCCAGGATGACTTGTTGG
AGAACATTAAAAGGAAGGTTTCATCTTCAAAACCAGAAGAAAATAAAATTCGCCAGGAAGATTT
AACAAAAATTATAAGTAGTGCTCAGAAGGTTCAAATAAAACAGGAAACAATTGAGTCCAGACTT
TCAGAATTAAAAAGTGAGAATGAGTCCCTTTGGAAGGAGGTGTCTGAATTAAGAGCAAAGCATG
CACAGCAGCAACAGGTTATTCGAAAGATTGTCCAATTTATTGTTACATTGGTTCAGAATAACCA
ACTTGTGAGTTTAAAACGCAAAAGGCCTCTACTTCTGAACACTAATGGAGCCCAGAAGAAGAAT
TTATTTCAGCACATAGTCAAAGAACCAGCTGATAATCATCATCATAAAGTTCCACACAGTAGAA
CTGAAGGTTTAAAGCCAAGAGAGCGGATTTCAGATGACATTATTATTTATGATGTTACTGATGA
TAATGCGGATGAAGAAAATATCCCAGTTATTCCAGAAACTAATGAGGATGTTATATCTGATCCC
TCCAACTGTAGCCAGTACCCTGATATTGTCATTGTTGAAGATGACAATGAAGATGAGTATGCAC
CTGTCATTCAGAGTGGAGATCTGAGTGAACCAGCCAGAGAATCCCTAAGTTCAGGCAGTGATGG
CATCAACCCTCTCATGTCTAGTGCTGTCCAGCTAAATGGTTCATCCAGTCTGACCACAGAAGAT
CCTGTGACCATGATGGATTCCATTTTGAATGATAACATCAATCTTTTAGGAAAGGTTGAACTGT
TGGATTATCTTGATAGTATTGATTGCAGTTTAGAGGACTTCCAAGCTATGCTGTCAGGAAGACA
GTTTAGCATAGACCCAGATCTCCTGGTTGATCTTTTCACTAGTTCTGTGCAGATGAATCCCACA
GATTACATCAATAATACAAAATCTGAGAATAAAGGATTAGAAGCTACCAAGAACAATGTAGTTC
AACCAGTTTCAGAAGAAGGAAGAAAATCTAAGTCTAAACCAGATAAGCAGCTTATCCAGTACAC
TGCCTTTCCACTTCTTGCATTCCTCGATGGGAATCCTGCTTCTGCTGTTGAACAGGGGAGTACA
ACAGCATCATCAGAAGTTATGTCCTCTGTAGATAAACCCATAGAAGTCGATGAGCTTTTGGATA
GCAGCCTGGACCCAGAACCAACCCAAAGTAAGCTTGTTCGCCTGGAGCCATTGACTGAAGCTGA
AGCTAGTGAAGCTACACTGTTTTATTTATGTGAACTTGCTCCTGCACCTCTGGATAGTGACATG
CCACTTTTAGATAGCTAAATCCCTAAGAAGTGGACTCAACATGTATATATTCATCAAAATGATG
AACTATTTATTTTAAAGTATCATTTGGTACTTTTCTTTTGTAAATTGCTTTGTTTTGTTTAATC
AGATACTGTGGAATAAAAGCACCTTTTGCTTTTCTCACTAACCATACACTCTTGCAAAGCTTTG
AAATGTTACTCAGCTGCCTAGATATACACAAAATTCAGTGCACATTATTGACAAATCTTTAAGT
TGGATTCAGATGGCCATTTTTCTCCAGTTGTAATTTGGATTTCATTTTACAGATATGACCATTA
ACAACAGTTATTTTTGTTTTACTTGTTTGATGGTGTCTGTCTGCGTTTGAGCGTAAGTCACTAG
AACTAATGATAGAACTTCTAAAGCTTTCTCTGTTCCAATTATTTTTATTAAATATTTTTCACTT
GGCTTATTTTTAAAACTGGGAACATAAAGTGCCTGTATCTTGTAAAACTTCATTTGTCTCTCTT
GGTTCGAAGAAGTTCATTTATGTTTGGAGTTCATTCATGTTCAACAGGAAGTGCAAAGTGTACA
CAAATACTCACTGATATGGTTCCAGCTCCATATATATAGAAAAAATGTGGGGATGAGTTGGGAG
TCTCATCCACTTAGTTGGACTAGTTTTAAGTAAAAGTTTTCTGGTTTTGTGTTTTTTTGAACCA
TACTATTTAGTAAAATAAATAATAATGAATGTTGAGTA

hide sequence

RefSeq Acc Id:

XM_040283243 ⟹ XP_040139177

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	112,680,808 - 112,706,663 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_021576053	(Get FASTA)	NCBI Sequence Viewer
	XP_040139177	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006670.3
GenBank Protein	KAG3290156	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021576053 ⟸ XM_021720378

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPPIYASFSSFKYISITGIAGYYSDCFNFLRNYYTLSIVATLLYSIGNSHEFKFLHIFINTYFL
FFALDHLNGYEVNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYGFRKVVHIDSGIVKQ
ERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRL
SELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAQKKN
LFQHIVKEPADNHHHKVPHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDP
SNCSQYPDIVIVEDDNEDEYAPVIQSGDLSEPARESLSSGSDGINPLMSSAVQLNGSSSLTTED
PVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPT
DYINNTKSENKGLEATKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASAVEQGST
TASSEVMSSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDM
PLLDS

hide sequence

RefSeq Acc Id:	XP_040139177 ⟸ XM_040283243
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000006670 ⟸ ENSSTOT00000007465

Protein Domains

HSF-type DNA-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007461	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007465.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	HSF_DNA-bd	UniProtKB/TrEMBL
	Vert_HSTF_C	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Hsf2	ENTREZGENE
PANTHER	PTHR10015	UniProtKB/TrEMBL
	PTHR10015:SF185	UniProtKB/TrEMBL
Pfam	HSF_DNA-bind	UniProtKB/TrEMBL
	Vert_HS_TF	UniProtKB/TrEMBL
PRINTS	HSFDOMAIN	UniProtKB/TrEMBL
PROSITE	HSF_DOMAIN	UniProtKB/TrEMBL
SMART	HSF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	I3M9S4_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD